Variabilidad de la frecuencia cardíaca como biomarcador para la evaluación del estrés

Introduction: chronic stress has a negative impact on both the individual's health and the economy. Physiologically, a cascade of stress hormones is triggered and autonomic nervous system activity increases. Heart rate variability is a commonly used tool to assess autonomic activity. Objective: to describe the utility of heart rate variability as a biomarker for stress assessment. Method: a bibliographic review was carried out where 23 documents extracted from Internet databases were consulted: VHL, PubMed and SciELO. Results: the autonomic nervous system is an important part in the control of different physiological systems. Its main function is homeostasis. Stress is associated with fluctuations in autonomic activity and causes disorganization of the balance of the organism. Heart rate variability is a tool used to assess autonomic activity. It is a simple and non-invasive method that describes the oscillations in the intervals between consecutive heartbeats. Indicates the heart's ability to respond to multiple events. Under stress conditions, it decreases and is associated with reduced parasympathetic activity. Working in multidisciplinary teams in Primary Health Care allows a more comprehensive evaluation and a more complete response to the solution of the patient's discomfort. Conclusions: sustained stress is associated with lower heart rate variability, specifically reduced parasympathetic activity. Therefore, its analysis can be used for objective assessment of mental health and stress.Translator  El estrés crónico tiene un impacto negativo tanto para la salud del individuo como para la economía. Fisiológicamente, se desencadena una cascada de hormonas de estrés y aumenta la actividad del sistema nervioso autónomo. La variabilidad de la frecuencia cardiaca es una herramienta usada comúnmente para evaluar la actividad autonómica. Con el objetivo de describir la utilidad de la variabilidad de la frecuencia cardiaca como biomarcador para la evaluación del estrés, se realizó una revisión bibliográfica donde se consultaron 23 documentos extraídos de bases de datos en Internet: BVS, PubMed y SciELO. Se concluye que el estrés mantenido se asocia con menor variabilidad de la frecuencia cardiaca, específicamente con reducida actividad parasimpática. Por ello, su análisis puede utilizarse para la evaluación objetiva de la salud mental y el estrés.

Adicción a la comida y estado nutricional en adolescentes de una preparatoria pública en México

Objective: To know the prevalence of food addiction according to age, sex, and body mass index and to determine the association between food addiction and nutritional status in adolescents from northern México. Method: Cross-sectional study with a descriptive and correlational design, carried out during August and September 2018; the study population was comprised by 630 adolescents, students, ranging from 15 to 17 years of age, from a public high school in Nuevo Leon, Mexico. Anthropometric measurements were taken and the Yale Food Addiction Scale questionnaire was used. Results: A sample of 245 adolescents predominantly female (53.1%), with a mean age of 15.83 years; mean body mass index was 23.18 kg/mt2 (S = 3.74) in males and 24.57 kg/mt2 (S = 4.00) in females; 87.8% of adolescents showed positive to the frustrated desire to stop consumption criterion, 36.3% tolerance, and 34.3% consumption despite the consequences; 20.7% of overweight adolescents showed food addiction. Conclusions: The majority of adolescents showed normal weight, while women showed a body mass index (BMI) higher than men; less than half of the participants had food addiction; positive criteria prevailed in women, and adolescents with overweight and obesity, and older. No association was found between food addiction and nutritional status.Objetivos: Conocer la prevalencia de la adicción a la comida de acuerdo a la edad, sexo e índice de masa corporal, y determinar la asociación entre la adicción a la comida y el estado nutricional en adolescentes del norte de México. Método: Estudio descriptivo correlacional de corte transversal, realizado durante agosto y septiembre de 2018. La población se conformó por 630 adolescentes estudiantes de 15 a 17 años de edad, de una preparatoria pública en Nuevo León, México, a los que se les realizaron mediciones antropométricas y se empleó el cuestionario Yale Food Addiction Scale. Resultados: Una muestra de 245 adolescentes, predominando el sexo femenino (53,1%), con una edad media de 15,83 años, la media de índice de masa corporal fue de 23,18 kg/mt2 (S = 3,74) en hombres y 24,57 kg/mt2 (S = 4,00) en mujeres. El 87,8% de los adolescentes presentó positivo el criterio “deseo frustrado de parar el consumo”, el 36,3% la tolerancia, y el 34,3% el consumo a pesar de las consecuencias. El 20,7% de los adolescentes con sobrepeso presentan adicción a la comida. Conclusiones: La mayoría de los adolescentes presentan peso normal, las mujeres presentaron un índice de masa corporal mayor que el de los hombres, menos de la mitad de los participantes presenta adicción a la comida predominando los criterios positivos en mujeres, adolescentes en condición de sobrepeso, obesidad y de mayor edad. No se encontró asociación entre adicción a la comida y estado nutricional

