Tele-rehabilitation versus local rehabilitation therapies assisted by robotic devices: a pilot study with patients

The present study aims to evaluate the advantages of a master-slave robotic rehabilitation therapy in which the patient is assisted in real-time by a therapist. We have also explored if this type of strategy is applicable in a tele-rehabilitation environment. A pilot study has been carried out involving 10 patients who have performed a point-to-point rehabilitation exercise supported by three assistance modalities: fixed assistance (without therapist interaction), local therapist assistance, and remote therapist assistance in a simulated tele-rehabiliation scenario. The rehabilitation exercise will be performed using an upper-limb rehabilitation robotic device that assists the patients through force fields. The results suggest that the assistance provided by the therapist is better adapted to patient needs than fixed assistance mode. Therefore, it maximizes the patient's level of effort, which is an important aspect to improve the rehabilitation outcomes. We have also seen that in a tele-rehabilitation environment it is more difficult to assess when to assist the patient than locally. However, the assistance suits patients better than the fixed assistance mode

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe

Development of an active exosketeton for forearm and wrist rehabilitation using a single actuator

[Resumen] Las previsiones más recientes determinan que el número de accidentes cerebrovasculares serán esenciales para acelerar la recuperación del paciente el empleo de nuevas terapias de rehabilitación asistidas por sistemas robóticos. Este artículo describe el diseño, desarrollo y control de un exoesqueleto ligero para el antebrazo y la muñeca utilizando un único actuador. Además, se ha llevado a cabo un estudio piloto con pacientes en el Hospital la Pedrera de Dénia con el objetivo de analizar la usabilidad del sistema, y los resultados se recogen en el presente estudio.[Abstract] Recent research states that the number of strokes will increase in the future. For this reason, it is paramount to introduce new rehabilitation therapies to accelerate the recovery of the patient. This article describes the design, development and control of a light exoskeleton for the forearm and wrist using a single actuator. Furthermore, a pilot study has been done with patients in La Pedrera Hospital in Denia to analyse the system’s usability. The results are presented in this study.Agència Valenciana de la Innovació; NNVAL10/19/065Ministerio de Ciencia, Innovación y Universidades; PEJ2018-002670-AMinisterio de Ciencia, Innovación y Universidades; PEJ2018-002684-AGeneralitat Valenciana. Conselleria d'Educació, Cultura i Esport; APOTIP/2020/01

Marine Biodiversity of Eastern Tropical Pacific Coral Reefs

The eastern tropical Pacific (ETP) is an isolated oceanic region exposed to extreme oceanographic conditions, including low salinity, low pH, high temperatures during El Niño, and low temperatures during La Niña and seasonal upwelling. The coral reefs in this region have a relatively limited suite of species compared to other coral reef areas of the world, but much like more diverse reefs the species present interact in complex ways. Here we synthezise the knowledge of taxonomic groups of reef organisms from prokaryotes to vertebrates, including algae, sponges, cnidarians, annelids and other worms, molluscs, crustaceans, echinoderms and fishes. We also present summaries on the biodiversity of associated functional groups and habitats, including (a) reef zooplankton and cryptic fauna, and (b) soft benthic environments, rhodolith beds and mesophotic environments. Several factors that structure the biodiversity of ETP coral reefs are explored, including biological, physical and chemical controls. ETP coral reefs are relatively simple systems that can be used as models for studying biodiversity and interactions among species. We conclude this review by highlighting pressing research needs, from very basic inventories to more sophisticated studies of cryptic assemblages, and to investigations on the impacts of natural and anthropogenic effects on ETP coral reef biodiversity.National Geographic Society/[NGS 5831–96]//Estados UnidosFondo Nacional de Ciencia y Tecnología/[1130167]/FONDECYT/ChileUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Ciencias del Mar y Limnología (CIMAR)UCR::Vicerrectoría de Docencia::Ciencias Básicas::Facultad de Ciencias::Escuela de Biologí

Formin Homology 2 Domain Containing 3 (FHOD3) Is a Genetic Basis for Hypertrophic Cardiomyopathy.

The genetic cause of hypertrophic cardiomyopathy remains unexplained in a substantial proportion of cases. Formin homology 2 domain containing 3 (FHOD3) may have a role in the pathogenesis of cardiac hypertrophy but has not been implicated in hypertrophic cardiomyopathy. This study sought to investigate the relation between FHOD3 mutations and the development of hypertrophic cardiomyopathy. FHOD3 was sequenced by massive parallel sequencing in 3,189 hypertrophic cardiomyopathy unrelated probands and 2,777 patients with no evidence of cardiomyopathy (disease control subjects). The authors evaluated protein-altering candidate variants in FHOD3 for cosegregation, clinical characteristics, and outcomes. The authors identified 94 candidate variants in 132 probands. The variants' frequencies were significantly higher in patients with hypertrophic cardiomyopathy (74 of 3,189 [2.32%]) than in disease control subjects (18 of 2,777 [0.65%]; p  FHOD3 is a novel disease gene in hypertrophic cardiomyopathy, accounting for approximately 1% to 2% of cases. The phenotype and the rate of cardiovascular events are similar to those reported in unselected cohorts. The FHOD3 gene should be routinely included in hypertrophic cardiomyopathy genetic testing panels