Simulator evaluation of display concepts for pilot monitoring and control of space shuttle approach and landing. Phase 2: Manual flight control

A study of the display requirements for final approach management of the space shuttle orbiter vehicle is presented. An experimental display concept, providing a more direct, pictorial representation of the vehicle's movement relative to the selected approach path and aiming points, was developed and assessed as an aid to manual flight path control. Both head-up, windshield projections and head-down, panel mounted presentations of the experimental display were evaluated in a series of simulated orbiter approach sequence. Data obtained indicate that the experimental display would enable orbiter pilots to exercise greater flexibility in implementing alternative final approach control strategies. Touchdown position and airspeed dispersion criteria were satisfied on 91 percent of the approach sequences, representing various profile and wind effect conditions. Flight path control and airspeed management satisfied operationally-relevant criteria for the two-segment, power-off orbiter approach and were consistently more accurate and less variable when the full set of experimental display elements was available to the pilot. Approach control tended to be more precise when the head-up display was used; however, the data also indicate that the head-down display would provide adequate support for the manual control task

Improved display support for flight management during low visibility approach and landing. A simulator evaluation of an ILS-independent runway perspective display Final report

Low visibility approach and landing simulation for jet transport

Tracking and Improving Bedside Procedures Through Standardized Documentation

Proposal and Goals: We propose to create a standardized electronic procedure note that will replace all documentation for bedside procedures without sedation. ◦Makes notes legible and easily identified ◦Allows uniform tracking of metrics necessary to identify outcomes from a procedure (blood loss, specimens, post-procedure studies, complications) 2.The procedure note will be created in such a way as to allow specialized procedures to be added over time with minor customization to improve physician/nursing work flows and increase efficiency ◦Allows procedures to be sorted and tracked by type ◦Will be constructed to allow attaching CPT codes to patient charts via documentation 3. We propose using this procedure note to create a running database of all bedside procedures ◦Can be utilized by existing software (Qlik) to query all procedure notes to create large anonymized patient listshttps://jdc.jefferson.edu/patientsafetyposters/1071/thumbnail.jp

A rolling-horizon quadratic-programming approach to the signal control problem in large-scale congested urban road networks

The paper investigates the efficiency of a recently developed signal control methodology, which offers a computationally feasible technique for real-time network-wide signal control in large-scale urban traffic networks and is applicable also under congested traffic conditions. In this methodology, the traffic flow process is modeled by use of the store-and-forward modeling paradigm, and the problem of network-wide signal control (including all constraints) is formulated as a quadratic-programming problem that aims at minimizing and balancing the link queues so as to minimize the risk of queue spillback. For the application of the proposed methodology in real time, the corresponding optimization algorithm is embedded in a rolling-horizon (model-predictive) control scheme. The control strategy’s efficiency and real-time feasibility is demonstrated and compared with the Linear-Quadratic approach taken by the signal control strategy TUC (Traffic-responsive Urban Control) as well as with optimized fixed-control settings via their simulation-based application to the road network of the city centre of Chania, Greece, under a number of different demand scenarios. The comparative evaluation is based on various criteria and tools including the recently proposed fundamental diagram for urban network traffic

Western Wheatgrass Recovery From Drought

Native grasses are predictably taller in wet years than in dry years and their density also increases with favorable precipitation. These responses of western wheatgrass are more dramatic on mechanically treated rangeland when precipitation is adequate. Measurements taken in July 1991 confirmed that western wheatgrass was slightly taller and density at least two times greater on mechanically treated claypan soils compared with untreated soils 13 and 18 years following treatment. Increases of this magnitude constitute a potentially greater carrying capacity which livestock producers should be prepared to utilize. This report briefly summarizes the effects of mechanical treatment on height and density of western wheatgrass 13 and 18 years following treatment and in a wet year following several dry years

Super-resolution imaging reveals the sub-diffraction phenotype of Zellweger Syndrome ghosts and wild-type peroxisomes.

Peroxisomes are ubiquitous cell organelles involved in many metabolic and signaling functions. Their assembly requires peroxins, encoded by PEX genes. Mutations in PEX genes are the cause of Zellweger Syndrome spectrum (ZSS), a heterogeneous group of peroxisomal biogenesis disorders (PBD). The size and morphological features of peroxisomes are below the diffraction limit of light, which makes them attractive for super-resolution imaging. We applied Stimulated Emission Depletion (STED) microscopy to study the morphology of human peroxisomes and peroxisomal protein localization in human controls and ZSS patients. We defined the peroxisome morphology in healthy skin fibroblasts and the sub-diffraction phenotype of residual peroxisomal structures ('ghosts') in ZSS patients that revealed a relation between mutation severity and clinical phenotype. Further, we investigated the 70 kDa peroxisomal membrane protein (PMP70) abundance in relationship to the ZSS sub-diffraction phenotype. This work improves the morphological definition of peroxisomes. It expands current knowledge about peroxisome biogenesis and ZSS pathoethiology to the sub-diffraction phenotype including key peroxins and the characteristics of ghost peroxisomes

A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination

A T cell mounts an immune response by measuring the binding strength of its T cell receptor (TCR) for peptide-loaded MHCs (pMHC) on an antigen-presenting cell. How T cells convert the lifetime of the extracellular TCR-pMHC interaction into an intracellular signal remains unknown. Here, we developed a synthetic signaling system in which the extracellular domains of the TCR and pMHC were replaced with short hybridizing strands of DNA. Remarkably, T cells can discriminate between DNA ligands differing by a single base pair. Single-molecule imaging reveals that signaling is initiated when single ligand-bound receptors are converted into clusters, a time-dependent process requiring ligands with longer bound times. A computation model reveals that receptor clustering serves a kinetic proofreading function, enabling ligands with longer bound times to have disproportionally greater signaling outputs. These results suggest that spatial reorganization of receptors plays an important role in ligand discrimination in T cell signaling

Store-and-forward based methods for the signal control problem in large-scale congested urban road networks

The problem of designing network-wide traffic signal control strategies for large-scale congested urban road networks is considered. One known and two novel methodologies, all based on the store-and-forward modeling paradigm, are presented and compared. The known methodology is a linear multivariable feedback regulator derived through the formulation of a linear-quadratic optimal control problem. An alternative, novel methodology consists of an open-loop constrained quadratic optimal control problem, whose numerical solution is achieved via quadratic programming. Yet a different formulation leads to an open-loop constrained nonlinear optimal control problem, whose numerical solution is achieved by use of a feasible-direction algorithm. A preliminary simulation-based investigation of the signal control problem for a large-scale urban road network using these methodologies demonstrates the comparative efficiency and real-time feasibility of the developed signal control methods

Formation of targeted monovalent quantum dots by steric exclusion

Precise control over interfacial chemistry between nanoparticles and other materials remains a significant challenge limiting the broad application of nanotechnology in biology. To address this challenge, we use “Steric Exclusion” to completely convert commercial quantum dots (QDs) into monovalent imaging probes by wrapping the QD with a functionalized oligonucleotide. We demonstrate the utility of these QDs as modular and non-perturbing imaging probes by tracking individual Notch receptors on live cells