2,758 research outputs found
Real Property
Covers cases on the conveyance of after-acquired title by quitclaim deed—effect of habendum clause
New data and the hard pomeron
New structure-function data are in excellent agreement with the existence of
a hard pomeron, with intercept about 1.4. It gives a very economical
description of the data. Having fixed 2 parameters from the data for the
real-photon cross section , we need just 5 further
parameters to fit the data for with . The available
data range from to 35 GeV. With guesses consistent with
dimensional counting for the dependences of our three separate terms, the
fit extends well to larger and to GeV. With no additional
parameters, it gives a good description of data for the charm structure
function from to 130 GeV. The two pomerons also give
a good description of both the and the dependence of .Comment: 11 pages, plain tex, with 10 figures embedded using epsf. (Spurious
figure removed.
Scaling metagenome sequence assembly with probabilistic de Bruijn graphs
Deep sequencing has enabled the investigation of a wide range of
environmental microbial ecosystems, but the high memory requirements for {\em
de novo} assembly of short-read shotgun sequencing data from these complex
populations are an increasingly large practical barrier. Here we introduce a
memory-efficient graph representation with which we can analyze the k-mer
connectivity of metagenomic samples. The graph representation is based on a
probabilistic data structure, a Bloom filter, that allows us to efficiently
store assembly graphs in as little as 4 bits per k-mer, albeit inexactly. We
show that this data structure accurately represents DNA assembly graphs in low
memory. We apply this data structure to the problem of partitioning assembly
graphs into components as a prelude to assembly, and show that this reduces the
overall memory requirements for {\em de novo} assembly of metagenomes. On one
soil metagenome assembly, this approach achieves a nearly 40-fold decrease in
the maximum memory requirements for assembly. This probabilistic graph
representation is a significant theoretical advance in storing assembly graphs
and also yields immediate leverage on metagenomic assembly
The mutation Ser2117Leu, in the second hydrophobic spike of the factor V C2 domain, increases phospholipid affinity and specific activity
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106082/1/jth05227.pd
Renewed investigations at Taung; 90 years after the discovery of Australopithecus africanus
2015 marked the 90th anniversary of the description of the first fossil ofAustralopithecus africanus, commonly known as the Taung Child,
which was unearthed during blasting at the Buxton-Norlim Limeworks (referred to as the BNL) 15 km SE of the town of Taung, South
Africa. Subsequently, this site has been recognized as a UNESCOWorld Heritage site on the basis of its importance to southern African
palaeoanthropology. Some other sites such as Equus Cave and Black Earth Cave have also been investigated; but the latter not since the
1940s. These sites indicate that the complex of palaeontological and archaeological localities at the BNL preserve a time sequence
spanning the Pliocene to the Holocene. The relationship of these various sites and how they fit into the sequence of formation of tufa,
landscapes and caves at the limeworks have also not been investigated or discussed in detail since Peabody’s efforts in the 1940s. In
this contribution we mark the 90th anniversary of the discovery and description of the Taung Child by providing a critical review of
previous work at Taung based on our recent preliminary work at the site. This includes a reassessment of the Taung Child Type Site, as
well as renewed excavations at Equus Cave and the lesser-known locality and little-investigated Black Earth Cave. Preliminary results
suggest that much of our previous understandings of the BNL’s formational history and site formation processes need to be reassessed.
Only through detailed analysis on the BNLas a whole can we understand this complex depositional environment.Australian Research Council Future Fellowship grant FT120100399
Palaeontological Scientific Trust (PAST)
National Geographic grants (8774-10 and 3212)JNC2016https://www.wits.ac.za/esi/palaeontologia-africana
Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer:a nested case-control study
Vitamin D pathway single nucleotide polymorphisms (SNPs) are potentially useful proxies for investigating whether circulating vitamin D metabolites [total 25-hydroxyvitamin-D, 25(OH)D; 1,25-dihydroxyvitamin, 1,25(OH)2D] are causally related to prostate cancer. We investigated associations of sixteen SNPs across seven genes with prostate-specific antigen-detected prostate cancer
Genetic Predisposition Impacts Clinical Changes in a Lifestyle Coaching Program.
