Characterization of a buried paleosol under the upper tertiary sediments of As Pontes de García Rodríguez. (A Coruña, Galice, NW Spain)

[Resumen] Se estudia un perfil de meteorización y edáfico sobre filitas que se encuentra enterrado bajo los sedimentos de la cuenca terciaria de As Pontes de García Rodríguez (NO de España). El análisis mineralógico y los rasgos micromorfológicos (esferosideritas) ponen de manifiesto que el proceso edafogenético se desarrolló bajo dos paleoambientes sucesivos: El inicial, bajo condiciones subaéreas, conduce a la formación de caolinita y goethita; el segundo, con hidromorfía permanente, afecta fundamentalmente a los compuestos de hierro, originándose siderita. Como ayuda para entender los antiguos procesos, se analiza un perfil situado en el borde de la cuenca.[Abstract] A soil profile developed from phyllites is studied, it is located under the sediments of the Tertiary basin of As Pontes de García Rodríguez (NW Spain). The mineralogical analysis and the micromorphological features show mat the pedogenetic process comprissed two successive paleoenvironmental steps: The initial stage under subaeric conditions, let to the formation of kaolinite and goethite. During the second one, under permanent hydromorphic conditions, the main feature was a redistribution of iron compounds, with the formation of siderite. For the understanding of paleoprocesses, a present hydromorphous profile located on the basin margen is also studied and compared

Granite paleoweathering: A case-study under the tertiary deposit of Xinzo de Limia

[Resumen] Se estudia una paleoalteración desarrollada sobre granito y situada bajo un espesor de 120 m. de sedimentos en la cuenca terciaria de Xinzo de Limia (Ourense). El cambio minera16gico más significativo es la transformaci6n de las plagioclasas en caolinita. Se detectan también pequeñas proporciones de esmectitas. El estudio geoquímico revela una clara lixiviaci6n de bases, como lo pone de manifiesto la disminución de todos los índices de alteración (Indices de Parker, Reiche y pH de abrasi6n). El proceso de meteorización dominante es la monosialitización, con una cierta tendencia bisialítica en las primeras fases de la alteración.[Abstract] A granite paleoweathering located under 120 m of tertiary sediments at Xinzo de Limia (Galicia, NW Spain) is studied. The transformation ofplagioclase in kaolinite is the most important mineralogical change ocurred during the process. Minor proportions of smectite- are detected too. The geochemistry study reveales an evident lixiviation of bases, so the different weathering rates decrease as the process progresses (Parker and Reiche indexes and abrasion-pH). The dominant process of weathering is the monosialitization (PEDRO, 1979) although the first phases show a bisialitic trend

Challenges to evaluation of multilingual geographic information retrieval in GeoCLEF

This is the third year of the evaluation of geographic information retrieval (GeoCLEF) within the Cross-Language Evaluation Forum (CLEF). GeoCLEF 2006 presented topics and documents in four languages (English, German, Portuguese and Spanish). After two years of evaluation we are beginning to understand the challenges to both Geographic Information Retrieval from text and of evaluation of the results of geographic information retrieval. This poster enumerates some of these challenges to evaluation and comments on the limitations encountered in the first two evaluations

GeoCLEF 2006: the CLEF 2006 Ccross-language geographic information retrieval track overview

After being a pilot track in 2005, GeoCLEF advanced to be a regular track within CLEF 2006. The purpose of GeoCLEF is to test and evaluate cross-language geographic information retrieval (GIR): retrieval for topics with a geographic specification. For GeoCLEF 2006, twenty-five search topics were defined by the organizing groups for searching English, German, Portuguese and Spanish document collections. Topics were translated into English, German, Portuguese, Spanish and Japanese. Several topics in 2006 were significantly more geographically challenging than in 2005. Seventeen groups submitted 149 runs (up from eleven groups and 117 runs in GeoCLEF 2005). The groups used a variety of approaches, including geographic bounding boxes, named entity extraction and external knowledge bases (geographic thesauri and ontologies and gazetteers)

