11 research outputs found
Organisation gestalten
- Author
- A Skalla
- Blegen Mary
- Borsi Gabriele
- Daan Van Kampenhout
- Daimler Renate
- G Ten Hövel
- Gary Yukl
- Gilbert JB Probst
- Graf-Götz Friedrich
- Graf-Götz Friedrich
- Holitzka Marlies
- Horn Klaus-Peter
- HS Laschinger
- Insa Sparrer
- Jenkins Marjorie
- Joyce Fitzpatrick
- Königswieser Roswita
- Lacey Susan
- Laurie Mullins
- M Manojlovich
- M Mrayyan
- Melny Bernadette
- Oltmanns Torsten
- Osland Jayce
- Parsons Mickey L
- R Hess
- Walter Simon
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Integrative Genomic Approaches to Studying Epigenetic Mechanisms of Phenotypic Plasticity in the Aphid
- Author
- A Dombrovsky
- A Fournier
- A Gallot
- A Gallot
- A Hellman
- A Ishikawa
- A Ishikawa
- A Loof De
- A Spannhoff
- AE Friedland
- AFG Dixon
- AI Tawfik
- AJ Zera
- AK Bromley
- AV Probst
- B Wiedenheft
- BG Hunt
- C Braendle
- C Braendle
- C The International Aphid Genomics
- CB Müller
- CC Schwedes
- CG Steel
- D Bhaya
- D Hsu Patrick
- DF Simola
- DJ McKay
- E Pennisi
- EC Oerke
- EC Snell-Rood
- EM Mendenhall
- F Legeai
- F Lyko
- F Lyko
- F Wolschin
- G Liang
- G Trionnaire Le
- G Trionnaire Le
- G Trionnaire Le
- G Trionnaire Le
- HF Nijhout
- HF Nijhout
- J Hardie
- JA Brisson
- JB Kring
- JC Cheng
- JIM Hardie
- JK Joung
- KE Holde Van
- L Ho
- L Song
- L Zhou
- L-J Liu
- LI Gilbert
- M Ghanim
- M Jinek
- M Jong de
- M Mandrioli
- M Mandrioli
- MAH Smith
- MG Goll
- MH Larson
- MJ West-Eberhard
- ML Anstey
- ML Maeder
- MM Suzuki
- MP Terns
- N Aubin-Horth
- N Rusk
- NS Mutti
- O Bell
- O Christiaens
- P Beldade
- P Zhou
- P Zhou
- PA Jones
- PB Koch
- R Blackman
- R Bonasio
- R Kucharski
- RD Hawkins
- RL Blackman
- RM Terns
- S Foret
- S Jaubert-Possamai
- S Shukla
- SD Rider Jr
- SR Purandare
- T Cortes
- T Miura
- TK Walsh
- VW Zhou
- WC Mueller
- WP Morrison
- WY Hwang
- Y Shi
- Z Ma
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2015
- Field of study
Phenotypic plasticity is the nongenic variation in phenotype due to environmental factors. It is a common phenomenon in the animal kingdom that is not well understood at the molecular level. A tenable form of phenotypic plasticity for molecular research is polyphenism, which is an extreme form of phenotypic plasticity that results in discrete, alternative morphs. Epigenetic mechanisms have been hypothesized as the molecular regulators of polyphenism, in particular DNA methylation and chromatin remodeling. The pea aphid exhibits multiple polyphenisms including winged and wingless females during summer (wing polyphenism) and asexual and sexual morphs during summer and fall, respectively (reproductive polyphenism). The aphid is ideally situated for research into the molecular basis of polyphenism, with a sequenced genome and multiple transcriptomic studies that have begun identifying key molecular regulators of these two polyphenisms. The aphid also possesses the genes necessary for DNA methylation and chromatin remodeling. The pea aphid system is thus primed for future research into the epigenetic regulation of polyphenism
Infectious Bovine Rhinotracheitis / Vulvovaginitis (BHV1)
- Author
- A Afshar
- A Aguilar-Setién
- A Aguilar-Setién
- A Aguilar-Setién
- A Aguilar-Setién
- A Bouffard
- A Gough
- A Mayr
- A Mayr
- A Mayr
- A Schwers
- A Silim
- A Wiseman
- A Zuffa
- A Zuffa
- AA Schudel
- AE Metzler
- AE Metzler
- AJ Davison
- AJ Forman
- AJ Forman
- AJ Forman
- AJ Tousimis
- AJF Schwartz
- AK Eugster
- AM Menanteau-Horta
- AS Greig
- AS Grewal
- B Lema
- B Roizman
- B Roizman
- B Roizman
- BD Hill
- BE Beck
- BE Sheffy
- BJ Carrillo
- BS Seal
- BT Rouse
- BT Rouse
- BT Rouse
- BT Rouse
- BT Rouse
- BT Rouse
- C Darcel
- C Darcel
- C Darcel
- C Ek-Kommonen
- C Onyekaba
- C Riggenbach
- C Spirig
- C Terpstra
- CA Riegel
- CA Whetstone
- CE Bush
- CJ Kucera
- CJ York
- CL Kelling
- CN Hebert
- CO Darcel le
- CO Darcel le
- CP Bowling
- CP Peter
- CQ Darcel le
- CQ Darcel le
- CR Rossi
- CR Rossi
- CS Roney
- CW Czarniecki
- D Brunner
- D Burger
- D Freifelder
- DC Bolton
- DC Bolton
- DC Bolton
- DC Dunn
- DD Porter
- DE Reed
- DF Kelly
- DG McKercher
- DG McKercher
- DG McKercher
- DG McKercher
- DG McKercher
- DJ Brister
- DL Rock
- DL Rock
- DL Rock
- DL Rock
- DM Inglis
- E Forschner
- E Helgstrand
- E Peterhans
- E Thiry
- E Thiry
- E Thiry
- E Thiry
- E Thiry
- E Thiry
- E Thiry
- E Thiry
- EJ Homan
- EJ Homan
- EJ Homan
- EK Wagner
- EL French
- EM Allan
- EPJ Gibbs
- F Blecha
- F Brake
- F Lomba
- F Lomba
- F Steck
- F Steck
- F Ulbrich
- FD Kirby
- G Baljer
- G Castrucci
- G Castrucci
- G Dannacher
- G Florent
- G Hanton
- G Hanton
- G Kubin
- G Malderen Van
- G Pauli
- G Stuker
- G Wellemans
- G Wizigmann
- GA Splitter
- GA Splitter
