Desarrollo del sistema de gestión logística de servicios en la empresa Fotel S.A.S.

El presente proyecto se enfoca en el diseño de un modelo de asignación y ruteo que permita la solución al problema con el cual cuenta actualmente FOTEL S.AS para los vehículos que posee la empresa para realizar el servicio inherente a su actividad económica. Luego de comparar los modelos y métodos teóricos de optimización para asignación y ruteo con el caso de esta empresa; el trabajo precisa un modelo que establece la asignación de vehículos a cada localidad de mayor prevalencia de acuerdo con una demanda histórica determinada y teniendo en cuenta variables como son indicadores de consumo, costos y tiempos de transporte. El modelo consiste en optimizar los recursos. El estudio empieza desde la elaboración de un diagnóstico al sistema de gestión actual de la empresa identificando debilidades, oportunidades, fortalezas y amenazas para la definición de las principales problemáticas que aquejan a la organización para así identificar las posibles estrategias, por medio de la conformación de los procesos que permitan las mejoras deseadas en el sistema de gestión logística acordes a las necesidades de la empresa. Posteriormente por medio de técnicas como un análisis estadístico, aplicación de técnicas cuantitativas de ingeniería para la estructuración y mejora del sistema de gestión logística., entre otros se desarrolla el modelo de ahorros en Excel que permite la optimización de los recursos y tiempos aumentando el nivel de servicio para su posterior aplicación. Para finalizar el desarrollo del sistema logístico se garantiza todo el flujo de información asociado a las actividades relacionadas con el transporte de forma tal que la rentabilidad presente y futura de la empresa sea maximizada en términos de costos y efectividad para lo cual se realiza un estudio costo beneficio para la implementación del sistema logístico mediante un estudio financiero.This project focuses on the study of logistics processes of inventory, shipping, and customer service of a telecommunications company, in order to improve their operations. The study starts from the elaboration of a diagnosis of the current system of company management identifying weaknesses, opportunities, strengths and threats to the definition of the main problems faced by the organization in order to identify possible strategies, through the formation of processes that allow the desired improvements in the logistics management system according to the needs of the company. Subsequently through techniques such as statistical analysis, simulation techniques, decision analysis models, including the logistics management system is validated in different settings, to analyze its impact on the company. To complete the development of the logistics system the entire flow of information associated with activities guaranteed: inventory, transportation and customer service, so that current and future profitability is maximized in terms of cost effectiveness for which a cost benefit to the implementation of the logistics system by a financial study being done

Methodology to address radioprotection and safety issues in the IFMIF/EVEDA accelerator prototype

In the IFMIF/EVEDA accelerator prototype, deuterons (with energies up to 9 MeV) interact with the materials of the accelerator components due to beam losses and in the beam dump, where the beam is stopped. The productions of neutrons/photons together with radioactive inventories due to deuteron-induced reactions are some major issues for radioprotection and safety assessment. Here, we will focus on the proposal of a computational approach able to simulate deuteron transport and evaluate deuteron interactions and production of secondary particles with acceptable precision. Current Monte Carlo codes, such as MCNPX or PHITS, when applied for deuteron transport calculation, use built-in semi-analytical models to describe deuteron interactions. These models are found unreliable in predicting neutron and photon generated by low energy deuterons, typically present in the IFMIF/EVEDA prototype accelerator. In this context, a new computational methodological approach is proposed based on the use of an extended version of current MC codes capable to use evaluated deuteron libraries for neutron (and gamma) production. The TALYS nuclear reaction code is found to be an interesting potential candidate to produce the evaluated data for double-differential neutron and photon emission cross sections for incident deuterons in the energy range of interest for IFMIF/EVEDA applications. The recently-released deuteron Talys-based Evaluated Nuclear Data Library, TENDL-2009, is considered a good starting point in the road to achieve deuteron data files of enough quality for deuteron transport problems in EVEDA. Unfortunately, current Monte Carlo transport codes are not able to handle light ion libraries except for protons. To overcome this drawback the MCNPX code has been extended to handle deuteron (also triton, helion and alpha) nuclear data libraries. In this new extended MCNPX version called MCUNED, a new variance reduction technique has also been implemented for the production of secondary particles induced by light ions nuclear reactions, which allow reducing drastically the computing time needed in transport and nuclear response function calculations. Verification of these new capabilities for Monte 2 Carlo simulation of deuteron transport and secondary products generation included in MCUNED is successfully achieved. The existence of the MCUNED code allows us for the first time testing the deuteron crosssection TENDL package by simulation of integral experiments. Some preliminary efforts are addressed to compare existing experimental data on thick target neutron yields for Copper with those computed by the MCUNED code using TENDL cross sections

