Estudio del proceso de cambio conceptual y la construcción del modelo científico precursor de ser vivo en niños de pre-escolar

La presente investigación estudia el cambio conceptual y la construcción de modelos científicos precursores en un contexto socioconstructivista con niños pequeños, utilizando una metodología cualitativa. Se analizan los cambios epistemológicos y ontológicos en las concepciones de los niños acerca de los seres vivos y cómo una estrategia didáctica basada en la construcción de un modelo científico precursor basado en propiedades biológicas los promueven. Los cambios en la comprensión de los niños fueron significativos en las dimensiones ontológicas y epistemológicas, presentando diferentes patones. Los segundos proporcionaron una mejor coherencia explicativa en su sistema conceptual contribuyendo, de esta forma, a los cambios ontológicos y promoviendo, a su vez, la construcción del modelo científico precursor de ser vivo

¿Es realmente fiable la evaluación no individualizada en el trabajo cooperativo?

Se presentan y discuten los resultados de una experiencia de trabajo cooperativo empleando la plataforma BSCW en alumnos de la titulación de Maestro de Educación Infantil de la Universidad de Barcelona, con el fin de detectar posibles sesgos de las coevaluaciones y las autoevaluaciones, y para valorar la incidencia que tienen los comportamientos disruptivos en el proceso cooperativo de evaluación. Los resultados muestran que el alumnado es honesto en las calificaciones que otorga, y que los comportamientos disruptivos detectados en los distintos grupos de trabajo cooperativo, causados por una baja ciudadanía de equipo, no tienen una incidencia significativa en las calificaciones otorgadas por el grupo clase. Por tanto, se legitiman las coevaluaciones y las autoevaluaciones como instrumentos fiables de evaluación en un contexto de trabajo cooperativo

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

A talin intermolecular interaction autoinhibits its own activation and regulates β3-integrin binding. When bound, β3-integrin undergoes structural alterations that prevent its β and α subunits from associating, maintaining β3-integrin's clustering capability

Unprecedented study of the broadband emission of Mrk 421 during flaring activity in March 2010

A flare from the TeV blazar Mrk 421, occurring in March 2010, was observed for 13 consecutive days from radio to very high energy (VHE, E > 100 GeV) gamma-rays with MAGIC, VERITAS, Whipple, FermiLAT, MAXI, RXTE, Swift, GASP-WEBT, and several optical and radio telescopes. We model the day-scale SEDs with one-zone and two-zone synchrotron self-Compton (SSC) models, investigate the physical parameters, and evaluate whether the observed broadband SED variability can be associated to variations in the relativistic particle population. Flux variability was remarkable in the X-ray and VHE bands while it was minor or not significant in the other bands. The one-zone SSC model can describe reasonably well the SED of each day for the 13 consecutive days. This flaring activity is also very well described by a two-zone SSC model, where one zone is responsible for the quiescent emission while the other smaller zone, which is spatially separated from the first one, contributes to the daily-variable emission occurring in X-rays and VHE gamma-rays. Both the one-zone SSC and the two-zone SSC models can describe the daily SEDs via the variation of only four or five model parameters, under the hypothesis that the variability is associated mostly to the underlying particle population. This shows that the particle acceleration and cooling mechanism producing the radiating particles could be the main one responsible for the broadband SED variations during the flaring episodes in blazars. The two-zone SSC model provides a better agreement to the observed SED at the narrow peaks of the low- and high-energy bumps during the highest activity, although the reported one-zone SSC model could be further improved by the variation of the parameters related to the emitting region itself ($\delta$, $B$ and $R$), in addition to the parameters related to the particle population.Comment: Published in A&A, 30 pages, 15 figures, 6 tables. Online-data: multi-wavelength light curves (data in Fig. 1) and broadband spectral energy distributions (the data in Figs. 6, and B1-B4) are available at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/578/A22. Corresponding authors: David Paneque ([email protected]), Shangyu Sun ([email protected]), Hajime Takami ([email protected]

Estudio del proceso de cambio conceptual y la construcción del modelo científico precursor de ser vivo en niños de pre-escolar

