Fractura de piso orbitario en un jugador de béisbol

Presentamos un caso de un paciente, jugador de béisbol que sufrió una fractura de piso orbitario al recibir un golpe directo (blowout) con un bate que se le escapó a otro jugador, esta fractura fue reparada con un bloque de Hidroxiapatita Porosa HAP -200 .Una vez reconstruido el defecto óseo, el paciente volvió a su vida normal y comenzó de nuevo a jugar béisbol, debido a que desaparecieron la diplopía y el enoftalmo, por lo que tuvo una completa rehabilitación estética y funcional. En los exámenes radiográficos postoperatorios se observó una excelente reconstrucción del piso de la orbita y una osteointegegración del material implantológicoWe attend one patient, baseball player that suffer floor orbital fracture when he received hit in his eye (blowout) during practice baseball. He was operating and repaired this fracture with Porous Hidroxyapatite HAP-200.After operation he returned to play baseball because disappear the signs and symptoms (diplopia and enophthalmo).The radiography study showed excellent result after one yea

Índice de Liam: prueba física funcional

Made very important test (Liam) in the medical students in Medical Faculty in Artemisa city, because with this examination proof the functional and physical conditions before and after training. All students after training received best results than before. It is very important to because the students obtained some abilities in this subject when will be doctorsSe realizó un análisis de la prueba funcional de Liam en un grupo de estudiantes de 2do año de Medicina de Artemisa con el objetivo de valorar el grado de aptitud cardiovascular y el nivel de entrenamiento de este grupo, donde se obtuvo que la mayoría de los estudiantes el 77,8% estaba apto físicamente y solo dos para un 22,2% se encontraba en la categoría de pobre en la prueba que se realizó al inicio del curso .Esta prueba es de gran utilidad en nuestra formación como futuro Medico Generales Integrales y sobre todo que es muy fácil su proceder y lo podemos aplicar en área de salud con nuestros pacientes ,una vez graduados como médicos .En el mes de Abril después de seis meses de práctica sistemática de ejercicios físicos todos los estudiantes mejoraron de forma considerable su aptitud cardiovascular y el nivel de entrenamiento a las categorías de muy bien y bie

Correction to: A Phase II Study Evaluating Combined Neoadjuvant Cetuximab and Chemotherapy Followed by Chemoradiotherapy and Concomitant Cetuximab in Locoregional Oesophageal Cancer Patients

Errors were subsequently identified in the article and the following corrections should be note

A school-based physical activity promotion intervention in children: rationale and study protocol for the PREVIENE Project

The lack of physical activity and increasing time spent in sedentary behaviours during childhood place importance on developing low cost, easy-toimplement school-based interventions to increase physical activity among children. The PREVIENE Project will evaluate the effectiveness of five innovative, simple, and feasible interventions (active commuting to/from school, active Physical Education lessons, active school recess, sleep health promotion, and an integrated program incorporating all 4 interventions) to improve physical activity, fitness, anthropometry, sleep health, academic achievement, and health-related quality of life in primary school children. The PREVIENE Project will provide the information about the effectiveness and implementation of different school-based interventions for physical activity promotion in primary school children.The PREVIENE Project was funded by the Spanish Ministry of Economy and Competitiveness (DEP2015-63988-R, MINECO-FEDER). MAG is supported by grants from the Spanish Ministry of Economy and Competitivenes

Objetivos ambientales de la agricultura española: recomendaciones científicas para su implementacion efectiva según la nueva política agraria común 2023-2030

