ESPAÇOS HISTÓRICOS, DEUSES HIERÁRQUICOS — GEOGRAFIAS NEGRAS COMO ABERTURA EPISTÊMICA DIASPÓRICA

Este ensaio fotográfico, parte de um projeto maior intitulado “Espaços históricos, deuses hierárquicos”, usa a metodologia da autora de uma caminhada epistêmica para argumentar visual e textualmente a importância do conceito de geografias negras para estudos da África e da diáspora que interrogam e exploram espacialmente, bem como temporalmente, uma série de questões, incluindo histórias e memória pública da escravidão, a estética embutida nas contra-paisagens negras, o lugar da ancestralidade nas religiões afro-diaspóricas, e as manifestações globais do anti-racismo negro contemporâneo

TRANSNACIONALISMO NEGRO: A ENCRUZILHADA DE AMEFRICAN@S

Este artigo utiliza duas narrativas de jornadas pessoais de transna-cionalismo negro a partir dos escritos e das ideias de Lelia Gonzalez e Ella Baker, mulheres negras pensadoras ativistas, seminais e radicais, para refletir sobre a carga tripla enfrentada por trabalhadoras domésticas negras no Brasil e nos EUA. Consideram-se as ideiase formas de vida da aldeia contemporânea de quilombolas pescadores e pescadoras, visto do jardim de uma marisqueira, para refletir sobre o espaço de contribuição potencial e equitativo, a práxis e o pensamento, e as aberturas epistêmicas possíveis no universo acadêmico, quando conhecimentos marginalizados e multifacetados são postos. Utilizou-se os conceitos teóricos de Amefricanidade, interseccionalidade e afeto comum, bem como a noção de encruzilhada encontrada em muitas tradições culturais do pensamento Afrodescendente

Thrombosis in vasculitis: from pathogenesis to treatment

In recent years, the relationship between inflammation and thrombosis has been deeply investigated and it is now clear that immune and coagulation systems are functionally interconnected. Inflammation-induced thrombosis is by now considered a feature not only of autoimmune rheumatic diseases, but also of systemic vasculitides such as Behçet’s syndrome, ANCA-associated vasculitis or giant cells arteritis, especially during active disease. These findings have important consequences in terms of management and treatment. Indeed, Behçet’syndrome requires immunosuppressive agents for vascular involvement rather than anticoagulation or antiplatelet therapy, and it is conceivable that also in ANCA-associated vasculitis or large vessel-vasculitis an aggressive anti-inflammatory treatment during active disease could reduce the risk of thrombotic events in early stages. In this review we discuss thrombosis in vasculitides, especially in Behçet’s syndrome, ANCA-associated vasculitis and large-vessel vasculitis, and provide pathogenetic and clinical clues for the different specialists involved in the care of these patients

Infected pancreatic necrosis: outcomes and clinical predictors of mortality. A post hoc analysis of the MANCTRA-1 international study

: The identification of high-risk patients in the early stages of infected pancreatic necrosis (IPN) is critical, because it could help the clinicians to adopt more effective management strategies. We conducted a post hoc analysis of the MANCTRA-1 international study to assess the association between clinical risk factors and mortality among adult patients with IPN. Univariable and multivariable logistic regression models were used to identify prognostic factors of mortality. We identified 247 consecutive patients with IPN hospitalised between January 2019 and December 2020. History of uncontrolled arterial hypertension (p = 0.032; 95% CI 1.135-15.882; aOR 4.245), qSOFA (p = 0.005; 95% CI 1.359-5.879; aOR 2.828), renal failure (p = 0.022; 95% CI 1.138-5.442; aOR 2.489), and haemodynamic failure (p = 0.018; 95% CI 1.184-5.978; aOR 2.661), were identified as independent predictors of mortality in IPN patients. Cholangitis (p = 0.003; 95% CI 1.598-9.930; aOR 3.983), abdominal compartment syndrome (p = 0.032; 95% CI 1.090-6.967; aOR 2.735), and gastrointestinal/intra-abdominal bleeding (p = 0.009; 95% CI 1.286-5.712; aOR 2.710) were independently associated with the risk of mortality. Upfront open surgical necrosectomy was strongly associated with the risk of mortality (p < 0.001; 95% CI 1.912-7.442; aOR 3.772), whereas endoscopic drainage of pancreatic necrosis (p = 0.018; 95% CI 0.138-0.834; aOR 0.339) and enteral nutrition (p = 0.003; 95% CI 0.143-0.716; aOR 0.320) were found as protective factors. Organ failure, acute cholangitis, and upfront open surgical necrosectomy were the most significant predictors of mortality. Our study confirmed that, even in a subgroup of particularly ill patients such as those with IPN, upfront open surgery should be avoided as much as possible. Study protocol registered in ClinicalTrials.Gov (I.D. Number NCT04747990)