- GA Splitter
- GA Weinmaster
- GCN Zyambo
- GCN Zyambo
- GD Mechor
- GF Plebani
- GH Smith
- GN Frerichs
- GV Ludwig
- H Bergmann
- H Fraenkel-Conrat
- H Ludwig
- H Ludwig
- H Ludwig
- H Meyer
- H Meyer
- H Meyer
- H Rödder
- HB Ohmann
- HD Gründer
- HD Lehmkuhl
- HJ Cho
- HJ Field
- HJ Rziha
- HL Bachrach
- HP Krause
- HS Joo
- HW Lupton
- HW Lupton
- HW Reid
- IA Schipper
- J Espinasse
- J Espinasse
- J Mensik
- JA Bradley
- JA House
- JA House
- JB Derbyshire
- JB Gratzek
- JD Gerber
- JD Todd
- JE Farley
- JE Mayfield
- JH Gillespie
- JH Gillespie
- JJ Rychner
- JK Collins
- JK Collins
- JK Collins
- JK Collins
- JM Cummins
- JM Miller
- JM Miller
- JP Descoteaux
- JP Gregersen
- JP Gregersen
- JP Gregersen
- JP Lawman
- JP Soulebot
- JS Wafula
- JW Kendrick
- JW Kendrick
- JW Kendrick
- K Bauer
- K Friedli
- K Gunkel
- K Okazaki
- K Okazaki
- K Okazaki
- KG Loewen
- KJ Wojciechowski
- KJI Thorne
- KVF Jubb
- KWF Jericho
- KYS Liu
- L Babiuk
- L Dhennin
- L Geder
- L Geder
- L Meyer
- L Meyer
- L Reisinger
- L Rothschuh
- L Weber
- LA Babiuk
- LA Babiuk
- LA Babiuk
- LA Babiuk
- LA Babiuk
- LA Babiuk
- LA Babiuk
- LG Doyle
- LG Filion
- LJ Bello
- LJ Chow
- LJ Owen
- LL Rodriguez
- LND Potgieter
- LND Potgieter
- LT Talens
- LWS Chang
- M Ackermann
- M Ackermann
- M Bellwer-Gallent
- M Campos
- M Campos
- M Engels
- M Engels
- M Ferrari
- M Goffaux
- M Goffaux
- M Lazarowicz
- M Metzner
- M Miller
- M Miller-Edge
- M Narita
- M Narita
- M Norval
- M Pacciarini
- M Solsona
- M Spieck
- M Trudel
- M Trudel
- MA Dorman
- MA Lum
- MASY Elazhary
- MASY Elazhary
- MB White
- MJP Lawman
- MR Gardiner
- MS Trueblood
- N Lapierre
- NA Scott
- NS Swack
- O Bwangamoi
- O Bwangamoi
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OC Straub
- OH Bielefeldt
- OH Bielefeldt
- OH Bielefeldt
- OH Bielefeldt
- OH Bielefeldt
- P Payment
- P Rüsch
- P Trépanier
- P Trépanier
- PA Meuron De
- PD Conlon
- PF Nettleton
- PF Nettleton
- PM Msolla
- PM Msolla
- PM Msolla
- PM Msolla
- PN Nyaga
- PP Pastoret
- PP Pastoret
- PP Pastoret
- PP Pastoret
- PP Pastoret
- PP Pastoret
- PP Pastoret
- PP Pastoret
- R Ahl
- R Assaf
- R Bohrmann
- R Böttcher
- R Hirchert
- R Kokles
- R Kokles
- R Weiblen
- RA Crandell
- RA Crandell
- RA Crandell
- RB Miller
- RD Schultz
- RE Pierson
- REL Taylor
- RF Kahrs
- RF Kahrs
- RF Kahrs
- RFJ Kahrs
- RH Andino
- RH Rosadio
- RL Levings
- RL Levings
- RL Marshall
- RW Fulton
- RW Fulton
- S Bernath
- S Chung
- S Drunen Littel-Van Den Hurk Van
- S Drunen Littel-Van Den Hurk Van
- S Drunen Littel-Van Den Hurk Van
- S Edwards
- S Edwards
- S Edwards
- S Edwards
- S Kit
- S Kit
- S Kit
- S Van Drunen Littel-Van Den Hurk
- S Van Drunen Littel-Van Den Hurk Den
- S Van Drunen Littel-Van Den Hurk Den
- SAH Brigham
- SB Mohanty
- SB Mohanty
- SB Mohanty
- Scottish Veterinary Investigation Service
- SH Brigham
- SH Madin
- SP Morzaria
- T Toth
- TJ Hill
- TJ Hill
- TJJ Bagust
- TW Drew
- TW Munro
- U Kihm
- U Köchli
- U Probst
- UV Wirth
- V Bitsch
- V Bitsch
- V Bitsch
- V Bitsch
- V Bitsch
- V Misra
- V Misra
- V Misra
- W Hammerschmidt
- W Hammerschmidt
- W Zwick
- WC Lawrence
- WC Rebhun
- WDG Yates
- WDG Yates
- WTK Hall
- Y Gilbert
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1989
- Field of study
Pluriglanduläre endokrine Regulationsstörungen
- Author
- A Czyzyk
- A Fagraeus
- A Fanconi
- A Kojima
- A Lupulescu
- A Probst
- A Talerman
- AA Eisenberg
- AC MacCuish
- AD Bankhurst
- AE Braley
- AE Kalderon
- AG Cudworth
- AG Engel
- AG Knudson Jr.
- AG Wangel
- AGE Pearse
- AGE Pearse
- AGE Pearse
- AGE Pearse
- AH Rule
- AL Ellenberg
- AL Steiner
- AM Minno
- AO Vladutiu
- AS Glushien
- AT Masi
- AWH Evans
- B Arnesjö
- B Castleman
- B Castleman
- B Egloff
- B Griffel
- B Harvald
- BA Clinton
- BA Lamberg
- BD Jankovic
- BH Landing
- BL Munger
- BM Segal
- BR Boshell
- C Calmettes
- C Hedinger
- C Ramsey
- CB Lamers
- CC Berdjis
- CC Capen
- CCJ Carpenter
- CF Gastineau
- CH Brown
- CJM Lips
- CJM Lips
- D Bronsky
- D Cameron
- D Cattan
- D Doniach
- D Doniach
- D Doniach
- D Doniach
- D Doniach
- D Felix-Davies
- D Makaresz
- D Schmechel
- D Schmechel
- DA Scholz
- DE Goldstein
- DF Steiner
- DF Steiner
- DGD Barr
- DJ Lulu
- DM Robertson
- DP LeGolvan
- DS Nourok
- DW Beaven
- DW Nibbelink
- E Altenähr
- E Pusteria
- ED Williams
- ED Williams
- ED Williams
- ED Williams
- EF Gilbert
- EG Saint
- EJ Dunning
- EL Mazzaferri
- EM Hoenig
- ES Heikkinen
- F Fahri
- F Feyrter
- F Feyrter
- F Melani
- F Milgrom
- FB Mandeville
- G Goldstein
- G Hennen
- G Klöppel
- G Klöppel
- G Klöppel
- G Krassas
- G Milhaud
- G Pohl
- G Senyk
- G Wick
- GA Williams
- GB Appel
- GC Chong
- GF Bottazzo
- GF Dockray
- GH Freytag
- GH Jeffries
- GJ Johnson
- GL Miller
- GM Folger Jr.
