Diagnosis of Errors in Stalled Inter-Organizational Workflow Processes

Fault-tolerant inter-organizational workflow processes help participant organizations efficiently complete their business activities and operations without extended delays. The stalling of inter-organizational workflow processes is a common hurdle that causes organizations immense losses and operational difficulties. The complexity of software requirements, incapability of workflow systems to properly handle exceptions, and inadequate process modeling are the leading causes of errors in the workflow processes. The dissertation effort is essentially about diagnosing errors in stalled inter-organizational workflow processes. The goals and objectives of this dissertation were achieved by designing a fault-tolerant software architecture of workflow system’s components/modules (i.e., workflow process designer, workflow engine, workflow monitoring, workflow administrative panel, service integration, workflow client) relevant to exception handling and troubleshooting. The complexity and improper implementation of software requirements were handled by building a framework of guiding principles and the best practices for modeling and designing inter-organizational workflow processes. Theoretical and empirical/experimental research methodologies were used to find the root causes of errors in stalled workflow processes. Error detection and diagnosis are critical steps that can be further used to design a strategy to resolve the stalled processes. Diagnosis of errors in stalled workflow processes was in scope, but the resolution of stalled workflow process was out of the scope in this dissertation. The software architecture facilitated automatic and semi-automatic diagnostics of errors in stalled workflow processes from real-time and historical perspectives. The empirical/experimental study was justified by creating state-of-the-art inter-organizational workflow processes using an API-based workflow system, a low code workflow automation platform, a supported high-level programming language, and a storage system. The empirical/experimental measurements and dissertation goals were explained by collecting, analyzing, and interpreting the workflow data. The methodology was evaluated based on its ability to diagnose errors successfully (i.e., identifying the root cause) in stalled processes caused by web service failures in the inter-organizational workflow processes. Fourteen datasets were created to analyze, verify, and validate hypotheses and the software architecture. Amongst fourteen datasets, seven datasets were created for end-to-end IOWF process scenarios, including IOWF web service consumption, and seven datasets were for IOWF web service alone. The results of data analysis strongly supported and validated the software architecture and hypotheses. The guiding principles and the best practices of workflow process modeling and designing conclude opportunities to prevent processes from getting stalled. The outcome of the dissertation, i.e., diagnosis of errors in stalled inter-organization processes, can be utilized to resolve these stalled processes

The Effect of Nutrition on Immune System Review Paper

The most basic definition of immunity is the ability of the organism to resist the invasion of microorganisms and harmful substances. Blood plays an important role in immune development due to the presence of certain types of white blood cells in the blood and in some other tissues have the ability to eliminate strange organisms and destroy it as well the blood plasma contains antibodies made by certain immune cells to resist any strange proteins or any other substances linked to proteins, such proteins that stimulate the body tissues to form antibodies called antigen generators or antigens.Some objects work on precipitation these strange proteins to isolate them, so it called precipitins, while others work on the conglomerate of microorganisms or red blood cells. These are called agglutinins, while some act on neutralizing of toxins, called antitoxins.Immunizations are either natural immunity or innate immunity or acquired immunity. When the body resists the invasion of a particular species of microorganisms for the first time, it will have natural immunity, But the immunity acquired by the individual as a result of immunizations or vaccination of such microorganisms is known as acquired immunity, However, acquired immunity may be natural or artificial. The immunity generated in the individual an actual measles infection is known as naturally acquired immunity, but the immunity that is formed as a result of vaccinating the individual of typhoid or diphtheria vaccine is artificially acquired immunity (1, 2, 3, 4, 5).However, acquired immunity may be natural or artificial. The immunity generated in the individual following an actual measles infection is known as naturally acquired immunity (6). DOI: 10.7176/FSQM/90-06 Publication date:September 30th 201

