Ökonomie und Zukunft

What does modern economics mean when it talks about the future and predicts the future? Where does it reach out to when it wants to secure the future for people or keep it open? How was the future experienced and thought of in Greek times, an epoch in which the possibility of theory formation first arose, and thus the foundation was laid for a knowledge of the future? This volume brings together the contributions to two colloquia held at the Free University of Bozen-Bolzano in 2013 and 2014 on the relationship between economics and the future and aims to point out the questionable nature of this relationship. With this intention, the terms "economy" and "future" lose their unambiguity and become questionable in their turn.; Was meint die moderne Wirtschaftswissenschaft, wenn sie von Zukunft redet und Künftiges vorhersagt? Wohin greift sie aus, wenn sie die Zukunft für den Menschen sichern oder offen halten will? Wie wurde Zukunft im Griechentum erfahren und gedacht, einer Epoche, in der zuerst die Möglichkeit einer Theoriebildung aufkam, und damit der Grundstein gelegt wurde für ein Wissen von Zukunft? Der vorliegende Band versammelt die Beiträge zu zwei in den Jahren 2013 und 2014 an der Freien Universität Bozen abgehaltenen Kolloquien zum Verhältnis von Ökonomie und Zukunft und möchte auf das Fragwürdige dieses Verhältnisses hinweisen. In dieser Absicht verlieren die Begriffe „Ökonomie“ und „Zukunft“ ihre Eindeutigkeit und werden ihrerseits fragwürdig

Novel human anti-claudin 1 mAbs inhibit hepatitis C virus infection and may synergize with anti-SRB1 mAb

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and liver carcinoma and new therapies based on novel targets are needed. The tight junction protein claudin 1 (CLDN-1) is essential for HCV cell entry and spread, and anti-CLDN-1 rat and mouse mAbs are safe and effective in preventing and treating HCV infection in a human liver chimeric mouse model. To accelerate translation of these observations into a novel approach to treat HCV infection and disease in humans, we screened a phage display library of human single-chain antibody fragments by using a panel of CLDN-1-positive and -negative cell lines and identified phage specifically binding to CLDN-1. The 12 clones showing the highest levels of binding were converted into human IgG4. Some of these mAbs displayed low-nanomolar affinity, and inhibited infection of human hepatoma Huh7.5 cells by different HCV isolates in a dose-dependent manner. Cross-competition experiments identified six inhibitory mAbs that recognized distinct epitopes. Combination of the human anti-SRB1 mAb C-1671 with these anti-CLDN-1 mAbs could either increase or reduce inhibition of cell culture-derived HCV infection in vitro. These novel human anti-CLDN-1 mAbs are potentially useful to develop a new strategy for anti-HCV therapy and lend support to the combined use of antibodies targeting the HCV receptors CLDN-1 and SRB1, but indicate that care must be taken in selecting the proper combination

Hsp60 response in experimental and human temporal lobe epilepsy

The mitochondrial chaperonin Hsp60 is a ubiquitous molecule with multiple roles, constitutively expressed and inducible by oxidative stress. In the brain, Hsp60 is widely distributed and has been implicated in neurological disorders, including epilepsy. A role for mitochondria and oxidative stress has been proposed in epileptogenesis of temporal lobe epilepsy (TLE). Here, we investigated the involvement of Hsp60 in TLE using animal and human samples. Hsp60 immunoreactivity in the hippocampus, measured by Western blotting and immunohistochemistry, was increased in a rat model of TLE. Hsp60 was also increased in the hippocampal dentate gyrus neurons somata and neuropil and hippocampus proper (CA3, CA1) of the epileptic rats. We also determined the circulating levels of Hsp60 in epileptic animals and TLE patients using ELISA. The epileptic rats showed circulating levels of Hsp60 higher than controls. Likewise, plasma post-seizure Hsp60 levels in patients were higher than before the seizure and those of controls. These results demonstrate that Hsp60 is increased in both animals and patients with TLE in affected tissues, and in plasma in response to epileptic seizures, and point to it as biomarker of hippocampal stress potentially useful for diagnosis and patient management.peer-reviewe

