General care patients with noninvasive mechanical ventilation

Objetivos: Homogeneizar los criterios de actuación de Enfermería para mejorar la calidad asistencial. Proporcionar una herramienta de trabajo para los trabajadores de nueva incorporación fomentando el trabajo en equipo y mejorando la organización y planificación de los cuidados hacia el paciente. Método: Estudio descriptivo elaborado tras una revisión bibliográfica como apoyo a la experiencia profesional. Resultados: La descripción del procedimiento que se emplea, nos sirve de guía para el buen funcionamiento del proceso. Conclusiones: La implicación de la enfermería es de suma importancia en el proceso del paciente que precisa de Ventilación Mecánica no Invasiva (VMNI). La comparación de los artículos con el resultado obtenido y la puesta en común, nos ha llevado a la conclusión de la importancia de establecer unas bases que sirvan de motivación a los profesionales sanitarios para conseguir el mayor éxito posible en los objetivos planteados. Una adecuada secuencia de técnicas aplicadas correctamente, condicionan el éxito de la VMNI. Es imprescindible que enfermería tenga los conocimientos y las habilidades necesarios para un correcto inicio de la VMNI.Objectives: Mix the performance criteria to improve nursing care quality. Provide a working tool for fostering new workers teamwork and improving the organization and planning of care to the patient. Method: A descriptive study was developed following a literature review to support the experience. Results: The description of the procedure used, serves as a guide for the proper functioning of the process. Conclusions: The involvement of nursing is of utmost importance in the process of patients who need Noninvasive Mechanical Ventilation (NIV). The comparison of items with the result and sharing has led us to conclude the importance of establishing a foundation that will serve as motivation to healthcare professionals to achieve the greatest possible success in the objectives. A proper sequence of techniques properly applied, determine the success of NIV. It is imperative that nurses have the knowledge and skills necessary for proper initiation of NIV

One-year efficacy and safety of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: KYONAL study

Cancer; Constipation; PainCàncer; Restrenyiment; DolorCáncer; Estreñimiento; DolorAbstract Objectives Naloxegol is a peripherally acting µ-opioid receptor antagonist (PAMORA) for treatment of opioid-induced constipation (OIC). The main objective was to analyse the long-term efficacy, quality of life (QOL) and safety of naloxegol in patients with cancer in a real-world study. Methods This one-year prospective study included patients older than 18 years, with active oncological disease who were under treatment with opioids for pain control and Karnofsky≥50 and OIC with inadequate response to treatment with laxative (s). All the patients received treatment with naloxegol according to clinical criteria. The main efficacy objectives were measured by the patient assessment of constipation QOL questionnaire (PAC-QOL), the PAC symptoms (PAC-SYM), the response rate at day 15, and months 1-3-6-12, and global QOL (EuroQoL-5D-5L). Results A total of 126 patients (58.7% males) with a mean age of 61.5 years (95% CI 59.4 to 63.7) were included. PAC-SYM and PAC-QOL total score and all their dimensions improved from baseline (p<0.0001). At 12 months, 77.8% of the patients were responders to naloxegol treatment. Global QOL was conserved from baseline. A total of 28 adverse reactions, mainly gastrointestinal were observed in 15.1% of the patients (19/126), being 75% (21) mild, 17.9% (5) moderate and 7.1% (2) severe. Most adverse reactions (67.9%) appeared the first 15 days of treatment. Conclusion The results of this first long-term and real-world-data study in patients with cancer, showed the sustained efficacy and safety of naloxegol for the treatment of OIC in this group of patients.This study was sponsored by Kyowa Kirin Farmacéutica S.L., Spain. The funders participated in the design of the study and the drafting of the manuscript

Catalytic Ozonation Using Edge-Hydroxylated Graphite-Based Materials

"This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Sustainable Chemistry & Engineering, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acssuschemeng.9b04646"[EN] This work reports the catalytic ozonation activity of high surface area graphite materials selectively functionalized at the edges with hydroxyl groups. The graphite-based catalyst shows higher activity than the parent graphite, commercial activated carbon, commercial multiwall carbon nanotubes, commercial diamond nanoparticles, graphene oxide, or reduced graphene oxide. Importantly, the catalytic activity of the graphite-based material is also higher than those of benchmark ozonation catalysts such as Co3O4 or Fe2O3. The graphite catalyst was reused up to 10 times with only a minor decrease in the catalytic activity. Catalytic activation of O-3 leads to the generation of hydroperoxide radicals and O-1(2). These results have been interpreted as derived from the combination of a suitable work function and the presence of phenolic/semiquinone-like redox pairs, as well as high dispersibility in water due to the presence of -OH groups. This work highlights the possibility of engineering active and stable carbocatalysts for reactions typically promoted by transition metals.Financial support by the Spanish Ministry of Science and Innovation (Severn Ochoa and RTI2018-098237-CO21) and Generalitat Valenciana (Prometeo 2017/083) is gratefully acknowledged. S.N. is thankful for financial support from the Fundacion Ramon Areces (XVIII Concurso Nacional para la Adjudication de Ayudas a la Investigacion en Ciencias de la Vida y de la Materia, 2016), Ministerio de Ciencia, Innovacion y Universidades RTI2018-099482-A-I00 project and Generalitat Valenciana grupos de investigacion consolidables 2019 (ref: AICO/2019/214) project.Bernat-Quesada, F.; Espinosa-López, JC.; Barbera, V.; Alvaro Rodríguez, MM.; Galimberti, M.; Navalón Oltra, S.; García Gómez, H. (2019). Catalytic Ozonation Using Edge-Hydroxylated Graphite-Based Materials. ACS Sustainable Chemistry & Engineering. 7(20):17443-17452. https://doi.org/10.1021/acssuschemeng.9b04646S174431745272

