400 research outputs found

    The Vehiculatio in Roman Imperial Regulation: Particular Solutions to a Systematic Problem

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    Category: World History As the Roman Empire pushed its frontiers beyond the Mediterranean world, imperial authorities from Augustus onward faced a serious challenge: information transfer. The government of the early Roman Empire was famously lean in its bureaucracy and relied on small teams of imperial specialists (hated as spies) and military officers selected by governors to carry official documents great distances. These individuals traveled using an ad hoc system designed to take advantage of whatever hospitality existed along the Roman roadways. Messengers commandeered food, buildings, animals, and even guides for most legs of their journey. Official travel passes issued with imperial and gubernatorial authority granted the messengers the power to conduct these impromptu seizures of valuable resources, but this led to a problem: forged travel documents and abuses of the system. Such abuses placed onerous burdens on the citizens living under Roman rule, whose only recourse was to appeal to the emperors and governors for recompense. Literary sources from the Roman Empire lay out basic information about the imperial transport system, known as the vehiculatio, and other primary documents, including regulatory inscriptions and papyri, provide glimpses into how this system functioned (or failed) on the ground. The pleas of Roman provincials seeking restitution for excessive and unlawful vehiculatio requisitions continued throughout the early Roman Empire, as attested by fifteen documents selected for this analysis. A look at these primary documents reveals two serious flaws in the imperial government of the ancient vehiculatio: 1) Roman emperors found fault with morally corrupt individuals and sought to punish these persons rather than investigate problems with the ad hoc transportation itself; 2) Roman emperors issued orders and proscribed punishments without properly considering the provincial governors’ practical ability to deal with problems on the ground. The mistake of the emperors was to adopt particular solutions to what was a systematic problem—a failure of leadership with broader implications about systematic problems in government throughout world history

    Concepts for Reusing Composite Materials from Decommissioned Wind Turbine Blades in Affordable Housing

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    The very rapid growth in wind energy technology in the last 15 years has led to a rapid growth in the amount of non-biodegradable, thermosetting fiber reinforced polymer (FRP) composite materials used in wind turbine blades. This paper discusses conceptual architectural and structural options for recycling these blades by reusing parts of wind turbine blades in new or retrofitted housing projects. It focuses on large-sized FRP pieces that can be salvaged from the turbine blades and can potentially be useful in infrastructure projects where harsh environmental conditions (water and high humidity) exist. Since reuse design should be for specific regional locations and architectural characteristics the designs presented in this paper are for the coastal regions of the Yucatan province in Mexico on the Gulf of Mexico where low-quality masonry block informal housing is vulnerable to severe hurricanes and flooding. To demonstrate the concept a prototype 100 m long wind blade model developed by Sandia National Laboratories is used to show how a wind blade can be broken down into parts, thus making it possible to envision architectural applications for the different wind blade segments for housing applications

    Wastewater surveillance beyond COVID-19: a ranking system for communicable disease testing in the tri-county Detroit area, Michigan, USA

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    IntroductionThroughout the coronavirus disease 2019 (COVID-19) pandemic, wastewater surveillance has been utilized to monitor the disease in the United States through routine national, statewide, and regional monitoring projects. A significant canon of evidence was produced showing that wastewater surveillance is a credible and effective tool for disease monitoring. Hence, the application of wastewater surveillance can extend beyond monitoring SARS-CoV-2 to encompass a diverse range of emerging diseases. This article proposed a ranking system for prioritizing reportable communicable diseases (CDs) in the Tri-County Detroit Area (TCDA), Michigan, for future wastewater surveillance applications at the Great Lakes Water Authority's Water Reclamation Plant (GLWA's WRP).MethodsThe comprehensive CD wastewater surveillance ranking system (CDWSRank) was developed based on 6 binary and 6 quantitative parameters. The final ranking scores of CDs were computed by summing the multiplication products of weighting factors for each parameter, and then were sorted based on decreasing priority. Disease incidence data from 2014 to 2021 were collected for the TCDA. Disease incidence trends in the TCDA were endowed with higher weights, prioritizing the TCDA over the state of Michigan.ResultsDisparities in incidences of CDs were identified between the TCDA and state of Michigan, indicating epidemiological differences. Among 96 ranked CDs, some top ranked CDs did not present relatively high incidences but were prioritized, suggesting that such CDs require significant attention by wastewater surveillance practitioners, despite their relatively low incidences in the geographic area of interest. Appropriate wastewater sample concentration methods are summarized for the application of wastewater surveillance as per viral, bacterial, parasitic, and fungal pathogens.DiscussionThe CDWSRank system is one of the first of its kind to provide an empirical approach to prioritize CDs for wastewater surveillance, specifically in geographies served by centralized wastewater collection in the area of interest. The CDWSRank system provides a methodological tool and critical information that can help public health officials and policymakers allocate resources. It can be used to prioritize disease surveillance efforts and ensure that public health interventions are targeted at the most potentially urgent threats. The CDWSRank system can be easily adopted to geographical locations beyond the TCDA

