Cidofovir intralesional para el tratamiento de la papilomatosis respiratoria recurrente, revisión sistemática de la literatura

Antecedentes. La papilomatosis respiratoriarecurrente es una afección viral rara y su tratamientocontrovertido.Objetivo. Establecer la efectividad y seguridaddel cidofovir como medicamento coadyuvante enel tratamiento de la papilomatosis respiratoriarecurrente severa.Material y métodos. Revisión sistemática dela literatura y lectura crítica de los artículos. Búsquedaexhaustiva de todos los artículos relacionadoscon el uso de cidofovir para el tratamientode la papilomatosis respiratoria recurrente en labase de datos Medline, utilizando como términosde búsqueda: papilomatosis laríngea y cidofovir,papilomatosis respiratoria y cidofovir, limitandola búsqueda al idioma inglés, usando operadorboleano and, or, desde enero 1990 hasta diciembrede 2003 se obtuvieron 24 artículos, de loscuales 11 se refieren estrictamente al usointralesional de cidofovir para el tratamiento dela papilomatosis laríngea o respiratoria.Se consiguieron 10 artículos, que reportaban seriesde casos del uso de cidofovir en papilomatosisrespiratoria recurrente en niños y adultos.Se realizó una lectura crítica de dichos artículosy teniendo en cuenta las limitaciones desu diseño y las diferencias entre ellos se buscóestablecer información más clara acerca de laefectividad y seguridad del medicamento.Resultados. Diez series de casos, 78 pacientes,promedio de edad de 25.5 años, puntaje inicialpromedio de severidad 11.6, tratamiento con6.8 inyecciones de cidofovir en promedio, disminucióndel puntaje de severidad en 2.9 de promedio.Conclusión. Series de casos con resultadosde difícil comparación, que muestran alcidofovir intralesional como tratamientocoadyuvante efectivo para la papilomatosis respiratoria recurrente

Faculty of Public Accounting. Volume 10 No. 9 June 1992

Las nuevas tendencias en tecnologías blandas o administrativas introducen una buena dosis de cambio, oportunidad y pragmatismo. Nuestra disciplina contable parece no atinar hacia nuevos desarrollos que satisfaga estas necesidades y cada vez más está quedando en la puerta trasera del desarrollo. Otras áreas diferentes a la propiamente contable como los desarrollos en sistemas de información gerencial, avances informáticos en aplicaciones comerciales, nuevos conceptos de medición, evaluación y control producto de enfoques administrativos como la calidad total y gerencia de la velocidad, están motivando cambios estructurales a lo contable. La pasividad frente a estas situaciones motivadas talvez por una pésima interpretación del principio contable de la prudencia, debe ser revaluada en forma urgente en el seno de gremios profesionales y círculos académicos e investigativos. En Colombia la nueva constitución política abrió un horizonte completamente diferente a la disciplina contable. Ya no lo tradicional operativo del presupuesto oficial Sino nuevos conceptos como auditoría de gestión, vigilancia del medio ambiente, agresividad en la participación de la auditoría oficial frente a las necesidades del país. El nuevo auditor fiscal tiene un enfoque interdisciplinario, moderno pragmático. Las Facultades de Contaduría Pública del país están obligadas a mirar por la ventana del cambio y no el encerramiento actual bajo una tradición completamente obsoleta.PRESENTACION. ENFOQUE TOTAL DE CALIDAD FRENTE A LAS ESCUELAS ORGANIZACIONALES QUE LES PRECEDIERON PROPOSITO DE LAS FACULTADES DE CONTADURIA PUBLICA HISTORIA DE LA CONTADURIA PUBLICA DURANTE LA EPOCA DE ESTADO SOBERANO DE SANTANDER HASTA LA MISION KENMERER METODOLOGIA PARA LA ELABORACION DE NOTAS A LOS-ESTABOS:FINANCIEROS MANUACDE AUDITORIA DE MERCADEO PROPOSICION DEL FLUJO DE EFECTIVO COMO ESTADO FINANCIERO MANUAL DE PROCEDIMIENTOS DE CONTROL POSTERIOR PARA LA CONTRALORIA DEL DEPARTAMENTO DE SANTANDER ANALISIS Y EVALUACION DE LAS COOPERATIVAS DEL SUR DE SANTANDER FRENTE A LA INFLACION Y SUS EFECTOSThe new trends in soft or administrative technologies introduce a good dose of change, opportunity and pragmatism. Our accounting discipline seems to be missing new developments that meet these needs and is increasingly falling behind in development. Other areas different from the accounting itself, such as developments in management information systems, computer advances in commercial applications, new concepts of measurement, evaluation and control resulting from administrative approaches such as total quality and speed management, are motivating structural changes throughout accountant. Passivity in the face of these situations, perhaps motivated by a bad interpretation of the accounting principle of prudence, must be urgently reassessed within professional associations and academic and research circles. In Colombia, the new political constitution opened a completely different horizon for accounting discipline. No longer the traditional operating of the official budget, but new concepts such as management audit, environmental surveillance, aggressiveness in the participation of the official audit against the needs of the country. the new listener prosecutor has an interdisciplinary, modern pragmatic approach. The Public Accounting Faculties of the country are obliged to look through the window of change and not the current closure under a completely obsolete tradition