Engineering of activated carbon surface to enhance the catalytic activity of supported cobalt oxide nanoparticles in peroxymonosulfate activation

[EN] Commercial activated carbon has been functionalized by chemical or thermal treatments to introduce surface oxygen functional groups able to anchor small cobalt nanoparticles with superior catalytic activity for peroxymonosulfate activation. The resulting activated carbon supports where characterized by combustion elemental analysis, Fourier-transformed infrared spectroscopy, Raman spectroscopy, isothermal N-2 adsorption, temperature programmed desorption/mass spectrometry, X-ray diffraction and scanning electron microscopy. Activated carbon functionalization by nitric acid resulted the most appropriated method to provide a higher population of oxygenated functional groups able to anchor small cobalt nanoparticles. The catalytic activity of supported oxidized metal nanoparticles (4.7 +/- 0.05 nm) was higher than analogous non-oxidized cobalt nanoparticles (2.9 +/- 0.14 nm). The use of analogous supported oxidized iron or copper nanoparticles resulted in lower catalytic activity. Importantly, the supported oxidized cobalt nanoparticles at 0.2 wt% loading exhibit higher activity than benchmark catalysts such as unsupported Co3O4 solid or even homogeneous Co2+ ions. This is a reflection of the relatively low estimated activation energy for both processes, peroxymonosulfate decomposition and phenol degradation. The estimated activation energy values are about 30 and 32 kJ mol(-1). The stability of the most active catalyst was assessed by performing eight consecutive uses without observing decrease of catalytic activity, neither metal leaching or metal nanoparticle aggregation. Turnover numbers/turnover frequencies values as high as 440(5)/8.10(5)h(-1) for peroxymonosulfate activation and 39.10(3)/68.10(3) h(-1) for phenol degradation at pH 7 and 20 degrees C have been estimated, respectively. Electron paramagnetic resonance measurements and selective quenching experiments revealed that the generated sulfate radicals from peroxymonosulfate rapidly are transformed in highly reactive hydroxyl radicals. In excellent agreement with previous reports, this work demonstrates the importance of an adequate activated carbon functionalization to obtain superior and stable catalysts for peroxymonosulfate activation.Financial support by the Spanish Ministry of Economy and Competitiveness (Severo Ochoa, CTQ2015-65963-CQ-R1) and CTQ2014-53292-R is gratefully acknowledged. Generalitat Valenciana is also thanked for funding (Prometeo 2017/083). S.N. thanks financial support by the Fundacion Ramon Areces (XVIII Concurso Nacional para la Adjudicacion de Ayudas a la Investigacion en Ciencias de la Vida y de la Materia, 2016).Espinosa-López, JC.; Manickam-Periyaraman, P.; Bernat-Quesada, F.; Sivanesan, S.; Alvaro Rodríguez, MM.; García Gómez, H.; Navalón Oltra, S. (2019). Engineering of activated carbon surface to enhance the catalytic activity of supported cobalt oxide nanoparticles in peroxymonosulfate activation. Applied Catalysis B Environmental. 249:42-53. https://doi.org/10.1016/j.apcatb.2019.02.043S425324

Selective Implantation of Diamines for Cooperative Catalysis in Isoreticular Heterometallic Titanium-Organic Frameworks

