Taller práctico de coordinación Open BIM en proyectos de ejecución con el software de CYPE Ingenieros y BIMserver.center

Las imágenes de la jornada fueron tomadas por la ponente y coordinadora, que cuenta con la autorización de cada asistente para su publicación, facilitada al inscribirse a la jornada.El Taller práctico de coordinación Open BIM en proyectos de ejecución con el software de CYPE Ingenieros y BIMserver.center se encuadró en el marco de las conferencias científicas organizadas por la Escuela de Arquitectura de Málaga, en noviembre de 2017, sobre la temática de las nuevas tecnologías aplicadas a la arquitectura. Éstas fueron promovidas por el Proyecto de Innovación Educativa PIE 17-140 “Estrategias para la integración del BIM en el Grado de Arquitectura” y por la dirección del Título Propio de la UMA de “I Experto Universitario en BIM con Autodesk Revit Architecture. Sus ponentes fueron Álvaro de Fuentes, Colaborador de CYPE, y María Jesús García Granja, PDI de la UMA, investigadora del PIE 17-140 y codirectora del TP, que también actuó como coordinadora. En esta jornada se realizó un repaso de los procesos de desarrollo de un proyecto de ejecución por técnicos especializados deslocalizados. Mediante la simulación en diferentes programas, y la coordinación BIM a través de BIMserver.center con ficheros IFC, se analizararon las ventajas que el uso de estas herramientas ofrece: 1. BIMserver.center. 2. Recomendaciones de modelado para comunicación vía IFC mediante IFC Builder, complemento Open BIM para Revit y conexión con ficheros IFC de otros programas de modelado (ArchiCAD, AllPlan…). 3. Coordinación BIM en fase de cálculo de estructura. 4. Coordinación BIM en diseño prestacional del edificio y sus instalaciones. 5. Calificación Energética alternativa a HULC con CYPETHERM. 6. Complemento Revit-Arquímedes

OptEEmAL: Decision-Support Tool for the Design of Energy Retrofitting Projects at District Level

Designing energy retrofitting actions poses an elevated number of problems, as the definition of the baseline, selection of indicators to measure performance, modelling, setting objectives, etc. This is time-consuming and it can result in a number of inaccuracies, leading to inadequate decisions. While these problems are present at building level, they are multiplied at district level, where there are complex interactions to analyse, simulate and improve. OptEEmAL proposes a solution as a decision-support tool for the design of energy retrofitting projects at district level. Based on specific input data (IFC(s), CityGML, etc.), the platform will automatically simulate the baseline scenario and launch an optimisation process where a series of Energy Conservation Measures (ECMs) will be applied to this scenario. Its performance will be evaluated through a holistic set of indicators to obtain the best combination of ECMs that complies with user's objectives. A great reduction in time and higher accuracy in the models are experienced, since they are automatically created and checked. A subjective problem is transformed into a mathematical problem; it simplifies it and ensures a more robust decision-making. This paper will present a case where the platform has been tested.This research work has been partially funded by the European Commission though the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 680676. All related information to the project is available at https://www.opteemal-project.eu

Modelos de gestión en nutrición clínica. Puntos débiles y puntos fuertes

En el VIº Foro de Debate Abbott-SENPE se establece una discusión multidisciplinar y multiprofesional para buscar el o los modelos de gestión clínica que consideramos más adecuados para la Unidades de Nutrición Clínica y Dietética (UNCyD) en España. Se valoran los puntos débiles y fuertes así como las oportunidades de los actuales sistemas y se concluye en la observación de una cierta disparidad vinculada no solo a las comunidades autónomas sino también a los diferentes tipos de hospital. Se propone, desde SENPE, la creación de un grupo de trabajo que ayude a la normalización de los modelos y a potenciar la cultura del Cuadro de Mandos Integral y de Gestión del Cambio.At the 6th Abbott-SENPE Debate Forum a multidisciplinary and multiprofessional discussion was established in order to seek for the model or the models of clinical management most appropriate for Clinical Nutrition and Dietetics Units (CNAD) in Spain. The weaknesses and strengths as well as opportunities for the current systems were assessed concluding that a certain degree of disparity was observed not only due to regional differences but also to different hospital types. It was proposed, from SENPE, the creation of a working group helping to standardize the models and promote the culture of Integral Control and Change Management

Patología del lenguaje (II)