β-Decay Half-Lives of 76;77Co, 79;80Ni, and 81Cu: Experimental Indication of a Doubly Magic 78Ni

published_or_final_versio

Evolution of the dipole polarizability in the stable tin isotope chain

The dipole polarizability of stable even-mass tin isotopes 112,114,116,118,120,124 was extracted from inelastic proton scattering experiments at 295 MeV under very forward angles performed at RCNP. Predictions from energy density functionals cannot account for the present data and the polarizability of 208Pb simultaneously. The evolution of the polarizabilities in neighboring isotopes indicates a kink at 120Sn while all model results show a nearly linear increase with mass number after inclusion of pairing corrections.Comment: 10 pages, 6 figures, submitted to Phys. Lett.

Serum α-Tocopherol Concentration in Relation to Subsequent Colorectal Cancer: Pooled Data From Five Cohorts

Background Numerous monoclonal antibodies (MAbs) have been produced to antigens found in human melanomas. Three of the best characterized melanoma antigens include the melanoma-associated glycoproteins (MAGs) defined by two reagent families—the ME491 family (including ME491, 8-1H, and 8-2A) and the NKI/C-3 family (including NKI/C-3 and NKI/black-13)—as well as the neuroglandular antigen (NGA) defined by MAbs LS59, LS62, and LS140. These three antigens have significant similarities in tissue distribution, biosynthesis, and structure. The ME491 MAG has been cloned, mapped, and sequenced. Numerous non-melanoma-associated proteins (Sm23, CO-029, R2, TAPA-1, CD9, CD37, CD53, and CD63) have recently been shown to have significant homology to this sequence. Purpose We conducted this study to investigate the similarity between the two MAG antigens and NGA. Methods Several reagents defining the three different melanoma antigens were compared, using competition immunoprecipitation, immunoas-say, and inhibition radioimmunoassay techniques. Results Immunoassay experiments show that MAbs defining the three melanoma antigens bind to affinity-purified ME491 antigen and inhibit each other from binding in an inhibition radioimmunoassay. Competition immunoprecipitation ex-periments demonstrate that the ME491 and NKI/C-3 antibodies bind to NGA. Rabbit anti-ME491 idiotype serum recognizes determinants shared by NKI/C-3 and the anti-NGA MAbs. A competition immunoprecipitation experiment also confirms the identity of CD63, as defined by MAb RUU-SP 2.28, with the three melanoma antigens. Conclusion These data indicate that the MAGs defined by ME491 and NKI/C-3 as well as the anti-NGA antibodies are epitopes of the same molecule, which is identical to CD63 by both immunochemical and molecular genetic investigations. Implications Our results indicate that the data obtained in studies of these three melanoma antigens may be pooled, and we propose that the molecule recognized by these reagents be classified as CD63. [J Natl Cancer Inst 84:422-429, 1992

