Quantum non-Markovian behavior at the chaos border

In this work we study the non-Markovian behaviour of a qubit coupled to an environment in which the corresponding classical dynamics change from integrable to chaotic. We show that in the transition region, where the dynamics has both regular islands and chaotic areas, the average non-Markovian behaviour is enhanced to values even larger than in the regular regime. This effect can be related to the non-Markovian behaviour as a function of the the initial state of the environment, where maxima are attained at the regions dividing separate areas in classical phase space, particularly at the borders between chaotic and regular regions. Moreover, we show that the fluctuations of the fidelity of the environment -- which determine the non-Markovianity measure -- give a precise image of the classical phase portrait.Comment: 23 pages, 9 figures (JPA style). Closest to published versio

Soft, collinear and non-relativistic modes in radiative decays of very heavy quarkonium

We analyze the end-point region of the photon spectrum in semi-inclusive radiative decays of very heavy quarkonium (m alpha_s^2 >> Lambda_QCD). We discuss the interplay of the scales arising in the Soft-Collinear Effective Theory, m, m(1-z)^{1/2} and m(1-z) for z close to 1, with the scales of heavy quarkonium systems in the weak coupling regime, m, m alpha_s and m alpha_s^2. For 1-z \sim alpha_s^2 only collinear and (ultra)soft modes are seen to be relevant, but the recently discovered soft-collinear modes show up for 1-z << alpha_s^2. The S- and P-wave octet shape functions are calculated. When they are included in the analysis of the photon spectrum of the Upsilon (1S) system, the agreement with data in the end-point region becomes excellent. The NRQCD matrix elements and are also obtained.Comment: Revtex, 11 pages, 6 figures. Minor improvements and references added. Journal versio

Evangelical Visitor- October 2, 1911. Vol. XXV. No. 20.

Evangelical Visitor published in Harrisburg, Pa., for the exposition of true, practical piety and devoted to the spread of evangelical truths and the unity of the church. Published in the interest of the church of the Brethren in Christ on October 2, 1911. Vol. XXV. No. 20

Altered brain responses to specific negative emotions in schizophrenia

Esquizofrènia; Estímuls escènics; fMRIEsquizofrenia; Estímulos escénicos; fMRISchizophrenia; Scenic stimuli; fMRIDeficits in emotion processing are a core feature of schizophrenia, but their neurobiological bases are poorly understood. Previous research, mainly focused on emotional face processing and emotion recognition deficits, has shown controverted results. Furthermore, the use of faces has been questioned for not entailing an appropriate stimulus to study emotional processing. This highlights the importance of investigating emotional processing abnormalities using evocative stimuli. For the first time, we have studied the brain responses to scenic stimuli in patients with schizophrenia. We selected scenes from the IAPS that elicit fear, disgust, happiness, and sadness. Twenty-six patients with schizophrenia and thirty age-, sex- and premorbid IQ-matched healthy controls were included. Behavioral task results show that patients tended to misclassify disgust and sadness as fear. Brain responses in patients were different from controls in images eliciting disgust and fear. In response to disgust images, patients hyperactivated the right temporal cortex, which was not activated by the controls. With fear images, hyperactivation was observed in brain regions involved in fear processing, including midline regions from the medial frontal cortex to the anterior cingulate cortex, the superior frontal gyrus, inferior and superior temporal cortex, and visual areas. These results suggest that schizophrenia is characterized by hyper-responsivity to stimuli evoking high-arousal, negative emotions, and a bias towards fear in emotion recognition

Gauge invariant definition of the jet quenching parameter

In the framework of Soft-Collinear Effective Theory, the jet quenching parameter, $\hat{q}$, has been evaluated by adding the effect of Glauber gluon interactions to the propagation of a highly-energetic collinear parton in a medium. The result, which holds in covariant gauges, has been expressed in terms of the expectation value of two Wilson lines stretching along the direction of the four-momentum of the parton. In this paper, we show how that expression can be generalized to an arbitrary gauge by the addition of transverse Wilson lines. The transverse Wilson lines are explicitly computed by resumming interactions of the parton with Glauber gluons that appear only in non-covariant gauges. As an application of our result, we discuss the contribution to $\hat{q}$ coming from transverse momenta of order $g^2T$ in a medium that is a weakly-coupled quark-gluon plasma.Comment: 31 pages, 7 figures; journal versio