    Greenway pedestrian and cycle bridges from repurposed wind turbine blades

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    Greenways are long-distance walking and cycling routes, often developed along the routes of disused railways. Greenways therefore are a means of repurposing underused infrastructure to provide sustainable transport. They also offer benefits for leisure activities, rural development and tourism. The network of greenways in the Republic of Ireland is projected to grow to 240 km by 2022, and a further 800 km of long-distance pathways has been proposed. The Irish government announced â ¬64m in funding for greenway projects in 2020, with further commitments to sustainable transport spending in the 2020 Programme for Government. In Northern Ireland there is 1,000 km of abandoned former transport routes with the potential for development as greenways. Many of the proposed greenway routes will need extensive works. In many cases, bridges and overpasses are in poor condition and will require complete reconstruction. Alongside the repurposing of disused railways as sustainable transport routes, there is an opportunity to reuse another type of repurposed infrastructure to create functional and attractive new bridges on greenways: end-of-life decommissioned wind turbine blades. Wind turbine blades are made of durable, lightweight and strong fibre-reinforced polymer (FRP) materials. They are difficult to recycle by conventional methods, but are ideally suited to repurposing. A US-Ireland-Northern Ireland initiative, the Re-Wind network, has created designs for several new artefacts from repurposed wind turbine blades, including a pedestrian bridge. In this paper we will show the advantages of the blade bridge design for deployment on greenways, show details of the testing and design of the worldâ s first repurposed greenway blade bridge, scheduled for installation on the Midleton-Youghal Greenway in Co. Cork in 2021, and outline the environmental and social advantages of using repurposed FRP blades in new infrastructure such as bridges. The paper also discusses the future expected flow of end-of-life blades from decommissioned wind turbines in Ireland and how this can be aligned with repurposing opportunities

    Reported patterns of vaping to support long-term abstinence from smoking: a cross-sectional survey of a convenience sample of vapers

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    Background: E-cigarettes are the most popular aid to smoking cessation attempts in England and the USA. This research examined associations between e-cigarette device characteristics and patterns of use, tobacco-smoking relapse, and smoking abstinence. Methods: A convenience sample of 371 participants with experience of vaping, and tobacco-smoking abstinence and/or relapse completed an online cross-sectional survey about e-cigarettes. Factors associated with smoking relapse were examined using multiple linear and logistic regression models. Results: Most participants were self-reported long-term abstinent smokers (86.3%) intending to continue vaping. Most initiated e-cigarette use with a vape pen (45.8%) or cig-a-like (38.7%) before moving onto a tank device (89%). Due to missing data, managed through pairwise deletion, only around 70 participants were included in some of the main analyses. Those using a tank or vape pen appeared less likely to relapse than those using a cig-a-like (tank vs. cig-a-like OR = 0.06, 95% CI 0.01-0.64, p = 0.019). There was an inverse association between starting self-reported e-cigarette liquid nicotine concentration and relapse, interacting with device type (OR = 0.79, 95% CI 0.63-0.99, p = 0.047), suggesting that risk of relapse may have been greater if starting with a low e-cigarette liquid nicotine concentration and/or cig-a-like device. Participants reported moving from tobacco-flavored cig-a-likes to fruit/sweet/food flavors with tank devices. Conclusions: Knowledge of how people have successfully maintained tobacco-smoking abstinence using vaping could help other tobacco smokers wishing to quit tobacco smoking through vaping

    Global diversification of a tropical plant growth form: environmental correlates and historical contingencies in climbing palms

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    Tropical rain forests (TRF) are the most diverse terrestrial biome on Earth, but the diversification dynamics of their constituent growth forms remain largely unexplored. Climbing plants contribute significantly to species diversity and ecosystem processes in TRF. We investigate the broad-scale patterns and drivers of species richness as well as the diversification history of climbing and non-climbing palms (Arecaceae). We quantify to what extent macroecological diversity patterns are related to contemporary climate, forest canopy height and paleoclimatic changes. We test whether diversification rates are higher for climbing than non-climbing palms and estimate the origin of the climbing habit. Climbers account for 22% of global palm species diversity mostly concentrated in Southeast Asia. Global variation in climbing palm species richness can be partly explained by past and present-day climate and rain forest canopy height, but regional differences in residual species richness after accounting for current and past differences in environment suggest a strong role of historical contingencies in climbing palm diversification. Climbing palms show a higher net diversification rate than non-climbers. Diversification analysis of palms detected a diversification rate increase along the branches leading to the most species-rich clade of climbers. Ancestral character reconstructions revealed that the climbing habit originated between early Eocene and Miocene. These results imply that changes from non-climbing to climbing habit may have played an important role in palm diversification, resulting in the origin of one fifth of all palm species. We suggest that, in addition to current climate and paleoclimatic changes after the late Neogene, present-day diversity of climbing palms can be explained by morpho-anatomical innovations, the biogeographic history of Southeast Asia, and/or ecological opportunities due to the diversification of high-stature dipterocarps in Asian TRFs

    Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial

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    BACKGROUND: Pre-clinical models demonstrate that platelet activation is involved in the spread of malignancy. Ongoing clinical trials are assessing whether aspirin, which inhibits platelet activation, can prevent or delay metastases. METHODS: Urinary 11-dehydro-thromboxane B2 (U-TXM), a biomarker of in vivo platelet activation, was measured after radical cancer therapy and correlated with patient demographics, tumour type, recent treatment, and aspirin use (100 mg, 300 mg or placebo daily) using multivariable linear regression models with log-transformed values. RESULTS: In total, 716 patients (breast 260, colorectal 192, gastro-oesophageal 53, prostate 211) median age 61 years, 50% male were studied. Baseline median U-TXM were breast 782; colorectal 1060; gastro-oesophageal 1675 and prostate 826 pg/mg creatinine; higher than healthy individuals (~500 pg/mg creatinine). Higher levels were associated with raised body mass index, inflammatory markers, and in the colorectal and gastro-oesophageal participants compared to breast participants (P < 0.001) independent of other baseline characteristics. Aspirin 100 mg daily decreased U-TXM similarly across all tumour types (median reductions: 77-82%). Aspirin 300 mg daily provided no additional suppression of U-TXM compared with 100 mg. CONCLUSIONS: Persistently increased thromboxane biosynthesis was detected after radical cancer therapy, particularly in colorectal and gastro-oesophageal patients. Thromboxane biosynthesis should be explored further as a biomarker of active malignancy and may identify patients likely to benefit from aspirin
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