Digital integrated circuit implementation of an identification stage for the detection of illegal hunting and logging

https://www.scopus.com/inward/record.url?eid=2-s2.0-84945156734&partnerID=40&md5=314bbbafa852daae1ff0c96b8de9f2beResults of the VLSI implementation of an acoustic classification system's identification stage, intended for the detection of gunshots and chainsaws in a protected tropical area, are shown, with the idea of later building a surveillance wireless sensor network with similar nodes. The system performs from signal preprocessing to feature extraction, with results of the HDL description of the system tested on a FPGA against a golden reference, using real data taken from a protected rain forest area. Final classification of signals, using HMM, is in the final stages of testing. Some post-place-and-route results of the code ported to a commercial 130nm CMOS technology are also given

Endoparasitic infections in captive wild mammals under human care in San Luis Potosí, Mexico

Objective: Determine parasite prevalence, richness and load in wild mammals of Tangamanga I and II Parks in San Luis Potosí, SLP. Evaluate if infections are related to diet and/or climatic seasons. Design/methodology/approach: Analysis of fresh feces collected during three consecutive days in two sampling periods. Passive flotation techniques with sodium nitrate (qualitative) and McMaster (quantitative) were performed. Results: General prevalence observed was 36% (n=242). The parasite richness is formed by protozoa: Eimeria sp, Isospora sp and Cystoisospora sp; by the cestode Moniezia expansa and nematodes: Toxocara sp, Toxascaris sp, Ancylostoma sp/Uncinaria sp, Strongyloides sp, Trichuris suis and eggs from the Strongyles group. The parasite load observed in the case of protozoa ranged from 0 – 8,505 Oocysts per Gram of Feces, and from 0 – 1,400 Eggs per Gram of Feces in the case of helminths. Statistical analyzes showed that the prevalence of parasites does not depend on the climatic season, and only in Tangamanga II Park is the prevalence dependent on the diet (herbivores). Study limitations/implications: The preservation method used limits the coproparasitoscopic techniques that can be used (coproculture or coccidia sporulation). Findings/conclusions: The observed endoparasitic infections can be a potential risk to the health of animals, especially those of great genetic value (i.e., endangered species). In addition, the potentially zoonotic parasites observed represent a threat to the health of their keepers.Objective: To determine the prevalence, richness and parasitic load in wild mammals of Tangamanga I and II Parks in San Luis Potosí, SLP. To assess whether infections are related to the type of feeding and weather seasons. Design/methodology/approach: Analysis of fresh feces collected for three consecutive days at two sampling stations. Passive flotation techniques with sodium nitrate (qualitative) and McMaster (quantitative) were used. Results: The overall prevalence observed was 36% (n=242). The parasitic wealth is formed by protozoa: Eimeria sp., Isospora sp. and Cystoisospora sp.; by the cestode Moniezia expansa, nematodes: Toxocara sp., Toxascaris sp., Ancylostoma sp./Uncinaria sp., Strongyloides sp., Trichuris suis and Strongylid eggs. The parasite load in the case of protozoa was in the range of 0 – 8505 oocysts per gram of faeces, and 0 – 1400 eggs per gram of faeces in the case of helminths. Statistical analyses showed that the prevalence of parasites does not depend on the climatic season, and only in Tangamanga II Park is the prevalence dependent on the type of feeding (herbivores). Study limitations/implications: The conservation method used limits the stool test techniques that can be employed (stool culture or sporulation). Findings/conclusions: Endoparasitic infections can be a potential risk to the health of animals. In particular to those of great genetic value such as species threatened with extinction. In addition, the potentially zoonotic parasites observed pose a threat to the health of caregiver

Plan de responsabilidad social empresarial empresa Freskaleche S.A.

Apéndice A. Video Marketing Social y Marketing Corporativo, (https://www.powtoon.com/online-presentation/fTORVakUEf1/?mode=movie)El presente trabajo contiene información recopilada de la empresa Freskaleche seleccionada por el grupo evaluando los aspectos más importantes como el desempeño económico, social y ambiental de la organización tanto interno como externo y se diseña el plan de responsabilidad social empresarial, además se produce el código de conducta teniendo en cuenta la justificación y el análisis de desempeño en las tres dimensiones (económica, social y ambiental). Teniendo en cuenta los conceptos, se determina la realización de un video de contextualización donde se evidencia el concepto propio de cada estudiante sobre marketing social y corporativo. Construyendo el mapa genérico de los Stakeholders de la empresa Freskaleche, en el cual se utilizaron estrategias y metodologías identificando algunos impactos en los aspectos: económico, social y ambiental generados por la empresa, incluyendo las diferentes tácticas de solución o mitigación de estos; para así aportar el valor a la organización, por ende, favorecer la sostenibilidad global.This work contains information collected from the company Freskaleche refers to the group assesses the issue of corporate social responsibility, in addition to producing the code of conduct taking into account the justification and performance analysis in the three dimensions (economic, social and environmental). Taking into account the concepts, the creation of a contextualization video is determined where the concept of each student about social and corporate marketing is evident. Constructing the generic map of the Stakeholders of the company Freskaleche, in which strategies and methodologies are used identifying some impacts in the aspects: economic, social and environmental generated by the company, including the different tactics of solution or mitigation of these; in order to contribute value to the organization, therefore, promote global sustainability