- GP Laroche
- GP McNicol
- GR Tudhope
- GW Sizemore
- H Claude
- H Claude
- H Claude
- H Cushing
- H Dralle
- H Gharib
- H Heath III
- H Ludwig
- H Meyenburg von
- H Neracher
- H Rousset
- H Steiner
- H Steiner
- H Toyoda
- H-C Drube
- HG Wells
- HH Miller
- HJ Kappeler
- HJ Wolfe
- HJ Wolfe
- HJ Wolfe
- HL Eichner
- HR Keiser
- HS Ballard
- HY Lee
- I Kao
- IM Roitt
- IM Roitt
- IMD Jackson
- J Abels
- J Bertrams
- J Colover
- J Erdheim
- J Nerup
- J Nerup
- J Nerup
- J Nerup
- J Nerup
- J Schlichtkrull
- JA Andrada
- JA Andrada
- JA Carney
- JA Carney
- JA Carney
- JA Clagett
- JA Fischer
- JA Fischer
- JB Hazard
- JC Mershon
- JC Sloper
- JE Craighead
- JE Vance
- JE Vance
- JF Rehfeld
- JH Sipple
- JL Baum
- JL Croisier
- JL DeCourcy
- JL Markson
- JM Polak
- JP Phair
- JR Anderson
- JR Anderson
- JT Peurifoy
- K Arulanantham
- K Federlin
- K Federlin
- K Federlin
- K Federlin
- K Grace
- K Terplan
- K Tevelde
- KA Huizenga
- KA Norberg
- KC Hertz
- KD Wuepper
- KD Wuepper
- KE Osserman
- KE Osserman
- KEW Melvin
- KEW Melvin
- KFR Schiller
- KL Janson
- KL Melmon
- KS Wise
- KV Toyka
- L Gutmann
- LA Pohorecky
- LB Woolner
- LE Glynn
- LE Underwood
- LI Larsson
- LJ Deftos
- LM Wolf
- LO Underdahl
- M Casseye van de
- M Edmonds
- M Guisan
- M Muller
- M Pinget
- M Tzagournis
- MB Schmidt
- MD Ram
- MH Flax
- MI Luster
- MJ Finegold
- ML Ibanez
- MM Melicow
- MRA Khairi
- MT Hull
- MT Kahn
- MW Spinner
- MW Spinner
- N Seemann
- N Snyder III
- N Snyder III
- N Solomon
- NA Samaan
- NA Samaan
- NJ O’Higgins
- NP Christy
- NR Rose
- NW Swinton Jr.
- O Brenner
- O Engelberth
- O Ljungberg
- O Ljungberg
- O Werdelin
- O Werdelin
- O Werdelin
- O Werdelin
- OP Hansen
- P Cushman Jr.
- P Kerkhoven
- P Mathis
- P Nève
- P Ries
- P Robberecht
- P Wermer
- P Wermer
- P Wermer
- PA Bastenie
- PA Mclntyre
- PC Manning Jr.
- PE Bigazzi
- PE Lacy
- PH Rossier
- PJ Barnard
- PU Heitz
- PU Heitz
- PU Heitz
- PU Heitz
- PU Heitz
- R Aach
- R Bubenhofer
- R Hall
- R Hume
- R Roessle
- R Schlaeger
- R Tateishi
- R Volpe
- RA DeLellis
- RA DeLellis
- RA DeLellis
- RA DeLellis
- RB Goudie
- RB Goudie
- RB Goudie
- RC Bartlett
- RC Chapman
- RC Turner
- RE Cutler
- RF Weichert
- RF Weichert
- RG Strickland
- RIC Wesdorp
- RJ Gorlin
- RJ Poljak
- RK Mead
- RL Miller
- RM Blizzard
- RM Blizzard
- RM Blizzard
- RN Schimke
- RN Schimke
- RN Schimke
- RW Turkington
- S Ardeman
- S Bergman
- S Bevan
- S Hamada
- S Levine
- S Levine
- SA Shelburne
- SA Tischler
- SA Wells Jr.
- SA Wells Jr.
- SB Baylin
- SB Baylin
- SC Kukreja
- SC Kukreja
- SD Wilson
- SD Wilson
- SI Roth
- SJ Marx
- SM Milcou
- SR Friesen
- SR Friesen
- SS Miller
- ST Callender
- T Deckert
- T Deckert
- T Kodama
- TEW Feltkamp
- TS Danowski
- TS Harrison
- U Schwarz
- V Becker
- V Fatourechi
- VA LiVolsi
- VA McKusick
- W Böcker
- W Falta
- W Gepts
- W Pierpaoli
- W Schürch
- WC Mieher
- WH Remine
- WJ Catalona
- WJ Cunliffe
- WJ German
- WJ Irvine
- WJ Irvine
- WJ Irvine
- WJ Irvine
- WJ Irvine
- WJ Irvine
- WJ Penhale
- WM Keynes
- WM Manger
- WO Weigle
- WO Weigle
- WP Longmire Jr.
