52 research outputs found
Mytilus edulis and Styela clava assimilate picophytoplankton carbon through feces and pseudofeces ingestion
Seasonal variations of <i>Quercus pubescens</i> isoprene emissions from an in natura forest under drought stress and sensitivity to future climate change in the Mediterranean area
Corrigendum en annexeInternational audienceAt a local level, biogenic isoprene emissions can greatly affect the air quality of urban areas surrounded by large vegetation sources, such as in the Mediterranean region. The impacts of future warmer and drier conditions on isoprene emissions from Mediterranean emitters are still under debate. Seasonal variations of Quercus pubescens gas exchange and isoprene emission rates (ER) were studied from June 2012 to June 2013 at the O3HP site (FrenchMediterranean) under natural (ND) and amplified (AD, 32 %) drought. While AD significantly reduced stomatal conductance to water vapour throughout the research period excluding August, it did not significantly preclude CO2 net assimilation, which was lowest in summer (ââ1 ÎŒmol CO2 mâ2sâ1). ER followed a significant seasonal pattern regardless of drought intensity, with mean ER maxima of 78.5 and 104.8 ÎŒgC gâ1DMhâ1 in July (ND) and August (AD) respectively and minima of 6 and < 2 ÎŒgC gâ1DMhâ1 in October and April respectively. The isoprene emission factor increased significantly by a factor of 2 in August and September under AD (137.8 and 74.3 ÎŒgC gâ1DMhâ1) compared with ND (75.3 and 40.21 ÎŒgC gâ1DMhâ1), but no significant changes occurred on ER. Aside from the June 2012 and 2013 measurements, the MEGAN2.1 (Model of Emissions of Gases and Aerosols from Nature version 2.1) model was able to assess the observed ER variability only when its soil moisture activity factorÎł SM was not operating and regardless of the drought intensity; in this case more than 80 % and 50 % of ER seasonal variability was assessed in the ND and AD respectively. We suggest that a specific formulation of Îł SM be developed for the drought-adapted isoprene emitter, according to that obtained for Q. pubescens in this study ( ÎłSM=0.192e51.93 SW with SW the soil water content). An isoprene algorithm (G14) was developed using an optimised artificial neural network (ANN) trained on our experimental dataset (ER+O3HP climatic and edaphic parameters cumulated over 0 to 21 days prior to the measurements). G14 assessed more than 80 % of the observed ER seasonal variations, regardless of the drought intensity. ERG14 was more sensitive to higher (0 toâ7 days) frequency environmental changes under AD in comparison to ND. Using IPCC RCP2.6 and RCP8.5 climate scenarios, and SW and temperature as calculated by the ORCHIDEE land surface model, ERG14 was found to be mostly sensitive to future temperature and nearly insensitive to precipitation decrease (an annual increase of up to 240 % and at the most 10 % respectively in the most severe scenario). The main impact of future drier conditions in the Mediterranean was found to be an enhancement (+ 40 %) of isoprene emissions sensitivity to thermal stress
Serum persistent organic pollutants and diminished ovarian reserve: a single-exposure and mixture exposure approach from a French case-control study
International audienceSTUDY QUESTION Are persistent organic pollutants (POPs) associated with a diminished ovarian reserve (DOR) in women of reproductive age? SUMMARY ANSWER Amongst 17 POPs detected in over 20% of serum samples, only p,p '-DDE was significantly associated with an increased risk of DOR, and beta-hexachlorocyclohexane (beta-HCH) was significantly associated with a decreased risk of DOR whilst mixture analyses yielded non-significant associations and did not detect any interactions between POPs. WHAT IS KNOWN ALREADY Animal studies have shown that several POPs can alter folliculogenesis and increase follicle depletion. However, only a few studies have been conducted in humans, with small sample sizes and inconsistent results. STUDY DESIGN, SIZE, DURATION Our study included 138 cases and 151 controls from the AROPE case-control study. Study participants were women between 18 and 40 years of age recruited amongst couples consulting for infertility in four fertility centres in western France between 2016 and 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS Cases of DOR were defined as women with anti-Mullerian hormone (AMH) levels <= 1.1 ng/ml and/or antral follicle count (AFC) <7, and controls were women with AMH levels between 1.1 and 5 ng/ml and AFC >= 7, without genital malformations and with a menstrual cycle length between 26 and 35 days. A total of 43 POPs (including 15 organochlorine pesticides, 17 polychlorinated biphenyls, and 9 polybromodiphenylethers) were measured in the serum at inclusion into the study. We conducted logistic regression adjusted for potential confounders using a directed acyclic graph to study the effect of each POP on DOR as single exposures, and used Bayesian kernel machine regression (BKMR) to measure the mixture effect of POPs on DOR. MAIN RESULTS AND THE ROLE OF CHANCE Of the 43 POPs, 17 were detected in over 20% of the serum samples. In the single-exposure multivariate logistic regressions, p,p '-DDE (median 165.0 IQR 161.0 ng/l in controls) as a continuous exposure was significantly associated with an increased risk of DOR (odds ratio (OR) 1.39, 95% CI 1.10-1.77) and non-significantly associated with an increased risk of DOR for the second and third terciles (OR 1.46, 95% CI 0.74-2.87, and OR 1.72, 95% CI 0.88-3.37, respectively). beta-HCH (median 24.2 IQR 21.5 ng/l in controls) was significantly associated with a decreased risk of DOR when beta-HCH was treated as a continuous exposure (OR 0.63, 95% CI 0.44-0.89) and for the third tercile of exposure (OR 0.43, 95% CI 0.21-0.84) and non-significantly associated with