Testing the stress gradient hypothesis in soil bacterial communities associated with vegetation belts in the Andean Atacama Desert

17 Pág.Soil microorganisms are in constant interaction with plants, and these interactions shape the composition of soil bacterial communities by modifying their environment. However, little is known about the relationship between microorganisms and native plants present in extreme environments that are not affected by human intervention. Using high-throughput sequencing in combination with random forest and co-occurrence network analyses, we compared soil bacterial communities inhabiting the rhizosphere surrounding soil (RSS) and the corresponding bulk soil (BS) of 21 native plant species organized into three vegetation belts along the altitudinal gradient (2400-4500 m a.s.l.) of the Talabre-Lejía transect (TLT) in the slopes of the Andes in the Atacama Desert. We assessed how each plant community influenced the taxa, potential functions, and ecological interactions of the soil bacterial communities in this extreme natural ecosystem. We tested the ability of the stress gradient hypothesis, which predicts that positive species interactions become increasingly important as stressful conditions increase, to explain the interactions among members of TLT soil microbial communities.This study was funded by ANID FONDECYT Grants 1201278 to MG, 11200319 to DM, 3190194 to JM and 1211893 to VC, and ANID-MILENIO-CN2021-044. LAC was supported by ANID FB21006 and ACT210038. AG was supported by ANID Ph.D. Fellowship 21210808. Research was supported by the "Severo Ochoa Program for Centers of Excellence in R&D" from the Agencia Estatal de Investigación of Spain (Grant SEV-2016-0672 (2017-2021)) to the CBGP. BG-J was supported by a Postdoctoral contract associated to the Severo Ochoa Program. In addition, this research was partially supported by the supercomputing infrastructure of the NLHPC (ECM-02) (Powered@NLHPC).Peer reviewe

Prospective Latin American cohort evaluating outcomes of patients with COVID-19 and abnormal liver tests on admission

Introduction & objectives: The independent effect of liver biochemistries as a prognostic factor in patients with COVID-19 has not been completely addressed. We aimed to evaluate the prognostic value of abnormal liver tests on admission of hospitalized patients with COVID-19. Materials & methods: We performed a prospective cohort study including 1611 hospitalized patients with confirmed SARS-CoV-2 infection from April 15, 2020 through July 31, 2020 in 38 different Hospitals from 11 Latin American countries. We registered clinical and laboratory parameters, including liver function tests, on admission and during hospitalization. All patients were followed until discharge or death. We fit multivariable logistic regression models, further post-estimation effect through margins and inverse probability weighting. Results: Overall, 57.8% of the patients were male with a mean age of 52.3 years, 8.5% had chronic liver disease and 3.4% had cirrhosis. Abnormal liver tests on admission were present on 45.2% (CI 42.7–47.7) of the cohort (n = 726). Overall, 15.1% (CI 13.4–16.9) of patients died (n = 244). Patients with abnormal liver tests on admission presented higher mortality 18.7% (CI 15.9–21.7), compared to those with normal liver biochemistries 12.2% (CI 10.1–14.6); P 30. Conclusions: The presence of abnormal liver tests on admission is independently associated with mortality and severe COVID-19 in hospitalized patients with COVID-19 infection and may be used as surrogate marker of inflammation.Fil: Mendizabal, Manuel. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Piñero, Federico. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Anders, Margarita. Hospital Aleman; ArgentinaFil: Silveyra, María Dolores. Sanatorio Anchorena; ArgentinaFil: Torre, Aldo. Centro Médico ABC; MéxicoFil: Montes, Pedro. Hospital Nacional Daniel A. Carrión; PerúFil: Urzúa, Alvaro. Hospital Clínico de la Universidad de Chile; ChileFil: Pages, Josefina. Universidad Austral. Hospital Universitario Austral; ArgentinaFil: Toro, Luis G.. Hospitales de San Vicente Fundación de Medellín y Rionegro; ColombiaFil: Díaz, Javier. Hospital Nacional Edgardo Rebagliati Martins; PerúFil: Gonzalez Ballerga, Esteban. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Miranda Zazueta, Godolfino. Instituto Nacional de Ciencias Médicas y Nutrición; MéxicoFil: Peralta, Mirta. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Gutiérrez, Isabel. Centro Médico ABC; MéxicoFil: Michelato, Douglas. Hospital Especializado en Enfermedades Infecciosas Instituto Couto Maia; BrasilFil: Venturelli, Maria Grazia. Hospital Nacional Guillermo Almenara Irigoyen; PerúFil: Varón, Adriana. Fundación Cardio-Infantil; ColombiaFil: Vera Pozo, Emilia. Hospital Regional Dr. Teodoro Maldonado Carbo; EcuadorFil: Tagle, Martín. Clínica Anglo-Americana; PerúFil: García, Matías. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Tassara, Alfredo. Hospital Aleman; ArgentinaFil: Brutti, Julia. Sanatorio Anchorena; ArgentinaFil: Ruiz García, Sandro. Hospital de Víctor Lazarte Echegaray; PerúFil: Bustios, Carla. Clínica Delgado; PerúFil: Escajadillo, Nataly. Hospital Nacional Almanzor Aguinaga Asenjo; PerúFil: Macias, Yuridia. No especifíca;Fil: Higuera de la Tijera, Fátima. Hospital General de México “Dr. Eduardo Liceaga"; MéxicoFil: Gómez, Andrés J.. Hospital Universitario Fundación Santa Fé de Bogotá; ColombiaFil: Dominguez, Alejandra. Hospital Padre Hurtado; ChileFil: Castillo Barradas, Mauricio. Hospital de Especialidades del Centro Médico Nacional La Raza; MéxicoFil: Contreras, Fernando. No especifíca;Fil: Scarpin, Aldana. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; ArgentinaFil: Schinoni, Maria Isabel. Hospital Alianza; BrasilFil: Toledo, Claudio. Universidad Austral de Chile; ChileFil: Girala, Marcos. Universidad Nacional de Asunción; ParaguayFil: Mainardi, Victoria. Hospital Central De las Fuerzas Armadas; UruguayFil: Sanchez, Abel. Hospital Roosevelt; GuatemalaFil: Bessone, Fernando. Provincia de Santa Fe. Ministerio de Salud y Medio Ambiente - Rosario. Hospital Provincial del Centenario; ArgentinaFil: Rubinstein, Fernando Adrian. Instituto de Efectividad Clínica y Sanitaria; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Silva, Marcelo Oscar. Universidad Austral. Hospital Universitario Austral; Argentin