- WS Markey
- WW Buchanan
- WW Buchanan
- Å Andersson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1981
- Field of study
Cerebrale Kinderlähmung
- Author
- A Capper
- A Czerny
- A Czerny
- A Dechamps
- A Dereymaker
- A Eckstein
- A Heymanowitsch
- A Jakob
- A Jakob
- A Jakob
- A Jakob
- A Jakob
- A Juba
- A Levinson
- A Meyer
- A Meyer
- A Opalski
- A Pentschew
- A Pentschew
- A Randall
- A Schmincke
- A Westrienen V
- A Windorfer
- A Ylppö
- A Ylppö
- AA Strauss
- AJ Rasanoff
- Aldama
- Alpers
- Altegöhr
- Anderson
- Anton
- Anton
- Anton
- Anton
- Anton
- B Gerberdin
- B Hechst
- B Horanyi-Hechst
- B Ostertag
- B Van
- B Van
- Bailey
- Bamatter
- Bannwarth
- Bannwarth
- Bartels
- Batten
- BB Burgemeister
- Benda
- BH Fouracre
- Bielschowsky
- Bielschowsky
- Bielschowsky
- Bielschowsky
- Bielschowsky
- Birk
- Birk
- Bischoff
- BJ Alpers
- BJ Alpers
- Bogaertl
- Bogaertl VAN
- Bourquin
- Brand
- Bratz
- Brenner
- Bresler
- Brocher
- Brun
- C Boenheim
- C Krücke
- C Lange DE
- C Lange DE
- C Le
- C Löwenstein
- C Schneider
- C Vogt
- C Vogt
- CA Heyman
- CA Heyman
- CA Patten
- CA Patten
- CA Patten
- Carpenter
- Casamajor
- CE Benda
- CE Benda
- CE Benda
- CE Benda
- CE Benda
- CE Lumsden
- Christensen
- Christensen
- Christensen
- Clara
- CO Vogt
- Conel
- Conel
- Cooper
- Creutzfeld
- CUO Vogt
- CUO Vogt
- D Davidoff
- D Gilmour
- D Leigh
- D Müller
- D Russel
- DA Thom
- DF Cappell
- Diezel
- Divry
- E Burghard
- E Engelhart
- E Keller
- E Laine
- E Moser
- E Opitz
- E Opitz
- E Rydberg
- E Sierig
- E Sorrel
- E Stettner
- E Wildi
- E Wohlwill
- Earle
- Ebbs
- EC Büchi
- EC Roosen-Runge
- Edinger
- Ehlers
- Eicke
- Erdmann
- Erskine
- F Beckmann
- F Beyme
- F Bonner
- F Faust
- F Griepentrog
- F Griepentrog
- F Hiller
- F Hollinger
- F Keller
- F Koller
- F Laubenthal
- F Netjbürger
- F Schob
- F Schob
- F Schreiber
- F Wohlwill
- F Wohlwill
- F Wohlwill
- F Wohlwill
- F Wohlwill
- F Wohlwill
- Fanconi
- FE Johnson
- Fernandes
- Filimonoef
- Finkelnburg
- FJ Warner
- Flechsig
- FO Höring
- Foerster
- Ford
- Fortanier
- FR Ford
- FR Ford
- FR Ford
- FR Ford
- Freud
- G Bodechtel
- G Fanconi
- G Gruber
- G Göllnitz
- G Ilberg
- G Kloos
- G Le
- G Morsier DE
- G Patten
- G Schaltenbrand
- G Schaltenbrand
- G Schorsch
- G Strietzel
- G Tardieu
- G Ule
- G Ule
- G Ule
- G Wilke
- GA Jervis
- GA Jervts
- Gamper
- Gasser
- Ghizetti
- Globus
- Gohrband
- Gowers
- Greenfield
- Groh
- Grosser
- GW Gustavson
- H Alajouanine
- H Aron
- H Becker
- H Becker
- H Becker
- H Becker
- H Becker
- H Becker
- H Becker
- H Beneke
- H Eckardt
- H Elias
- H Geyer
- H Geyer
- H Geyer
- H Geyer
- H Grebe
- H Greving
- H Hegnauer
- H Hosemann
- H Jacob
- H Jacob
- H Jacob
- H Jacob
- H Josephy
- H Krukenberg
- H Lange-Cosack
- H Lange-Cosack
- H Lange-Cosack
- H Meessen
- H Naujoks
- H Naujoks
- H Netjbürger
- H Netjbürger
- H Nevinny
- H Noetzel
- H Noetzel
- H Noetzel
- H Noetzel
- H Noetzel
- H Noetzel
- H Noetzel
- H Patzer
- H Pette
- H Probst
- H Schleussing
- H Schröder
- H Siegmund
- H Singer
- H Singer
- H Stolte
- H Stüssberg
- H Willi
- H Yannet
- H Yannet
- H Yannet
- H Zellweger
- H Zellweger
- Hajashi
- Hallervorden
- Hallervorden
- Hallervorden
- Hallervorden
- Hallervorden
- Hallervorden
- Handwerck
- Hanhart
- Hasenjäger
- Hassin
- Hassler
- Hausbrandt
- HD Pache
- Hedinger
- Heschl
- Heschl
- Heschl
- Heubner
- HG Huber
- Hirvensalo
- HJ Notti
- HJ Scherer
- HK Faber
- HK Faber
- HM Keith
- HM Zimmermann
- HM Zimmermann
- HM Zimmermann
- HM Zimmermann
- HN Zollinger
- Holle
- Holzer
- Horanyi-Hechst
- HT Patrick
- HU Sauerbrei
- Hunt
- Hunziker
- Hörstadius
- Höstermann
- I Bertrand
- Ibrahim
- Ilberg
- Inose
- IP Wyatt
- J Becker
- J Comby
- J Cseh V
- J Govern
- J Hallervorden
- J Hallervorden
- J Hallervorden
- J Hallervorden
- J Hallervorden
- J Hallervorden
- J Hallervorden
- J Hallervorden
- J Husler
- J Ibrahim
- J Jorgensen V
- J Kasanin
- J Kopp
- J Kramár
- J Sturma
- J Zappert
- JA Gilbert
- JB Arey
- JB Diamond
- JC Schippers
- JD Rolleston
- JD Russ
- JE Meyer
- JE Meyer
- JE Meyer
- JE Meyer
- JE Meyer
- JE Meyer
- JE Meyer
- JE Meyer
- JE Meyer
- JF Fazekas
- JG Brochtein
- JJ Mossberger
- JL Entres
- JM Mackenzie
- Jochheim
- Josephy
- Juba
- Juba
- K Apitz
- K Apitz
- K Balthasar
- K Lenggenhager
- K Sträussleru
- KH Pospiech
- KH Stauder
- KJ Zülch
- Klaue
- Kloos
- Koch
- Kowitz
- Kreyenberg
- Kroll
- Kundrat
- Köppen
- Köppen
- L Bogaert
- L Bogaert
- L Bogaert VAN
- L Crome
- L Goldstein
- L Richter
- L Richter
- L Rimbaud
- L Vellguth
- Laforet
- Lange-Cosack
- Langer
- Leigh
- LF Bushnell
- Link
- Linzenmeier
- LS Meriwether
- LS Penrose
- Löwenberg
- M Bielschowsky
- M Bielschowsky
- M Biro
- M Hirvensalo
- M Lange
- M Schachter
- M Schachter
- M Schachter
- M Sorba
- M Staemmler
- M Thiemich
- MA Lennox
- MA Perlstein
- MA Perlstein
- Marburg
- Marie
- Marie
- Messing
- MF Palmer
- MG Marinesco
- MG Petermann
- MI Dunsdon
- Miskolczy
- MJ Fox
- MJ Fox
- MJ Neurath
- Mohr
- Moore
- MU Spatz