a decreased risk of DOR for the second tercile (OR 0.77, 95% CI 0.42-1.42). All sensitivity analyses confirmed our results. BKMR showed similar associations for single exposures but found no significant associations for the total mixture effect. In addition, the BKMR results did not suggest any interactions between POPs. LIMITATIONS, REASONS FOR CAUTION Controls were recruited amongst infertile couples and thus may not be representative of all women of reproductive age. However, their POP concentrations were in the same range as in the general French population. WIDER IMPLICATIONS OF THE FINDINGS This study is the first to examine the associations between serum POPs and DOR. The well-recognized anti-androgenic properties of p,p '-DDE and estrogenic properties of beta-HCH could explain these associations of opposite direction. If these results are replicated elsewhere, this could have an impact on fertility prevention messages and help in understanding the impact of POPs on the female reproductive system. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by the Fondation de France (grant numbers 2014-50537 and 00110196) and the French Biomedicine Agency (2016). None of the authors have any conflicts of interest to declare
18,19-Dihydroxydeoxycorticosterone, a new metabolite produced from 18-hydroxydeoxycorticosterone by cytochrome P-45011.beta.. Chemical synthesis and structural analysis by proton NMR
Study of isospin diffusion from CaCa experimental data at Fermi energies: direct comparisons with transport model calculations
This article presents an investigation of isospin equilibration in cross-bombarding CaCa reactions at MeV/nucleon, by comparing experimental data with filtered transport model calculations. Isospin diffusion is studied using the evolution of the isospin transport ratio with centrality. The asymmetry parameter of the quasiprojectile (QP) residue is used as isospin-sensitive observable, while a recent method for impact parameter reconstruction is used for centrality sorting.A benchmark of global observables is proposed to assess the relevance of the antisymmetrized molecular dynamics (AMD) model, coupled to GEMINI++, in the study of dissipative collisions. Our results demonstrate the importance of considering cluster formation to reproduce observables used for isospin transport and centrality studies.Within the AMD model, we prove the applicability of the impact parameter reconstruction method, enabling a direct comparison to the experimental data for the investigation of isospin diffusion.For both, we evidence a tendency to isospin equilibration with an impact parameter decreasing from to fm, while the full equilibration is not reached.A weak sensitivity to the stiffness of the equation of state employed in the model is also observed, with a better reproduction of the experimental trend for the neutron-rich reactions
Study of isospin diffusion from CaCa experimental data at Fermi energies: direct comparisons with transport model calculations
This article presents an investigation of isospin equilibration in cross-bombarding CaCa reactions at MeV/nucleon, by comparing experimental data with filtered transport model calculations. Isospin diffusion is studied using the evolution of the isospin transport ratio with centrality. The asymmetry parameter of the quasiprojectile (QP) residue is used as isospin-sensitive observable, while a recent method for impact parameter reconstruction is used for centrality sorting.A benchmark of global observables is proposed to assess the relevance of the antisymmetrized molecular dynamics (AMD) model, coupled to GEMINI++, in the study of dissipative collisions. Our results demonstrate the importance of considering cluster formation to reproduce observables used for isospin transport and centrality studies.Within the AMD model, we prove the applicability of the impact parameter reconstruction method, enabling a direct comparison to the experimental data for the investigation of isospin diffusion.For both, we evidence a tendency to isospin equilibration with an impact parameter decreasing from to fm, while the full equilibration is not reached.A weak sensitivity to the stiffness of the equation of state employed in the model is also observed, with a better reproduction of the experimental trend for the neutron-rich reactions
Study of isospin diffusion from CaCa experimental data at Fermi energies: direct comparisons with transport model calculations
This article presents an investigation of isospin equilibration in cross-bombarding CaCa reactions at MeV/nucleon, by comparing experimental data with filtered transport model calculations. Isospin diffusion is studied using the evolution of the isospin transport ratio with centrality. The asymmetry parameter of the quasiprojectile (QP) residue is used as isospin-sensitive observable, while a recent method for impact parameter reconstruction is used for centrality sorting.A benchmark of global observables is proposed to assess the relevance of the antisymmetrized molecular dynamics (AMD) model, coupled to GEMINI++, in the study of dissipative collisions. Our results demonstrate the importance of considering cluster formation to reproduce observables used for isospin transport and centrality studies.Within the AMD model, we prove the applicability of the impact parameter reconstruction method, enabling a direct comparison to the experimental data for the investigation of isospin diffusion.For both, we evidence a tendency to isospin equilibration with an impact parameter decreasing from to fm, while the full equilibration is not reached.A weak sensitivity to the stiffness of the equation of state employed in the model is also observed, with a better reproduction of the experimental trend for the neutron-rich reactions
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