Representación cartográfica mediante técnicas de SIG de formas del relieve y procesos geomorfológicos activos en el sector de Veguellina de Órbigo (León, noroeste de España)

En el presente trabajo se ha realizado un estudio de las formas del relieve y de procesos geomorfológicos activos en las proximidades de Veguellina de Órbigo (provincia de León). El objetivo es la caracterización detallada del medio físico de la zona de estudio como base para estudios de susceptibilidad de riesgos geológicos y su representación en un mapa geomorfológico y de procesos activos a escala 1:25000. El procedimiento metodológico ha consistido en una primera fase de estudio bibliográfico sobre trabajos previos en la zona. En una segunda fase se ha abordado el análisis geomorfológico del territorio, que se ha realizado combinando técnicas de fotointerpretación estereoscópica, trabajos de campo y con la ayuda de la cartografía base (curvas de nivel, ortofotos y MDT del Instituto Geográfico Nacional), identificando los relieves y los procesos de toda la zona, con su validación sobre el terreno en 28 puntos de observación. En la tercera fase se ha creado una base de datos en ArcGis tanto espacial como de atributos, que ha supuesto la digitalización de las distintas unidades cartográficas diferenciadas en la fase anterior, siguiendo durante el proceso de edición del mapa el método propuesto por el Instituto Geológico y Minero de España (IGME). Como resultados, se han determinado tres grandes unidades geomorfológicas en las que se dan procesos geomorfológicos específicos que se han Mapa Geomorfológico y de Procesos Activos final. Este mapa permite identificar los distintos procesos superficiales que han dado y dan lugar al relieve actual, reconocer las interacciones entre ellos y establecer la evolución del relieve a lo largo del tiempo, sirviendo como base del conocimiento del medio físico para su uso en distintos aspectos relacionados con el Medio Ambiente, como son la planificación territorial y el análisis de riesgos geológicos.Trabajo financiado por la Junta de Castilla y León, proyecto LE311A12-

Regioselective synthesis of elusive 4,9-Dihydro-1H-Carbazoles by gold-catalyzed cycloisomerization of 3-Allenylmethylindoles

A general and efficient synthesis of 4,9-dihydro- 1H-carbazoles from 3-allenylmethylindoles is reported. The process, catalyzed by a cationic gold(I) complex, involves a formal C2−H bond activation of the indole unit by reaction with the allene. The nature of the substituents at the allylic and terminal positions of the allene moiety has a crucial effect on the regioselectivity of the cyclization, which is also influenced by the catalyst and the solvent employed. Moreover, some evidence of the contribution of different reaction routes is provided, which led us to propose a plausible multipathway mechanism consistent with all of the results described.MICINN and FEDER (CTQ2010-15358 and CTQ2009-09949/BQU) for financial support. E.A. thanks MEC for an FPU predoctoral fellowship. P.G.-G. and M.A.F.-R. thank MICINN for "Juan de la Cierva" and "Ramon y Cajal" contractsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of organic chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher

Deshojado precoz en Viura y Malvasía riojana

En este trabajo se ha estudiado la aplicación de deshojado precoz en las variedades blancas Viura y Malvasía riojana como herramienta para el control del rendimiento y la mejora de la sanidad de la uva, con el objetivo de incrementar la calidad de sus vinos. Estas variedades presentan una producción elevada y racimos de gran tamaño, muy compactos, por lo que son bastante sensibles a Botrytis cinerea. Los resultados obtenidos indican que esta práctica puede plantearse como un método eficaz para el control del rendimiento y la mejora del estado sanitario de la uva; asimismo, favorece una correcta evolución del proceso de maduración, mejorando la composición de la uva debido al incremento del contenido de sólidos solubles y de compuestos fenólicos. La disminución de la acidez total y el aumento de pH que se producen en la uva, debido a la modificación del microclima de los racimos y al control del rendimiento, podría considerarse un inconveniente a tener en cuenta, sobre todo en el caso de variedades blancas que se caracterizan por un déficit de acidez total.Peer Reviewe

Solvent- and ligand-induced switch of selectivity in gold(I)-catalyzed tandem reactions of 3-propargylindoles

The selectivity of our previously described gold-catalyzed tandem reaction, 1,2-indole migration followed by aura-iso-Nazarov cyclization, of 3-propargylindoles bearing (hetero)aromatic substituents at both the propargylic and terminal positions, was reversed by the proper choice of the catalyst and the reaction conditions. Thus, 3-(inden-2-yl)indoles, derived from an aura-Nazarov cyclization (instead of an aura-iso-Nazarov cyclization), were obtained in moderate to good yields from a variety of 3-propargylindolesMICINN (CTQ2010-15358 and CTQ2009-09949), Junta de Castilla y Leon (BU021A09 and GR-172), MEC (FPU predoctoral fellowship to D.M.), Ramón y Cajal (contract to M.A F R.), Juan de la Cierva (contract to P.G.G.

Oral mucosa symptoms, signs and lesions, in end stage renal disease and non-end stage renal disease diabetic patients

Aim: To assess oral signs, symptoms and oral lesions (OL) type and prevalence, in diabetic patients with end stage renal disease (ESRD DM), and compare them with analogous findings in a non-ESRD DM group; analyze the possible association between oral manifestations, as well as with relevant laboratory findings. Research design. Two adult groups were studied: Group A: ESRD DM on dialysis, and group B: non-ESRD DM (serum creatinine <2.0 mg/dl). Known DM evolution time, dialysis treatment type and duration, and laboratory results were recorded. An oral exam was performed, searching for signs, symptoms and ESRD-associated OL. Associations were analyzed using Chi square, Fisher?s exact test, and odds ratios (OR) with 95% confidence intervals. Ages, time on dialysis, and laboratory results were compared with Student?s t test. Results: 229 individuals were examined, group A 99, and group B 130 pts. Signs and symptoms prevalence was higher in group A: 77.8% vs. 57.6%, (P<0.001), uremic breath (48.5%), unpleasant taste (45.5%) and xerostomia (44.4%) being the most frequent ones. OL were also more prevalent in group A; 65.6% vs. 36.9% (P<0.001). The most frequent OL were dry, fissured lips (28.3%), saburral tongue (18.2%) and candidiasis (17.2%). No difference was found in candidiasis prevalence between groups. Candidiasis was found associated to xerostomia (P<0.05) and smooth tongue (P<0.05) only in group A. Conclusions. ESRD DM patients had a significantly higher prevalence of signs, symptoms and OLs, as compared to non-ESRD DM pts. The high prevalence of uremic fetor, xerostomia, saburral tongue and candidiasis in group A, could be tried as warning signs on the possibility of non diagnosed advanced renal disease in other diabetic patients

Lesiones bucales en un grupo de pacientes con trasplante renal

Objetivo: Determinar la prevalencia de lesiones de la mucosa bucal (LB) en un grupo de pacientes con trasplante renal (TR), y analizar las posibles asociaciones de las lesiones entre sí, con el uso de fármacos y con variables clínicas y de laboratorio relevantes. Metodología. Estudio transversal, en el que se examinó a pacientes consecutivos con TR de la consulta de nefrología de un hospital General de Zona del Instituto Mexicano del Seguro Social. Se determinó la frecuencia y el tipo de lesiones bucales. Se analizaron las posibles asociaciones de las LB entre sí y con la cuenta de leucocitos totales, la función renal, el índice de higiene oral simplificado (IHO-S), los niveles de ciclosporina A (CsA) en sangre y el uso de nifedipina. Se utilizó un modelo de regresión logística para analizar la asociación entre hiperplasia gingival (HG) y la dosis de CsA y de nifedipina. Resultados. Se examinaron 50 (55.6%) hombres y 40 (44.4%) mujeres. El 60% de los pacientes presentaron al menos una lesión bucal. Se presentó candidosis bucal (CB) en 18.7%, lesiones clínicamente compatibles con leucoplasia vellosa (CLV) en 13%. Se identificó asociación entre la presencia de CB y CLV (P<0.05). Se encontró lengua saburral (LS) en 22% de los pacientes, e HG en 49%; Grado 1 en 11 (12.2%); Grado 2 en 26 (28.9%) y Grado 3 en 7 (7.8%). Los resultados de la regresión logística demostraron asociación de HG con mala higiene bucal (P<0.001), pero no con la dosis o los niveles de CsA, ni con el uso de nifedipina (P=0.075). Conclusión. El 60% de los pacientes con TR presentó al menos una lesión en la mucosa bucal. La asociación entre HG y mala higiene bucal demuestra la necesidad de supervisar la higiene bucal en el paciente trasplantado.Aim: To assess the prevalence of oral mucosa lesions (OL) in a group of kidney transplant (KT) patients, and analyze possible OL associations with one another and with drugs use and relevant clinical and laboratory variables. Methodology. Transversal study, in which consecutive KT patients from the nephrology outpatient service at a General Zonal Hospital were examined. The prevalence of several types of OL was assessed, and their possible statistical associations with one another and total leukocyte count, renal function, the simplified oral hygiene index (S-OHI), cyclosporin-A (CsA) dose and blood levels, and nifedipine use was analyzed. A logistic regression model was used to analyze the association between gingival hyperplasia (GH) and CsA dose and nifedipine use. Results. Fifty (55.6%) men and forty (44.4%) women were studied. Sixty percent of the patients had at least one OL. Oral candidiasis (OC) was found in 18.7%; 13% had lesions clinically compatible with hairy leukoplakia (CHL). An association was found between OC and CHL (P<0.05). Saburral tongue (ST) was found in 22% of the patients and gingival hyperplasia (GH) in 49%, which was distributed as follows: Grade 1 in 11 (12.2%); Grade 2 in 26 (28.9%), and Grade 3 in 7 (7.8%). Logistic regression results showed an association between GH and poor oral hygiene (P<0.001), but not to either CsA dose or blood levels, or nifedipine use (P=0.075). Conclusion. Sixty percent of the KT patients had at least one OL. The association between GH and poor oral hygiene corroborate the need for oral hygiene practices supervision in the transplant patient

Characterizing a novel hyposialylated erythropoietin by intact glycoprotein and glycan analysis

NeuroEPO plus is a recently developed recombinant human erythropoietin (rhEPO) without erythropoietic activity and shorter plasma half-life due to its low sialic acid content. This novel rhEPO product is under investigation as therapeutic protein in the treatment of neurodegenerative diseases owing to its neuroprotective and neurodegenerative properties. In this study, an in-depth characterization of NeuroEPO plus N-glycans was performed by a glycan isotope [12C6]/[13C6] coded aniline labeling strategy followed by capillary zwitterionic hydrophilic interaction liquid chromatography-mass spectrometry (CapZIC-HILIC-MS). A superior amount of low sialylated glycans and less branched structures were detected in NeuroEPO plus compare to other commercial rhEPOs. At the intact glycoprotein level, NeuroEPO plus glycoforms were separated by capillary zone electrophoresis with ultraviolet detection (CE-UV), optimizing the composition and pH of the separation electrolyte. Moreover, an isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) method was also optimized for the simultaneous analysis of this basic rhEPO and conventional acidic rhEPO products. The proposed glycomic and intact glycoprotein methods provide a robust and reliable analytical platform for NeuroEPO plus characterization and for its future implementation as biopharmaceutical in neurodegenerative diseases

The symbiotic binary system RX Puppis: a possible recurrent nova with a Mira companion

We present an analysis of photometric and spectroscopic observations of the symbiotic binary system RX Pup with the aim of developing a reliable binary model for the system and identifying mechanisms responsible for its spectacular activity. The binary is composed of a long-period Mira variable surrounded by a thick dust shell and a hot ,0:8M( white dwarf companion. The hot component produces practically all activity observed in the UV, optical and radio range, while variable obscuration of the Mira by circumstellar dust is responsible for long-term changes in the near-infrared magnitudes. The observations show that RX Pup underwent a nova-like eruption during the last three decades. The hot component contracted in radius at roughly constant luminosity from 1975 to 1986, and was the source of a strong stellar wind, which prevented it from accreting material lost in the Mira wind. Around 1988/9 the hot component turned over in the Hertzsprung±Russell (HR) diagram and by 1991 its luminosity had faded by a factor of ,30 with respect to the maximum plateau value and the hot wind had practically ceased. By 1995 the nova remnant started to accrete material from the Mira wind, as indicated by a general increase in intensity of the optical continuum and Hi emission. The quiescent spectrum resembles the quiescent spectra of symbiotic recurrent novae, and its intensity indicates that the hot component must accrete as much as ,1 per cent of the Mira wind, which is more or less the amount predicted by Bondi±Hoyle theory. The earliest observational records from the 1890s suggest that another nova-like eruption of RX Pup occurred around 1894.Facultad de Ciencias Astronómicas y Geofísica

Skills acquisition: Transference of cooperative learning experiences from the University to Secondary Education

[SPA] La sociedad necesita ciudadanos capaces de adaptarse y cooperar con otros. Estas habilidades necesitan ser desarrolladas, pero hasta qué punto el uso de ciertas metodologías de aprendizaje, tales como el aprendizaje cooperativo (AC), permiten el desarrollo de dichas habilidades es todavía una incógnita. En este trabajo realizamos un ejercicio de transferencia de nuestra experiencia en la aplicación del AC en la Universidad de Murcia a centros de enseñanza secundaria de Murcia. Aunque se trata de un proyecto a largo plazo, el primer análisis de esta experiencia a nivel de enseñanza secundaria nos muestra una mejora en los resultados académicos de los alumnos. A fin de cumplir nuestros objetivos, este estudio se efectúa en dos etapas. En la primera, se aplica el AC a una muestra de 208 estudiantes de tres institutos de Murcia con el objetivo de determinar si se produce una mejora en los resultados académicos en aquellas unidades didácticas impartidas mediante AC frente al uso del método tradicional. El análisis de los resultados muestra un mayor porcentaje de alumnos aprobados (90,38% vs. 50%), así como una mejora en las notas medias en las actividades trabajadas a través del AC (6,71 frente a 4,7). En una segunda etapa, aún en fase de realización y con una nueva muestra de estudiantes, comprobaremos la mejora en las habilidades sociales de los estudiantes y su impacto en la integración de los estudiantes de diferente etnia o raza. [ENG] Society needs citizens able to adapt to and cooperate with others, and these abilities need to be developed. However, how some learning methodologies, such as cooperative learning, help to the development of the abovementioned abilities is still unknown. In this research we transfer our knowledge and experience in cooperative learning methodology in the University of Murcia to a group of secondary schools in Murcia. Although this is a long-term project, the first analyses of this experience in secondary school education show an improvement in students’ academic performance after the implementation of cooperative learning in class. To reach our objectives the paper has been divided into two stages. First, we implemented cooperative learning in a sample of 208 students from three different secondary schools, in order to test if the students get better academic results in those didactic units where the teacher used cooperative learning. Quantitative analysis of the data confirm that students not only got a higher pass rate (90.38% vs. 50%) but also a higher average mark (6.71 vs 4.7). In the second stage, still on process, and with a new sample of students, we will check the students’ social skills improvement and the impact of this methodology on class integration of students from different ethnic and race groups

Real-world Implementation of a Smartphone-Based Psychoeducation Program for Bipolar Disorder: Observational Ecological Study

Background: SIMPLe is an internet-delivered self-management mobile app for bipolar disorder (BD) designed to combine technology with evidence-based interventions and facilitate access to psychoeducational content. The SIMPLe app was launched to the real world to make it available worldwide within the context of BD treatment. Objective: The main aims of this study are as follows: to describe app use, engagement, and retention rates based on server data; to identify patterns of user retention over the first 6-month follow-up of use; and to explore potential factors contributing to discontinuation of app use. Methods: This was an observational ecological study in which we pooled available data from a real-world implementation of the SIMPLe app. Participation was open on the project website, and the data-collection sources were a web-based questionnaire on clinical data and treatment history administered at inclusion and at 6 months, subjective data gathered through continuous app use, and the use patterns captured by the app server. Characteristics and engagement of regular users, occasional users, and no users were compared using 2-tailed t tests or analysis of variance or their nonparametric equivalent. Survival analysis and risk functions were applied to regular users' data to examine and compare use and user retention. In addition, a user evaluation analysis was performed based on satisfaction, perceived usefulness, and reasons to discontinue app use. Results: We included 503 participants with data collected between 2016 and 2018, of whom 77.5% (n=390) used the app. Among the app users, 44.4% (173/390) completed the follow-up assessment, and data from these participants were used in our analyses. Engagement declined gradually over the first 6 months of use. The probability of retention of the regular users after 1 month of app use was 67.4% (263/390; 95% CI 62.7%-72.4%). Age (P=.002), time passed since illness onset (P<.001), and years since diagnosis of BD (P=.048) correlate with retention duration. In addition, participants who had been diagnosed with BD for longer used the app on more days (mean 97.73, SD 69.15 days; P=.002) than those who had had a more recent onset (mean 66.49, SD 66.18 days; P=.002) or those who had been diagnosed more recently (mean 73.45, SD 66 days; P=.01). Conclusions: The user retention rate of the app decreased rapidly after each month until reaching only one-third of the users at 6 months. There exists a strong association between age and app engagement of individuals with BD. Other variables such as years lived with BD, diagnosis of an anxiety disorder, and taking antipsychotics seem relevant as well. Understanding these associations can help in the definition of the most suitable user profiles for predicting trends of engagement, optimization of app prescription, and management