The Mid-Infrared Instrument for the James Webb Space Telescope, V: Predicted Performance of the MIRI Coronagraphs

The imaging channel on the Mid-Infrared Instrument (MIRI) is equipped with four coronagraphs that provide high contrast imaging capabilities for studying faint point sources and extended emission that would otherwise be overwhelmed by a bright point-source in its vicinity. Such bright sources might include stars that are orbited by exoplanets and circumstellar material, mass-loss envelopes around post-main-sequence stars, the near-nuclear environments in active galaxies, and the host galaxies of distant quasars. This paper describes the coronagraphic observing modes of MIRI, as well as performance estimates based on measurements of the MIRI flight model during cryo-vacuum testing. A brief outline of coronagraphic operations is also provided. Finally, simulated MIRI coronagraphic observations of a few astronomical targets are presented for illustration

The effect of communication between the right and left liver on the outcome of surgical drainage for jaundice due to malignant obstruction at the hilus of the liver

Debate continues regarding the optimal management of irresectable malignant proximal biliary obstruction. Controversy exists concerning the ability of unilateral drainage to provide adequate biliary decompression with tumors that have occluded the communication between the right and left hepatic ductal systems. Between October 1986 and October 1989, 18 patients with malignant proximal biliary obstruction were treated by an intrahepatic biliary enteric bypass. Patients were divided into two groups based on the presence or absence of a communication between the right and left biliary systems. In Group I (n = 9), there was free communication; and in Group II (n = 9) there was no communication. There were two perioperative deaths (11%) one due to persistent cholangitis and the other to myocardial insufficiency both with one death in each group. The median survival (excluding perioperative deaths) was 5.6 months. Comparison of pre- and postoperative serum levels of bilirubin and alkaline phosphatase showed a significant decrease in each group, but no difference between the groups in the size of the reduction. Sixteen patients survived at least three months and the palliation was judged as excellent in eight, fair in five, and unchanged in three. These results demonstrate the effectiveness of biliary enteric bypass regardless of communication between the left and right biliary ductal systems.H. U. Baer, M. Rhyner, S. C. Stain, P. W. Glauser, A. R. Dennison, G. J. Maddern, and L. H. Blumgar

Lipopolysaccharide (LPS)-binding protein in human serum determines the tumor necrosis factor response of monocytes to LPS

Lipopolysaccharide (LPS)-binding protein (LBP) and CD14 represent key elements in monocyte activation by LPS. The mean concentration of LBP was 18.1 microgram/mL in normal serum and 40-60 micrograms/mL in serum of patients with septic shock, independent of the fact that patients had gram-negative or other infections. Ten percent normal serum presented large concentrations of LPS (in the microgram range) to monocytes. Only when diluted 1:100 was LBP in plasma a limiting factor for monocyte activation, as measured by tumor necrosis factor (TNF) release. When LBP was depleted from serum with anti-LBP antibodies, the resulting serum did not support TNF release of monocytes upon LPS challenge. In conclusion, monocyte activation resulting in TNF secretion was related to LBP, which is abundantly present in normal serum, and elevated two to three times in patients with septic shock

Treatment options of invasive fungal infections in adults.

A panel of infectious disease specialists, clinical microbiologists and hospital epidemiologists of the five Swiss university hospitals reviewed the current literature on the treatment of invasive fungal infections in adults and formulated guidelines for the management of patients in Switzerland. For empirical therapy of Candida bloodstream infection, fluconazole is the drug of choice in non-neutropenic patients with no severe sepsis or septic shock or recent exposure to azoles. Amphotericin B deoxycholate or caspofungin would be the treatment option for patients with previous azole exposure. In neutropenic patients, empirical therapy with amphotericin B deoxycholate is considered first choice. In patients with severe sepsis and septic shock, caspofungin is the drug of first choice. For therapy of microbiologically-documented Candida infection, fluconazole is the drug of choice for infections due to C. albicans, C. tropicalis or C. parapsilosis. When infections are caused by C. glabrata or by C. krusei, caspofungin or amphotericin B deoxycholate are first line therapies. Treatment guidelines for invasive aspergillosis (IA) were stratified into primary therapy, salvage therapy and combination therapy in critically ill patients. Voriconazole is recommended for primary (ie upfront) therapy. Caspofungin, voriconazole (if not used for primary therapy) or liposomal amphotericin B are recommended for salvage therapy for refractory disease. Combination therapy with caspofungin plus voriconazole or liposomal amphotericin B should be considered in critically ill patients. Amphotericin B deoxycholate is recommended as initial therapy for the empirical therapy in patients with neutropenia and persistent fever with close monitoring of adverse events

Characterizing Exoplanets in the Visible and Infrared: A Spectrometer Concept for the EChO Space Mission

