478 research outputs found
A Variational Procedure for Time-Dependent Processes
A simple variational Lagrangian is proposed for the time development of an
arbitrary density matrix, employing the "factorization" of the density. Only
the "kinetic energy" appears in the Lagrangian. The formalism applies to pure
and mixed state cases, the Navier-Stokes equations of hydrodynamics, transport
theory, etc. It recaptures the Least Dissipation Function condition of
Rayleigh-Onsager {\bf and in practical applications is flexible}. The
variational proposal is tested on a two level system interacting that is
subject, in one instance, to an interaction with a single oscillator and, in
another, that evolves in a dissipative mode.Comment: 25 pages, 4 figure
Integrative genomic analysis identifies ancestry-related expression quantitative trait loci on DNA polymerase β and supports the association of genetic ancestry with survival disparities in head and neck squamous cell carcinoma
BACKGROUND: African Americans with head and neck squamous cell carcinoma (HNSCC) have a lower survival rate than whites. This study investigated the functional importance of ancestry-informative single-nucleotide polymorphisms (SNPs) in HNSCC and also examined the effect of functionally important genetic elements on racial disparities in HNSCC survival.
METHODS: Ancestry-informative SNPs, RNA sequencing, methylation, and copy number variation data for 316 oral cavity and laryngeal cancer patients were analyzed across 178 DNA repair genes. The results of expression quantitative trait locus (eQTL) analyses were also replicated with a Gene Expression Omnibus (GEO) data set. The effects of eQTLs on overall survival (OS) and disease-free survival (DFS) were evaluated.
RESULTS: Five ancestry-related SNPs were identified as cis-eQTLs in the DNA polymerase β (POLB) gene (false discovery rate [FDR] < 0.01). The homozygous/heterozygous genotypes containing the African allele showed higher POLB expression than the homozygous white allele genotype (P < .001). A replication study using a GEO data set validated all 5 eQTLs and also showed a statistically significant difference in POLB expression based on genetic ancestry (P = .002). An association was observed between these eQTLs and OS (P < .037; FDR < 0.0363) as well as DFS (P = .018 to .0629; FDR < 0.079) for oral cavity and laryngeal cancer patients treated with platinum-based chemotherapy and/or radiotherapy. Genotypes containing the African allele were associated with poor OS/DFS in comparison with homozygous genotypes harboring the white allele.
CONCLUSIONS: Analyses show that ancestry-related alleles could act as eQTLs in HNSCC and support the association of ancestry-related genetic factors with survival disparities in patients diagnosed with oral cavity and laryngeal cancer. Cancer 2017;123:849-60. © 2016 American Cancer Society
Capillary pressure of van der Waals liquid nanodrops
The dependence of the surface tension on a nanodrop radius is important for
the new-phase formation process. It is demonstrated that the famous Tolman
formula is not unique and the size-dependence of the surface tension can
distinct for different systems. The analysis is based on a relationship between
the surface tension and disjoining pressure in nanodrops. It is shown that the
van der Waals interactions do not affect the new-phase formation thermodynamics
since the effect of the disjoining pressure and size-dependent component of the
surface tension cancel each other.Comment: The paper is dedicated to the 80th anniversary of A.I. Rusano
Resonant nonstationary amplification of polychromatic laser pulses and conical emission in an optically dense ensemble of neon metastable atoms
Experimental and numerical investigation of single-beam and pump-probe
interaction with a resonantly absorbing dense extended medium under strong and
weak field-matter coupling is presented. Significant probe beam amplification
and conical emission were observed. Under relatively weak pumping and high
medium density, when the condition of strong coupling between field and
resonant matter is fulfilled, the probe amplification spectrum has a form of
spectral doublet. Stronger pumping leads to the appearance of a single peak of
the probe beam amplification at the transition frequency. The greater probe
intensity results in an asymmetrical transmission spectrum with amplification
at the blue wing of the absorption line and attenuation at the red one. Under
high medium density, a broad band of amplification appears. Theoretical model
is based on the solution of the Maxwell-Bloch equations for a two-level system.
Different types of probe transmission spectra obtained are attributed to
complex dynamics of a coherent medium response to broadband polychromatic
radiation of a multimode dye laser.Comment: 9 pages, 13 figures, corrected, Fig.8 was changed, to be published in
Phys. Rev.
More is the Same; Phase Transitions and Mean Field Theories
This paper looks at the early theory of phase transitions. It considers a
group of related concepts derived from condensed matter and statistical
physics. The key technical ideas here go under the names of "singularity",
"order parameter", "mean field theory", and "variational method".
In a less technical vein, the question here is how can matter, ordinary
matter, support a diversity of forms. We see this diversity each time we
observe ice in contact with liquid water or see water vapor, "steam", come up
from a pot of heated water. Different phases can be qualitatively different in
that walking on ice is well within human capacity, but walking on liquid water
is proverbially forbidden to ordinary humans. These differences have been
apparent to humankind for millennia, but only brought within the domain of
scientific understanding since the 1880s.