Hsp60 response in experimental and human temporal lobe epilepsy

The mitochondrial chaperonin Hsp60 is a ubiquitous molecule with multiple roles, constitutively expressed and inducible by oxidative stress. In the brain, Hsp60 is widely distributed and has been implicated in neurological disorders, including epilepsy. A role for mitochondria and oxidative stress has been proposed in epileptogenesis of temporal lobe epilepsy (TLE). Here, we investigated the involvement of Hsp60 in TLE using animal and human samples. Hsp60 immunoreactivity in the hippocampus, measured by Western blotting and immunohistochemistry, was increased in a rat model of TLE. Hsp60 was also increased in the hippocampal dentate gyrus neurons somata and neuropil and hippocampus proper (CA3, CA1) of the epileptic rats. We also determined the circulating levels of Hsp60 in epileptic animals and TLE patients using ELISA. The epileptic rats showed circulating levels of Hsp60 higher than controls. Likewise, plasma post-seizure Hsp60 levels in patients were higher than before the seizure and those of controls. These results demonstrate that Hsp60 is increased in both animals and patients with TLE in affected tissues, and in plasma in response to epileptic seizures, and point to it as biomarker of hippocampal stress potentially useful for diagnosis and patient management.peer-reviewe

Importance of the Initial Conditions for Star Formation - III: Statistical Properties of Embedded Protostellar Clusters

We investigate the formation of protostellar clusters during the collapse of dense molecular cloud cores with a focus on the evolution of potential and kinetic energy, the degree of substructure, and the early phase of mass segregation. Our study is based on a series of hydrodynamic simulations of dense cores, where we vary the initial density profile and the initial turbulent velocity. In the three-dimensional adaptive mesh refinement simulations, we follow the dynamical formation of filaments and protostars until a star formation efficiency of 20%. Despite the different initial configurations, the global ensemble of all protostars in a setup shows a similar energy evolution and forms sub-virial clusters with an energy ratio $E_\mathrm{kin}/|E_\mathrm{pot}|\sim0.2$. Concentrating on the innermost central region, the clusters show a roughly virialised energy balance. However, the region of virial balance only covers the innermost $\sim10-30$ of all the protostars. In all simulations with multiple protostars, the total kinetic energy of the protostars is higher than the kinetic energy of the gas cloud, although the protostars only contain 20% of the total mass. The clusters vary significantly in size, mass, and number of protostars, and show different degrees of substructure and mass segregation. Flat density profiles and compressive turbulent modes produce more subclusters then centrally concentrated profiles and solenoidal turbulence. We find that dynamical relaxation and hence dynamical mass segregation is very efficient in all cases from the very beginning of the nascent cluster, i.e., during a phase when protostars are constantly forming and accreting.Comment: 19 pages, MNRAS accepte

Expression and Activity of a Novel Cathelicidin from Domestic Cats

Cathelicidins are small cationic antimicrobial peptides found in many species including primates, mammals, marsupials, birds and even more primitive vertebrates, such as the hagfish. Some animals encode multiple cathelicidins in their genome, whereas others have only one. This report identifies and characterizes feline cathelicidin (feCath) as the sole cathelicidin in domestic cats (Felis catus). Expression of feCath is predominantly found in the bone marrow, with lower levels of expression in the gastrointestinal tract and skin. By immunocytochemistry, feCath localizes to the cytoplasm of neutrophils in feline peripheral blood. Structurally, the mature feCath sequence is most similar to a subgroup of cathelicidins that form linear α-helices. feCath possesses antimicrobial activity against E. coli D31, Salmonella enterica serovar Typhimurium (IR715), Listeria monocytogenes and Staphylococcus pseudintermedius (clinical isolate) similar to that of the human ortholog, LL-37. In contrast, feCath lacks the DNA binding activity seen with LL-37. Given its similarity in sequence, structure, tissue expression, and antimicrobial activity, the cathelicidin encoded by cats, feCath, belongs to the subgroup of linear cathelicidins found not only in humans, but also non-human primates, dogs, mice, and rats