Protein profiling during mesocarp development in oil palm fruit

This study was aimed at investigating the overall protein profiles of oil palm fruit during the mesocarp tissue development by means of isoelectric focusing (IEF) and two-dimensional gel electrophoresis (2-DE). Total protein was extracted from different stages of fruit development (namely, 5, 12, 15, 17, and 20 weeks after anthesis [WAA]) from Elaeis guineensis Jacq. Teñera and E. oleifera (17 WAA). The IEF separation was carried out on pH values ranging from 4.0-8.0. Changes in the patterns of protein after IEF were observed during mesocarp development and between the two species. The analysis of oil palm mesocarp gave rise to a protein map, comprising approximately 150 spots that were detectable by silver staining following high resolution 2-DE, with a pH range of 4.5-8.0 and a mass range of 8-100 kDa. Meanwhile, twenty five spots of protein showing variations in their intensity during the development of the mesocarp, with their pI ranging from 4.5-7.8 and Mr 20-85 kDa, were analyzed. Continuous but non-uniform disappearance of some proteins and formation of new proteins were observed at the early stages of mesocarp development and during certain periods of oil synthesis and fruit ripening. The results of this study indicate that developing mesocarp revealed significant changes in the protein profiles during fruit development. However, further studies are still required to identify the proteins that are differentially expressed during fruit development

Interference control at the response level: Functional networks reveal higher efficiency in the bilingual brain

RÉSUMÉ: The bilingual advantage in interference control tasks has been studied with the Simon task, among others. The mixed evidence from the existing studies has led to contradictions in the literature regarding the bilingual advantage. Moreover, fMRI evidence on the neural basis of interference control mechanisms with the Simon task is limited. Previous work by our team showed that equivalent performance on the Simon task was associated with different activation maps in elderly bilinguals and monolinguals. This study aims to pro- vide a more in-depth perspective on the neural bases of performance on the Simon task in elderly bilinguals and monolinguals, by adopting a network perspective for the functional connectivity analysis. A node-by-node analysis led to the identification of the specific topology that characterized the bilingual and monolingual functional networks and the degree of connectivity between each node across groups. Results showed greater con- nectivity in bilinguals in the inferior temporal sulcus, which plays a role in visuospatial processing. On the other hand, in monolinguals, brain areas involved in visual, motor, executive functions and interference control were more connected to resolve the same task. In other words, in comparison to the monolingual brain, the bilingual brain resolves visuospatial interference economically, by allocating fewer and more clustered regions. These results demonstrate a larger global efficiency in task performance in bilinguals as compared to monolinguals. Also, the provided evidence filters out the task-specific so- called bilingual advantage discussed in the literature and posits that bilinguals are stra- tegically more efficient in a given performance than monolinguals, thus enhancing our understanding of successful aging

A Network Analysis Approach to fMRI Condition-Specific Functional Connectivity

In this work we focus on examination and comparison of whole-brain functional connectivity patterns measured with fMRI across experimental conditions. Direct examination and comparison of condition-specific matrices is challenging due to the large number of elements in a connectivity matrix. We present a framework that uses network analysis to describe condition-specific functional connectivity. Treating the brain as a complex system in terms of a network, we extract the most relevant connectivity information by partitioning each network into clusters representing functionally connected brain regions. Extracted clusters are used as features for predicting experimental condition in a new data set. The approach is illustrated on fMRI data examining functional connectivity patterns during processing of abstract and concrete concepts. Topological (brain regions) and functional (level of connectivity and information flow) systematic differences in the ROI-based functional networks were identified across participants for concrete and abstract concepts. These differences were sufficient for classification of previously unseen connectivity matrices as abstract or concrete based on training data derived from other people

Consanguinity and reproductive health among Arabs

Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity

Mapping geographical inequalities in access to drinking water and sanitation facilities in low-income and middle-income countries, 2000-17