Geographic patterns of tree dispersal modes in Amazonia and their ecological correlates

Aim: To investigate the geographic patterns and ecological correlates in the geographic distribution of the most common tree dispersal modes in Amazonia (endozoochory, synzoochory, anemochory and hydrochory). We examined if the proportional abundance of these dispersal modes could be explained by the availability of dispersal agents (disperser-availability hypothesis) and/or the availability of resources for constructing zoochorous fruits (resource-availability hypothesis). Time period: Tree-inventory plots established between 1934 and 2019. Major taxa studied: Trees with a diameter at breast height (DBH) ≥ 9.55 cm. Location: Amazonia, here defined as the lowland rain forests of the Amazon River basin and the Guiana Shield. Methods: We assigned dispersal modes to a total of 5433 species and morphospecies within 1877 tree-inventory plots across terra-firme, seasonally flooded, and permanently flooded forests. We investigated geographic patterns in the proportional abundance of dispersal modes. We performed an abundance-weighted mean pairwise distance (MPD) test and fit generalized linear models (GLMs) to explain the geographic distribution of dispersal modes. Results: Anemochory was significantly, positively associated with mean annual wind speed, and hydrochory was significantly higher in flooded forests. Dispersal modes did not consistently show significant associations with the availability of resources for constructing zoochorous fruits. A lower dissimilarity in dispersal modes, resulting from a higher dominance of endozoochory, occurred in terra-firme forests (excluding podzols) compared to flooded forests. Main conclusions: The disperser-availability hypothesis was well supported for abiotic dispersal modes (anemochory and hydrochory). The availability of resources for constructing zoochorous fruits seems an unlikely explanation for the distribution of dispersal modes in Amazonia. The association between frugivores and the proportional abundance of zoochory requires further research, as tree recruitment not only depends on dispersal vectors but also on conditions that favour or limit seedling recruitment across forest types

Geography and ecology shape the phylogenetic composition of Amazonian tree communities

AimAmazonia hosts more tree species from numerous evolutionary lineages, both young and ancient, than any other biogeographic region. Previous studies have shown that tree lineages colonized multiple edaphic environments and dispersed widely across Amazonia, leading to a hypothesis, which we test, that lineages should not be strongly associated with either geographic regions or edaphic forest types.LocationAmazonia.TaxonAngiosperms (Magnoliids; Monocots; Eudicots).MethodsData for the abundance of 5082 tree species in 1989 plots were combined with a mega-phylogeny. We applied evolutionary ordination to assess how phylogenetic composition varies across Amazonia. We used variation partitioning and Moran's eigenvector maps (MEM) to test and quantify the separate and joint contributions of spatial and environmental variables to explain the phylogenetic composition of plots. We tested the indicator value of lineages for geographic regions and edaphic forest types and mapped associations onto the phylogeny.ResultsIn the terra firme and várzea forest types, the phylogenetic composition varies by geographic region, but the igapó and white-sand forest types retain a unique evolutionary signature regardless of region. Overall, we find that soil chemistry, climate and topography explain 24% of the variation in phylogenetic composition, with 79% of that variation being spatially structured (R2 = 19% overall for combined spatial/environmental effects). The phylogenetic composition also shows substantial spatial patterns not related to the environmental variables we quantified (R2 = 28%). A greater number of lineages were significant indicators of geographic regions than forest types.Main ConclusionNumerous tree lineages, including some ancient ones (>66 Ma), show strong associations with geographic regions and edaphic forest types of Amazonia. This shows that specialization in specific edaphic environments has played a long-standing role in the evolutionary assembly of Amazonian forests. Furthermore, many lineages, even those that have dispersed across Amazonia, dominate within a specific region, likely because of phylogenetically conserved niches for environmental conditions that are prevalent within regions