La presente investigación estudia el cambio conceptual y la construcción de modelos científicos precursores en un contexto socioconstructivista con niños pequeños, utilizando una metodología cualitativa. Se analizan los cambios epistemológicos y ontológicos en las concepciones de los niños acerca de los seres vivos y cómo una estrategia didáctica basada en la construcción de un modelo científico precursor basado en propiedades biológicas los promueven. Los cambios en la comprensión de los niños fueron significativos en las dimensiones ontológicas y epistemológicas, presentando diferentes patones. Los segundos proporcionaron una mejor coherencia explicativa en su sistema conceptual contribuyendo, de esta forma, a los cambios ontológicos y promoviendo, a su vez, la construcción del modelo científico precursor de ser vivo

Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing

Integrin-dependent cell adhesion and spreading are critical for morphogenesis, tissue regeneration, and immune defense but also tumor growth. However, the mechanisms that induce integrin-mediated cell spreading and provide mechanosensing on different extracellular matrix conditions are not fully understood. By expressing β3-GFP-integrins with enhanced talin-binding affinity, we experimentally uncoupled integrin activation, clustering, and substrate binding from its function in cell spreading. Mutational analysis revealed Tyr747, located in the first cytoplasmic NPLY(747) motif, to induce spreading and paxillin adapter recruitment to substrate- and talin-bound integrins. In addition, integrin-mediated spreading, but not focal adhesion localization, was affected by mutating adjacent sequence motifs known to be involved in kindlin binding. On soft, spreading-repellent fibronectin substrates, high-affinity talin-binding integrins formed adhesions, but normal spreading was only possible with integrins competent to recruit the signaling adapter protein paxillin. This proposes that integrin-dependent cell-matrix adhesion and cell spreading are independently controlled, offering new therapeutic strategies to modify cell behavior in normal and pathological conditions

MAGIC observations and multifrequency properties of the flat spectrum radio quasar 3C 279 in 2011

Aims - We study the multifrequency emission and spectral properties of the quasar3C 279 aimed at identifying the radiation processes taking place in the source. Methods - We observed 3C 279 in very-high-energy (VHE, E> 100 GeV) γ-rays, with the MAGIC telescopes during 2011, for the first time in stereoscopic mode. We combined these measurements with observations at other energy bands: in high-energy (HE, E> 100 MeV) γ-rays from Fermi-LAT; in X-rays from RXTE; in the optical from the KVA telescope; and in the radio at 43 GHz, 37 GHz, and 15 GHz from the VLBA, Metsähovi, and OVRO radio telescopes – along with optical polarisation measurements from the KVA and Liverpool telescopes. We examined the corresponding light curves and broadband spectral energy distribution and we compared the multifrequency properties of 3C 279 at the epoch of the MAGIC observations with those inferred from historical observations. Results - During the MAGIC observations (2011 February 8 to April 11) 3C 279 was in a low state in optical, X-ray, and γ-rays. The MAGIC observations did not yield a significant detection. The derived upper limits are in agreement with the extrapolation of the HE γ-ray spectrum, corrected for EBL absorption, from Fermi-LAT. The second part of the MAGIC observations in 2011 was triggered by a high-activity state in the optical and γ-ray bands. During the optical outburst the optical electric vector position angle (EVPA) showed a rotation of ~180°. Unlike previous cases, there was no simultaneous rotation of the 43 GHz radio polarisation angle. No VHE γ-rays were detected by MAGIC, and the derived upper limits suggest the presence of a spectral break or curvature between the Fermi-LAT and MAGIC bands. The combined upper limits are the strongest derived to date for the source at VHE and below the level of the previously detected flux by a factor of ~2. Radiation models that include synchrotron and inverse Compton emissions match the optical to γ-ray data, assuming an emission component inside the broad line region with size R = 1.1 × 1016 cm and magnetic field B = 1.45 G responsible for the high-energy emission, and another one outside the broad line region and the infrared torus (R = 1.5 × 1017 cm and B = 0.8 G) causing the optical and low-energy emission. We also study the optical polarisation in detail and interpret it with a bent trajectory model