Legislative framework for sediment management in the United States

[EN] Sediment erosion is a serious issue, with approximately 75 billion tons of soil is eroded annually around the world (Pimentel and Kounang, 1998). Although erosion is a natural process, it can accelerate due to human activity and land use changes. Increasing soil erosion beyond its natural threshold can result in significant environmental degradation and decreased economic productivity. Implementing sediment management laws and practices is critical to significantly decrease soil erosion and preserve environmental resources. In the United States, there is a comprehensive system of laws and regulations at national, state, county, and city level that govern erosion and sediment control. The laws and voluntary incentives outlined in our paper have significantly reduced the negative impacts of sediment carried in urban and storm-generated runoff, have reduced chemical and biological pollutants in sediment transported in aquatic ecosystems, and have improved the air quality in several cities with air pollution problems. Having a multi-faceted approach to monitoring erosion and improving soil management is important for a healthy, productive environment and economy.[ES] La erosión de sedimentos es un problema serio, con aproximadamente 75.000 millones de toneladas de suelo erosionadas anualmente en todo el mundo (Pimentel y Kounang, 1998). Aunque la erosión es un proceso natural, ésta puede acelerarse debido a la actividad humana y a los cambios en el uso de la tierra. El incremento de la erosión del suelo más allá de su umbral natural puede resultar en una degradación ambiental significativa y una disminución de la productividad económica. La implementación de leyes y prácticas de gestión de sedimentos es fundamental para disminuir significativamente la erosión del suelo y preservar los recursos ambientales. En los Estados Unidos, existe un sistema integral de leyes y regulaciones a nivel nacional, estatal, del condado y de ciudad que gobiernan la erosión y el control de sedimentos. Las leyes y los incentivos voluntarios descritos en nuestro trabajo han reducido significativamente los impactos negativos de los sedimentos transportados en las escorrentías urbanas y rurales, han reducido los contaminantes químicos y biológicos en los sedimentos transportados hacia los ecosistemas acuáticos y han mejorado la calidad del aire en varias ciudades con problemas de contaminación atmosférica. Tener un enfoque multifacético para monitorizar la erosión y mejorar la gestión del suelo es importante para un ambiente y una economía sanos y productivos.Los autores agradecen la colaboración de las agencias federales y estatales norteamericanas que colaboraron en la elaboración de este artículo.Garcia-Chevesich, PA.; Jones, SL.; Daniels, JM.; Valdés-Pineda, R.; Venegas-Quiñones, H.; Pizarro, R. (2018). Marco legislativo para la gestión de sedimentos en los Estados Unidos. Ingeniería del Agua. 22(2):53-67. doi:10.4995/ia.2018.7916SWORD5367222Arizona Department of Environmental Quality. 2017. Air Quality Forecast. Recuperado de http://www.azdeq.gov/programs/airquality-programs/air-forecasting. Fecha de acceso 8 Mayo, 2017.California Environmental Protection Agency. 2017. Air Quality Resources Board. Recuperado de https://www.arb.ca.gov/. Fecha de acceso 8 Mayo, 2017.City of Lone Tree. 2015. Grading, erosion and control fact sheet. Public Works Department.Elliot, W.J., Miller, M.E., Enstice, N. 2016. Targeting forest management through fire and erosion modelling. International Journal of Wildland Fire, 25, 876-887. https://doi.org/10.1071/WF15007Farm Policy Facts. 