[Resumen] La presente comunicación trata de relacionar las dificultades del lenguaje con los Trastornos Generalizados de la Personalidad (TGP), especialmente con el autismo. Consta de un marco legal que refleja la evolución histórica de los trastornos del lenguaje a partir de la década de los 70; de la patología del lenguaje del niño autista en sus subapartados: habilidades prelingüísticas, ecolalia, inversión pronominal, semántica, lenguaje y memoria, pragmática, fonética, sintaxis, prosodia, comunicación no verbal y trastonos varios. Partimos de una muestra de 70 sujetos autistas de 4 centros de atención específica, ASPANAES, de la provincia de La Coruña, en edades comprendidas entre 2 y 26 años. Nuestro objetivo es determinar la frecuencia y como se distribuyen los trastornos del lenguaje en esta patología

Cross-country migration linked to people who inject drugs challenges the long-term impact of national HCV elimination programmes

To the Editor: As of 2018, the majority of Western European countries – including Spain – have lifted restrictions to therapy based on disease severity in the context of HCV infections.1 Long overdue, most national elimination programmes now also include access to care for people who inject drugs (PWID), 2 who are at the core of ongoing HCV transmission.3 Macías et al.4 have recently shown in this Journal that high viral cure rates can be achieved in this group, hereby providing evidence that targeting PWID in treatment programmes is worthwhile. However, the extent to which such national efforts can reduce the HCV burden not only depends on the uptake into care and treatment success rates, it is also determined by the relative importance of within-country transmission and virus importation from elsewhere. As the chronic nature of most HCV infections hampers reliably reconstructing contact networks from patient interviews, virus genetic data can be a valuable alternative source of information for elucidating the geographic history of virus lineages (e.g. [5], [6]). Using such data, we have recently shown that for the most prevalent subtype among PWID in Spain (40%, 7), HCV1a, infections often link to infections abroad – in recent years >50% link to Western European countries, mostly European Union (EU) member states – as opposed to other infections ..

Self-assembled hyaluronan nanocapsules for the intracellular delivery of anticancer drugs

Preparation of sophisticated delivery systems for nanomedicine applications generally involve multi-step procedures using organic solvents. In this study, we have developed a simple self-assembling process to prepare docetaxel-loaded hyaluronic acid (HA) nanocapsules by using a self-emulsification process without the need of organic solvents, heat or high shear forces. These nanocapsules, which comprise an oily core and a shell consisting of an assembly of surfactants and hydrophobically modified HA, have a mean size of 130 nm, a zeta potential of −20 mV, and exhibit high docetaxel encapsulation efficiency. The nanocapsules exhibited an adequate stability in plasma. Furthermore, in vitro studies performed using A549 lung cancer cells, showed effective intracellular delivery of docetaxel. On the other hand, blank nanocapsules showed very low cytotoxicity. Overall, these results highlight the potential of self-emulsifying HA nanocapsules for intracellular drug delivery

Improvement of learning through European educational projects

Proceedings TEEM 2020: Eighth International Conference on Technological Ecosystems for Enhancing Multiculturality.[EN]The purpose of this article is to set out the research plan for the doctoral thesis, which deals with the definition of a methodological guide for the successful use of digital technologies in education, especially in eLearning, taking as a reference European educational projects that have been successful in achieving an improvement in the teaching and learning process. We live in an increasingly digital society that requires citizens to be prepared to adapt to the needs of the moment and to solve the problems that arise. For this to be possible, the education system must be prepared to adequately train future citizens who will join a changing labor market. To this end, teachers must be trained and know how to carry out efficient educational projects that allow them to make the most of the potential of ICT in the classroom or in distance education. The situation experienced during the 2019-2020 school year with the COVID-19 pandemic has tested the education system and its ability to adapt to a situation where the use of distance education was required and where ICT was very much needed in most of the cases to bring education to the homes. These factors make it very necessary to work for a better teaching professionalization. Therefore, the main objective of this PhD work is to enable teachers to design their projects, involving electronic learning, in a more effective way. To achieve this, what better than to use the educational projects compiled in the Erasmus+ results platform, which allow the analysis of project typology, outcomes, topics and to see those that have been catalogued as a good practice or success story. This database will be a key tool to gather information together with the collaboration of the main actors of those projects that have been successful. A methodological guide would allow teachers and teacher trainers to know the key factors that help to achieve a good design of educational projects and allow an optimal use of ICT resources and the greatest impact on the teaching-learning process

