Composizione polifenolica e capacità antiradicalica "<i>in vitro</i>" di estratti di frutti di corbezzolo (<i>Arbutus unedo</i> L.) in differenti stadi di maturazione

La nostra ricerca attualmente in corso ha come obiettivo la valutazione dell'attività antiossidante di specie vegetali tipiche delle coltivazioni o della flora spontanea della Sardegna e la caratterizzazione chimica dei principali composti responsabili di tale attività

Toxicity abatement of wastewaters from tourism units by constructed wetlands

The present research intended to investigate the toxicity abatement of domestic wastewater after passing a biosystem composed of a constructed wetland (CW) followed by a pond. The wastewater was generated in a tourism house in a rural and mountainous context and passed through a septic tank before being diverted to a CW followed by a pond. A battery of ecotoxicological tests, comprising microalgae (Raphidocelis subcapitata), macrophytes (Lemna minor), cladocerans (Daphnia magna), and bacteria (Aliivibrio fischeri), was used to assess the toxicity of the wastewater collected before and after the CW and the water of the pond. Physicochemical parameters (pH, conductivity, chemical oxygen demand, biochemical oxygen demand, total suspended solids, phosphates, ammonium, and nitrate) were also determined. The CW was able to remove carbon and nutrients from the water with a concomitant reduction of its toxicity. This study, reinforced the added value of using toxicity tests as a complement to CW operational monitoring to validate the solution and to analyze possible readjustments that may be required to improve efficiency. This study lends further support to the claim that CWs can be a sustainable solution for treating small volumes of domestic wastewater in a rural context.info:eu-repo/semantics/publishedVersio

Determinants of left ventricular hypertrophy before and after surgical treatment of aortic stenosis: clinical, morphofunctional, genetic and molecular correlations

Gréard Octave. Mémoire sur la question des programmes dans l'enseignement secondaire, présenté au Conseil académique de Paris, dans la séance du 1er juillet 1884, par M. Gréard, membre de l'Institut, vice-recteur de l'Académie de Paris. In: Bulletin administratif de l'instruction publique. Tome 36 n°625, 1884. pp. 380-408

Operacionalização do heart team em Portugal

© 2013 Sociedade Portuguesa de Cardiologia Published by Elsevier España, S.L. All rights reserved.Whenever several therapeutic options exist, multidisciplinary decision-making is beneficial for the patient and for society at large. The main obstacles to the establishment of heart teams in Portugal are organizational and logistical. Implementing a heart team approach entails definition of the situations requiring multidisciplinary discussion, creation of clear lines of communication, written protocols and obtaining patient informed consent. The European Society of Cardiology guidelines define the clinical scenarios where intervention of the heart team is recommended.A decisão médica tomada em equipas multidisciplinares é uma mais-valia indiscutível para o doente e para a sociedade, particularmente quando existem várias opções terapêuticas. A falta de disponibilidade dos intervenientes, problemas logísticos e barreiras interdisciplinares são alguns dos obstáculos à operacionalização do Heart Team em Portugal. A operacionalização passa pela definição das situações que necessitam discussão multidisciplinar, a elaboração de protocolos escritos, a criação de vias de comunicação claras, a consignação das decisões tomadas e a informação fornecida ao doente. As situações, na doença coronária e na doença valvular, que requerem a intervenção do Heart Team estão definidas nas recomendações da Sociedade Europeia de Cardiologia.info:eu-repo/semantics/publishedVersio

Caratterizzazione della frazione polifenolica di mieli sardi di origini floreali diverse e valutazione della loro attività antiossidante

L’obiettivo di questo lavoro è stato quello di estrarre, identificare e quantificare la frazione polifenolica (polifenoli totali, flavonoidi, flavanoli) di diversi tipi di mieli monofloreali, provenienti da diverse parti della Sardegna, e valutarne l’attività antiossidante (DPPH, ABTS, FRAP e ac. linoleico test) correlandola con l’origine floreale e il contenuto in polifenoli

Dataset of the preparation and characterization of an artificial sludge for ecotoxicological purposes