Geography and ecology shape the phylogenetic composition of Amazonian tree communities

Aim: Amazonia hosts more tree species from numerous evolutionary lineages, both young and ancient, than any other biogeographic region. Previous studies have shown that tree lineages colonized multiple edaphic environments and dispersed widely across Amazonia, leading to a hypothesis, which we test, that lineages should not be strongly associated with either geographic regions or edaphic forest types. Location: Amazonia. Taxon: Angiosperms (Magnoliids; Monocots; Eudicots). Methods: Data for the abundance of 5082 tree species in 1989 plots were combined with a mega-phylogeny. We applied evolutionary ordination to assess how phylogenetic composition varies across Amazonia. We used variation partitioning and Moran\u27s eigenvector maps (MEM) to test and quantify the separate and joint contributions of spatial and environmental variables to explain the phylogenetic composition of plots. We tested the indicator value of lineages for geographic regions and edaphic forest types and mapped associations onto the phylogeny. Results: In the terra firme and várzea forest types, the phylogenetic composition varies by geographic region, but the igapó and white-sand forest types retain a unique evolutionary signature regardless of region. Overall, we find that soil chemistry, climate and topography explain 24% of the variation in phylogenetic composition, with 79% of that variation being spatially structured (R$^{2}$ = 19% overall for combined spatial/environmental effects). The phylogenetic composition also shows substantial spatial patterns not related to the environmental variables we quantified (R$^{2}$ = 28%). A greater number of lineages were significant indicators of geographic regions than forest types. Main Conclusion: Numerous tree lineages, including some ancient ones (>66 Ma), show strong associations with geographic regions and edaphic forest types of Amazonia. This shows that specialization in specific edaphic environments has played a long-standing role in the evolutionary assembly of Amazonian forests. Furthermore, many lineages, even those that have dispersed across Amazonia, dominate within a specific region, likely because of phylogenetically conserved niches for environmental conditions that are prevalent within regions

Mapping density, diversity and species-richness of the Amazon tree flora

Using 2.046 botanically-inventoried tree plots across the largest tropical forest on Earth, we mapped tree species-diversity and tree species-richness at 0.1-degree resolution, and investigated drivers for diversity and richness. Using only location, stratified by forest type, as predictor, our spatial model, to the best of our knowledge, provides the most accurate map of tree diversity in Amazonia to date, explaining approximately 70% of the tree diversity and species-richness. Large soil-forest combinations determine a significant percentage of the variation in tree species-richness and tree alpha-diversity in Amazonian forest-plots. We suggest that the size and fragmentation of these systems drive their large-scale diversity patterns and hence local diversity. A model not using location but cumulative water deficit, tree density, and temperature seasonality explains 47% of the tree species-richness in the terra-firme forest in Amazonia. Over large areas across Amazonia, residuals of this relationship are small and poorly spatially structured, suggesting that much of the residual variation may be local. The Guyana Shield area has consistently negative residuals, showing that this area has lower tree species-richness than expected by our models. We provide extensive plot meta-data, including tree density, tree alpha-diversity and tree species-richness results and gridded maps at 0.1-degree resolution

Geography and ecology shape the phylogenetic composition of Amazonian tree communities

