Influence of Geometric Simplifications on Lightning Strike Simulations

This paper discusses the influence of simplifications in models used in the design of electromagnetic protection against indirect effects of lightning strikes. A real and complex test case such as the power plant of an A400M aircraft, simulated with the FDTD method, is chosen for this. The parameters studied are the inclusion/removal of installations, modification of electrical contacts, material properties, and changes in the cable characteristics. The simulations performed allow us to quantify the impact of different simplification approaches and, in consequence, to draw conclusions on the relative importance of different model features, being the most important ones to maintain the electrical contacts, to include installations and cables carrying high currents, to consider different materials, to respect the accurate cable routes or to take care of isolated equipment.This work has received funding from the Projects TEC2013-48414-C3-01, TEC2013-48414-C3-2-R, TEC2016-79214-C3-1-R, TEC2016-79214-C3-3-R, and TEC2015-68766-REDC (Spanish MINECO, EU FEDER), P12-TIC-1442 (J. de Andalucia, Spain), Alhambra-UGRFDTD (AIRBUS DS), and by the CSIRC alhambra.ugr.es supercomputing center

Efectividad de un programa de medicina complementaria como coadyuvante en el tratamiento de la fibromialgia

La fibromialgia es síndrome de dolor crónico que afecta a muchas mujeres jóvenes en nuestro país. Objetivo: Determinar la efectividad de un programa de medicina complementaria como coadyuvante en el tratamiento de la fibromialgia. Métodos: Investigación pre experimental, se comparó el puntaje del índice Lattinen y la frecuencia de sus dimensiones antes y después de una intervención con un programa de medicina complementaria, en 129 pacientes entre 25 y 65 años con fibromialgia en tratamiento convencional. El programa de medicina complementaria consistió en acupuntura, fitoterapia y terapia mente cuerpo durante 8 semanas. Las covariables fueron edad, sexo, procedencia, tiempo de enfermedad y tipo de tratamiento farmacológico. Se analizaron los resultados a través de una prueba t de Student para muestras relacionadas y la prueba U de Mann-Whitney. Finalmente, se aplicó análisis de regresión lineal simple y ajustada. Resultados: De los 129 pacientes voluntarios, el 93,0% fueron mujeres. La mediana de edad fue 52 años, 70,1% procedentes de Trujillo, con una mediana 0,5 (0,2-3,0) de años de enfermedad. Se observó una reducción significativa en la intensidad del dolor, la frecuencia del dolor, el consumo de analgésicos, la incapacidad y la necesidad de hipnóticos después de la intervención (p<0,001). El puntaje promedio del índice de Lattinen disminuyó de 10,3±2,9 antes de la intervención a 3,9±1,6 después de la intervención (p<0,001). Conclusión: El programa de medicina complementaria evaluado fue efectivo como coadyuvante para mejorar el control de la fibromialgia, mejorando significativamente el puntaje del índice de Lattinen

Psychological impact on care professionals due to the SARS-Cov-2 virus in Spain

Objective:To analyze the psychological impact of the SARS-Cov-2 pandemic on nursesin Spain in three different dimensions: exposure to stressors, perceived emotions, andstress coping. Background: On March 11, 2019, the World Health Organization recognized a globalpandemic caused by a SARS-Cov-2 virus, COVID-19, which rapidly spread across theplanet, involving a community health emergency of international scope.Introduction:The pandemic situation in health centers has led to significant changesin the work environment, compromising care professionals’ physical and psychologicalhealth and resulting in strong physical and mental exhaustion.Methods: An observational, descriptive, cross-sectional study was carried out, betweenFebruary and April 2021, in a large sample of 1360 participants. The researchers con-ducted the dissemination of a validated questionnaire to working nurses in Spain.Results:The sex variable in relation to the study dimensions (stressors, perceived emo-tions, and coping strategies) showed a mean for stressors of 62.2±10.5 in women and59.8±12.5 in men (p=0.010), showing statistically significant differences. Age was aprotective factor for all dimensions (p<0.001). Time of experience showed statisticallysignificant differences for stressors and coping strategies in professionals with more than15 years of experience. Discussion: Female nurses who are younger, have less work experience, have not builta family of their own, and live in smaller or indoor flats may be more vulnerable to theeffects of the COVID-19 pandemic on their mental health. Other national and inter-national studies, in this line, have shown an important psychological impact on theseprofessionals.Conclusion:It is necessary to design and adopt effective strategies and measures for theprotection of nurses’ mental health, as well as for the prevention and early diagnosis ofpossible mental health problems

