Conceptions on Interdisciplinarity between Teachers of the College Education

With the implementation of Interdisciplinary Bachelor s degrees in Brazilian universities new dynamics of teaching and research proved necessary but few analyzes were made to better clarify the concepts about interdisciplinarity present among teachers This study aims to present a possibility of understanding on this topic from the perspectives of some teachers who teach in interdisciplinary degrees For that the Free Word Association Test TALP was applied and semi-structured interviews were conducted with them The corpus was organized in Word Wordle and Iramuteq and evaluated according to Bardin s Content Analysis The results of this study corroborate and at the same time ratify the idea of interdisciplinarity as pluriconceptual and polysemic covering from the simple to the most complex way of understanding the hyperdynamic structure of knowledge in which we are faced with several possibilities of interpretation understanding and practices they point above all to the subjects attitudes as evidenced by the basic literature about this them

Melatonin supplementation in the management of obesity and obesity-associated disorders: a review of physiological mechanisms and clinical applications

Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In the present review, we have amalgamated the evidence so far available on physiological effects of melatonin supplementation in obesity therapies, addressing its effects upon neuroendocrine systems, cardiometabolic biomarkers and body composition. Most studies herein appraised employed melatonin supplementation at dosages ranging from 1 to 20 mg/day, and most studies followed up participants for periods from 3 weeks to 12 months. Overall, it was observed that melatonin plays an important role in glycaemic homeostasis, in addition to modulation of white adipose tissue activity and lipid metabolism, and mitochondrial activity. Additionally, melatonin increases brown adipose tissue volume and activity, and its antioxidant and anti-inflammatory properties have also been demonstrated. There appears to be a role for melatonin in adiposity reduction; however, several questions remain unanswered, for example melatonin baseline levels in obesity, and whether any seeming hypomelatonaemia or melatonin irresponsiveness could be clarifying factors. Supplementation dosage studies and more thorough clinical trials are needed to ascertain not only the relevance of such findings but also the efficacy of melatonin supplementation

Zebrafish as a Model of Neurodevelopmental Disorders

Neurodevelopmental disorders (NDDs) caused by aberrant brain growth and development are life-long, debilitating illnesses that markedly impair the quality of life. Animal models are a valuable tool for studying NDD pathobiology and therapies. Mounting evidence suggests the zebrafish (Danio rerio) as a useful model organism to study NDDs, possessing both high physiological homology to humans and sensitivity to pharmacological and genetic manipulations. Here, we summarize experimental models of NDDs in zebrafish and highlight the growing translational significance of zebrafish NDD-related phenotypes. We also emphasize the need in further development of zebrafish models of NDDs to improve our understanding of their pathogenesis and therapeutic treatments. © 2019 IBROThis research is supported by the Russian Science Foundation grant 19-05-00053. KAD is supported by the Russian Foundation for Basic Research grant 18‐34‐00996, the President of Russia PhD Fellowship and the SPSU Rector's Productivity Fellowship for PhD students. ACVVG is supported by the Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551-0001-269-0. AVK is the President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior .com) and the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this multi-laboratory collaborative project

The Influence of Behavioral, Social, and Environmental Factors on Reproducibility and Replicability in Aquatic Animal Models

The publication of reproducible, replicable, and translatable data in studies utilizing animal models is a scientific, practical, and ethical necessity. This requires careful planning and execution of experiments and accurate reporting of results. Recognition that numerous developmental, environmental, and test-related factors can affect experimental outcomes is essential for a quality study design. Factors commonly considered when designing studies utilizing aquatic animal species include strain, sex, or age of the animal; water quality; temperature; and acoustic and light conditions. However, in the aquatic environment, it is equally important to consider normal species behavior, group dynamics, stocking density, and environmental complexity, including tank design and structural enrichment. Here, we will outline normal species and social behavior of 2 commonly used aquatic species: zebrafish (Danio rerio) and Xenopus (X. laevis and X. tropicalis). We also provide examples as to how these behaviors and the complexity of the tank environment can influence research results and provide general recommendations to assist with improvement of reproducibility and replicability, particularly as it pertains to behavior and environmental complexity, when utilizing these popular aquatic models. © The Author(s) 2020. Published by Oxford University Press on behalf of the National Academies of Sciences, Engineering, and Medicine. All rights reserved.A.V.K. research was supported by the Russian Science Foundation grant 19-15-00053. He is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC). This collaboration was supported, in part, through the NIH/NCI Cancer Center Support Grant P30 CA008748. The authors would like to thank Gregory Paull for sharing his photographs and insight into the natural habitat of zebrafish in Bangladesh

Controle preditivo aplicado a um helicóptero com dois graus de liberdade.

This work presents an embedded model predictive control application to a 2-DOF Helicopter Process. The mathematical modeling of the plant is first presented along with an analysis of the linear model. Then, the incremental state-space representations used in the MPC formulation are derived. The MPC technique is then defined, along with how to rewrite the physical constraints into the problem formulation. After that, a discussion on the utilized Quadratic Programming solver is presented along with possible alternatives to it, showing some considerations on which matrices to calculate beforehand for an embedded application. Finally, system identification is performed and the experimental results are presented.Este trabalho apresenta uma aplicação de controle preditivo embarcado em um helicóptero de bancada com dois graus de liberdade. A modelagem matemática é apresentada, junto com uma análise do modelo linear obtido. São obtidas duas representações de modelos de espaço de estados considerando a entrada incremental, que serão usadas posteriormente para a formulação do controlador. Então, é definida a técnica de controle utilizada, juntamente com a inclusão das restrições físicas da planta na formulação do problema. Após isto, é feita uma discussão sobre qual solver para a programação quadrática utilizar, junto com algumas alternativas ao solver escolhido, bem como algumas considerações sobre a aplicação embarcada. Finalmente, são apresentados os resultados da identificação de sistemas aplicadas ao protótipo, bem como os resultados experimentais obtidos