Aim: Amazonia hosts more tree species from numerous evolutionary lineages, both young and ancient, than any other biogeographic region. Previous studies have shown that tree lineages colonized multiple edaphic environments and dispersed widely across Amazonia, leading to a hypothesis, which we test, that lineages should not be strongly associated with either geographic regions or edaphic forest types. Location: Amazonia. Taxon: Angiosperms (Magnoliids; Monocots; Eudicots). Methods: Data for the abundance of 5082 tree species in 1989 plots were combined with a mega‐phylogeny. We applied evolutionary ordination to assess how phylogenetic composition varies across Amazonia. We used variation partitioning and Moran's eigenvector maps (MEM) to test and quantify the separate and joint contributions of spatial and environmental variables to explain the phylogenetic composition of plots. We tested the indicator value of lineages for geographic regions and edaphic forest types and mapped associations onto the phylogeny. Results: In the terra firme and várzea forest types, the phylogenetic composition varies by geographic region, but the igapó and white‐sand forest types retain a unique evolutionary signature regardless of region. Overall, we find that soil chemistry, climate and topography explain 24% of the variation in phylogenetic composition, with 79% of that variation being spatially structured (R2 = 19% overall for combined spatial/environmental effects). The phylogenetic composition also shows substantial spatial patterns not related to the environmental variables we quantified (R2 = 28%). A greater number of lineages were significant indicators of geographic regions than forest types. Main Conclusion: Numerous tree lineages, including some ancient ones (>66 Ma), show strong associations with geographic regions and edaphic forest types of Amazonia. This shows that specialization in specific edaphic environments has played a long‐standing role in the evolutionary assembly of Amazonian forests. Furthermore, many lineages, even those that have dispersed across Amazonia, dominate within a specific region, likely because of phylogenetically conserved niches for environmental conditions that are prevalent within regions

Author correction: One sixth of Amazonian tree diversity is dependent on river floodplains

In the version of the article initially published, the affiliation of Edgardo Manuel Latrubesse was incorrect and has now been amended to Environmental Sciences Graduate Program-CIAMB, Federal University of Goiás, Goiânia, Brazil in the HTML and PDF versions of the article

Mapping density, diversity and species-richness of the Amazon tree flora

Using 2.046 botanically-inventoried tree plots across the largest tropical forest on Earth, we mapped tree species-diversity and tree species-richness at 0.1-degree resolution, and investigated drivers for diversity and richness. Using only location, stratified by forest type, as predictor, our spatial model, to the best of our knowledge, provides the most accurate map of tree diversity in Amazonia to date, explaining approximately 70% of the tree diversity and species-richness. Large soil-forest combinations determine a significant percentage of the variation in tree species-richness and tree alpha-diversity in Amazonian forest-plots. We suggest that the size and fragmentation of these systems drive their large-scale diversity patterns and hence local diversity. A model not using location but cumulative water deficit, tree density, and temperature seasonality explains 47% of the tree species-richness in the terra-firme forest in Amazonia. Over large areas across Amazonia, residuals of this relationship are small and poorly spatially structured, suggesting that much of the residual variation may be local. The Guyana Shield area has consistently negative residuals, showing that this area has lower tree species-richness than expected by our models. We provide extensive plot meta-data, including tree density, tree alpha-diversity and tree species-richness results and gridded maps at 0.1-degree resolution

One sixth of Amazonian tree diversity is dependent on river floodplains

Amazonia’s floodplain system is the largest and most biodiverse on Earth. Although forests are crucial to the ecological integrity of floodplains, our understanding of their species composition and how this may differ from surrounding forest types is still far too limited, particularly as changing inundation regimes begin to reshape floodplain tree communities and the critical ecosystem functions they underpin. Here we address this gap by taking a spatially explicit look at Amazonia-wide patterns of tree-species turnover and ecological specialization of the region’s floodplain forests. We show that the majority of Amazonian tree species can inhabit floodplains, and about a sixth of Amazonian tree diversity is ecologically specialized on floodplains. The degree of specialization in floodplain communities is driven by regional flood patterns, with the most compositionally differentiated floodplain forests located centrally within the fluvial network and contingent on the most extraordinary flood magnitudes regionally. Our results provide a spatially explicit view of ecological specialization of floodplain forest communities and expose the need for whole-basin hydrological integrity to protect the Amazon’s tree diversity and its function