Memoria del segundo simposium sobre historia, sociedad y cultura de México y América Latina

La presente obra reúne 20 ponencias de las 27 que se presentaron en el “Segundo simposium sobre historia, sociedad y cultura de México y América Latina”, realizado el 8 y 9 de noviembre de 2006, en el Centro de Investigación en Ciencias Sociales y Humanidades (CICSyH) de la Universidad Autónoma del Estado de México (UAEM), en Toluca, Estado de México

Relaciones de poder en el Estado de México. Ayer y hoy

Como su título indica, el presente libro gira en torno a las relaciones de poder en el Estado de México, tanto en el pasado como en el presente. El estudio de las relaciones de poder desde periodos remotos hasta la actualidad, tanto en sus manifestaciones democráticas como en las autoritarias, constituye el objeto de estudio del cuerpo académico denominado “El poder en América Latina. Ayer y hoy”, adscrito al Centro de Investigación en Ciencias Sociales y Humanidades (cicsyh) de la Universidad Autónoma del Estado de México (uaem), si bien, de acuerdo con su denominación, este grupo de investigación también estudia lugares distintos al que se refiere el presente libro

Viral RNA load in plasma is associated with critical illness and a dysregulated host response in COVID‑19

Background. COVID-19 can course with respiratory and extrapulmonary disease. SARS-CoV-2 RNA is detected in respiratory samples but also in blood, stool and urine. Severe COVID-19 is characterized by a dysregulated host response to this virus. We studied whether viral RNAemia or viral RNA load in plasma is associated with severe COVID-19 and also to this dysregulated response. Methods. A total of 250 patients with COVID-19 were recruited (50 outpatients, 100 hospitalized ward patients and 100 critically ill). Viral RNA detection and quantification in plasma was performed using droplet digital PCR, targeting the N1 and N2 regions of the SARS-CoV-2 nucleoprotein gene. The association between SARS-CoV-2 RNAemia and viral RNA load in plasma with severity was evaluated by multivariate logistic regression. Correlations between viral RNA load and biomarkers evidencing dysregulation of host response were evaluated by calculating the Spearman correlation coefficients. Results. The frequency of viral RNAemia was higher in the critically ill patients (78%) compared to ward patients (27%) and outpatients (2%) (p < 0.001). Critical patients had higher viral RNA loads in plasma than non-critically ill patients, with non-survivors showing the highest values. When outpatients and ward patients were compared, viral RNAemia did not show significant associations in the multivariate analysis. In contrast, when ward patients were compared with ICU patients, both viral RNAemia and viral RNA load in plasma were associated with critical illness (OR [CI 95%], p): RNAemia (3.92 [1.183–12.968], 0.025), viral RNA load (N1) (1.962 [1.244–3.096], 0.004); viral RNA load (N2) (2.229 [1.382–3.595], 0.001). Viral RNA load in plasma correlated with higher levels of chemokines (CXCL10, CCL2), biomarkers indicative of a systemic inflammatory response (IL-6, CRP, ferritin), activation of NK cells (IL-15), endothelial dysfunction (VCAM-1, angiopoietin-2, ICAM-1), coagulation activation (D-Dimer and INR), tissue damage (LDH, GPT), neutrophil response (neutrophils counts, myeloperoxidase, GM-CSF) and immunodepression (PD-L1, IL-10, lymphopenia and monocytopenia). Conclusions. SARS-CoV-2 RNAemia and viral RNA load in plasma are associated with critical illness in COVID-19. Viral RNA load in plasma correlates with key signatures of dysregulated host responses, suggesting a major role of uncontrolled viral replication in the pathogenesis of this disease.This work was supported by awards from the Canadian Institutes of Health Research, the Canadian 2019 Novel Coronavirus (COVID-19) Rapid Research Funding initiative (CIHR OV2 – 170357), Research Nova Scotia (DJK), Atlantic Genome/Genome Canada (DJK), Li-Ka Shing Foundation (DJK), Dalhousie Medical Research Foundation (DJK), the “Subvenciones de concesión directa para proyectos y programas de investigación del virus SARS‐CoV2, causante del COVID‐19”, FONDO–COVID19, Instituto de Salud Carlos III (COV20/00110, CIBERES, 06/06/0028), (AT) and fnally by the “Convocatoria extraordinaria y urgente de la Gerencia Regional de Salud de Castilla y León, para la fnanciación de proyectos de investigación en enfermedad COVID-19” (GRS COVID 53/A/20) (CA). DJK is a recipient of the Canada Research Chair in Translational Vaccinology and Infammation. APT was funded by the Sara Borrell Research Grant CD018/0123 funded by Instituto de Salud Carlos III and co-fnanced by the European Development Regional Fund (A Way to Achieve Europe programme). The funding sources did not play any role neither in the design of the study and collection, not in the analysis, in the interpretation of data or in writing the manuscript