Both genetic and lifestyle factors contribute to an individual\u27s disease risk, suggesting a multi-omic approach is essential for personalized prevention. Studies have examined the effectiveness of lifestyle coaching on clinical outcomes, however, little is known about the impact of genetic predisposition on the response to lifestyle coaching. Here we report on the results of a real-world observational study in 2531 participants enrolled in a commercial Scientific Wellness program, which combines multi-omic data with personalized, telephonic lifestyle coaching. Specifically, we examined: 1) the impact of this program on 55 clinical markers and 2) the effect of genetic predisposition on these clinical changes. We identified sustained improvements in clinical markers related to cardiometabolic risk, inflammation, nutrition, and anthropometrics. Notably, improvements in HbA1c were akin to those observed in landmark trials. Furthermore, genetic markers were associated with longitudinal changes in clinical markers. For example, individuals with genetic predisposition for higher LDL-C had a lesser decrease in LDL-C on average than those with genetic predisposition for average LDL-C. Overall, these results suggest that a program combining multi-omic data with lifestyle coaching produces clinically meaningful improvements, and that genetic predisposition impacts clinical responses to lifestyle change
Leukotriene antagonists as first-line or add-on asthma controller therapy
Most randomized trials of treatment for asthma study highly selected patients under idealized conditions. METHODS: We conducted two parallel, multicenter, pragmatic trials to evaluate the real-world effectiveness of a leukotriene-receptor antagonist (LTRA) as compared with either an inhaled glucocorticoid for first-line asthma-controller therapy or a long-acting beta(2)-agonist (LABA) as add-on therapy in patients already receiving inhaled glucocorticoid therapy. Eligible primary care patients 12 to 80 years of age had impaired asthma-related quality of life (Mini Asthma Quality of Life Questionnaire [MiniAQLQ] score =6) or inadequate asthma control (Asthma Control Questionnaire [ACQ] score =1). We randomly assigned patients to 2 years of open-label therapy, under the care of their usual physician, with LTRA (148 patients) or an inhaled glucocorticoid (158 patients) in the first-line controller therapy trial and LTRA (170 patients) or LABA (182 patients) added to an inhaled glucocorticoid in the add-on therapy trial. RESULTS: Mean MiniAQLQ scores increased by 0.8 to 1.0 point over a period of 2 years in both trials. At 2 months, differences in the MiniAQLQ scores between the two treatment groups met our definition of equivalence (95% confidence interval [CI] for an adjusted mean difference, -0.3 to 0.3). At 2 years, mean MiniAQLQ scores approached equivalence, with an adjusted mean difference between treatment groups of -0.11 (95% CI, -0.35 to 0.13) in the first-line controller therapy trial and of -0.11 (95% CI, -0.32 to 0.11) in the add-on therapy trial. Exacerbation rates and ACQ scores did not differ significantly between the two groups. CONCLUSIONS: Study results at 2 months suggest that LTRA was equivalent to an inhaled glucocorticoid as first-line controller therapy and to LABA as add-on therapy for diverse primary care patients. Equivalence was not proved at 2 years. The interpretation of results of pragmatic research may be limited by the crossover between treatment groups and lack of a placebo group
A meta-analysis of perceptions of defeat and entrapment in depression, anxiety problems, posttraumatic stress disorder, and suicidality
This document is the Accepted Manuscript version of the following article: Andy P. Siddaway, Peter J. Taylor, Alex M. Wood, and Joerg Schulz, ‘A meta-analysis of perceptions of defeat and entrapment in depression, anxiety problems, posttraumatic stress disorder, and suicidality’, Journal of Affective Disorders, Vol. 184: 149-159, September 2015. The final, published version is available online at: DOI: https://doi.org/10.1016/j.jad.2015.05.046Background: There is a burgeoning literature examining perceptions of being defeated or trapped in different psychiatric disorders. The disorders most frequently examined to date are depression, anxiety problems, posttraumatic stress disorder (PTSD), and suicidality. Aims: To quantify the size and consistency of perceptions of defeat and entrapment in depression, anxiety problems, PTSD and suicidality, test for differences across psychiatric disorders, and examine potential moderators and publication bias. Method:Random-effects meta-analyses based on Pearson's correlation coefficient r. Results: Forty studies were included in the meta-analysis (n=10,072). Perceptions of defeat and entrapment were strong (around r=0.60) and similar in size across all four psychiatric disorders. Perceptions of defeat were particularly strong in depression (r=0.73). There was no between-study heterogeneity; therefore moderator analyses were conducted in an exploratory fashion. There was no evidence of publication bias. Limitations: Analyses were cross-sectional, which precludes establishing temporal precedence or causality. Some of the meta-analyses were based on relatively small numbers of effect sizes, which may limit their generalisability. Conclusions: Perceptions of defeat and entrapment are clinically important in depression, anxiety problems, PTSD, and suicidality. Similar-sized, strong relationships across four different psychiatric disorders could suggest that perceptions of defeat and entrapment are transdiagnostic constructs. The results suggest that clinicians and researchers need to become more aware of perceptions of defeat and entrapmentPeer reviewedFinal Accepted Versio
Experimental Bounds on Masses and Fluxes of Nontopological Solitons
We have re-analyzed the results of various experiments which were not
originally interested as searches for the Q-ball or the Fermi-ball. Based on
these analyses, in addition to the available data on Q-balls, we obtained
rather stringent bounds on flux, mass and typical energy scale of Q-balls as
well as Fermi-balls. In case these nontopological solitons are the main
component of the dark matter of the Galaxy, we found that only such solitons
with very large quantum numbers are allowed. We also estimate how sensitive
future experiments will be in the search for Q-balls and Fermi-balls.Comment: 19 pages, 7 eps figures, RevTeX, psfig.st
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