- Myslivecek
- N Damier
- N Klingmann
- N Malamud
- N Malamud
- Noetzel
- Norman
- Norman
- Norman
- Norman
- Norman
- Norman
- NW Winkelmann
- O Kinnunen
- O Marburg
- O Sittig
- O Soltmann
- O Ullrich
- OA Patten
- Obersteiger
- Onari
- Ostertag
- OT Bailey
- P Armand-Delile
- P Asher
- P Hertzman
- P Schwartz
- P Schwartz
- P Schwartz
- P Schwartz
- P Schwartz
- Patzig
- Patzig
- PB Diezel
- Pekelsky
- Pfeiffer
- PJ Yakovlev
- PM Levin
- Pommer
- Potter
- PR Evans
- Prtjijs
- R Altschul
- R Beneke
- R Dubois
- R Lindenberg
- R Marburg
- R Maresch
- R Neurath
- R Rössle
- R Rössle
- R Sorel
- R Voigt
- RA Hingson
- Reuben
- RG Mitchell
- RG Pauly
- RM Norman
- RM Norman
- RM Norman
- RM Norman
- Roback
- Ross
- Rydberg
- S Clement
- S Crefeld
- S Ernst
- S Környey
- S Liebe
- S Sawchuk
- Scharapow
- Scharapow
- Schattenberg
- Scheer VAN DER
- Scheyer
- Schlesinger
- Schob
- Schob
- Schob
- Schröer
- Schwartz
- Schäffer
- Schütte
- SchützO
- Seitz
- Siegmund
- Spadolini
- Spatz
- Spatz
- Spatz
- Spatz
- Spatz
- Spielmeyer
- Spielmeyer
- Spielmeyer
- Spruth
- SR Rosenthal
- ST Ederer
- Sternberg
- Stroh
- T Alajottanne
- T Brander
- T Brander
- T Lüers
- TF Hellbrügge
- Thums
- TJ Case
- TJ Putnam
- Tschernyscheff
- Turhan
- Töndury
- Töndury
- Urechia
- V Kahlden
- V Monakow
- V Monakow
- V Monakow
- V Monakow
- VB Dolgopol
- W Birk
- W Catell
- W Catell
- W Drude
- W Dublin
- W Dublin
- W Giese
- W Haymaker
- W Kahle
- W Kramer
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Scholz
- W Spielmeyer
- W Weygandt
- WA Campbell
- WE King
- Weed
- Wertkin
- Westphal
- Westphal
- WF Windle
- WF Windle
- WG Lennox
- WG Wyllie
- Wilke
- Wille
- WJ Eicke
- WJ Eicke
- WJ Eicke
- Wohal
- Wohlwill
- Wohlwill
- Wohlwill
- Wohlwill
- Wolff
- WS Craig
- Y Akerrén
- Y Yamaoka
- Yakovlev
- Yakovlev
- Zngerle
- Zngerle
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1956
- Field of study
Development and developmental disorders of the forebrain
- Author
- A Aeby
- A Bulfone
- A Bulfone
- A Chédotal
- A Dekaban
- A Dufour
- A Ghosh
- A Hellström
- A Hori
- A Hori
- A Hori
- A Hori
- A Kakita
- A Kakita
- A Kalsbeek
- A Mallamacci
- A Morel
- A Morishima
- A Nobin
- A Parent
- A Parent
- A Prader
- A Santos
- A Simeone
- A Simeone
- A Smith-Fernández
- A Stoykova
- A Stoykova
- A Vortkamp
- AA Khan
- AA Khan
- AA Lavdas
- AA Pearson
- AA Pearson
- AA Pearson
- AAM Gribnau
- AAM Gribnau
- AB Droogleever Fortuyn
- AF Schier
- AH Hoon Jr
- AJ Barkovich
- AJ Barkovich
- AJ Barkovich
- AJ Barkovich
- AJ Barkovich
- AJ Lewis
- AJ McGeorge
- AJM Keyser
- AJM Keyser
- AJM Lohman
- AM Graybiel
- AM Graybiel
- AM Graybiel
- AM Graybiel
- AM Graybiel
- AM Graybiel
- AM Maguire
- AR Kriegstein
- ART Colohan
- AS LaMantia
- B Drayer
- B Feldman
- B Franco
- B Gulyas
- BATF Gabreëls
- BATF Gabreëls
- BATF Gabreëls
- BD Solomon
- BF Sparks
- BL Hogan
- BL Hogan
- BP Brooks
- BW Chong
- C Auladell
- C Bendavid
- C Bergeron
- C Blakemore
- C Brana
- C Brana
- C Chiang
- C Danesin
- C Danesin
- C Dodé
- C Dodé
- C Dulac
- C Houart
- C Houart
- C Kiecker
- C Kioussi
- C Lois
- C Métin
- C Onye
- C Schuurmans
- C Sergi
- C Vermeij-Keers
- C Vermeij-Keers
- C Verney
- C Verney
- C Verney
- C Verney
- C Verney
- C Verney
- C Walther
- CA Garcia
- CB Saper
- CF Parsa
- CG Eden van
- CJ Herrick
- CJ Shatz
- CJ Shatz
- CJ Shatz
- CJ Shatz
- CL Dou
- CL Truwit
- CM Korff
- CM Schumann
- CM Schumann
- CP Harris
- CR Gerfen
- CR Lin
- CW Chow
- CW Larsen
- CWRJ Cremers
- CY Brazel
- D Acampora
- D Cordero
- D Kooy Van der
- D Lazzaro
- D Leigh
- D Martin
- D Pilavdzic
- D Sanlaville
- D Soffer
- D Trottier
- DB Brewer
- DD Eisenstat
- DE Pineda-Alvarez
- DE Wallis
- DE Watkins-Chow
- DF Swaab
- DF Swaab
- DF Swaab
- DF Swaab
- DG Amaral
- DG Amaral
- DH Hubel
- DH Hubel
- DJ Holt
- DJ Wolfram
- DK Rieger
- DL Berliner
- DM Dacey
- DM Gelman
- DM Greig
- DP Szeto
- DR Kornack
- DT Moran
- E Armstrong
- E Belloni
- E Broaddus
- E Cau
- E Colombo
- E Colombo
- E Fazzi
- E Fernández-Alvarez
- E Kaplan
- E Marsh
- E Matsunaga
- E Meisami
- E Roessler
- E Roessler
- E Roessler
- E Roessler
- E Roessler
- E Roessler
- E Roessler
- E Steingrimsson
- EA Grove
- EC Crosby
- EC Crosby
- ED Louis
- EG Jones
- EH Magoon
- EI Rugarli
- EI Rugarli
- EM Miyashita-Lin
- EM Simon
- EM Simon
- EM Simon
- EN Meyers
- ERA Cooper
- ERA Cooper
- ERA Cooper
- ES Monuki
- ES Monuki
- EV Semina
- EV Semina
- F Guillemot
- F Hochstetter
- F Marlow
- F Müller
- F Müller
- F Müller
- F Müller
- F Müller
- F Pichaud
- FJ Kallmann
- FP Mall
- FP Probst
- G Brückner
- G González
- G López-Bendito
- G Macchi
- G Morsier de
- G Padberg
- G Panganiban
- G Percheron
- G Pinto
- G Schwalbe
- GA Pyatkina
- GD Field
- GE Alexander
- GE Alexander
- GF Alheid
- GF Alheid
- GF Alheid
- GF Couly
- GF Hoffmann
- GJ Brewer
- GK Brown
- GM Shepherd
- GM Truslove
- GS Mastick
- GW Bruyn
- GW Eagleson
- GW Hoesen Van
- H Andersen
- H Bergquist
- H Braak
- H Braak
- H Gastaut
- H Ikeda
- H Ikeda
- H Kawano
