Gestión del talento humano y satisfacción laboral de los docentes en la IE 3945 Ugel 02, Lima – 2021

La investigación tuvo como objetivo determinar la relación que existe entre gestión del talento humano y satisfacción laboral de los docentes en la IE 3045 UGEL 02, Lima 2021. La metodología de esta investigación fue correlacional, con un enfoque cuantitativo, de tipo básica, no experimental y transversal. Para ello se trabajó con una muestra de 60 docentes, por medio de la técnica de la encuesta y el instrumento del cuestionario, compuesto por 33 ítems. Los resultados obtenidos determinaron que la relación es significativa entre la gestión del talento humano y la satisfacción laboral de los docentes de IE 3045 UGEL 02, Lima – 2021, porque se obtuvo un valor igual a 0.00 < 0.05 con un coeficiente de correlación Rho Spearman 0, 556. Asimismo, se determinó que la dimensión retención de los recursos humanos de la gestión del talento humano es significativa con la satisfacción laboral de los docentes de la institución encuestada, ya que se halló un valor igual a 0.00 < 0.05 con un coeficiente de correlación Rho Spearman 0,544 siendo la mayoría de docentes que participaron en este estudio docentes nombrados del nivel secundario y del sexo femenino. En base a los resultados obtenidos, se concluye que a mayor gestión del talento humano mayor satisfacción de los docentes de la IE 3045 UGEL 02 Lima 2021

A Multimethod Approach for Investigating Algal Toxicity of Platinum Nanoparticles

The ecotoxicity of platinum nanoparticles (PtNPs) widely used in for example automotive catalytic converters, is largely unknown. This study employs various characterization techniques and toxicity end points to investigate PtNP toxicity toward the green microalgae Pseudokirchneriella subcapitata and Chlamydomonas reinhardtii. Growth rate inhibition occurred in standard ISO tests (EC50 values of 15–200 mg Pt/L), but also in a double-vial setup, separating cells from PtNPs, thus demonstrating shading as an important artifact for PtNP toxicity. Negligible membrane damage, but substantial oxidative stress was detected at 0.1–80 mg Pt/L in both algal species using flow cytometry. PtNPs caused growth rate inhibition and oxidative stress in P. subcapitata, beyond what was accounted for by dissolved Pt, indicating NP-specific toxicity of PtNPs. Overall, P. subcapitata was found to be more sensitive toward PtNPs and higher body burdens were measured in this species, possibly due to a favored binding of Pt to the polysaccharide-rich cell wall of this algal species. This study highlights the importance of using multimethod approaches in nanoecotoxicological studies to elucidate toxicity mechanisms, influence of NP-interactions with media/organisms, and ultimately to identify artifacts and appropriate end points for NP-ecotoxicity testing

Cardiomyocyte hypertrophy induced by Endonuclease G deficiency requires reactive oxygen radicals accumulation and is inhibitable by the micropeptide humanin

The endonuclease G gene (Endog), which codes for a mitochondrial nuclease, was identified as a determinant of cardiac hypertrophy. How ENDOG controls cardiomyocyte growth is still unknown. Thus, we aimed at finding the link between ENDOG activity and cardiomyocyte growth. Endog deficiency induced reactive oxygen species (ROS) accumulation and abnormal growth in neonatal rodent cardiomyocytes, altering the AKT-GSK3 beta and Class-II histone deacethylases (HDAC) signal transduction pathways. These effects were blocked by ROS scavengers. Lack of ENDOG reduced mitochondrial DNA (mtDNA) replication independently of ROS accumulation. Because mtDNA encodes several subunits of the mitochondrial electron transport chain, whose activity is an important source of cellular ROS, we investigated whether Endog deficiency compromised the expression and activity of the respiratory chain complexes but found no changes in these parameters nor in ATP content. MtDNA also codes for humanin, a micropeptide with possible metabolic functions. Nanomolar concentrations of synthetic humanin restored normal ROS levels and cell size in Endog-deficient cardiomyocytes. These results support the involvement of redox signaling in the control of cardiomyocyte growth by ENDOG and suggest a pathway relating mtDNA content to the regulation of cell growth probably involving humanin, which prevents reactive oxygen radicals accumulation and hypertrophy induced by Endog deficiency.This work was supported by Grant SAF2013-44942R from the Ministerio de Economia y Competitividad (MINECO) to DS, Grant 20153810 from Fundacio La Marato de TV3 to DS, Program ``Redes Tematicas de Investigacion Cooperativa en Salud´´ (RETICS) Grants RD12/0042/0035, RD12/0042/0056 and RD12/0042/0021, Red de Investigacion Cardiovascular (RIC) from the Institute de Salud Carlos-III (ISCIII) to DS, DG-D and JV, Grant 2009SGR-346 from the Agencia de Gestic d'Ajuts Universitaris i de Recerca (AGAUR) from the Government of Catalonia to DS. AB is supported by Fundacio La Marato de TV3 and GB is supported by a predoctoral contract from the Universitat de Lleida.S

Identification and evaluation of clinical factors in high-risk pregnancies

The identification of high-risk pregnancies is very important, because it allows correct protection of pregnancy and puerperium. In order to simplify this procedure, a risk chart containing four groups of clinical factors which might determine or aggravate high-risk pregnancies, is presented.É de grande importância atual, a identificação das gestantes de alto risco, no sentido de se poder oferecer uma eficiente assistência durante o ciclo gravídico puerperal. Nesse sentido objetivou-se facilitar tal identificação, estabelecendo uma tabela dividida em 4 grupos de fatores clínicos, que possam a vir determinar ou agravar a gestação de alto risco