Operation and Application of a Regional High-Frequency Radar Network in the Mid-Atlantic Bight

The Mid-Atlantic Regional Coastal Ocean Observing System (MARCOOS) High- Frequency Radar Network, which comprises 13 long-range sites, 2 medium-range sites, and 12 standard-range sites, is operated as part of the Integrated Ocean Observing System. This regional implementation of the network has been operational for 2 years and has matured to the point where the radars provide consistent coverage from Cape Cod to Cape Hatteras. A concerted effort was made in the MARCOOS project to increase the resiliency of the radar stations from the elements, power issues, and other issues that can disable the hardware of the system. The quality control and assurance activities in the Mid-Atlantic Bight have been guided by the needs of the Coast Guard Search and Rescue Office. As of May,, 2009, these quality-controlled MARCOOS High-Frequency Radar totals are being served through the Coast Guard\u27s Environmental Data Server to the Coast Guard Search and Rescue Optimal Planning System. In addition to the service to U.S. Coast Guard Search and Rescue Operations, these data support water quality, physical oceanographic, and fisheries research throughout the Mid-Atlantic Bight

Differences in sEMG Between Normal Squats and Accentuated Eccentric Loaded Squats in Competitive Collegiate Weightlifters

The purpose of the present work was to compare the effect of accentuated eccentric loaded (AEL) squats to normally loaded (NOR) squats on surface measured muscle activation (sEMG) in competitive weightlifters. Eight experienced, competitive weightlifters (six males, two females) completed both an AEL and NOR squat session (seven days apart), comprised of nine sets of squats, and was identical to their normal scheduled training. sEMG data from the vastus medialis (VM), vastus lateralis (VL), and biceps femoris (BF) was collected (at 1000Hz) during the entirety of the concentric (CON) phases of the AEL and NOR sessions. RMANOVAs (set x session-type) were calculated and no statistical differences were found (p \u3e 0.05) while promising statistical effect sizes (?2 partial 0.073 to 0.273) were observed

First Approaches to Standard protocols and Reference Materials for the Assessment of Potential Hazards Associated with Nanomaterialss

All new technologies have an inherent risk, which is typically assessed alongside the development of applications of the technology. This is also the case for nanotechnology: a key concern in the case of engineered nanomaterials (ENMs) is that due to their very small size, NMs can reach areas such as the cell that are inaccessible to other materials, such as implants and drugs. As a result of their large surface area, NMs may be more reactive than other larger materials. The large physical and chemical variability of NMs, and the fact that small changes can have large consequences, mean that there is insufficient data on which to make safety or risk assessments at present. Thus, a widely supported scientific basis and sufficient high quality data upon which to base regulatory decisions are required urgently. NanoImpactNet (NIN) can support the development and dissemination of such data. This report presents the outcome of the discussions of 60 experts in the field of safety assessment of manufactured NMs from academia, industry, government and non-profit organizations on some of the critical issues pertaining to the development of standard protocols and reference materials for assessment of the potential hazards associated with ENMs. It should be noted here that there was a separate NIN workshop on determining the best metrics for assessing NP safety, and that this workshop was directed specifically to how best to standardise testing protocols and develop reference materials for human health assessment

Franchises lost and gained: post-coloniality and the development of women’s rights in Canada

The Canadian constitution is to some extent characterised by its focus on equality, and in particular gender equality. This development of women’s rights in Canada and the greater engagement of women as political actors is often presented as a steady linear process, moving forwards from post-enlightenment modernity. This article seeks to disturb this ‘discourse of the continuous,’ by using an analysis of the pre-confederation history of suffrage in Canada to both refute a simplistic linear view of women’s rights development and to argue for recognition of the Indigenous contribution to the history of women’s rights in Canada. The gain of franchise and suffrage movements in Canada in the late nineteenth and early twentieth century are, rightly, the focus of considerable study (Pauker 2015), This article takes an alternative perspective. Instead, it examines the exercise of earlier franchises in pre-confederation Canada. In particular it analyses why franchise was exercised more widely in Lower Canada and relates this to the context of the removal of franchises from women prior to confederation

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Animal proteins.

References at ends of most chapters.Mode of access: Internet

Farmer-Herder Conflict in Burkina Faso Between the Mossi and Fulani Examined Through Agent-Based Modeling (ABM)

In 1970, the AVV began relocating Fulani pastoralists to the southern region of Burkina Faso. While there was plenty of available grazing land at the time, this changed as populations grew and climate change worsened. This “saturation of space” led to high levels of conflict between the groups, a phenomenon modeled using NetLogo in this thesis. Analysis of the ABM showed that conflicts were directly linked to population growth and occurred as a result of the saturation of space in the region—not due to historical tensions, as many scholars have previously argued. It also reinforced the notion that these conflicts are not random, but rather occur in strategically important locations.Bachelor of Art