2017. A Short History and Summary of the Farm Bill. Recuperado de https://www.farmpolicyfacts.org/farmpolicy-history/. Fecha de acceso 23 Marzo, 2017.Fryirs, K. 2013. (Dis)connectivity in catchment sediment cascades: a fresh look at the sediment delivery problem. Earth Surface Processes and Landforms, 38, 30-46. https://doi.org/10.1002/esp.3242Garcia-Chevesich, P. 2015. Control de la erosión y recuperación de suelos degradados. Outskirts Press. Denver, CO. 486 p.Garcia-Chevesich, P., Alvarado, S., Neary, D., Valdes, R., Valdes, J., Aguirre, J., Mena, M., Pizarro, R., Jofré, P., Vera, M., Olivares, C. 2014. Respiratory disease and particulate air pollution in Santiago Chile: Contribution of erosion particles from fine sediments. Journal of Environmental Pollution, 187(April), 202-205. https://doi.org/10.1016/j.envpol.2013.12.028Garcia-Chevesich, P., Etra, J. 2012. Using vegetation to stabilize slopes. Environmental Connection, 6(1), 28-29.García-Ruiz, J.M., Beguería, S., Nadal-Romero, E., Gonzáles-Hidalgo, J.C., Lana-Renault, N., Sanjuán, Y. 2015. A meta-analysis of soil erosion rates across the world. Geomorphology, 239, 160-173. https://doi.org/10.1016/j.geomorph.2015.03.008Illinois Natural Resource Conservation Service. Electronic Field Office Technical Guide. (eFOTG). USDA-NRCS. Recuperado de http://www.nrcs.usda.gov/technical/efotg/.Minnesota Pollution Control Agency. 2013. Spicer State Highway 23 - stormwater management for linear projects. Recuperado de https://stormwater.pca.state.mn.us/index.php?title=Spicer_State_Highway_23_-_stormwater_management_for_linear_projects. Fecha de acceso 30 Abril, 2017.Mitas, L., Mitasova, H. 1998. Distributed soil erosion simulation for effective erosion prevention. Water Resource Research, 34(3), 505-516. https://doi.org/10.1029/97WR03347New York State Department of Environmental Conservation. 2017. Air. Recuperado de http://www.dec.ny.gov/chemical/281.html. Fecha de acceso 8 Mayo, 2017.Renwick, W.H., Smith, S.V., Bartley, J.D., Buddemeier, R.W. 2005. The role of impoundments in the sediment budget of the conterminous United States. Geomorphology, 71, 99-111. https://doi.org/10.1016/j.geomorph.2004.01.010U.S. Army Corps of Engineers. 2013. Grass GIS turns 30 - ERDC's CERL was there at the start. Recuperado de http://www.erdc.usace.army.mil/Media/News-Stories/Article/476565/grass-gis-turns-30-erdcs-cerl-was-there-at-the-start/. Fecha de acceso 30 Abril, 2017.U.S. Army Corps of Engineers. 2017. "Introduction." A brief history. Recuperado de http://www.usace.army.mil/About/History/Brief-History-of-the-Corps/Introduction/. Fecha de acceso 30 Abril, 2017.U.S. Department of Agriculture. 2007. Construction site soil erosion and sediment control fact sheet. Natural Resource Conservation Service. October, Illinois.U.S. Department of Agriculture. 2007. Soil Quality. Forest Service. Recuperado de https://www.nrs.fs.fed.us/fia/topics/soils//. Fecha de acceso 23 Abril, 2017.U.S. Department of Agriculture. 2008. Urban Soil Erosion and Sediment Control. Conservation practices for protecting and enhancing soil water resources in growing and changing communities. Association of Illinois Soil and Water Conservation Districts. Natural Resource Conservation Service. p1-16.U.S. Department of Agriculture. 2010. 2007 National Resource Inventory: Soil Erosion on Cropland. Natural Resource Conservation Service. Inventory and Assessment Division, Washington DC. 1-27.U.S. Department of Agriculture. 2017a. Research. Natural Resource Conservation Service. October, Illinois. Recuperado de https://www.ars.usda.gov/midwest-area/west-lafayette-in/national-soil-erosion-research/docs/wepp/research/. Fecha de acceso 21 Abril, 2017.U.S. Department of Agriculture. 2017b. Natural Resource Conservation Service. Recuperado de https://www.nrcs.usda.gov/wps/portal/nrcs/site/national/home/. Fecha de acceso 21 Marzo, 2017.U.S. Department of Agriculture. 