A Comprehensive Mixed-Mode Time-Domain Load- and Source-Pull Measurement System

We present a novel test set devised for nonlinear balanced device characterization using load-pull techniques. The system is capable of measuring the voltage and current waveforms at the calibration reference planes while independently tuning the device under test (DUT) source and load differential- and common-mode terminations. The test set is designed to address present and future large-signal multiport measurement needs, easing the characterization task while developing new multiport active device

Performance Analysis of the ARIA Adaptive Media Processing Workflows using Colored Petri Nets

AbstractMultimedia systems are one of the most complex and interesting applications that are nowadays proposed to the users. Their complexity derives mainly from the fact that multimedia systems have to process huge amounts of data, while respecting real-time deadlines. For this reason performance evaluation of the underlaying workflow is a key issue in the design process of a new Multimedia system.In this paper we consider the ARchitecture for Interactive Arts (ARIA), an adaptive media processing workflow, developed at the Arizona State University, and outline a semi-automatic procedure to translate its specification into Colored Petri Nets. We then provide guidelines on how to compute the parameters for the performance models, and apply the proposed methodology to a realistic example of a face recognition application

A Novel Calibration Algorithm for a Special Class of Multiport Vector Network Analyzers

A new error model for a special class of multiport vector network analyzers (VNAs) is presented in this paper. This model can be applied to multiport network analyzers with noncomplete reflectometers, i.e., when the measurement of the incident waves at each port is not always available. The method used to compute the error coefficients proposed here is based on a compact and easy formulation. This method is an extension of the already existing general theory for complete reflectometer multiport network analyzers. Furthermore, the new error model generalizes the theory for three-sampler two-port VNAs. The proposed model has been tested against the complete reflectometer one and exhibits the same accuracy leve

Coupling Concept of two Parallel Research Codesfor Two and Three Dimensional Fluid Structure Interaction Analysis

This paper discuss a coupling strategy of two different software packages to provide fluid structure interaction (FSI) analysis. The basic idea is to combine the advantages of the two codes to create a powerful FSI solver for two and three dimensional analysis. The fluid part is computed by a program called PETSc-FEM a software developed at Centro de Investigacion de Metodos Computacionales CIMEC. The structural part of the coupled process is computed by the research code elementary Parallel Solver (ELPASO) of the Technische Universitat Braunschweig, Institut fur Konstruktionstechnik (IK).Fil: Garelli, Luciano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones En Metodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones En Metodos Computacionales; ArgentinaFil: Schauer, Marco. Technische Universität Braunschweig; AlemaniaFil: D'elia, Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones En Metodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones En Metodos Computacionales; ArgentinaFil: Storti, Mario Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Centro de Investigaciones En Metodos Computacionales. Universidad Nacional del Litoral. Centro de Investigaciones En Metodos Computacionales; ArgentinaFil: Langer, Sabine C.. Technische Universität Braunschweig; Alemani

A W-Band On-Wafer Active Load-Pull System Based on Down-Conversion Techniques

A new W-band active load-pull system is presented. It is the first load-pull system to implement a 94 GHz load by means of an active loop exploiting frequency conversion techniques. The active loop configuration demonstrates a number of advantages that overcome the typical limitations of W-band passive tuners or conventional active open loop techniques in a cost effective way: load reflection coefficients Γ L as high as 0.95 in magnitude can be achieved at 94 GHz, thus providing a nearly full coverage of the Smith Chart. Possible applications of the setup include technology assessment, large-signal device model verification at sub-THz frequencies, and W-band MMIC design and characterization. The availability of direct and accurate load-pull measurements at W-band should prove an asset in the development of sub-THz integrated circuits. First measure- ments performed on high performance InP double heterojunction bipolar transistors (DHBTs) and GaN high electron mobility transistors (HEMTs) are presente

Simultaneous Integrated Boost in Once-weekly Hypofractionated Radiotherapy for Breast Cancer in the Elderly: Preliminary Evidence

Aim: To evaluate once-weekly hypofractionated radiotherapy in elderly patients affected by early breast cancer, reporting acute and late toxicity profiles, and treatment feasibility. Patients and Methods: Fifty patients were treated with a hypofractionated regimen: 28.5\ub12.5 Gy in five fractions at one fraction weekly. Simultaneous integrated boost (SIB) to the tumor bed in high-risk cases. Inclusion criteria: patients over 70 years old, pT1-2, N0-1a. Acute and late toxicities were assessed based on Radiation Therapy Oncology Group. Results: The median follow-up was 20 months and the median patient age was 79 years. SIB was added for 22 patients (44%). Grade 3-4 acute cutaneous toxicities were not observed; grade 2 toxicity occurred only in four patients (8%). Late subcutaneous tissue toxicity consisted of grade 2 fibrosis in two patients (4%), grade 1 in five (10%) and grade 0 in 41(85%). Conclusion: Limiting fraction numbers with a safer profile may improve the management of breast cancer for the elderly

Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior

Background: Obesity and related co-morbidities represent a major health challenge nowadays, with a rapidly increasing incidence worldwide. The gut microbiome has recently emerged as a key modifier of human health that can affect the development and progression of obesity, largely due to its involvement in the regulation of food intake and metabolism. However, there are still few studies that have in-depth explored the functionality of the human gut microbiome in obesity and even fewer that have examined its relationship to eating behaviors. Methods: In an attempt to advance our knowledge of the gut-microbiome-brain axis in the obese phenotype, we thoroughly characterized the gut microbiome signatures of obesity in a well-phenotyped Italian female cohort from the NeuroFAST and MyNewGut EU FP7 projects. Fecal samples were collected from 63 overweight/obese and 37 normal-weight women and analyzed via a multi-omics approach combining 16S rRNA amplicon sequencing, metagenomics, metatranscriptomics, and lipidomics. Associations with anthropometric, clinical, biochemical, and nutritional data were then sought, with particular attention to cognitive and behavioral domains of eating. Results: We identified four compositional clusters of the gut microbiome in our cohort that, although not distinctly associated with weight status, correlated differently with eating habits and behaviors. These clusters also differed in functional features, i.e., transcriptional activity and fecal metabolites. In particular, obese women with uncontrolled eating behavior were mostly characterized by low-diversity microbial steady states, with few and poorly interconnected species (e.g., Ruminococcus torques and Bifidobacterium spp.), which exhibited low transcriptional activity, especially of genes involved in secondary bile acid biosynthesis and neuroendocrine signaling (i.e., production of neurotransmitters, indoles and ligands for cannabinoid receptors). Consistently, high amounts of primary bile acids as well as sterols were found in their feces. Conclusions: By finding peculiar gut microbiome profiles associated with eating patterns, we laid the foundation for elucidating gut-brain axis communication in the obese phenotype. Subject to confirmation of the hypotheses herein generated, our work could help guide the design of microbiome-based precision interventions, aimed at rewiring microbial networks to support a healthy diet-microbiome-gut-brain axis, thus counteracting obesity and related complications

Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws

[EN] This work revisits the dynamic behaviour of stirred continuous reactors in which a single bioreaction with unknown kinetics occurs. Conditions on the feeding strategy to avoid washing out the biomass and falling in batch operation are obtained. These conditions derive in a closed positively invariant region including the desired operating point. It is stated that no closed orbits may exist in this region and, furthermore, that no fixed point exists but on one of its borders. Therefore, global stability is achieved by finding a feeding law that fulfils the aforementioned invariant conditions and gives a single equilibrium for a first-order dynamics. These results are useful to determine the stability properties of different control laws and, more importantly, to design new ones. The main advantages of the proposed approach are its simplicity and that, differing from previous results, input saturation does not affect stability results. The potentiality of the developed tools is illustrated by means of classical and novel feeding laws. (C) 2017 Elsevier Ltd. All rights reserved.Financed by I216-2016 (UNLP), PICT2014-2394 (ANPCyT) and PIP112-2015-01-00837 (CONICET), Argentina; and by DPI2014-55276-C5-1-R MINECO/AEI/FEDER, UE. The material in this paper was not presented at any conference.De Battista, H.; Jamilis, M.; Garelli, F.; Picó, J. (2018). Global stabilisation of continuous bioreactors: tools for analysis and design of feeding laws. Automatica. 89:340-348. https://doi.org/10.1016/j.automatica.2017.12.041S3403488

Prevalence of SARS-CoV-2 positivity in infants with bronchiolitis: a multicentre international study

Background Bronchiolitis is the leading acute respiratory tract infection in infants during the winter season. Since the beginning of the SARS-CoV-2 pandemic, a reduction in the number of bronchiolitis diagnoses has been registered. Objective The present study aimed to describe the incidence and clinical features of bronchiolitis during the 2020-2021 winter season in a large cohort of children in Europe and Israel, and to clarify the role of SARS-CoV-2. Setting, patients, interventions We conducted a multicentre observational cross-sectional study in 23 paediatric emergency departments in Europe and Israel. Clinical and demographic data about all the cases of infants diagnosed with bronchiolitis from 1 October 2020 to 30 April 2021 were collected. For each enrolled patient, diagnostic tests, treatments and outcomes were reported. Main outcome measures The main outcome was the prevalence of SARS-CoV-2-positive bronchiolitis. Results Three hundred and fourteen infants received a diagnosis of bronchiolitis during the study period. Among 535 infants who tested positive for SARS-CoV-2, 16 (3%) had bronchiolitis. Median age, male sex predominance, weight, history of prematurity and presence of comorbidities did not differ between the SARS-CoV-2-positive and SARS-CoV-2-negative groups. Rhinovirus was the most common involved pathogen, while respiratory syncytial virus (RSV) was detected in one case. SARS-CoV-2 bronchiolitis had a mild clinical course, with one patient receiving oxygen supplementation and none requiring paediatric or neonatal intensive care unit admission. Conclusions During the SARS-CoV-2 pandemic, a marked decrease in the number of bronchiolitis diagnoses and the disappearance of the RSV winter epidemic were observed. SARS-CoV-2-related bronchiolitis was rare and mostly displayed a mild clinical course.During the SARS-CoV-2 pandemic, very few infants with SARS-CoV-2 had bronchiolitis and mostly displayed a mild clinical course. Overall there was a marked decrease in bronchiolitis cases, indeed the RSV winter epidemic did not occur