Contributions to the Nearby Stars (NStars) Project: Spectroscopy of Stars Earlier than M0 within 40 parsecs: The Northern Sample I

We have embarked on a project, under the aegis of the Nearby Stars (NStars)/ Space Interferometry Mission Preparatory Science Program to obtain spectra, spectral types, and, where feasible, basic physical parameters for the 3600 dwarf and giant stars earlier than M0 within 40 parsecs of the sun. In this paper we report on the results of this project for the first 664 stars in the northern hemisphere. These results include precise, homogeneous spectral types, basic physical parameters (including the effective temperature, surface gravity and the overall metallicity, [M/H]) and measures of the chromospheric activity of our program stars. Observed and derived data presented in this paper are also available on the project's website at http://stellar.phys.appstate.edu/

A Pilot Weight Loss Program for Parents of Children with a Disability

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The pleistocene species pump past its prime:Evidence from European butterfly sister species

This is the final version. Available on open access from Wiley via the DOI in this recordData availability statement: Read data are available from the ENA at PRJEB43082. Sequence alignments for the COI barcode locus were obtained from the dataset DS-EUGENMAP (dx.doi.org/10.5883/DS-EUGENMAP) on BOLD at www.boldsystems.org and were originally produced by Dincӑ et al., (2021). The script used for calculating diversity and divergence is available at https://github.com/samebdon/orthodiver/blob/master/orthodiver.py.The Pleistocene glacial cycles had a profound impact on the ranges and genetic make-up of organisms. Whilst it is clear that the contact zones that have been described for many sister taxa are secondary and have formed during the last interglacial, it is unclear when the taxa involved began to diverge. Previous estimates based on small numbers of loci are unreliable given the stochasticity of genetic drift and the contrasting effects of incomplete lineage sorting and gene flow on gene divergence. Here we use genome-wide transcriptome data to estimate divergence for 18 sister species pairs of European butterflies showing either sympatric or contact zone distributions. We find that in most cases species divergence predates the mid-Pleistocene transition or even the entire Pleistocene period. We also show that although post divergence gene flow is restricted to contact zone pairs, they are not systematically younger than sympatric pairs. This suggests that contact zones are not limited to the initial stages of the speciation process, but can involve notably old taxa. Finally, we show that mitochondrial and nuclear divergence are only weakly correlated and mitochondrial divergence is higher for contact-zone pairs.Biotechnology & Biological Sciences Research Council (BBSRC)Natural Environment Research Council (NERC)European Union Horizon 202

Population genomics supports clona reproduction and multiple independent gains and losses of parasitic abilities in the most devastating nematode pest.

International audienc

Pharmacoeconomic analysis of adjuvant oral capecitabine vs intravenous 5-FU/LV in Dukes' C colon cancer: the X-ACT trial

Oral capecitabine (Xeloda<sup>®</sup>) is an effective drug with favourable safety in adjuvant and metastatic colorectal cancer. Oxaliplatin-based therapy is becoming standard for Dukes' C colon cancer in patients suitable for combination therapy, but is not yet approved by the UK National Institute for Health and Clinical Excellence (NICE) in the adjuvant setting. Adjuvant capecitabine is at least as effective as 5-fluorouracil/leucovorin (5-FU/LV), with significant superiority in relapse-free survival and a trend towards improved disease-free and overall survival. We assessed the cost-effectiveness of adjuvant capecitabine from payer (UK National Health Service (NHS)) and societal perspectives. We used clinical trial data and published sources to estimate incremental direct and societal costs and gains in quality-adjusted life months (QALMs). Acquisition costs were higher for capecitabine than 5-FU/LV, but higher 5-FU/LV administration costs resulted in 57% lower chemotherapy costs for capecitabine. Capecitabine vs 5-FU/LV-associated adverse events required fewer medications and hospitalisations (cost savings £3653). Societal costs, including patient travel/time costs, were reduced by >75% with capecitabine vs 5-FU/LV (cost savings £1318), with lifetime gain in QALMs of 9 months. Medical resource utilisation is significantly decreased with capecitabine vs 5-FU/LV, with cost savings to the NHS and society. Capecitabine is also projected to increase life expectancy vs 5-FU/LV. Cost savings and better outcomes make capecitabine a preferred adjuvant therapy for Dukes' C colon cancer. This pharmacoeconomic analysis strongly supports replacing 5-FU/LV with capecitabine in the adjuvant treatment of colon cancer in the UK