Background: Universal access to safe drinking water and sanitation facilities is an essential human right, recognised in the Sustainable Development Goals as crucial for preventing disease and improving human wellbeing. Comprehensive, high-resolution estimates are important to inform progress towards achieving this goal. We aimed to produce high-resolution geospatial estimates of access to drinking water and sanitation facilities. Methods: We used a Bayesian geostatistical model and data from 600 sources across more than 88 low-income and middle-income countries (LMICs) to estimate access to drinking water and sanitation facilities on continuous continent-wide surfaces from 2000 to 2017, and aggregated results to policy-relevant administrative units. We estimated mutually exclusive and collectively exhaustive subcategories of facilities for drinking water (piped water on or off premises, other improved facilities, unimproved, and surface water) and sanitation facilities (septic or sewer sanitation, other improved, unimproved, and open defecation) with use of ordinal regression. We also estimated the number of diarrhoeal deaths in children younger than 5 years attributed to unsafe facilities and estimated deaths that were averted by increased access to safe facilities in 2017, and analysed geographical inequality in access within LMICs. Findings: Across LMICs, access to both piped water and improved water overall increased between 2000 and 2017, with progress varying spatially. For piped water, the safest water facility type, access increased from 40·0% (95% uncertainty interval [UI] 39·4–40·7) to 50·3% (50·0–50·5), but was lowest in sub-Saharan Africa, where access to piped water was mostly concentrated in urban centres. Access to both sewer or septic sanitation and improved sanitation overall also increased across all LMICs during the study period. For sewer or septic sanitation, access was 46·3% (95% UI 46·1–46·5) in 2017, compared with 28·7% (28·5–29·0) in 2000. Although some units improved access to the safest drinking water or sanitation facilities since 2000, a large absolute number of people continued to not have access in several units with high access to such facilities (>80%) in 2017. More than 253 000 people did not have access to sewer or septic sanitation facilities in the city of Harare, Zimbabwe, despite 88·6% (95% UI 87·2–89·7) access overall. Many units were able to transition from the least safe facilities in 2000 to safe facilities by 2017; for units in which populations primarily practised open defecation in 2000, 686 (95% UI 664–711) of the 1830 (1797–1863) units transitioned to the use of improved sanitation. Geographical disparities in access to improved water across units decreased in 76·1% (95% UI 71·6–80·7) of countries from 2000 to 2017, and in 53·9% (50·6–59·6) of countries for access to improved sanitation, but remained evident subnationally in most countries in 2017. Interpretation: Our estimates, combined with geospatial trends in diarrhoeal burden, identify where efforts to increase access to safe drinking water and sanitation facilities are most needed. By highlighting areas with successful approaches or in need of targeted interventions, our estimates can enable precision public health to effectively progress towards universal access to safe water and sanitation

Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey

Background: SARS-CoV-2 pandemic has had many significant impacts within the surgical realm, and surgeons have been obligated to reconsider almost every aspect of daily clinical practice. Methods: This is a cross-sectional study reported in compliance with the CHERRIES guidelines and conducted through an online platform from June 14th to July 15th, 2020. The primary outcome was the burden of burnout during the pandemic indicated by the validated Shirom-Melamed Burnout Measure. Results: Nine hundred fifty-four surgeons completed the survey. The median length of practice was 10 years; 78.2% included were male with a median age of 37 years old, 39.5% were consultants, 68.9% were general surgeons, and 55.7% were affiliated with an academic institution. Overall, there was a significant increase in the mean burnout score during the pandemic; longer years of practice and older age were significantly associated with less burnout. There were significant reductions in the median number of outpatient visits, operated cases, on-call hours, emergency visits, and research work, so, 48.2% of respondents felt that the training resources were insufficient. The majority (81.3%) of respondents reported that their hospitals were included in the management of COVID-19, 66.5% felt their roles had been minimized; 41% were asked to assist in non-surgical medical practices, and 37.6% of respondents were included in COVID-19 management. Conclusions: There was a significant burnout among trainees. Almost all aspects of clinical and research activities were affected with a significant reduction in the volume of research, outpatient clinic visits, surgical procedures, on-call hours, and emergency cases hindering the training. Trial registration: The study was registered on clicaltrials.gov "NCT04433286" on 16/06/2020

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030