Piloting the informed health choices resources in Barcelona primary schools: A mixed methods study

IntroductionThe main objective of the Informed Health Choices (IHC) project is to teach people to assess treatment claims and make informed health choices. For this purpose, the IHC learning resources were developed for primary school children. The aim of this study is to explore students' and teachers' experience when using the IHC resources in primary schools in Barcelona (Spain). MethodsWe conducted a mixed methods study for piloting the IHC resources in a convenience sample of primary schools in Barcelona. The intervention included a workshop with teachers, and nine lessons with students. We collected data using multiple approaches. We performed quantitative and qualitative analyses, and integrated the findings in a joint display. Finally, we formulated recommendations for using the IHC resources in this setting. ResultsTwo schools, with a total of 143 students in 4th and 5th grade and six teachers, participated in the study. One school followed the suggested IHC teaching plan and competed all the lessons; the other school modified the plan substantially and did not complete all the lessons. Overall, students and teachers from both schools understood, were interested in, and were able to apply the content of the lessons. During the lessons, the textbook was useful for students; nevertheless, for the teachers, the usefulness of the IHC resources was variable. Teachers adapted the IHC resources to increase student participation and used Information and Communications Technologies tools. We observed more facilitators than barriers to teach the lessons. The teachers suggested some ideas to improve the lessons based on activities they developed and implemented. The integration analysis showed great convergence of the quantitative and qualitative findings. We propose seven recommendations for using the IHC resources in this setting. ConclusionsStudents and teachers from primary schools in Barcelona showed a positive experience when using IHC resources; however, these resources should be adapted to promote classroom participation

Learning to make informed health choices: Protocol for a pilot study in schools in Barcelona.

--- - b: - "Introduction:" - "Methods:" - "Ethical considerations:" sup: - th - th i: - ad hoc content: - " The Informed Health Choices (IHC) project has developed learning resources to teach primary school children (10 to 12-year-olds) to assess treatment claims and make informed health choices. The aim of our study is to explore both the students' and teachers' experience when using these resources in the context of Barcelona (Spain). " - " During the 2019-2020 school year, we will conduct a pilot study with 4 " - " and 5 " - "-year primary school students (9 to 11-year-olds) from three schools in Barcelona. The intervention in the schools will include: 1) assessment of the IHC resources by the teachers before the lessons, 2) non-participatory observations during the lessons, 3) semi-structured interviews with the students after a lesson, 4) assessment of the lessons by the teachers after a lesson, 5) treatment claim assessment by the students at the end of the lessons, and 6) assessment of the IHC resources by the teachers at the end of the lessons. We will use " - " questionnaires and guides to register the data. We will perform a quantitative and qualitative analysis of the data to explore understandability, desirability, suitability, usefulness, facilitators and barriers of the resources. The most relevant results will be discussed and some recommendations on how to use, how to adapt (if needed), and how to implement the IHC resources to this context will be agreed. The findings of the contextualization activities could inform the design of a cluster-randomised trial, to determine the effectiveness of the IHC resources in this context prior to scaling-up its use. " - " The study protocol has obtained an approval exemption from the Ethics Committee of the Hospital de la Santa Creu i Sant Pau (Barcelona, Spain).