Factorisation of analytic representations in the unit disk and number-phase statistics of a quantum harmonic oscillator

The inner-outer part factorisation of analytic representations in the unit disk is used for an effective characterisation of the number-phase statistical properties of a quantum harmonic oscillator. It is shown that the factorisation is intimately connected to the number-phase Weyl semigroup and its properties. In the Barut-Girardello analytic representation the factorisation is implemented as a convolution. Several examples are given which demonstrate the physical significance of the factorisation and its role for quantum statistics. In particular, we study the effect of phase-space interference on the factorisation properties of a superposition state.Comment: to appear in J. Phys. A, LaTeX, 13 pages, no figures. More information on http://www.technion.ac.il/~brif/science.htm

The Stellar Composition of the Star Formation Region CMa R1 -- III. A new outburst of the Be star component in Z CMa

We report on a recent event in which, after more than a decade of slowly fading, the visual brightness of the massive young binary Z CMa suddenly started to rise by about 1 magnitude in December 1999, followed by a rapid decline to its previous brightness over the next six months. This behaviour is similar to that exhibited by this system around its eruption in February 1987. A comparison of the intrinsic luminosities of the system with recent evolutionary calculations shows that Z CMa may consist of a 16 M_sun B0 IIIe primary star and a ~ 3 M_sun FUOr secondary with a common age of ~ 3 x 10^5 yr. We also compare new high-resolution spectra obtained in Jan. and Feb. 2000, during the recent rise in brightness, with archive data from 1991 and 1996. The spectra are rich in emission lines, which originate from the envelope of the early B-type primary star. The strength of these emission lines increased strongly with the brightness of Z CMa. We interpret the collected spectral data in terms of an accretion disc with atmosphere around the Herbig B0e component of Z CMa, which has expanded during the outbursts of 1987 and 2000. A high resolution profile of the 6300 A [O I] emission line, obtained by us in March 2002 shows an increase in flux and a prominent blue shoulder to the feature extending to ~ -700 km/s, which was much fainter in the pre-outburst spectra. We propose that this change in profile is a result of a strong change in the collimation of a jet, as a result of the outburst at the start of this century.Comment: 22 pages, 12 figures, accepted for publication in MNRA

Downregulation of Mcl-1 has anti-inflammatory pro-resolution effects and enhances bacterial clearance from the lung

Phagocytes not only coordinate acute inflammation and host defense at mucosal sites, but also contribute to tissue damage. Respiratory infection causes a globally significant disease burden and frequently progresses to acute respiratory distress syndrome, a devastating inflammatory condition characterized by neutrophil recruitment and accumulation of protein-rich edema fluid causing impaired lung function. We hypothesized that targeting the intracellular protein myeloid cell leukemia 1 (Mcl-1) by a cyclin-dependent kinase inhibitor (AT7519) or a flavone (wogonin) would accelerate neutrophil apoptosis and resolution of established inflammation, but without detriment to bacterial clearance. Mcl-1 loss induced human neutrophil apoptosis, but did not induce macrophage apoptosis nor impair phagocytosis of apoptotic neutrophils. Neutrophil-dominant inflammation was modelled in mice by either endotoxin or bacteria (Escherichia coli). Downregulating inflammatory cell Mcl-1 had anti-inflammatory, pro-resolution effects, shortening the resolution interval (R(i)) from 19 to 7 h and improved organ dysfunction with enhanced alveolar–capillary barrier integrity. Conversely, attenuating drug-induced Mcl-1 downregulation inhibited neutrophil apoptosis and delayed resolution of endotoxin-mediated lung inflammation. Importantly, manipulating lung inflammatory cell Mcl-1 also accelerated resolution of bacterial infection (R(i); 50 to 16 h) concurrent with enhanced bacterial clearance. Therefore, manipulating inflammatory cell Mcl-1 accelerates inflammation resolution without detriment to host defense against bacteria, and represents a target for treating infection-associated inflammation