This is the peer reviewed version of the following article: Selective Implantation of Diamines for Cooperative Catalysis in Isoreticular Heterometallic Titanium-Organic Frameworks, which has been published in final form at https://doi.org/10.1002/anie.202100176. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] We introduce the first example of isoreticular titanium-organic frameworks, MUV-10 and MUV-12, to show how the different affinity of hard Ti(IV) and soft Ca(II) metal sites can be used to direct selective grafting of amines. This enables the combination of Lewis acid titanium centers and available -NH, sites in two sizeable pores for cooperative cycloaddition of CO2 to epoxides at room temperature and atmospheric pressure. The selective grafting of molecules to heterometallic clusters adds up to the pool of methodologies available for controlling the positioning and distribution of chemical functions in precise positions of the framework required for definitive control of pore chemistry.This work was supported by the EU (ERC Stg Chem-fs-MOF 714122) and Spanish Government (CTQ2017-83486-P, RTI2018-098568-A-I00 & CEX2019-000919-M). E.L.-M. and S.T. thanks the Spanish Government for their Juan de la Cierva Fellowship (FJCI-2017-32956) and Ramon y Cajal contract (RYC-2016-1981), respectively. A.R.G. acknowledges funding from Generalitat Valencia (ACIF/2020/090)and Fondo Social Europeo. N.M.P. thanks the European Union for a Marie Sklodowska-Curie Global Fellowship (H2020MSCA-IF-2016-GF-749359-EnanSET) and to the "2020 Postdoctoral Junior Leader-Retaining Fellowship, la Caixa Foundation (ID 100010434 and fellowship code LCF/BQ/PR20/11770014)". F.G.C. acknowledges the support of a fellowship from "la Caixa" Foundation (ID 100010434 and the fellowship code LCF/BQ/PI19/11690011). S.N. thanks financial support by the Ministerio de Ciencia, Innovacion y Universidades (RTI 2018-099482-A-I00 project), Fundacion Ramon Areces (XVIII Concurso Nacional para la Adjudicacion de Ayudas a la Investigacion en Ciencias de la Vida y de la Materia, 2016) and Agencia Valenciana de la Innovacion (AVI-GVA, Carboagua project, INNEST/2020/111).López-Maya, E.; Padial, NM.; Castells-Gil, J.; Ganivet, CR.; Rubio-Gaspar, A.; García Cirujano, F.; Almora-Barrios, N.... (2021). Selective Implantation of Diamines for Cooperative Catalysis in Isoreticular Heterometallic Titanium-Organic Frameworks. Angewandte Chemie International Edition. 60(21):11868-11873. https://doi.org/10.1002/anie.2021001761186811873602

Efficacy of naloxegol on symptoms and quality of life related to opioid-induced constipation in patients with cancer: a 3-month follow-up analysis

Objectives: Opioid-induced constipation (OIC) can affect up to 63% of all patients with cancer. The objectives of this study were to assess quality of life as well as efficacy and safety of naloxegol, in patients with cancer with OIC. Methods: An observational study was made of a cohort of patients with cancer and with OIC exhibiting an inadequate response to laxatives and treated with naloxegol. The sample consisted of adult outpatients with a Karnofsky performance status score ≥50. The Patient Assessment of Constipation Quality of Life Questionnaire (PAC-QOL) and the Patient Assessment of Constipation Symptoms (PAC-SYM) were applied for 3 months. Results: A total of 126 patients (58.2% males) with a mean age of 61.3 years (range 34-89) were included. Clinically relevant improvements (>0.5 points) were recorded in the PAC-QOL and PAC-SYM questionnaires (p<0.0001) from 15 days of treatment. The number of days a week with complete spontaneous bowel movements increased significantly (p<0.0001) from 2.4 to 4.6 on day 15, 4.7 after 1 month and 5 after 3 months. Pain control significantly improved (p<0.0001) during follow-up. A total of 13.5% of the patients (17/126) presented some gastrointestinal adverse reaction, mostly of mild (62.5%) or moderate intensity (25%). Conclusions: Clinically relevant improvements in OIC-related quality of life, number of bowel movements and constipation-related symptoms were recorded as early as after 15 days of treatment with naloxegol in patients with cancer and OIC, with a good safety profile

Territorial plannig and competitivity. A vision to the tourist spaces

La ordenación del territorio en áreas turísticas sigue frecuentemente las mismas estrategias de desarrollo espacial que las periferias urbanas. Sus definiciones iniciales y descripciones territoriales presentan claros paralelismos. Sin embargo, no resulta claro que esta importante actividad económica deba seguir ordenándose según una normativa meramente residencial, que no reconoce sus peculiaridades. Este trabajo, pretende valorizar la necesidad de un tratamiento de las periferias turísticas, centrado en términos de la calidad ambiental como clave del mantenimiento de la competitividad y dinamismo de los espacios litorales.Planning tourist places use the same development strategies as urban peripheries. Their initial definition and territorial descriptions present clear parallelisms. However, it does not seem appropiate that the first industry of the country must follow a plan according with a simple urban normative, that does not recognize its peculiarities. A planning more centred in environmental qualities, could be the key to keep competitiveness and dynamism of litoral places

Ordenación territorial y competitividad. Una visión a los espacios turísticos

La ordenación del territorio en áreas turísticas sigue frecuentemente las mismas estrategias de desarrollo espacial que las periferias urbanas. Sus definiciones iniciales y descripciones territoriales presentan claros paralelismos. Sin embargo, no resulta claro que esta importante actividad económica deba seguir ordenándose según una normativa meramente residencial, que no reconoce sus peculiaridades. Este trabajo, pretende valorizar la necesidad de un tratamiento de las periferias turísticas, centrado en términos de la calidad ambiental como clave del mantenimiento de la competitividad y dinamismo de los espacios litorales