- H Kondoh
- H Kuhlenbeck
- H Kundrat
- H Künzle
- H Künzle
- H Künzle
- H Li
- H Nagasaki
- H Rathke
- H Stephan
- H Stephan
- H Suh
- H Takahashi
- H Toresson
- H Toresson
- H Wichterle
- H Wichterle
- H Yamanouchi
- H-GK Blaas
- HA Ferreyra
- HA Oelschläger
- HB Adelmann
- HB Adelmann
- HB Adelmann
- HB Adelmann
- HB Adelmann
- HB Sarnat
- HB Sarnat
- HC Kinney
- HG Karstensen
- HG Kim
- HJ Donkelaar ten
- HJ Donkelaar ten
- HJ Donkelaar ten
- HJ Donkelaar ten
- HJ Donkelaar ten
- HJ Lammers
- HO Nornes
- HT Chugani
- HZ Sheng
- HZ Sheng
- I Aubert
- I Cobos
- I Cobos
- I Cobos
- I Conte
- I Geoffroy Saint-Hilaire
- I Kjaer
- I Kjaer
- I Kostović
- I Kostović
- I Kostović
- I Krägeloh-Mann
- I Krägeloh-Mann
- I Naruse
- I Savic
- IC Mann
- IH Smart
- IJ Mitchell
- IW Lurie
- IW Lurie
- J Aicardi
- J Aicardi
- J Altman
- J Altman
- J Altman
- J Altman
- J Altman
- J Altman
- J Altman
- J Altman
- J Bossy
- J Favor
- J Graw
- J Graw
- J Hanaway
- J Holzschuh
- J Juranek
- J Mathieu
- J McConnell
- J Mitrofanis
- J Mitrofanis
- J Mojsilović
- J Olmos de
- J Olmos de
- J Pearson
- J Prosser
- J Seibt
- J Shih
- J Silver
- J Stein
- J Stenman
- J Towfighi
- J Voogd
- J Warkany
- J Zschocke
- J-P Hardelin
- J-P Hardelin
- J-P Hardelin
- JA Carlos de
- JA Carlos de
- JA Golden
- JAN Corsellis
- JB Angevine Jr
- JB Angevine Jr
- JB Demb
- JB Kerryson
- JC Fentress
- JC Grindley
- JC Grindley
- JC Larroche
- JD Boyd
- JE Braisted
- JE Dowling
- JE Long
- JE Long
- JE Long
- JE Ming
- JE Ming
- JE Ming
- JE Schwob
- JEH Smith
- JF Pasternak
- JG Corbin
- JG Corbin
- JG Parnavelas
- JH Kordower
- JI Berman
- JJ Chevrie
- JJ Nassi
- JJ Overbeeke van
- JJ Overbeeke van
- JK Liu
- JK Mai
- JL Conklin
- JL Price
- JL Price
- JL Schwind
- JLR Rubinstein
- JLR Rubinstein
- JM Brickman
- JM Hill
- JM Hébert
- JM Hébert
- JM Kemp
- JM Opitz
- JM Opitz
- JM Provis
- JM Provis
- JM Skidmore
- JP Martinez-Barbera
- JP McAllister
- JR Siebert
- JR Siebert
- JR Siebert
- JS Dasen
- JS Hahn
- JS Hahn
- JW Bainbridge
- JW Hinds
- JW Hinds
- K Campbell
- K Dierickx
- K Itoh
- K Kishi
- K Kitamura
- K Kitamura
- K Letinić
- K Letinić
- K Letinić
- K Miyai
- K Miyoshi
- K Sailaja
- K Sato
- K Shimamura
- K Shimamura
- K Shiota
- K Shiota
- K Theiler
- K Theiler
- K Yokochi
- K Yun
- KB El-Jaick
- KB Rohr
- KJ Lee
- KK Nakano
- KL Earle
- KV Hinrichsen
- KW Gripp
- KWS Ashwell
- L Basel-Vanagaite
- L Heimer
- L Heimer
- L Heimer
- L Heimer
- L Heimer
- L Jones
- L López-Mascaraque
- L Medina
- L Nagai
- L Nanni
- L Nanni
- L Olson
- L Olson
- L Olson
- L Puelles
- L Puelles
- L Puelles
- L Puelles
- L Puelles
- L Puelles
- L Puelles
- L Puelles
- L Puelles
- L Sussel
- L Zeltser
- LA Croen
- LA Specht
- LA Specht
- LD Selemon
- LE Braverman
- LE Muske
- LG Biesecker
- LM Oliveira
- LTL Sie
- M Burmeister
- M Dahme
- M García-López
- M Gilbert
- M Gulisano
- M Gérard
- M Halpern
- M Hynes
- M Ito
- M Kato
- M Kyllerman
- M Livingstone
- M Meredith
- M Morioka
- M Muenke
- M Olsson
- M Olsson
- M Pellegrini
- M Qiu
- M Rallu
- M Rallu
- M San de
- M Schwanzel-Fukuda
- M Schwanzel-Fukuda
- M Schwanzel-Fukuda
- M Sur
- M Tassabehji
- M Torres
- M Treier
- M Tulinius
- M Visser
- M Yoshida
- M Zeviani
- MA Rutherford
- MA Rutherford
- MA Rutherford
- MB Luskin
- MC Brodsky
- MC Mione
- MG Norman
- MG Price
- MH Porteus
- MI Shipley
- MJ Carson
- MJ Depew
- MJ Vaizey
- MM Cohen Jr
- MM Cohen Jr
- MM Cohen Jr
- MM Cohen Jr
- MM Cohen Jr
- MP Matise
- MP Ogren
- MP Smidt
- MP Smidt
- MR DeLong
- MR DeLong
- MT Dattani
- MT Dattani
- MT Dattani
- MV Johnston
- N Boehm
- N Dahmane
- N Darin
- N Flames
- N Hirsch
- N Malamud
- N Mazzitelli
- N Tamamaki
- N Ulfig
- N Ulfig
- N Ulfig
- N Ulfig
- N Ulfig
- N Ulfig
- N Zecevic
- N Zečević
- NM Jansonius
- NR Cohen
- O Baenziger
- O Marín
- O Marín
- O Marín
- O Marín
- OH Sundin
- OP Ottersen
- P Apkarian
- P Apkarian
- P Aza-Blanc
- P Flandin
- P Hertwig
- P Levitt
- P Marcorelles
- P Munckhof van den
- P Rakic
- P Rakic
- P Rakic
- P Rakic
- P Rakic
- P Rakić
- P Tvrdik
- P Vanderhaeghen
- P Volpe
- P Voorn
- PA Zaki
- PF Hitchcock
- PF Ippel
- PHMF Domburg van
- PI Yakovlev
- PI Yakovlev
- PJ Gage
- PM Almqvist
- PP Graziadei
- PQ Thomas
- PS Goldman
- PS Goldman-Rakic
- PS Goldman-Rakic
- Q Wang
- Q Xu
- Q Xu
- R Edison
- R Friede
- R Legouis
- R Macdonald
- R Marchand
- R Marchand
- R Marchand
- R Nieuwenhuys
- R Nieuwenhuys
- R Ortmann
- R O’Rahilly
- R O’Rahilly
- R O’Rahilly
- R Pooh
- R Quinton
- R Sachdeva
- R Tuttle
- RA Gorski
- RC Murray
- RC Switzer
- RD Lund
- RE Decker
- RE Hill
- RF Hevner
- RF Hevner
- RF Hevner
- RG Northcutt
- RH Zetterstrom
- RI Kelley
- RJ Lemire
- RK Koenekoop
- RL Albin
- RL Leibel
- RM Harris
- RM Norman
- RM Zetterstrom
- RP Rademakers
- RR Waclaw
- RW Guillery
- RW Leech
- RW Young
- S Brand
- S Brand
- S Camper
- S Casarosa
- S Clarke
- S Daikoku
- S Domené
- S Fertuzinhos
- S Fuhrmann
- S Garel
- S Kang
- S Kimura
- S Kimura
- S Kölker
- S Martínez
- S Nery
- S Rittig
- S Scholpp
- S Shanmugalingam
- S Tole
- S Tole
- S Wawersik
- S Willnow
- S Wray
- S Wray
- S Xuan
- S Yamada
- S Yamada
- S Zeki
- SA Anderson
- SA Anderson
- SA Anderson
- SA Anderson
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Bayer
- SA Brown
- SB Pulitzer
- SH Hendry
- SI Goodman
- SI Goodman
- SJ Butt
- SJ England
- SJ Hayflick
- SL Asa
- SL Asa
- SM Sisodiya
- SM Zeki
- SN Haber
- SP Miller
- SR Braddock
- SR Florell
- SS Tan
- T Franz
- T Glaser
- T Hirai
- T Hongo
- T Humphrey
- T Humphrey
- T Humphrey
- T Humphrey
- T Kouki
- T Marquardt
- T Mori
- T Shimogori
- T Stühmer
- T Theil
- T Voit
- T Wichmann
- T Yamadori
- T Zhao
- TB Freeman
- TD Sanger
- TL Kemper
- TS Kim
- TT Warner
- TT Warner
- TW Deacon
- U Bahnsen
- U Roessmann
- U Roessmann
- V Heyningen van
- V Heyningen Van
- V Paroder
- VB Ho
- VH Sousa
- VM Montero
- VM Pickel
- VM Tennyson
- W Ashton
- W Hewitt
- W Hewitt
- W His
- W His
- W Kahle
- W Schmahl
- W Squier
- W Wurst
- W Ye
- WE DeMyer
- WE DeMyer
- WE DeMyer
- WH Merigan
- WH Merigan
- WH Merigan
- WJ Atwell
- WJ Hamilton
- WJH Nauta
- X Li
- X Zhu
- Y Asakura
- Y Furuta
- Y Izumi
- Y Izumi
- Y Koutcherov
- Y Litingtung
- Y Nakagawa
- Y Ohkubo
- Y Suda
- Y Yilmaz
- YG Watanabe
- YR Barishak
- Z Ellison-Wright
- Z Molnár
- Z Molnár
- Z Molnár
- Z Molnár
- Z Molnár
- Z Molnár
- ZM Varga
- Å Seiger
- Publication venue
- Publication date
- 01/01/2014
- Field of study
Rationale, design, implementation, and baseline characteristics of patients in the DIG trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure
- Author
- Abernathy GT
- Abrams J
- Akhtar S
- Albitar I
- Amidi M
- Anand IS
- Arnold JMO
- Arnold JMO
- Arthur MM
- Ashton T
- Aubrey B
- Auger P
- Babb J
- Baigrie R
- Baird MG
- Baitz T
- Baker A
- Barber NC
- Barbour DJ
- Barnhill S
- Barr DM
- Basu AK
- Baughman KL
- Beaudoin J
- Beckham V
- BekheitSaad S
- Berkson DM
- Bertoglio M
- Bessoudo R
- Bhaskar G
- Binder A
- Bloomfield D
- Bodine K
- Boehmer JP
- Borgersen K
- Borts D
- Bouchard G
- Bourassa MG
- Boutros G
- Bozek B
- Brisbin D
- Bristow D
- Brophy J
- Brossoit R
- Brown E
- Brown J
- Bruinsma N
- Burns A
- Burton G
- Caleb H
- Cameron A
- Campbell R
- Campeau J
- Campos EE
- Cardello FP
- Carew B
- Carter RP
- Chacon F
- Chan YK
- Charles FR
- Chaudhry MA
- Chiaramida A
- Chiaramida S
- Chohan A
- Christie LG
- Clemson BS
- Cline DR
- Cohn JN
- Collin R
- Collins JF
- Collins R
- Cook TH
- Copen DL
- Cossett J
- Costantino T
- Crawford MH
- Croke RP
- Crowell R
- Dagenais GR
- DAmours G
- Danisa K
- Davidson S
- Davies ML
- Davies R
- Davies RA
- Delage F
- DeLarochelliere R
- DeLeon AC
- Denes P
- Dennish GW
- Denny DM
- DeVilla MA
- Deykin D
- DeYoung JP
- Dhurandhar RW
- DibnerDunlap M
- Dodek A
- Doherty JE
- Dominguez J
- Dubbin J
- Dufton J
- Effron MB
- Egan D
- Eladasari B
- ElSherif N
- Engelhardt HT
- Ericson K
- Fahrenholtz D
- Fast A
- Feldbush MW
- Fell DA
- Fishman S
- Fitchett D
- Fleg JL
- Flint E
- Fly D
- Folger JS
- Folkins D
- Forker AD
- Fowles RE
- Fraker TD
- Francis G
- Frerking TR
- Friesinger GC
- Fulop JC
- Fye C
- Gagne W
- Gagnon J
- Gamble L
- Ganjavi F
- Garg R
- Garrou BW
- Geller N
- Gent M
- Gervais PB
- Gheorghiade M
- Gilbert L
- Gillie E
- Glatter TR
- Godley ML
- Goeres M
- Gold J
- Goldberger MH
- Gollapudi A
- Goode JE
- Goodman LS
- Gordon R
- Gorlin R
- Gossard D
- Gosselin G
- Goulet C
- Graettinger WF
- Grant C
- Greene JG
- Greenwood PV
- Gregoratos G
- Gregory JJ
- Groden DL
- Grover J
- Gudapati R
- Guess MA
- Gupta SC
- Habib N
- Hack I
- Hagar S
- Hamilton WP
- Hankey TL
- Hanna M
- Harper D
- Harris DE
- Harris S
- Hassapoyannes CA
- Hatheway RJ
- Heinsimer J
- Heiselman DE
- Held CP
- Hennekens C
- Hess AR
- Hickey JE
- Hickner J
- Higgins T
- Higginson L
- Highfield DA
- Hill L
- Hobbins TE
- Hobbs RE
- Hockenbrock R
- Honos G
- Hood WB
- Horner BA
- Horney RA
- Horwitz L
- Hsieh A
- Hsueh JT
- Huang PC
- Hubbard J
- Hughes DF
- Hui W
- Hunsberger S
- Imrie JR
- Jacobs MH
- Jadwin LM
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- Publication venue
- Publication date
- 01/01/1996
- Field of study
This article provides a detailed overview of the rationale for key aspects of the protocol of the Digitalis Investigation Group (DIG) trial. It also highlights unusual aspects of the study implementation and the baseline characteristics. The DIG trial is a large, simple, international placebo-controlled trial whose primary objective is to determine the effect of digoxin on all cause mortality in patients with clinical heart failure who are in sinus rhythm and whose ejection fraction is less than or equal to 0.45. An ancillary study examines the effect in those with an ejection fraction > 0.45. Key aspects of the trial include the simplicity of the design, broad eligibility criteria, essential data collection, and inclusion of various types of centers. A total of 302 centers in the United States and Canada enrolled 7788 patients between February 1991 and September 1993. Follow-up continued until December 1995 with the results available in Spring 1996