Influence of dietary fiber upon in vitro microbial cecal fermentation in mexican hairless and mexican cuino pigs

The objective of the present study was to evaluate and compare the in vitro cecal fermentation (by the gas production technique), in Mexican hairless pig (MHP) and Mexican cuino pig (MCP), adding cellulose or starch as substrates (0, 100, 200, 300 and 400 mg/g DM). 12 pigs were slaughtered (BW= 104±0.5 kg), six of each genotype were collected from the cecal contents and there was a pool for every two pigs in each genotype, and thereafter, for each substrate (cellulose or starch) in its different concentration, three flasks were incubated with inoculum for each pool and made three series of incubation. The experimental design use the effect of genotype, substrate and concentration of the substrate added on the variables of in vitro fermentation. The averages of the data were compared by Tukey's method. In vitro gas production was higher (P<0.05) (mL/g DM) for MHP (206.8) vs MCP (180.2). The degradation fractional rate rhythm (b, 0.094 and c, -0.0127) and lag time (1.79) of the MHP was higher than MCP (b, 0.074; c -0.102) and lag time (1.26); with the addition of carbohydrates as substrates, in vitro gas production of potato starch was higher (P<0.05) than cellulose (238.3 vs 148.7 mL/g DM); the fractions b, c and lag time, there were differences (P<0.05) between substrates. The increasing addition of cellulose or starch had a lineal effect (P<0.05) with the gas production, level cero mg (133.46) to 400 mg of substrate (263.16 mL/g DM). MHP had a higher cecal fermentation than MCP, being higher the gas production at 9 and 12 h, there was higher gas production (cecal fermentation) when added starch as substrate

OptEEmAL: Decision-Support Tool for the Design of Energy Retrofitting Projects at District Level

Designing energy retrofitting actions poses an elevated number of problems, as the definition of the baseline, selection of indicators to measure performance, modelling, setting objectives, etc. This is time-consuming and it can result in a number of inaccuracies, leading to inadequate decisions. While these problems are present at building level, they are multiplied at district level, where there are complex interactions to analyse, simulate and improve. OptEEmAL proposes a solution as a decision-support tool for the design of energy retrofitting projects at district level. Based on specific input data (IFC(s), CityGML, etc.), the platform will automatically simulate the baseline scenario and launch an optimisation process where a series of Energy Conservation Measures (ECMs) will be applied to this scenario. Its performance will be evaluated through a holistic set of indicators to obtain the best combination of ECMs that complies with user's objectives. A great reduction in time and higher accuracy in the models are experienced, since they are automatically created and checked. A subjective problem is transformed into a mathematical problem; it simplifies it and ensures a more robust decision-making. This paper will present a case where the platform has been tested.This research work has been partially funded by the European Commission though the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement No 680676. All related information to the project is available at https://www.opteemal-project.eu

Impaired Mitophagy and Protein Acetylation Levels in Fibroblasts from Parkinson's Disease Patients

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disorder. While most PD cases are idiopathic, the known genetic causes of PD are useful to understand common disease mechanisms. Recent data suggests that autophagy is regulated by protein acetylation mediated by histone acetyltransferase (HAT) and histone deacetylase (HDAC) activities. The changes in histone acetylation reported to be involved in PD pathogenesis have prompted this investigation of protein acetylation and HAT and HDAC activities in both idiopathic PD and G2019S leucine-rich repeat kinase 2 (LRRK2) cell cultures. Fibroblasts from PD patients (with or without the G2019S LRRK2 mutation) and control subjects were used to assess the different phenotypes between idiopathic and genetic PD. G2019S LRRK2 mutation displays increased mitophagy due to the activation of class III HDACs whereas idiopathic PD exhibits downregulation of clearance of defective mitochondria. This reduction of mitophagy is accompanied by more reactive oxygen species (ROS). In parallel, the acetylation protein levels of idiopathic and genetic individuals are different due to an upregulation in class I and II HDACs. Despite this upregulation, the total HDAC activity is decreased in idiopathic PD and the total HAT activity does not significantly vary. Mitophagy upregulation is beneficial for reducing the ROS-induced harm in genetic PD. The defective mitophagy in idiopathic PD is inherent to the decrease in class III HDACs. Thus, there is an imbalance between total HATs and HDACs activities in idiopathic PD, which increases cell death. The inhibition of HATs in idiopathic PD cells displays a cytoprotective effect