Representing the Process of Machine Tool Calibration in First-order Logic

Machine tool calibration requires a wide range of measurement techniques that can be carried out in many different sequences. Planning a machine tool calibration is typically performed by a subject expert with a great understanding of International standards and industrial best-practice guides. However, it is often the case that the planned sequence of measurements is not the optimal. Therefore, in an attempt to improve the process, intelligent computing methods can be designed for plan suggestion. As a starting point, this paper presents a way of converting expert knowledge into first-order logic that can be expressed in the PROLOG language. It then shows how queries can be executed against the logic to construct a knowledge-base of all the different measurements that can be performed during machine tool calibration

Identifying complex sources in large astronomical data using a coarse-grained complexity measure

The volume of data that will be produced by the next generation of astrophysical instruments represents a significant opportunity for making unplanned and unexpected discoveries. Conversely, finding unexpected objects or phenomena within such large volumes of data presents a challenge that may best be solved using computational and statistical approaches. We present the application of a coarse-grained complexity measure for identifying interesting observations in large astronomical data sets. This measure, which has been termed apparent complexity, has been shown to model human intuition and perceptions of complexity. Apparent complexity is computationally efficient to derive and can be used to segment and identify interesting observations in very large data sets based on their morphological complexity. We show, using data from the Australia Telescope Large Area Survey, that apparent complexity can be combined with clustering methods to provide an automated process for distinguishing between images of galaxies which have been classified as having simple and complex morphologies. The approach generalizes well when applied to new data after being calibrated on a smaller data set, where it performs better than tested classification methods using pixel data. This generalizability positions apparent complexity as a suitable machine-learning feature for identifying complex observations with unanticipated features.Comment: 15 pages, 8 figures. New version to match that appearing in the journal. Appearing in PASP Focus on Machine Intelligence in Astronomy and Astrophysic

Crystal structures of PI3K-C2α PX domain indicate conformational change associated with ligand binding

<p>Abstract</p> <p>Background</p> <p>PX domains have specialized protein structures involved in binding of phosphoinositides (PIs). Through binding to the various PIs PX domains provide site-specific membrane signals to modulate the intracellular localisation and biological activity of effector proteins. Several crystal structures of these domains are now available from a variety of proteins. All PX domains contain a canonical core structure with main differences exhibited within the loop regions forming the phosphoinositide binding pockets. It is within these areas that the molecular basis for ligand specificity originates.</p> <p>Results</p> <p>We now report two new structures of PI3K-C2α PX domain that crystallised in a P3₁21 space group. The two structures, refined to 2.1 Å and 2.5 Å, exhibit significantly different conformations of the phosphoinositide-binding loops. Unexpectedly, in one of the structures, we have detected a putative-ligand trapped in the binding site during the process of protein purification and crystallisation.</p> <p>Conclusion</p> <p>The two structures reported here provide a more complete description of the phosphoinositide binding region compared to the previously reported 2.6 Å crystal structure of human PI3K-C2α PX where this region was highly disordered. The structures enabled us to further analyse PI specificity and to postulate that the observed conformational change could be related to ligand-binding.</p

K-1 Small Satellite Missions

Kistler Aerospace Corporation is building the K-1, the world’s first fully reusable aerospace vehicle. By reusing each K-1 multiple times, Kistler plans to reduce the cost of access to space while providing a reliable launch on-demand capability to lowearth orbit and beyond. The K-1 is designed to carry a wide range of payloads to a variety of orbits. Kistler and Astrium Ltd. (formerly Matra Marconi Space UK) have initiated an effort to design reusable dispensers for multiple small payloads for use on the K-1. One of these dispensers may be used to deploy small satellites during the K-1’s flight test program. Kistler is investigating the feasibility of flying dedicated, multiple small payload missions. Such a mission may launch multiple small payloads from a single customer or small payloads from different customers. To facilitate ride-sharing opportunities, Kistler may issue an Announcement of Opportunity for multiple small payloads to fly to a predetermined orbit at a predetermined date. The orbit would be selected to be compatible with the requirements of as many small payload customers as possible. To avoid expensive recurring costs, small payloads would make use of standard interfaces and verification plans determined by Kistler. Kistler may employ the services of a broker to coordinate integration of multiple customers. If there is sufficient demand, Kistler can schedule regular fixed “departures” for small payloads. This would eliminate the need to match small payloads with a compatible primary payload customer, increasing the number of access to space opportunities open to small satellites

Effect of phytate and zinc ions on fluoride toothpaste efficacy using an in situ caries model