This work describes the protocol developed for preparing an artificial digested sludge to be used for the ecotoxicological evaluation and risk assessment of chemical substances that are previewed to attain the soil through sewage sludge applications for fertilization (e.g. pharmaceutical compounds). Such evaluations have been made with standard protocols for ecotoxicological tests with terrestrial species in which the chemical substances are directly spiked to the test soil. This procedure lacks ecological relevance in terms of the role the sludge organic matter plays on the bioavailability and fate of chemical substances. Here we describe the protocol and the composition for obtaining the artificial sludge, prepared with commercial pet food and eggs white to mimic the composition of domestic sewage sludge in terms of proteins, carbon hydrates, fat and fibers content. Further, the conditions ascertained for the anaerobic digestion of the organic mixture are described, and the final properties of the sludge are presented, after repeating the procedure twice.info:eu-repo/semantics/publishedVersio

Sex differences in LDL-C control in a primary care population: the PORTRAIT-DYS study

© 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by- nc-nd/4.0/).Background and aims: Cardiovascular (CV) diseases show clear differences in clinical manifestation and treatment outcomes between men and women. To reduce sex disparities in achieving lipid-lowering therapy (LLT) goals, a sex-focused assessment is essential and more studies are needed to bring new evidence to clinicians. This study aims to assess the role of sex in attaining low-density lipoprotein cholesterol (LDL-C) goals, after correction for age, CV risk category, LLT intensity, and presence of mental health disorder and social deprivation. Methods: A retrospective cohort analysis of patients aged 40-85, followed in 1 hospital and 14 primary care centers in Portugal, using electronic health records from 1/1/2012 to 31/12/2020, was performed. The analysis considered an episode-based design, where exposure consists of any time when LLT was started or intensity changed. The likelihood of reaching the LDL-C goal according to contemporary ESC/EAS guidelines was modeled using multivariate Cox regression. LDL-C goal achievement at 180 days was defined as the outcome. The analysis was repeated at 30-day follow-up intervals up to 360 days, and also stratified by CV risk category. Results: We identified 40,032 exposure episodes (LLT initiation or intensity change) in 30,323 distinct patients. Male sex, older age, lower CV risk and increasing LLT intensity were associated with improved LDL-C control. Women were 22% less likely to reach the LDL-C goal than men (HR = 0.78, 95% CI:0.73, 0.82) independently of covariates. Conclusions: Women have a lower likelihood of attaining LDL-C goals than men after adjustment for LLT intensity, age, CV risk category, presence of mental health disorder and social deprivation. This finding underscores the need for further investigation and tailoring of LLT management strategies in women.This study was funded by Daiichi Sankyo Europeinfo:eu-repo/semantics/publishedVersio

Incorporation of different natural polyphenol extracts into a yoghurt and their effect on viability of a selected probiotic strain

The aims of our project were: (1) to prepare different extracts of strawberry-tree honey, Cynara scolymus L. (artichoke), Arbutus unedo L. fruits (strawberry-tree) and Prunus avium L. var. Bonnannaro fruits (cherry) and characterise them with respect to their polyphenol contents; (2) to study the effect of these extracts on viability of probiotic strain Lactobacillus casei ATCC 12116; (3) to incorporate these extracts into commercial yoghurt samples to verify if their presence improves the shelf-life of this food

Os custos da aterosclerose em Portugal

Copyright © 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L.U. All rights reserved.© 2020 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espa ̃na, S.L.U. This is an open access article under the CC-BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Introduction and objectives: Cardiovascular disease is the leading cause of death in Portugal and atherosclerosis is the most common underlying pathophysiological process. The aim of this study was to quantify the economic impact of atherosclerosis in Portugal by estimating disease-related costs. Methods: Costs were estimated based on a prevalence approach and following a societal perspective. Three national epidemiological sources were used to estimate the prevalence of the main clinical manifestations of atherosclerosis. The annual costs of atherosclerosis included both direct costs (resource consumption) and indirect costs (impact on population productivity). These costs were estimated for 2016, based on data from the Hospital Morbidity Database, the health care database (SIARS) of the Regional Health Administration of Lisbon and Tagus Valley including real-world data from primary care, the 2014 National Health Interview Survey, and expert opinion. Results: The total cost of atherosclerosis in 2016 reached 1.9 billion euros (58% and 42% of which was direct and indirect costs, respectively). Most of the direct costs were associated with primary care (55%), followed by hospital outpatient care (27%) and hospitalizations (18%). Indirect costs were mainly driven by early exit from the labor force (91%). Conclusions: Atherosclerosis has a major economic impact, being responsible for health expenditure equivalent to 1% of Portuguese gross domestic product and 11% of current health expenditure in 2016.info:eu-repo/semantics/publishedVersio