12 research outputs found
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations.
Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations
(TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable
clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p−) and gains
of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs www.impactjournals.com/oncotarget 80917 Oncotarget
However, the reported series were small, thus hindering definitive conclusions. To
gain insight into this issue, we assessed a series of 101 CLL patients harboring
TP53 disruption. The frequency of 8p− and 8q+ was 14.7% and 17.8% respectively.
Both were associated with a significantly (P < 0.05) higher incidence of a complex
karyotype (CK, ≥3 abnormalities) detected by chromosome banding analysis (CBA)
compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate
analysis for 10-year overall survival (OS), 8p− (P = 0.002), 8q+ (P = 0.012) and CK
(P = 0.009) were associated with shorter OS. However, in multivariate analysis only
CK (HR = 2.47, P = 0.027) maintained independent significance, being associated
with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our
results highlight the association of chromosome 8 abnormalities with CK amongst
CLL patients with TP53abs, while also revealing that CK can further aggravate the
prognosis of this aggressive subgroup.Instituto Carlos III, Ministerio de Economía y Competitividad, Unión Europea PI11/01621, PI15/00437, RD09/0076/00036, RD12/0036/0044, RD12/0036/0069 and PT13/0010/0005Generalitat de Catalunya 2014/SGR58
Analyzing derived metallicities and ionization parameters from model-based determinations in ionized gaseous nebulae
We analyze the reliability of oxygen abundances and ionization parameters
obtained from different diagnostic diagrams. For this, we compiled from the
literature observational emission line intensities and oxygen abundance of 446
star-forming regions whose O/H abundance was determined by direct estimation of
electron temperature. The abundances compiled were compared with the values
calculated in this work using different diagnostic diagrams in combination with
results from a grid of photoionization models. We found that the
[\ion{O}{iii}]/[\ion{O}{ii}] vs. [\ion{N}{ii}]/[\ion{O}{ii}],
[\ion{O}{iii}]/H vs. [\ion{N}{ii}]/[\ion{O}{ii}], and
([\ion{O}{iii}]/H)/([\ion{N}{ii}]/H) vs.
[\ion{S}{ii}]/[\ion{S}{iii}] diagnostic diagrams give O/H values close to the
-method, with differences of about 0.04 dex and dispersion of about
0.3 dex. Similar results were obtained by detailed models but with a dispersion
of 0.08 dex. The origin of the dispersion found in the use of diagnostic
diagrams is probably due to differences between the real N/O-O/H relation of
the sample and the one assumed in the models. This is confirmed by the use of
detailed models that do not have a fixed N/O-O/H relation. We found no
correlation between ionization parameter and the metallicity for the objects of
our sample. We conclude that the combination of two line ratio predicted by
photoionization models, one sensitive to the metallicity and another sensitive
to the ionization parameter, which takes into account the physical conditions
of star-forming regions, gives O/H estimates close to the values derived using
direct detections of electron temperatures.Comment: 12 pages, 9 figures, accepted by MNRA
A dataset of acoustic measurements from soundscapes collected worldwide during the COVID-19 pandemic
Political responses to the COVID-19 pandemic led to changes in city soundscapes around the globe. From March to October 2020, a consortium of 261 contributors from 35 countries brought together by the Silent Cities project built a unique soundscape recordings collection to report on local acoustic changes in urban areas. We present this collection here, along with metadata including observational descriptions of the local areas from the contributors, open-source environmental data, open-source confinement levels and calculation of acoustic descriptors. We performed a technical validation of the dataset using statistical models run on a subset of manually annotated soundscapes. Results confirmed the large-scale usability of ecoacoustic indices and automatic sound event recognition in the Silent Cities soundscape collection. We expect this dataset to be useful for research in the multidisciplinary field of environmental sciences
Discovery and characterization of an unknown blue-green Maya pigment: Veszelyite
Blue-green mosaic and polychrome masks and funerary offerings from the royal tombs of Calakmul, Mexico, were analysed by scanning electron microscope equipped with energy dispersive X-ray spectroscopy (SEM-EDS), X-ray diffraction (XRD), and particle induced X-ray emission (PIXE). This led to the first identification of the use of veszelyite, a rare hydrated copper-zinc phosphate, as green pigment. Analyses of a geological sample of this mineral have been done to confirm the characterization of this Mayan pigment, which might help determine pre-Columbian trade routes of precious and luxury objects in the ancient Maya Classic period (ad 250-800)
New Algorithms for Reference Generation in Symbolic Analysis or Large Analog Circuits
This paper addresses the problems arising in the calculation of numerical references (network function coefficients) , essential for an appropriate error control in simplification before and during generation algorithms for symbolic analysis of large analog circuits. The conventional polynomial interpolation method reveals to be unable to handle the large circuit sizes needed, mainly due to the dramatic effect of round-off errors. This paper introduces a new algorithm able to accurately calculate the network function coefficients of large analog circuits in an efficient way. 1. Introduction Symbolic circuit analysis refers to the calculation of network functions where all or part of the circuit parameters are represented by symbols. The applicability of symbolic simulation techniques to the analysis and synthesis of analog integrated circuits has been known for a long time. See for instance [1] for an actualized review of techniques and applications of symbolic analysis. Given the e..
FM14 Session 2: Communicating Astronomy in our Changing World
As the IAU heads towards its second century, many changes have simultaneously transformed Astronomy and the human condition world-wide. Amid the amazing recent discoveries of exoplanets, primeval galaxies, and gravitational radiation, the human condition on Earth has become blazingly interconnected, yet beset with ever-increasing problems of over-population, pollution, and never-ending wars. Fossil-fueled global climate change has begun to yield perilous consequences. And the displacement of people from war-torn nations has reached levels not seen since World War II. \ua9 International Astronomical Union 2020