Objectives To compare and explore the dose-response of phytate-containing 1150 ppm fluoride toothpastes on model caries lesions and to determine the impact of zinc ions. Methods This was a single-centre, randomised, blinded (examiner/laboratory analyst), six-treatment, four-period crossover, in situ study in adults with a removable bilateral maxillary partial denture. Study treatments were toothpastes containing: 0.425% phytate/F; 0.85% phytate/F; 0.85% phytate/Zn/F; F-only; Zn/F and a 0% F placebo. Where present, F was 1150 ppm as NaF; Zn was 0.3% as ZnCl2. Human enamel specimens containing early-stage, surface-softened (A-lesions) or more advanced, subsurface (B-lesions) caries lesions were placed into the buccal flanges of participants’ modified partial denture (one of each lesion type per side). A-lesions were removed after 14 days of twice-daily treatment use; B-lesions were removed after a further 14 days. A-lesions were analysed for surface microhardness recovery. Both lesion types were analysed by transverse microradiography and for enamel fluoride uptake, with B-lesions additionally analysed by quantitative light-induced fluorescence. Comparison was carried out using an analysis of covariance model. Results Statistically significant differences between 1150 ppm F and the placebo toothpastes (p < 0.05) were shown for all measures, validating the model. No differences between fluoride toothpastes were observed for any measure with little evidence of a dose-response for phytate. Study treatments were generally well-tolerated. Conclusions Results suggest phytate has little impact on fluoride’s ability to promote early-stage lesion remineralisation or prevent more advanced lesion demineralisation in this in situ caries model. Similarly, results suggest zinc ions do not impair fluoride efficacy

Effects of a sodium fluoride- and phytate-containing dentifrice on remineralisation of enamel erosive lesions—an in situ randomised clinical study

ObjectiveThe objective of this work was to evaluate effects of a dentifrice containing sodium fluoride (1150 ppm F) and the organic polyphosphate phytate (0.85% w/w of the hexa-sodium salt) on in situ remineralisation of early enamel erosive lesions and resistance to subsequent demineralisation.Materials and methodsSubjects (n = 62) wore palatal appliances holding eight bovine enamel specimens with pre-formed erosive lesions. They brushed their natural teeth with the phytate test dentifrice (TD); a positive control dentifrice (PC, 1150 ppm fluoride as NaF); a reference dentifrice (RD, disodium pyrophosphate + 1100 ppm fluoride as NaF) or a negative control dentifrice (NC, fluoride-free) in a randomised, double-blind, crossover design. Specimens were removed at 2, 4 and 8 h post-brushing and exposed to an ex vivo acid challenge. Surface microhardness (Knoop) was measured at each stage. The primary efficacy variable was relative erosion resistance (RER); other variables included the surface microhardness recovery (SMHR), acid resistance ratio (ARR) and enamel fluoride uptake (EFU).ResultsAfter 4 h, the results for RER, ARR and EFU were in the order PC > TD = RD > NC with PC > TD = RD = NC for SMHR. Results at 2 and 8 h were generally consistent with the 4 h data. Mineralisation progressed over time. Dentifrices were generally well-tolerated.ConclusionsIn this in situ model, addition of phytate or pyrophosphate to a fluoride dentifrice inhibited the remineralising effect of fluoride. Both formulations still delivered fluoride to the enamel and inhibited demineralisation, albeit to a lesser extent than a polyphosphate-free dentifrice.Clinical relevanceAddition of phytate or pyrophosphate to a fluoride dentifrice may reduce its net anti-erosive properties

Mechanistic in situ and ex situ studies of phase transformations in molecular co-crystals

Co‐crystallisation is widely explored as a route to improve the physical properties of pharmaceutical active ingredients, but little is known about the fundamental mechanisms of the process. Herein, we apply a hyphenated differential scanning calorimetry—X‐ray diffraction technique to mimic the commercial hot melt extrusion process, and explore the heat‐induced synthesis of a series of new co‐crystals containing isonicotinamide. These comprise a 1:1 co‐crystal with 4‐hydroxybenzoic acid, 2:1 and 1:2 systems with 4‐hydroxyphenylacetic acid and a 1:1 crystal with 3,4‐dihydroxyphenylactic acid. The formation of co‐crystals during heating is complex mechanistically. In addition to co‐crystallisation, conversions between polymorphs of the co‐former starting materials and co‐crystal products are also observed. A subsequent study exploring the use of inkjet printing and milling to generate co‐crystals revealed that the synthetic approach has a major effect on the co‐crystal species and polymorphs produced

Final report to Becta concerning the use of video-stimulated reflective dialogue for professional development in ICT

This report concerns one of the Becta Research Grants 2008-9, intended for self-contained research in the area of technology for learning, and in support of the Harnessing Technology strategy. The project sought to evaluate the efficacy of video-stimulated reflective dialogue as a school based professional development tool for improving pedagogy in the use of ICT to support dialogic teaching in mathematics and science classrooms

Editorial

Editoria