[EN]: The next reform ofthe EU Common Agricultural Policy (CAP) for the period 2021-2027 (currently extended to 2023-2030) requires the approval by the European Commission of a Strategic Plan with environmental objectives for each Member State. Here we use the best available scientific evidence on the relationships between agricultural practices and biodiversity to delineate specific recommendations for the development of the Spanish Strategic Plan. Scientific evidence shows that Spain should (1) identify clear regional biodiversity targets and the landscape-level measures needed to achieve them; (2) define ambitious and complementary criteria across the three environmental instruments (enhanced conditionality, eco-schemes, and agri-environmental and climate measures) of the CAP’s Green Architecture, especially in simple and complex landscapes; (3) ensure that other CAP instruments (areas of nature constraints, organic farming and protection of endangered livestock breeds and crop varieties) really support biodiversity; (4) improve farmers’ knowledge and adjust measures to real world constraints; and (5) invest in biodiversity and ecosystem service monitoring in order to evaluate how the Plan achieves regional and national targets andto improve measures if targets are not met. We conclude that direct assessments of environmental objectives are technically and economi- cally feasible, can be attractive to farmers, and are socially fair and of great interest for improving the environmental effectiveness of CAP measures. The explicit and rigorous association of assessments and monitoring, relating specific environmental indicators to regional objectives, should be the main criterion for the approval of the Strategic Plan in an environmentally-focused CAP2023-2030.[ES]: La reforma de la Política Agraria Común (PAC) para el periodo 2021-2027 (extendido en la actualidad a 2023-2030) exige que la Comisión Europea apruebe un Plan Estratégico por cada Estado Miembro con claros objetivos ambientales. En este trabajo desarrollamos recomendaciones específicas para la elaboración del Plan Estratégico para los sistemas agrícolas españoles, basadas en la mejor evidencia científica disponible sobre las relaciones entre la gestión agrícola y los componentes de la biodiversidad. La evidencia científica muestra que España debe 1) identificar objetivos regionales claros relativos a la biodiversidad de los medios agrarios y las medidas a nivel paisajístico necesarias para alcanzarlas; 2) definir criterios ambiciosos y complementarios para los tres instrumentos ambientales (condicionalidad extendida, eco-esquemas y medidas agroambientales y climáticas) de la Arquitectura Verde de la PAC, especialmente en paisajes sencillos y complejos; 3) garantizar que otros instrumentos de la PAC (zonas desfavorecidas, agricultura ecológica y protección de razas ganaderas y variedades de cultivos en peligro de extinción) favorecen realmente la diversidad biológica; 4) mejorar el conocimiento de los agricultores y ajustar las medidas a las limitaciones del mundo real; y 5) invertir en seguimiento de la biodiversidad y sus servicios ecosistémicos asociados con el fin de evaluar si el Plan alcanza los objetivos regionales y nacionales y mejorarlos adaptativamente si no lo consigue. Concluimos que la evaluación directa de los objetivos ambientales es técnica y económicamente viable, puede ser atractiva para los agricultores, es socialmente justa y de gran utilidad en la mejora de la efectividad de las medidas de la PAC. Una combinación rigurosa de seguimiento y evaluación de medidas y objetivos adaptados regionalmente mediante indicadores ambientales directos y claros debería ser el criterio que guíe la aprobación del Plan Estratégico para una PAC 2023-2030 centrada en el medio ambiente y orientada a la conservación de la biodiversidad.Peer reviewe

PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis

RATIONALE: Ischemic stroke is among the leading causes of adult disability. Part of the variability in functional outcome after stroke has been attributed to genetic factors but no locus has been consistently associated with stroke outcome. OBJECTIVE: Our aim was to identify genetic loci influencing the recovery process using accurate phenotyping to produce the largest GWAS (genome-wide association study) in ischemic stroke recovery to date. METHODS AND RESULTS: A 12-cohort, 2-phase (discovery-replication and joint) meta-analysis of GWAS included anterior-territory and previously independent ischemic stroke cases. Functional outcome was recorded using 3-month modified Rankin Scale. Analyses were adjusted for confounders such as discharge National Institutes of Health Stroke Scale. A gene-based burden test was performed. The discovery phase (n=1225) was followed by open (n=2482) and stringent joint-analyses (n=1791). Those cohorts with modified Rankin Scale recorded at time points other than 3-month or incomplete data on previous functional status were excluded in the stringent analyses. Novel variants in PATJ (Pals1-associated tight junction) gene were associated with worse functional outcome at 3-month after stroke. The top variant was rs76221407 (G allele, β=0.40, P=1.70×10-9). CONCLUSIONS: Our results identify a set of common variants in PATJ gene associated with 3-month functional outcome at genome-wide significance level. Future studies should examine the role of PATJ in stroke recovery and consider stringent phenotyping to enrich the information captured to unveil additional stroke outcome loci

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

19nonenoneSánchez-Danés A; Richaud-Patin Y; Carballo-Carbajal I; Jiménez-Delgado S; Caig C; Mora S; Di Guglielmo C; Ezquerra M; Patel B; Giralt A; Canals JM; Memo M; Alberch J; López-Barneo J; Vila M; Cuervo AM; Tolosa E; Consiglio A; Raya A.Sánchez Danés, A; Richaud Patin, Y; Carballo Carbajal, I; Jiménez Delgado, S; Caig, C; Mora, S; Di Guglielmo, C; Ezquerra, M; Patel, B; Giralt, A; Canals, Jm; Memo, Maurizio; Alberch, J; López Barneo, J; Vila, M; Cuervo, Am; Tolosa, E; Consiglio, A; Raya, A