Influence of Geometric Simplifications on HIRF Simulations

This paper analyzes the influence of simplifications in electromagnetic models used in thedesign of protections against High-Intensity Radiated Field (HIRF) threats. Both conductive andradiated effects are evaluated, covering the wide frequency range between 1 MHz and 6 GHz. A real andcomplex test case such as the power plant of an A400M aircraft was simulated using FDTD methodso as to analyse the impact of different simplification approaches. The parameters studied are theinclusion/removal of installations, modification of electrical contacts, material properties, and changesin the cable features. In consequence, we can conclude that for the frequency range around tens orhundreds of megahertzs every detail is important (all the pieces of the model, accuratebundle routes andcable properties), while for higher frequencies only the details nearby the analyzed point are relevant forthe results and it is not necessary to distinguish between different materials which are good conductorsat this frequency range

Memoria del cuarto encuentro internacional sobre el poder en el pasado y el presente de América Latina

Este volumen está compuesto por veinte trabajos que abordan temas relativos a las distintas manifestaciones -tanto democráticas como autoritarias- de un aspecto de la realidad presente en la vida de todas las personas: el poder. En ocasiones, constituyen reflexiones teóricas, pero en su mayoría enfrentan problemas sobre el pasado y el presente de México

Memoria del tercer encuentro internacional sobre el poder en el pasado y el presente de América Latina

Este volumen está compuesto por diecisiete trabajos que abordan temas relativos a las manifestaciones, tanto democráticas como autoritarias, de un aspecto de la realidad que está presente en la vida de toas las personas: el poder. En ocasiones, constituyen reflexiones teóricas, pero en su mayoría enfrentan problemas sobre el pasado y presente de México, sin omitir el proceso electoral que culminará en las elecciones que ya están inmersas la clase política y la opinión pública del país

Effect of Phosphodiesterase 7 (PDE7) Inhibitors in Experimental Autoimmune Encephalomyelitis Mice. Discovery of a New Chemically Diverse Family of Compounds

Phosphodiesterase (PDE) 7 is involved in proinflammatory processes, being widely expressed both on lymphocytes and on certain brain regions. Specific inhibitors of PDE7 have been recently reported as potential new drugs for the treatment of neurological disorders because of their ability to increase intracellular levels of cAMP and thus to modulate the inflammatory process, as a neuroprotective well-established strategy. Multiple sclerosis is an unmet disease in which pathologies on the immune system, T-cells, and specific neural cells are involved simultaneously. Therefore, PDE7 inhibitors able to interfere with all these targets may represent an innovative therapy for this pathology. Here, we report a new chemically diverse family of heterocyclic PDE7 inhibitors, discovered and optimized by using molecular modeling studies, able to increase cAMP levels in cells, decrease inflammatory activation on primary neural cultures, and also attenuate the clinical symptoms in the experimental autoimmune encephalomyelitis (EAE) mouse model. These results led us to propose the use of PDE7 inhibitors as innovative therapeutic agents for the treatment of multiple sclerosis