A phase transition is a change from one behavior to another. A first order
phase transition involves a discontinuous jump in a some statistical variable
of the system. The discontinuous property is called the order parameter. Each
phase transitions has its own order parameter that range over a tremendous
variety of physical properties. These properties include the density of a
liquid gas transition, the magnetization in a ferromagnet, the size of a
connected cluster in a percolation transition, and a condensate wave function
in a superfluid or superconductor. A continuous transition occurs when that
jump approaches zero. This note is about statistical mechanics and the
development of mean field theory as a basis for a partial understanding of this
phenomenon.Comment: 25 pages, 6 figure
The Geological Record of Ocean Acidification
Ocean acidification may have severe consequences for marine ecosystems; however, assessing its future impact is difficult because laboratory experiments and field observations are limited by their reduced ecologic complexity and sample period, respectively. In contrast, the geological record contains long-term evidence for a variety of global environmental perturbations, including ocean acidification plus their associated biotic responses. We review events exhibiting evidence for elevated atmospheric CO2, global warming, and ocean acidification over the past ~300 million years of Earth's history, some with contemporaneous extinction or evolutionary turnover among marine calcifiers. Although similarities exist, no past event perfectly parallels future projections in terms of disrupting the balance of ocean carbonate chemistry—a consequence of the unprecedented rapidity of CO2 release currently taking place
Terrestrial habitat requirements of nesting freshwater turtles
Because particular life history traits affect species vulnerability to development pressures, cross-species summaries of life history traits are useful for generating management guidelines. Conservation of aquatic turtles, many members of which are regionally or globally imperiled, requires knowing the extent of upland habitat used for nesting. Therefore, we compiled distances that nests and gravid females had been observed from wetlands. Based on records of \u3e 8000 nests and gravid female records compiled for 31 species in the United States and Canada, the distances that encompass 95% of nests vary dramatically among genera and populations, from just 8 m for Malaclemys to nearly 1400 m for Trachemys. Widths of core areas to encompass varying fractions of nesting populations (based on mean maxima across all genera) were estimated as: 50% coverage = 93 m, 75% = 154 m, 90% = 198 m, 95% = 232 m, 100% = 942 m. Approximately 6–98 m is required to encompass each consecutive 10% segment of a nesting population up to 90% coverage; thereafter, ca. 424 m is required to encompass the remaining 10%. Many genera require modest terrestrial areas (\u3c200 m zones) for 95% nest coverage (Actinemys, Apalone, Chelydra, Chrysemys, Clemmys, Glyptemys, Graptemys, Macrochelys, Malaclemys, Pseudemys, Sternotherus), whereas other genera require larger zones (Deirochelys, Emydoidea, Kinosternon, Trachemys). Our results represent planning targets for conserving sufficient areas of uplands around wetlands to ensure protection of turtle nesting sites, migrating adult female turtles, and dispersing turtle hatchlings
Resonant soft x-ray scattering, stripe order, and the electron spectral function in cuprates
We review the current state of efforts to use resonant soft x-ray scattering
(RSXS), which is an elastic, momentum-resolved, valence band probe of strongly
correlated electron systems, to study stripe-like phenomena in copper-oxide
superconductors and related materials. We review the historical progress
including RSXS studies of Wigner crystallization in spin ladder materials,
stripe order in 214-phase nickelates, 214-phase cuprates, and other systems.
One of the major outstanding issues in RSXS concerns its relationship to more
established valence band probes, namely angle-resolved photoemission (ARPES)
and scanning tunneling microscopy (STM). These techniques are widely understood
as measuring a one-electron spectral function, yet a relationship between RSXS
and a spectral function has so far been unclear. Using physical arguments that
apply at the oxygen edge, we show that RSXS measures the square modulus of
an advanced version of the Green's function measured with STM. This indicates
that, despite being a momentum space probe, RSXS is more closely related to STM
than to ARPES techniques.
Finally, we close with some discussion of the most promising future
directions for RSXS. We will argue that the most promising area lies in high
magnetic field studies, particularly of edge states in strongly correlated
heterostructures, and the vortex state in superconducting cuprates, where RSXS
may clarify the anomalous periodicities observed in recent quantum oscillation
experiments.Comment: 15 pages, 1 figure, submitted to special issue of Physica C, "Stripes
and Electronic Liquid Crystals in Strongly Correlated Systems.
Temporal fluctuations of waves in weakly nonlinear disordered media
We consider the multiple scattering of a scalar wave in a disordered medium
with a weak nonlinearity of Kerr type. The perturbation theory, developed to
calculate the temporal autocorrelation function of scattered wave, fails at
short correlation times. A self-consistent calculation shows that for
nonlinearities exceeding a certain threshold value, the multiple-scattering
speckle pattern becomes unstable and exhibits spontaneous fluctuations even in
the absence of scatterer motion. The instability is due to a distributed
feedback in the system "coherent wave + nonlinear disordered medium". The
feedback is provided by the multiple scattering. The development of instability
is independent of the sign of nonlinearity.Comment: RevTeX, 15 pages (including 5 figures), accepted for publication in
Phys. Rev.
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