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- Y. Miyake T. Abe, and T. Yamano, in International Symposium on Oxidases and Related Redox Systems
- YA Sharonov
- YA Sharonov
- YA Sharonov
- YE Erokhin
- YJ Kang
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- Z Zak
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1984
- Field of study
Komplextrauma und plastische Rekonstruktion
- Author
- A Biewener
- A Cacchio
- A Cracciolo
- A Daigeler
- A Hoffa
- A Kemmer
- A Kotter
- A Manoli
- A Manoli
- A Reigstad
- A Steindler
- A Taniguchi
- AA Zeligowski
- AC Masquelet
- AC Masquelet
- AE Beris
- AH Bashir
- AM Betz
- AR Burgess
- B Bardenheuer
- B Fildes
- B Kinner
- B Mollon
- B Swoboda
- BJ Gilbert
- BR Smith
- C Attinger
- C Attinger
- C Lindqvist
- C Probst
- C Rainer
- CE Attinger
- CH Siebert
- CJ Wei
- CR Wyss
- CW Hsiao
- DA Hidalgo
- DC Covey
- DC Turchin
- DH Boack
- DH Harrison
- DM Shah
- DN Collins
- DW Goodwin
- E Biemer
- E Castel
- E Fulkerson
- E Gür
- E Lang
- EJ MacKenzie
- EJ MacKenzie
- EL Bradley
- F Neudeck
- F Yuksel
- FJ Bartolomei
- FW Wagner
- G Bouachour
- G Cierny
- G Hohmann
- G Holle
- G Horne
- G Metak
- GD Stainsby
- GP Guyton
- GT Loo
- H Gollwitzer
- H Görres
- H Hantira
- H Menke
- H Seiler
- H Tscherne
- H Tscherne
- H Tscherne
- H Zwipp
- H Zwipp
- H Zwipp
- H Zwipp
- H Zwipp
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- H Zwipp
- H Zwipp
- HA Vallier
- HB Boyd
- HC Fayaz
- HG Ender
- HJ Oestern
- HR Howe
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- HU Steinau
- I Kuran
- J Andermahr
- J Lisfranc
- J Masquelet
- J Orr
- J Perry
- J Perry
- J Syme
- J Syme
- J Wright
- JA Goldberg
- JB Carr
- JC Vogt
- JD Heckman
- JD Heckman
- JD Heckman
- JMt Woods
- JO Anglen
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- JS Gould
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- JW Folk
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- K Johansen
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- Publication venue
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- Publication date
- Field of study
Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients
- Author
- A A
- Abbott Jd
- Abdullah S
- Abib E Jr
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- Wronska D
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- Wychota K
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- Zannad F
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- Zemour G
- Zeng X
- Zeno Ml
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- Zrazhevskiy K
- Zubek V
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Bococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin- kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODS In two parallel, multinational trials with different entry criteria for LDL cholesterol levels, we randomly assigned the 27,438 patients in the combined trials to receive bococizumab (at a dose of 150 mg) subcutaneously every 2 weeks or placebo. The primary end point was nonfatal myocardial infarction, nonfatal stroke, hospitalization for unstable angina requiring urgent revascularization, or cardiovascular death; 93% of the patients were receiving statin therapy at baseline. The trials were stopped early after the sponsor elected to discontinue the development of bococizumab owing in part to the development of high rates of antidrug antibodies, as seen in data from other studies in the program. The median follow-up was 10 months. RESULTS At 14 weeks, patients in the combined trials had a mean change from baseline in LDL cholesterol levels of -56.0% in the bococizumab group and +2.9% in the placebo group, for a between-group difference of -59.0 percentage points (P<0.001) and a median reduction from baseline of 64.2% (P<0.001). In the lower-risk, shorter-duration trial (in which the patients had a baseline LDL cholesterol level of ≥70 mg per deciliter [1.8 mmol per liter] and the median follow-up was 7 months), major cardiovascular events occurred in 173 patients each in the bococizumab group and the placebo group (hazard ratio, 0.99; 95% confidence interval [CI], 0.80 to 1.22; P = 0.94). In the higher-risk, longer-duration trial (in which the patients had a baseline LDL cholesterol level of ≥100 mg per deciliter [2.6 mmol per liter] and the median follow-up was 12 months), major cardiovascular events occurred in 179 and 224 patients, respectively (hazard ratio, 0.79; 95% CI, 0.65 to 0.97; P = 0.02). The hazard ratio for the primary end point in the combined trials was 0.88 (95% CI, 0.76 to 1.02; P = 0.08). Injection-site reactions were more common in the bococizumab group than in the placebo group (10.4% vs. 1.3%, P<0.001). CONCLUSIONS In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events in the trial involving lower-risk patients but did have a significant benefit in the trial involving higher-risk patients