Interleukin-2 therapy in patients with HIV infection

BACKGROUND Used in combination with antiretroviral therapy, subcutaneous recombinant interleukin-2 raises CD4+ cell counts more than does antiretroviral therapy alone. The clinical implication of these increases is not known. METHODS We conducted two trials: the Subcutaneous Recombinant, Human Interleukin-2 in HIV-Infected Patients with Low CD4+ Counts under Active Antiretroviral Therapy (SILCAAT) study and the Evaluation of Subcutaneous Proleukin in a Randomized International Trial (ESPRIT). In each, patients infected with the human immunodeficiency virus (HIV) who had CD4+ cell counts of either 50 to 299 per cubic millimeter (SILCAAT) or 300 or more per cubic millimeter (ESPRIT) were randomly assigned to receive interleukin-2 plus antiretroviral therapy or antiretroviral therapy alone. The interleukin-2 regimen consisted of cycles of 5 consecutive days each, administered at 8-week intervals. The SILCAAT study involved six cycles and a dose of 4.5 million IU of interleukin-2 twice daily; ESPRIT involved three cycles and a dose of 7.5 million IU twice daily. Additional cycles were recommended to maintain the CD4+ cell count above predefined target levels. The primary end point of both studies was opportunistic disease or death from any cause. RESULTS In the SILCAAT study, 1695 patients (849 receiving interleukin-2 plus antiretroviral therapy and 846 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 202 cells per cubic millimeter were enrolled; in ESPRIT, 4111 patients (2071 receiving interleukin-2 plus antiretroviral therapy and 2040 receiving antiretroviral therapy alone) who had a median CD4+ cell count of 457 cells per cubic millimeter were enrolled. Over a median follow-up period of 7 to 8 years, the CD4+ cell count was higher in the interleukin-2 group than in the group receiving antiretroviral therapy alone--by 53 and 159 cells per cubic millimeter, on average, in the SILCAAT study and ESPRIT, respectively. Hazard ratios for opportunistic disease or death from any cause with interleukin-2 plus antiretroviral therapy (vs. antiretroviral therapy alone) were 0.91 (95% confidence interval [CI], 0.70 to 1.18; P=0.47) in the SILCAAT study and 0.94 (95% CI, 0.75 to 1.16; P=0.55) in ESPRIT. The hazard ratios for death from any cause and for grade 4 clinical events were 1.06 (P=0.73) and 1.10 (P=0.35), respectively, in the SILCAAT study and 0.90 (P=0.42) and 1.23 (P=0.003), respectively, in ESPRIT. CONCLUSIONS Despite a substantial and sustained increase in the CD4+ cell count, as compared with antiretroviral therapy alone, interleukin-2 plus antiretroviral therapy yielded no clinical benefit in either study. (ClinicalTrials.gov numbers, NCT00004978 [ESPRIT] and NCT00013611 [SILCAAT study].

A Survey of Volunteered Open Geo-Knowledge Bases in the Semantic Web

Over the past decade, rapid advances in web technologies, coupled with innovative models of spatial data collection and consumption, have generated a robust growth in geo-referenced information, resulting in spatial information overload. Increasing 'geographic intelligence' in traditional text-based information retrieval has become a prominent approach to respond to this issue and to fulfill users' spatial information needs. Numerous efforts in the Semantic Geospatial Web, Volunteered Geographic Information (VGI), and the Linking Open Data initiative have converged in a constellation of open knowledge bases, freely available online. In this article, we survey these open knowledge bases, focusing on their geospatial dimension. Particular attention is devoted to the crucial issue of the quality of geo-knowledge bases, as well as of crowdsourced data. A new knowledge base, the OpenStreetMap Semantic Network, is outlined as our contribution to this area. Research directions in information integration and Geographic Information Retrieval (GIR) are then reviewed, with a critical discussion of their current limitations and future prospects

Decrease of pro-angiogenic monocytes predicts clinical response to anti-angiogenic treatment in patients with metastatic renal cell carcinoma

The modulation of subpopulations of pro-angiogenic monocytes (VEGFR-1+ CD14 and Tie2+ CD14) was analyzed in an ancillary study from the prospective PazopanIb versus Sunitinib patient preferenCE Study (PISCES) (NCT01064310), where metastatic renal cell carcinoma (mRCC) patients were treated with two anti-angiogenic drugs, either sunitinib or pazopanib. Blood samples from 86 patients were collected prospectively at baseline (T1), and at 10 weeks (T2) and 20 weeks (T3) after starting anti-angiogenic therapy. Various subpopulations of myeloid cells (monocytes, VEGFR-1+ CD14 and Tie2+ CD14 cells) decreased during treatment. When patients were divided into two subgroups with a decrease (defined as a >20% reduction from baseline value) (group 1) or not (group 2) at T3 for VEGFR-1+ CD14 cells, group 1 patients presented a median PFS and OS of 24 months and 37 months, respectively, compared with a median PFS of 9 months (p = 0.032) and a median OS of 16 months (p = 0.033) in group 2 patients. The reduction in Tie2+ CD14 at T3 predicted a benefit in OS at 18 months after therapy (p = 0.04). In conclusion, in this prospective clinical trial, a significant decrease in subpopulations of pro-angiogenic monocytes was associated with clinical response to anti-angiogenic drugs in patients with mRCC