17 research outputs found
Inverse Design of All-dielectric Metasurfaces with Bound States in the Continuum
Metasurfaces with bound states in the continuum (BICs) have proven to be a
powerful platform for drastically enhancing light-matter interactions,
improving biosensing, and precisely manipulating near- and far-fields. However,
engineering metasurfaces to provide an on-demand spectral and angular position
for a BIC remains a prime challenge. A conventional solution involves a fine
adjustment of geometrical parameters, requiring multiple time-consuming
calculations. In this work, to circumvent such tedious processes, we develop a
physics-inspired, inverse design method on all-dielectric metasurfaces for an
on-demand spectral and angular position of a BIC. Our suggested method predicts
the core-shell particles that constitute the unit cell of the metasurface,
while considering practical limitations on geometry and available materials.
Our method is based on a smart combination of a semi-analytical solution, for
predicting the required dipolar Mie coefficients of the meta-atom, and a
machine learning algorithm, for finding a practical design of the meta-atom
that provides these Mie coefficients. Although our approach is exemplified in
designing a metasurface sustaining a BIC, it can, also, be applied to many more
objective functions. With that, we pave the way toward a general framework for
the inverse design of metasurfaces in specific and nanophotonic structures in
general.Comment: 20 pages, 5 figures, Supplementary Materia
Inverse design of all-dielectric metasurfaces with accidental bound states in the continuum
Metasurfaces with bound states in the continuum (BICs) have proven to be a powerful platform for drastically enhancing light–matter interactions, improving biosensing, and precisely manipulating near- and far-fields. However, engineering metasurfaces to provide an on-demand spectral and angular position for a BIC remains a prime challenge. A conventional solution involves a fine adjustment of geometrical parameters, requiring multiple time-consuming calculations. In this work, to circumvent such tedious processes, we develop a physics-inspired, inverse design method on all-dielectric metasurfaces for an on-demand spectral and angular position of a BIC. Our suggested method predicts the core–shell particles that constitute the unit cell of the metasurface, while considering practical limitations on geometry and available materials. Our method is based on a smart combination of a semi-analytical solution, for predicting the required dipolar Mie coefficients of the meta-atom, and a machine learning algorithm, for finding a practical design of the meta-atom that provides these Mie coefficients. Although our approach is exemplified in designing a metasurface sustaining a BIC, it can, also, be applied to many more objective functions. With that, we pave the way toward a general framework for the inverse design of metasurfaces in specific and nanophotonic structures in general
The open-air site of Tolbor 16 (Northern Mongolia): Preliminary results and perspectives.
Numerous questions remain regarding the timing and the context of Upper Paleolithic emergence in Northeast Asia. Available data allow the recognition of a form of Initial Upper Paleolithic (IUP) documented in the Altai circa 45e40 ka 14C BP, and in the Cis- and Transbaikal around �37 ka 14C BP. In Northern Mongolia, a series of assemblages show intriguing similarities with IUP laminar assemblages from South Siberia and suggest long distance contact/movements of population during the first half of MIS3. These contacts are potentially enabled by the main river that drains into Lake Baikal, the Selenga. By cutting through the Sayan and the Yablonovy mountain ranges, the Selenga drainage system provides a potential corridor connecting South Siberia with the plains of Mongolia. The Tolbor 16 site (Ikh Tulberiin
Gol, Northern Mongolia) is located circa 13 km from the confluence with the Selenga. The first results presented here suggest that the lithic assemblage and the ornaments discovered at Tolbor 16 document the early appearance of Upper Paleolithic in the region. This newly discovered site offers the possibility to generate high-resolution contextual data on the first appearance of the blade assemblages in Mongolia and to test the ‘Selenga corridor hypothesis’
Coordination of selenium to molybdenum in formate dehydrogenase H from \u3ci\u3eEscherichia coli\u3c/i\u3e