Local Ecologies of Knowledge, National Systems of Innovation, and Nanotech Research in the Global South

Science and technology studies tend to focus on the global South, and especially on Africa, mainly when “following the [Northern] scientist” southwards, when seeking sites of pathology and data collection, or as novice partners in European and American research projects. Yet the fields of bio-, nano- and information technologies are rapidly converging in many regions of the world, and research is proceeding apace in several key centers of erstwhile developing countries. This presentation will examine the features of South Africa’s complex local ecology of knowledge and its national system of innovation, suggesting how bio-pasts may be shaping nano-futures there in specific ways which may provide important insights to, and raise provocative questions for, the study of nano-tech in societies

Gambling on interaction: natural drug development through practitioners\' eyes

No Abstract. Indilinga: African Journal of Indigenous Knowledge Systems (IAJIKS) Vol. 4(1) 2005: 184-20

Opening Symposium

As residents of South Florida, many of us are acutely aware of the tenuous balance between the forces of nature and human genius. Vulnerability to natural disaster has left its imprint on our fragile landscape and its inhabitants. As we respond to our changing climate and rising seas we need more than scientific and economic facts. History and culture help us move from data to human understanding, from fear to reslilience

The Borders Of E.U. Tax Policy And U.S. Competitiveness

International audiencePurposeData for ANCA-associated vasculitis (AAV) patients requiring intensive care are scarce.MethodsWe included 97 consecutive patients with acute AAV manifestations (new onset or relapsing disease), admitted to 18 intensive care units (ICUs) over a 10-year period (2002–2012). A group of 95 consecutive AAV patients with new onset or relapsing disease, admitted to two nephrology departments with acute vasculitis manifestations, constituted the control group.ResultsIn the ICU group, patients predominantly showed granulomatosis with polyangiitis and proteinase-3 ANCAs. Compared with the non-ICU group, the ICU group showed comparable Birmingham vasculitis activity score and a higher frequency of heart, central nervous system and lungs involvements. Respiratory assistance, renal replacement therapy and vasopressors were required in 68.0, 56.7 and 26.8% of ICU patients, respectively. All but one patient (99%) received glucocorticoids, 85.6% received cyclophosphamide, and 49.5% had plasma exchanges as remission induction regimens. Fifteen (15.5%) patients died during the ICU stay. The following were significantly associated with ICU mortality in the univariate analysis: the need for respiratory assistance, the use of vasopressors, the occurrence of at least one infection event in ICU, cyclophosphamide treatment, sequential organ failure assessment at admission and simplified acute physiology score II. After adjustment on sequential organ failure assessment or infection, cyclophosphamide was no longer a risk factor for mortality. Despite a higher initial mortality rate of ICU patients within the first hospital stay (p < 0.0001), the long-term mortality of hospital survivors did not differ between ICU and non-ICU groups (18.6 and 20.4%, respectively, p = 0.36). Moreover, we observed no renal survival difference between groups after a 1-year follow-up (82.1 and 80.5%, p = 0.94).ConclusionThis study supports the idea that experiencing an ICU challenge does not impact the long-term prognosis of AAV patients