Transit-spectroscopy of exoplanets is one of the key observational techniques to characterize the extrasolar planet and its atmosphere. The observational challenges of these measurements require dedicated instrumentation and only the space environment allows an undisturbed access to earth-like atmospheric features such as water or carbon-dioxide. Therefore, several exoplanet-specific space missions are currently being studied. One of them is EChO, the Exoplanet Characterization Observatory, which is part of ESA's Cosmic Vision 2015-2025 program, and which is one of four candidates for the M3 launch slot in 2024. In this paper we present the results of our assessment study of the EChO spectrometer, the only science instrument onboard this spacecraft. The instrument is a multi-channel all-reflective dispersive spectrometer, covering the wavelength range from 400 nm to 16 microns simultaneously with a moderately low spectral resolution. We illustrate how the key technical challenge of the EChO mission - the high photometric stability - influences the choice of spectrometer concept and drives fundamentally the instrument design. First performance evaluations underline the fitness of the elaborated design solution for the needs of the EChO mission.Comment: 20 pages, 8 figures, accepted for publication in the Journal of Astronomical Instrumentatio

The Taurus Spitzer Survey: New Candidate Taurus Members Selected Using Sensitive Mid-Infrared Photometry

We report on the properties of pre-main-sequence objects in the Taurus molecular clouds as observed in 7 mid- and far-infrared bands with the Spitzer Space Telescope. There are 215 previously-identified members of the Taurus star-forming region in our ~44 square degree map; these members exhibit a range of Spitzer colors that we take to define young stars still surrounded by circumstellar dust (noting that ~20% of the bonafide Taurus members exhibit no detectable dust excesses). We looked for new objects in the survey field with similar Spitzer properties, aided by extensive optical, X-ray, and ultraviolet imaging, and found 148 candidate new members of Taurus. We have obtained follow-up spectroscopy for about half the candidate sample, thus far confirming 34 new members, 3 probable new members, and 10 possible new members, an increase of 15-20% in Taurus members. Of the objects for which we have spectroscopy, 7 are now confirmed extragalactic objects, and one is a background Be star. The remaining 93 candidate objects await additional analysis and/or data to be confirmed or rejected as Taurus members. Most of the new members are Class II M stars and are located along the same cloud filaments as the previously-identified Taurus members. Among non-members with Spitzer colors similar to young, dusty stars are evolved Be stars, planetary nebulae, carbon stars, galaxies, and AGN.Comment: Accepted to ApJS. Two large online-only figures available with the preprint here: http://web.ipac.caltech.edu/staff/rebull/research.htm

Dust amorphization in protoplanetary disks

High-energy irradiation of the circumstellar material might impact the structure and the composition of a protoplanetary disk and hence the process of planet formation. In this paper, we present a study on the possible influence of the stellar irradiation, indicated by X-ray emission, on the crystalline structure of the circumstellar dust. The dust crystallinity is measured for 42 class II T Tauri stars in the Taurus star-forming region using a decomposition fit of the 10 micron silicate feature, measured with the Spitzer IRS instrument. Since the sample includes objects with disks of various evolutionary stages, we further confine the target selection, using the age of the objects as a selection parameter. We correlate the X-ray luminosity and the X-ray hardness of the central object with the crystalline mass fraction of the circumstellar dust and find a significant anti-correlation for 20 objects within an age range of approx. 1 to 4.5 Myr. We postulate that X-rays represent the stellar activity and consequently the energetic ions of the stellar winds which interact with the circumstellar disk. We show that the fluxes around 1 AU and ion energies of the present solar wind are sufficient to amorphize the upper layer of dust grains very efficiently, leading to an observable reduction of the crystalline mass fraction of the circumstellar, sub-micron sized dust. This effect could also erase other relations between crystallinity and disk/star parameters such as age or spectral type.Comment: accepted for publication by A&

The circumstellar disc in the Bok globule CB 26: Multi-wavelength observations and modelling of the dust disc and envelope

Circumstellar discs are expected to be the nursery of planets. Grain growth within such discs is the first step in the planet formation process. The Bok globule CB 26 harbours such a young disc. We present a detailed model of the edge-on circumstellar disc and its envelope in the Bok globule CB 26. The model is based on HST near-infrared maps in the I, J, H, and K bands, OVRO and SMA radio maps at 1.1mm, 1.3mm and 2.7mm, and the spectral energy distribution (SED) from 0.9 microns to 3mm. New photometric and spectroscopic data from the Spitzer Space Telescope and the Caltech Submilimeter Observatory have been obtained and are part of our analysis. Using the self-consistent radiative transfer code MC3D, the model we construct is able to discriminate parameter sets and dust properties of both its parts, namely envelope and disc. We find that the disc has an inner hole with a radius of 45 +/- 5 AU. Based on a dust model including silicate and graphite the maximum grain size needed to reproduce the spectral millimetre index is 2.5 microns. Features seen in the near-infrared images, dominated by scattered light, can be described as a result of a rotating envelope. Successful employment of ISM dust in both the disc and envelope hint that grain growth may not yet play a significant role for the appearance of this system. A larger inner hole gives rise to the assumption that CB 26 is a circumbinary disc.Comment: 18 pages, 15 figures, Accepted for publication in A&