2017c. Incentive Programs and Assistance for Producers. Natural Resource Conservation Service. Recuperado de https://www.nrcs.usda.gov/wps/portal/nrcs/detail/national/climatechange/resources/?cid=stelprdb1043608. Fecha de acceso 23 Marzo, 2017.U.S. Department of Agriculture. 2017d. National Water Quality Initiative. Natural Resource Conservation Service. Recuperado de https://www.nrcs.usda.gov/wps/portal/nrcs/detail/national/water/?cid=stelprdb1047761. Fecha de acceso 30 Abril, 2017.U.S. Department of Agriculture. 2017e. eDirective. Electronic Directives. Natural Resource Conservation Service. Recuperado de https://directives.sc.egov.usda.gov/Default.aspx. Fecha de acceso 23 Abril, 2017.U.S. Department of the Interior. 2004. Soil Resources Management. National Park Service. Recuperado de https://www.nature.nps.gov/rm77/soils/programguide.cfm. Fecha de acceso 23 Marzo, 2017.U.S. Environmental Protection Agency. 1998. The quality of our nation's waters, a summary of the National Water Quality Inventory: 1998 Report to Congress. EPA841-F-96-004G.U.S. Environmental Protection Agency. 2009. Developing your stormwater pollution prevention plan. A guide for industrial operators. EPA 833-B-09-002. 1-42.U.S. Environmental Protection Agency. 2014. Water quality standards handbook. Office of Water. 820-B-14-008.U.S. Environmental Protection Agency. 2017a. History of the Clean Water Act. Recuperado de https://www.epa.gov/laws-regulations/history-clean-water-act. Fecha de acceso 21 Marzo, 2017.U.S. Environmental Protection Agency. 2017b. National Pollutant Discharge Elimination System. Recuperado de https://www.epa.gov/npdes. Fecha de acceso 21 Marzo, 2017.U.S. Environmental Protection Agency. 2017c. PM-10 (1987) Nonattainment Area State/Area/County Report. Recuperado dehttps://www3.epa.gov/airquality/greenbook/pncs.html#AZ. Fecha de acceso 30 Abril, 2017.U.S. Environmental Protection Agency. 2018. Watershed Assessment, Tracking & Environmental Results System. Recuperado de https://www.epa.gov/waterdata/waters-watershed-assessment-tracking-environmental-results-system.U.S. Fish and Wildlife Service. 2015. Section 404 Permits. Charleston Ecological Services. Recuperado de https://www.fws.gov/charleston/404Permits.html. Fecha de acceso 23 Abril, 2017.U.S. Geological Survey. 2017a. Sediment Data Portal Guide. Recuperado de https://cida.usgs.gov/sediment/helpGuide.jsp. Fecha de acceso 23 Marzo, 2017.U.S. Geological Survey. 2017b. Sediment and Suspended Sediment. The effects of urbanization on water quality: Erosion and sedimentation. The USGS Water Science School. Recuperado de https://water.usgs.gov/edu/sediment.html. Fecha de acceso 23 Marzo, 2017.U.S. Geological Survey. 2017c. USGS Sediment Data Portal. Recuperado de https://cida.usgs.gov/sediment/. Fecha de acceso 7 Mayo 2017.U.S. Green Building Council. 2017. Erosion and sediment control. LEED O+M: Existing Buildings. LEED 2.0. Recuperado de http://www.usgbc.org/credits/existing-buildings/v20/ssp1. Fecha de acceso 30 Abril, 2017.Utah Department of Environmental Quality. 2017. Utah Division of Air Quality. Recuperado de https://deq.utah.gov/Divisions/daq/index.htm?id=l4. Fecha de acceso 8 May 2017.Voigt, C., Bozorth, T., Carey, B., Janes, E., Leonard, S. 1997. Sediment related issues and the public lands - Expanding sediment research capabilities in today's USGS - A bureau of land management overview. Proceedings of the U.S. Geological Survey (USGS) Sediment Workshop, February 4-7, 1997.Wolman, M.G. 1967. A cycle of sedimentation and erosion in urban river channels. Geografiska Annaler, 49A, 385-395. https://doi.org/10.1080/04353676.1967.11879766Wood, M.S., Teasdale, G.N. 2013, Use of surrogate technologies to estimate suspended sediment in the Clearwater River, Idaho, and Snake River, Washington, 2008-10: U.S. Geological Survey Scientific Investigations Report 2013-5052, 30 p