Quid: observatorio de medios

El informe está dividido en cuatro apartados: “Derecho a la información y transparencia”, “La televisión mexicana”, “Empresas y prácticas periodísticas” y “Los que se fueron”. En el primero de ellos se presenta un texto que ayuda a entender cuál es el momento en el que se encuentran las propuestas legislativas para regular a los medios y las telecomunicaciones en México, y una evaluación de los primeros cinco años del Instituto de Transparencia e Información Pública de Jalisco. El segundo apartado del informe es ecléctico, pues se compone de artículos que trabajan distintas temáticas de la televisión:la estructura y oferta de la televisión en nuestro país (en particular en la ciudad de Guadalajara), la televisión por cable (enfatizando el caso de Megacable), un recuento de cómo se gestó el Canal 44 y de sus prospectivas en 2011, y los mundiales de futbol. La tercera parte del informe documenta algunas de las situaciones más importantes que se viven en el periodismo local: estos trabajos presentan sistemas en crisis (alta vulnerabilidad de los periodistas mexicanos ante un clima de violencia que lejos de disminuir va en aumento, y la participación, por acción u omisión, del Estado mexicano en la sistemática violación de los derechos de quienes dedican su vida al trabajo periodístico. Los siguientes artículos tratan sobre las transformaciones de las empresas periodísticas, particularmente las del sector de la prensa escrita: la rápida e inexorable desaparición de los suplementos culturales, y una radiografía sobre las formas de producción de algunas secciones internacionales de los periódicos tapatíos. Al final se presentan las semblanzas de José Galindo, Raúl Mora Lomelí, S.J., Tomás Eloy Martínez y Juan Pablo Rosell.ITESO, A.C

Association of Maternal Microbiota and Diet in Cord Blood Cytokine and Immunoglobulin Profiles

Mothers confer natural passive immunization to their infants through the transplacental pathway during the gestation period. The objective of the present study was to establish at birth the maternal and cord plasma concentration and relationship of immunoglobulins (Igs), cytokines (CKs), and adipokines. In addition, the impact of the maternal microbiota and diet was explored. The plasma profile of these components was different between mothers and babies, with the levels of many CKs, IgM, IgG2a, IgE, IgA, and leptin significantly higher in mothers than in the cord sample. Moreover, the total Igs, all IgG subtypes, IgE, and the Th1/Th2 ratio positively correlated in the mother–infant pair. Maternal dietary components such as monounsaturated fatty acids-polyunsaturated fatty acids and fiber were positively associated with some immune factors such as IgA in cord samples. The microbiota composition clustering also influenced the plasma profile of some factors (i.e., many CKs, some Ig, and adiponectin). In conclusion, we have established the concentration of these immunomodulatory factors in the maternal–neonatal pair at birth, some positive associations, and the influence of maternal diet and the microbiota composition, suggesting that the immune status during pregnancy, in terms of CKs and Igs levels, can influence the immune status of the infant at birth.This work was supported by the research grant from LaMarató-TV3 (DIM-2-ELI, ref. 2018-27/30-31) and also by the European Research Council under the European Union’s Horizon 2020 research and innovation program (ERC starting grant, no. 639226). MS-R was supported by a Predoctoral Fellowship from Generalitat Valenciana—European Social Fund (ASCII2016). K.R-A holds a fellowship from the Spanish Ministry of Economy, Industry and Competitiveness (FPU 19/05150).Peer reviewe

Impact of mediterranean diet promotion on environmental sustainability: a longitudinal analysis

[EN]This article aims to estimate the differences in environmental impact (greenhouse gas [GHG] emissions, land use, energy used, acidification and potential eutrophication) after one year of promoting a Mediterranean diet (MD). Methods Baseline and 1-year follow-up data from 5800 participants in the PREDIMED-Plus study were used. Each participant's food intake was estimated using validated semi-quantitative food frequency questionnaires, and the adherence to MD using the Dietary Score. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The influence of diet on environmental impact was assessed through the EAT-Lancet Commission tables. The association between MD adherence and its environmental impact was calculated using adjusted multivariate linear regression models.SIPublicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

[EN] The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironi del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.SIThe Predimed-Plus trial was supported by the Spanish government’s official funding agency for biomedical research, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (three coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/0147, PI14/00636, PI14/00972, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01,332), the Special Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-PLUS grant to Jordi Salas-Salvadó, the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to Miguel Ángel Martínez-Gonzalez, the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant and FEDER funds (CB06/03 and CB12/03), Olga Castaner is funded by the JR17/00,022 grant, ISCIII. Christopher Papandreou is supported by a postdoctoral fellowship granted by the Autonomous Government of Catalonia (PERIS 2016–2020 Incorporació de Científics i Tecnòlegs, SLT002/0016/00,428). María Rosa Bernal-Lopez was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER, Ignacio M.Giménez-Alba is supported by a FPU predoctoral contract (reference FPU18/01703) from the Ministerio de Ciencia, Innovación y Universidades, Spain

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality