N-Nervonoylsphingomyelin (C24:1) prevents lateral heterogeneity in cholesterol-containing membranes

This study was conducted to explore how the nature of the acyl chains of sphingomyelin (SM) influence its lateral distribution in the ternary lipid mixture SM/cholesterol/1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), focusing on the importance of the hydrophobic part of the SM molecule for domain formation. Atomic force microscopy (AFM) measurements showed that the presence of a double bond in the 24:1 SM molecule in mixtures with cholesterol (CHO) or in pure bilayers led to a decrease in the molecular packing. Confocal microscopy and AFM showed, at the meso- and nanoscales respectively, that unlike 16:0 and 24:0 SM, 24:1 SM does not induce phase segregation in ternary lipid mixtures with DOPC and CHO. This ternary lipid mixture had a nanomechanical stability intermediate between those displayed by liquid-ordered (Lo) and liquid-disordered (Ld) phases, as reported by AFM force spectroscopy measurements, demonstrating that 24:1 SM is able to accommodate both DOPC and CHO, forming a single phase. Confocal experiments on giant unilamellar vesicles made of human, sheep, and rabbit erythrocyte ghosts rich in 24:1 SM and CHO, showed no lateral domain segregation. This study provides insights into how the specific molecular structure of SM affects the lateral behavior and the physical properties of both model and natural membranes. Specifically, the data suggest that unsaturated SM may help to keep membrane lipids in a homogeneous mixture rather than in separate domains.Instituto de Investigaciones Bioquímicas de La PlataFacultad de Ciencias Exacta

Non-motor symptom burden in patients with Parkinson's disease with impulse control disorders and compulsive behaviours : results from the COPPADIS cohort

The study was aimed at analysing the frequency of impulse control disorders (ICDs) and compulsive behaviours (CBs) in patients with Parkinson's disease (PD) and in control subjects (CS) as well as the relationship between ICDs/CBs and motor, nonmotor features and dopaminergic treatment in PD patients. Data came from COPPADIS-2015, an observational, descriptive, nationwide (Spain) study. We used the validated Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease-Rating Scale (QUIP-RS) for ICD/CB screening. The association between demographic data and ICDs/CBs was analyzed in both groups. In PD, this relationship was evaluated using clinical features and treatment-related data. As result, 613 PD patients (mean age 62.47 ± 9.09 years, 59.87% men) and 179 CS (mean age 60.84 ± 8.33 years, 47.48% men) were included. ICDs and CBs were more frequent in PD (ICDs 12.7% vs. 1.6%, p < 0.001; CBs 7.18% vs. 1.67%, p = 0.01). PD patients had more frequent previous ICDs history, premorbid impulsive personality and antidepressant treatment (p < 0.05) compared with CS. In PD, patients with ICDs/CBs presented younger age at disease onset, more frequent history of previous ICDs and premorbid personality (p < 0.05), as well as higher comorbidity with nonmotor symptoms, including depression and poor quality of life. Treatment with dopamine agonists increased the risk of ICDs/CBs, being dose dependent (p < 0.05). As conclusions, ICDs and CBs were more frequent in patients with PD than in CS. More nonmotor symptoms were present in patients with PD who had ICDs/CBs compared with those without. Dopamine agonists have a prominent effect on ICDs/CBs, which could be influenced by dose

7th Drug hypersensitivity meeting: part two

No abstract availabl

Measurement of the CKM angle γγ in B±→DK±B^\pm\to D K^\pm and B±→Dπ±B^\pm \to D π^\pm decays with D→KS0h+h−D \to K_\mathrm S^0 h^+ h^-

A measurement of $CP$-violating observables is performed using the decays $B^\pm\to D K^\pm$ and $B^\pm\to D \pi^\pm$, where the $D$ meson is reconstructed in one of the self-conjugate three-body final states $K_{\mathrm S}\pi^+\pi^-$ and $K_{\mathrm S}K^+K^-$ (commonly denoted $K_{\mathrm S} h^+h^-$). The decays are analysed in bins of the $D$-decay phase space, leading to a measurement that is independent of the modelling of the $D$-decay amplitude. The observables are interpreted in terms of the CKM angle $\gamma$. Using a data sample corresponding to an integrated luminosity of $9\,\text{fb}^{-1}$ collected in proton-proton collisions at centre-of-mass energies of $7$, $8$, and $13\,\text{TeV}$ with the LHCb experiment, $\gamma$ is measured to be $\left(68.7^{+5.2}_{-5.1}\right)^\circ$. The hadronic parameters $r_B^{DK}$, $r_B^{D\pi}$, $\delta_B^{DK}$, and $\delta_B^{D\pi}$, which are the ratios and strong-phase differences of the suppressed and favoured $B^\pm$ decays, are also reported

Measurement of the branching fraction of the B0→Ds+π−{{B} ^0} {\rightarrow }{{D} ^+_{s}} {{\pi } ^-} decay

International audienceA branching fraction measurement of the ${{B} ^0} {\rightarrow }{{D} ^+_{s}} {{\pi } ^-}$ decay is presented using proton–proton collision data collected with the LHCb experiment, corresponding to an integrated luminosity of $5.0\,\text {fb} ^{-1}$. The branching fraction is found to be ${\mathcal {B}} ({{B} ^0} {\rightarrow }{{D} ^+_{s}} {{\pi } ^-} ) =(19.4 \pm 1.8\pm 1.3 \pm 1.2)\times 10^{-6}$, where the first uncertainty is statistical, the second systematic and the third is due to the uncertainty on the ${{B} ^0} {\rightarrow }{{D} ^-} {{\pi } ^+}$, ${{D} ^+_{s}} {\rightarrow }{{K} ^+} {{K} ^-} {{\pi } ^+}$ and ${{D} ^-} {\rightarrow }{{K} ^+} {{\pi } ^-} {{\pi } ^-}$ branching fractions. This is the most precise single measurement of this quantity to date. As this decay proceeds through a single amplitude involving a $b{\rightarrow }u$ charged-current transition, the result provides information on non-factorisable strong interaction effects and the magnitude of the Cabibbo–Kobayashi–Maskawa matrix element $V_{ub}$. Additionally, the collision energy dependence of the hadronisation-fraction ratio $f_s/f_d$ is measured through ${{\overline{B}} {}^0_{s}} {\rightarrow }{{D} ^+_{s}} {{\pi } ^-}$ and ${{B} ^0} {\rightarrow }{{D} ^-} {{\pi } ^+}$ decays

Search for the doubly heavy baryons and decaying to and * * We acknowledge support from CERN and from the national agencies: CAPES, CNPq, FAPERJ and FINEP (Brazil); MOST and NSFC (China); CNRS/IN2P3 (France); BMBF, DFG and MPG (Germany); INFN (Italy); NWO (Netherlands); MNiSW and NCN (Poland); MEN/IFA (Romania); MSHE (Russia); MICINN (Spain); SNSF and SER (Switzerland); NASU (Ukraine); STFC (United Kingdom); DOE NP and NSF (USA). We acknowledge the computing resources that are provided by CERN, IN2P3 (France), KIT and DESY (Germany), INFN (Italy), SURF (Netherlands), PIC (Spain), GridPP (United Kingdom), RRCKI and Yandex LLC (Russia), CSCS (Switzerland), IFIN-HH (Romania), CBPF (Brazil), PL-GRID (Poland) and NERSC (USA). We are indebted to the communities behind the multiple open-source software packages on which we depend. Individual groups or members have received support from ARC and ARDC (Australia); AvH Foundation (Germany); EPLANET, Marie Skłodowska-Curie Actions and ERC (European Union); A*MIDEX, ANR, Labex P2IO and OCEVU, and Région Auvergne-Rhône-Alpes (France); Key Research Program of Frontier Sciences of CAS, CAS PIFI, CAS CCEPP, Fundamental Research Funds for the Central Universities, and Sci. Tech. Program of Guangzhou (China); RFBR, RSF and Yandex LLC (Russia); GVA, XuntaGal and GENCAT (Spain); the Leverhulme Trust, the Royal Society and UKRI (United Kingdom)

Abstract: The first search for the doubly heavy baryon and a search for the baryon are performed using collision data collected via the experiment from 2016 to 2018 at a centre-of-mass energy of , corresponding to an integrated luminosity of 5.2 . The baryons are reconstructed via their decays to and . No significant excess is found for invariant masses between 6700 and 7300 , in a rapidity range from 2.0 to 4.5 and a transverse momentum range from 2 to 20 . Upper limits are set on the ratio of the and production cross-section times the branching fraction to ( ) relative to that of the ( ) baryon, for different lifetime hypotheses, at 95% confidence level. The upper limits range from to for the ( ) decay, and from to for the ( ) decay, depending on the considered mass and lifetime of the ( ) baryon

Search for the rare decay B 0 → J / ψϕ * * Individual groups or members have received support from AvH Foundation (Germany); EPLANET, Marie Sk lodowska-Curie Actions and ERC (European Union); A*MIDEX, ANR, Labex P2IO and OCEVU, and R´egion Auvergne-Rhˆone-Alpes (France); Key Research Program of Frontier Sciences of CAS, CAS PIFI, Thousand Talents Program, and Sci. & Tech. Program of Guangzhou (China); RFBR, RSF and Yandex LLC (Russia); GVA, XuntaGal and GENCAT (Spain); the Royal Society and the Leverhulme Trust (United Kingdom)

Abstract: A search for the rare decay is performed using collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. No significant signal of the decay is observed and an upper limit of at 90% confidence level is set on the branching fraction

Search for the rare decay B 0 → J / ψϕ * * Individual groups or members have received support from AvH Foundation (Germany); EPLANET, Marie Sk lodowska-Curie Actions and ERC (European Union); A*MIDEX, ANR, Labex P2IO and OCEVU, and R´egion Auvergne-Rhˆone-Alpes (France); Key Research Program of Frontier Sciences of CAS, CAS PIFI, Thousand Talents Program, and Sci. & Tech. Program of Guangzhou (China); RFBR, RSF and Yandex LLC (Russia); GVA, XuntaGal and GENCAT (Spain); the Royal Society and the Leverhulme Trust (United Kingdom)

Abstract: A search for the rare decay is performed using collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. No significant signal of the decay is observed and an upper limit of at 90% confidence level is set on the branching fraction

Search for the rare decay B 0 → J / ψϕ * * Individual groups or members have received support from AvH Foundation (Germany); EPLANET, Marie Sk lodowska-Curie Actions and ERC (European Union); A*MIDEX, ANR, Labex P2IO and OCEVU, and R´egion Auvergne-Rhˆone-Alpes (France); Key Research Program of Frontier Sciences of CAS, CAS PIFI, Thousand Talents Program, and Sci. & Tech. Program of Guangzhou (China); RFBR, RSF and Yandex LLC (Russia); GVA, XuntaGal and GENCAT (Spain); the Royal Society and the Leverhulme Trust (United Kingdom)

Abstract: A search for the rare decay is performed using collision data collected with the LHCb dete-ctor at centre-of-mass energies of 7, 8 and 13 TeV, corresponding to an integrated luminosity of 9 fb−1. No significant signal of the decay is observed and an upper limit of at 90% confidence level is set on the branching fraction