Overexpression. of dehydrin tas14 gene improves the osmotic stress imposed by drought and salinity in tomato

[EN] One strategy to increase the level of drought and salinity tolerance is the transfer of genes codifying different types of proteins functionally related to macromolecules protection, such as group 2 of late embryogenesis abundant (LEA) proteins or dehydrins. The TAS14 dehydrin was isolated and characterized in tomato and its expression was induced by osmotic stress (NaCl and mannitol) and abscisic acid (ABA) [Godoy et al., Plant Mol Biol 1994;26:1921-1934], yet its function in drought and salinity tolerance of tomato remains elusive. In this study, transgenic tomato plants overexpressing tas14 gene under the control of the 35SCaMV promoter were generated to assess the function of tas14 gene in drought and salinity tolerance. The plants overexpressing tas14 gene achieved improved long-term drought and salinity tolerance without affecting plant growth under non-stress conditions. A mechanism of osmotic stress tolerance via osmotic potential reduction and solutes accumulation, such as sugars and K+ is operating in tas14 overexpressing plants in drought conditions. A similar mechanism of osmotic stress tolerance was observed under salinity. Moreover, the overexpression of tas14 gene increased Na+ accumulation only in adult leaves, whereas in young leaves, the accumulated solutes were K+ and sugars, suggesting that plants overexpressing tas14 gene are able to distribute the Na+ accumulation between young and adult leaves over a prolonged period in stressful conditions. Measurement of ABA showed that the action mechanism of tas14 gene is associated with an earlier and greater accumulation of ABA in leaves during short-term periods. A good feature for the application of this gene in improving drought and salt stress tolerance is the fact that its constitutive expression does not affect plant growth under non-stress conditions, and tolerance induced by overexpression of tas14 gene was observed at the different stress degrees applied to the long term. (C) 2011 Elsevier GmbH. All rights reserved.This work was supported by the Spanish Ministry of Science and Innovation through grant AGL2009-13388-C03 and by the Council of Science and Technology from the Region of Murcia (Spain) (Fundacion SENECA) through grant 04553/GERM/06.Muñoz Mayor, A.; Pineda Chaza, BJ.; García Abellán, JO.; Antón Martínez, MT.; García Sogo, B.; Sánchez Bel, P.; Flores, FB.... (2012). Overexpression. of dehydrin tas14 gene improves the osmotic stress imposed by drought and salinity in tomato. Journal of Plant Physiology. 169(5):459-468. https://doi.org/10.1016/j.jplph.2011.11.018S459468169

Incidence of and factors associated with SARS-CoV-2 infection among people living with HIV in Southern Spain after one year of pandemic

Whether people living with HIV (PLWH) are at greater risk of acquiring SARS-CoV-2 infection is currently unknown. Prospective serologic studies may allow seroincidence analyses, where all infections are accurately identified. Because of this, we evaluated the incidence of associated factors with and the clinical outcome of SARS-CoV-2 infection in PLWH in Southern Spain. This prospective cohort study included PLWH from a Tertiary University Hospital in Southern Spain. Patients were enrolled in the study if (1) they had attended as outpatients our Unit from 1 August 2019 to 8 February 2020 and (2) had two subsequent evaluations from 9 February 2020 to 4 March 2021. SARS-CoV-2 infections were diagnosed by PCR, antigen detection or serology. Seven hundred and nine PLWH were included in the study. Of them, 55 [7.8%, 95% confidence interval (95% CI) 5.9%-9.9%] patients developed SARS-CoV-2 infection. Between 18 May and 29 November 2020, the rate of seroconversion was 5.3% (95% CI: 3.1%-9.0%) for the general population in the area of Seville and 2.3% (95% CI: 1.3%-2.6%) for PLWH in this study (p = .001). After multivariable analysis, adjusted by age, sex, and risk factors for HIV infection, active tobacco use and CDC stage, active tobacco smoking was the only factor independently associated with lower risk of SARS-Cov-2 infection [Incidence rate ratio: 0.29 (95% CI 0.16-0.55) p < .001]. In conclusion, the incidence of SARS-CoV-2 infection among PLWH in Southern Spain during the ongoing pandemic was lower than that reported for the general population in the same area.This work was supported in part by the Instituto de Salud CarlosIII (Project ‘PI16/01443’), integrated in the national I+D+i 2013–2016andco-fundedbytheEuropeanUnion(ERDF/ESF,‘Investinginyour future’), by the Spanish Network for AIDS investigation (RIS)(www.red.es/redes/inicio)(RD16/0025/0010,RD16/0025/0040),asapartoftheNacionalI+D+I,ISCIIISubdirecciónGeneraldeEvaluaciónand the European Fund for Development of Regions (FEDER). JuanA.PinedareceivedaresearchextensiongrantfromtheProgramadeIntensificacióndelaActividaddeInvestigacióndelServicioNacionaldeSaludCarlosIII(I3SNS).FedericoGarciareceivedaresearchextensiongrantfromtheProgramadeIntensificacióndelaActividaddeInves-tigacióndelServicioAndaluzdeSalud.AnaïsCorma-GomezreceivedaRíoHortegagrantfromtheInstitutodeSaludCarlosIII(grantnum-ber CM19/00251). Funding for open access charge: Universidad deMálaga/CBU

Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism

Objective: To evaluate the taxonomic composition of the gut microbiome in gout patients with and without tophi formation, and predict bacterial functions that might have an impact on urate metabolism. Methods: Hypervariable V3–V4 regions of the bacterial 16S rRNA gene from fecal samples of gout patients with and without tophi (n=33 and n=25, respectively) were sequenced and compared to fecal samples from 53 healthy controls. We explored predictive functional profles using bioinformatics in order to identify diferences in taxonomy and metabolic pathways. Results: We identifed a microbiome characterized by the lowest richness and a higher abundance of Phascolarctobacterium, Bacteroides, Akkermansia, and Ruminococcus_gnavus_group genera in patients with gout without tophi when compared to controls. The Proteobacteria phylum and the Escherichia-Shigella genus were more abundant in patients with tophaceous gout than in controls. Fold change analysis detected nine genera enriched in healthy controls compared to gout groups (Bifdobacterium, Butyricicoccus, Oscillobacter, Ruminococcaceae_UCG_010, Lachnospiraceae_ND2007_group, Haemophilus, Ruminococcus_1, Clostridium_sensu_stricto_1, and Ruminococcaceae_ UGC_013). We found that the core microbiota of both gout groups shared Bacteroides caccae, Bacteroides stercoris ATCC 43183, and Bacteroides coprocola DSM 17136. These bacteria might perform functions linked to one-carbon metabo‑ lism, nucleotide binding, amino acid biosynthesis, and purine biosynthesis. Finally, we observed diferences in key bacterial enzymes involved in urate synthesis, degradation, and elimination. Conclusion: Our fndings revealed that taxonomic variations in the gut microbiome of gout patients with and with‑ out tophi might have a functional impact on urate metabolism. Keywords: Gout, Gut microbiota, Uric acid metabolis

Lipid Antigen Presentation by CD1b and CD1d in Lysosomal Storage Disease Patients

The lysosome has a key role in the presentation of lipid antigens by CD1 molecules. While defects in lipid antigen presentation and in invariant Natural Killer T (iNKT) cell response were detected in several mouse models of lysosomal storage diseases (LSD), the impact of lysosomal engorgement in human lipid antigen presentation is poorly characterized. Here, we analyzed the capacity of monocyte-derived dendritic cells (Mo-DCs) from Fabry, Gaucher, Niemann Pick type C and Mucopolysaccharidosis type VI disease patients to present exogenous antigens to lipid-specific T cells. The CD1b- and CD1d-restricted presentation of lipid antigens by Mo-DCs revealed an ability of LSD patients to induce CD1-restricted T cell responses within the control range. Similarly, freshly isolated monocytes from Fabry and Gaucher disease patients had a normal ability to present α-Galactosylceramide (α-GalCer) antigen by CD1d. Gaucher disease patients' monocytes had an increased capacity to present α-Gal-(1-2)-αGalCer, an antigen that needs internalization and processing to become antigenic. In summary, our results show that Fabry, Gaucher, Niemann Pick type C, and Mucopolysaccharidosis type VI disease patients do not present a decreased capacity to present CD1d-restricted lipid antigens. These observations are in contrast to what was observed in mouse models of LSD. The percentage of total iNKT cells in the peripheral blood of these patients is also similar to control individuals. In addition, we show that the presentation of exogenous lipids that directly bind CD1b, the human CD1 isoform with an intracellular trafficking to the lysosome, is normal in these patients.This work was financed by Gaucher Generation Program, supported by Sanofi-Genzyme and by Norte-01-0145-FEDER-000012—Structured program on bioengineered therapies for infectious diseases and tissue regeneration, supported by the Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). BP-C was temporally supported by a grant from the American Portuguese Biomedical Research Fund (APBRF).info:eu-repo/semantics/publishedVersio