Formate dehydrogenase H from Escherichia col contains multiple redox centers, which include a molybdopterin cofactor, an iron-sulfur center, and a selenocysteine residue (SeCys-140 in the polypeptide chain) that is essential for catalytic activity. Here we show that addition of formate to the native enzyme induces a signal typical of Mo(V) species. This signal is detected by electron pm etc resonance (EPR) spectroscopy. Substitution of 77Se for natural isotope abundance Se leads to transformation of this signal, indicating a direct coordination of Se with Mo. Mutant enzyme with cysteine substituted at position 140 for the selenocysteine residue has decreased catalytic activity and exhibits a different EPR signal. Since deternation of the Se content of wild-type enzyme indicates 1 gram atom per mol, we conclude that it is the Se atom of the SeCys-140 residue in the protein that is coordinated directly with Mo. The amino acd sequence flanking the selenocysteine residue in formate dehydrogenase H is s r to a conserved sequence found in several other prokaryotic molybdopterin-dependent enzymes. In most of these other enzymes a cysteine residue, or in a few cases a serine or a selenocysteine residue, occurs in the position corresonding to SeCys-140 of formate dehydrogeme H. By analogy with formate dehydrogenase H in these other enzymes, at least one of the ilgands to Mo should be provided by an amino acid residue of the protein. This igand could be the Se of a selenocysteine residue, sulfur of a cysteine residue, or, in the case of a serine residue, oxygen
Crystal Structure of Formate Dehydrogenase H: Catalysis Involving Mo, Molybdopterin, Selenocysteine, and an Fe\u3csub\u3e4\u3c/sub\u3eS\u3csub\u3e4\u3c/sub\u3e Cluster
Formate dehydrogenase H from Escherichia coli contains selenocysteine (SeCys), molybdenum, two molybdopterin guanine dinucleotide (MGD) cofactors, and an Fe4S4 cluster at the active site and catalyzes the two-electron oxidation of formate to carbon dioxide. The crystal structures of the oxidized [Mo( VI), Fe4S4(ox)] form of formate dehydrogenase H (with and without bound inhibitor) and the reduced [Mo(IV ), Fe4S4(red)] form have been determined, revealing a four-domain ab structure with the molybdenum directly coordinated to selenium and both MGD cofactors. These structures suggest a reaction mechanism that directly involves SeCys140 and His141 in proton abstraction and the molybdenum, molybdopterin, Lys44, and the Fe4S4 cluster in electron transfer
Characterization of Crystalline Formate Dehydrogenase H from \u3ci\u3eEscherichia coli\u3c/i\u3e
The selenocysteine-containing formate dehydrogenase H (FDH) is an 80-kDa component of the Escherichia coli formate-hydrogen lyase complex. The molybdenumcoordinated selenocysteine is essential for catalytic activity of the native enzyme. FDH in dilute solutions (30 μg/ml) was rapidly inactivated at basic pH or in the presence of formate under anaerobic conditions, but at higher enzyme concentrations ( 3 mg/ml) the enzyme was relatively stable. The formate-reduced enzyme was extremely sensitive to air inactivation under all conditions examined. Active formate-reduced FDH was crystallized under anaerobic conditions in the presence of ammonium sulfate and PEG 400. The crystals diffract to 2.6 Å resolution and belong to a space group of P41212 or P43212 with unit cell dimensions a = b = 146.1 Å and c = 82.7 Å. There is one monomer of FDH per crystallographic asymmetric unit. Similar diffraction quality crystals of oxidized FDH could be obtained by oxidation of crystals of formate-reduced enzyme with benzyl viologen. By EPR spectroscopy, a signal of a single reduced FeS cluster was found in a crystal of reduced FDH, but not in a crystal of oxidized enzyme, whereas Mo(V) signal was not detected in either form of crystalline FDH. This suggests that Mo(IV)- and the reduced FeS cluster-containing form of the enzyme was crystallized and this could be converted into Mo(VI)- and oxidized FeS cluster form upon oxidation. A procedure that combines anaerobic and cryocrystallography has been developed that is generally applicable to crystallographic studies of oxygen-sensitive enzymes. These data provide the first example of crystallization of a substrate-reduced form of a Se- and Mo-containing enzyme
Bound States in the Continuum in Multipolar Lattices
We develop a theory of bound states in the continuum (BICs) in multipolar
lattices -- periodic arrays of resonant multipoles. We predict that BICs are
completely robust to changes in lattice parameters remaining pinned to specific
directions in the -space. The lack of radiation for BICs in such structures
is protected by the symmetry of multipoles forming the lattice. We also show
that some multipolar lattices can host BICs forming a continuous line in the
-space and such BICs carry zero topological charge. The developed approach
sets a direct fundamental relation between the topological charge of BIC and
the asymptotic behavior of the Q-factor in its vicinity. We believe that our
theory is a significant step towards gaining deeper insight into the physics of
BICs and the engineering of high-Q states in all-dielectric metasurfaces.Comment: 7 pages, 4 figures, Supplemental materia