Duty free laguna

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Indications and complications of androgen deprivation therapy

OBJECTIVE: To review the indications for and side effects of androgen deprivation therapy (ADT) in men affected by prostate cancer. DATA SOURCES: National guidelines, evidence-based summaries, peer-reviewed studies, and websites. CONCLUSION: Indications for ADT include men with (1) intermediate- to high-risk localised prostate cancer undergoing radiation therapy, (2) biochemical recurrence after radical prostatectomy treated with salvage radiation therapy, or (3) metastatic prostate cancer. Several forms of ADT are available. To support self-management, body weight, diet, physical activity, alcohol consumption, and smoking should be discussed during clinical consultations. Important side effects of ADT may include flare-up phenomena of GnRH analogues, local reactions at injection sites, cardiovascular events, bone loss/fractures, drug-drug interactions, urinary tract dysfunction, hot flashes, cognitive impairment, seizure falls, and liver impairment. IMPLICATIONS FOR NURSING PRACTICE: Nurses have a role in personalized cancer care and should be familiar with indications, side effects, and interventions to optimize quality of life for men affected by prostate cancer receiving ADT

Chapter 18 - Gliadins in foods and the electronic tongue

The commercialization of safe foods is a main concern and should be ensured throughout the entire food supply chain. So, fast, sensitive, and reliable analytical methods are needed to identify food-related specific hazards, ensuring consumers protection and avoiding health problems. This chapter is focused on the emerging (bio)sensors to detect the heat-stable allergen gliadin in gluten-free foods. A brief overview concerning gliadin and its relation to celiac disease is provided. Several works related to the development of biosensors for gliadin detection are presented. Moreover, the use of electronic tongues to detect gliadin or gluten is reviewed and further investigated in an attempt to explain the possible detection mechanism based on gliadinlipid membranes interactions. The challenges, concerns, and potential application of these (bio)sensors are discussed. Finally, some future perspectives are included regarding the applicability of electronic tongue within this research field.This work was supported by Fundação para a Ciência e a Tecnologia (FCT) and the European Community fund FEDER, through Program COMPETE, under the scope of the Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462); under the Strategic funding of UID/BIO/04469/2013 unit; and under the Program PT2020 (Project UID/EQU/50020/2013)