Hugo Chávez: una década en el poder

Una década de Hugo Chávez Frías y su proyecto político en Venezuela trajo consigo un cambio de paradigmas que llama la atención de la sociedad en general. Este libro es el resultado del esfuerzo conjunto de un grupo de académicos de distintas nacionalidades que desde sus líneas de investigación realizan análisis que le brindan al lector elementos para comprender de manera global lo que significa una década de gobierno del Presidente Chávez en Venezuela.Este libro es el resultado del esfuerzo conjunto de un grupo de académicos de distintas nacionalidades que desde sus líneas de investigación realizan análisis que le brindan al lector elementos para comprender de manera global lo que significa una década de gobierno del Presidente Chávez en Venezuela

HFE Gene Variants Modify the Association between Maternal Lead Burden and Infant Birthweight: A Prospective Birth Cohort Study in Mexico City, Mexico

<p>Abstract</p> <p>Background</p> <p>Neonatal growth is a complex process involving genetic and environmental factors. Polymorphisms in the hemochromatosis (<it>HFE</it>) iron regulatory genes have been shown to modify transport and toxicity of lead which is known to affect birth weight.</p> <p>Methods</p> <p>We investigated the role of <it>HFE C282Y</it>, <it>HFE H63 D</it>, and transferrin <it>(TF) P570 S </it>gene variants in modifying the association of lead and infant birthweight in a cohort of Mexican mother-infant pairs. Subjects were initially recruited between 1994-1995 from three maternity hospitals in Mexico City and 411 infants/565 mothers had archived blood available for genotyping. Multiple linear regression models, stratified by either maternal/infant <it>HFE </it>or <it>TF </it>genotype and then combined with interaction terms, were constructed examining the association of lead and birthweight after controlling for covariates.</p> <p>Results</p> <p>3.1%, 16.8% and 17.5% of infants (N = 390) and 1.9%, 14.5% and 18.9% of mothers (N = 533) carried the <it>HFE C282Y</it>, <it>HFE H63D</it>, and <it>TF P570 S </it>variants, respectively. The presence of infant <it>HFE H63 D </it>variants predicted 110.3 g (95% CI -216.1, -4.6) decreases in birthweight while maternal <it>HFE H63 D </it>variants predicted reductions of 52.0 g (95% CI -147.3 to 43.2). Interaction models suggest that both maternal and infant <it>HFE H63 D </it>genotype may modify tibia lead's effect on infant birthweight in opposing ways. In our interaction models, maternal <it>HFE H63 D </it>variant carriers had a negative association between tibia lead and birthweight.</p> <p>Conclusions</p> <p>These results suggest that the <it>HFE H63 D </it>genotype modifies lead's effects on infant birthweight in a complex fashion that may reflect maternal-fetal interactions with respect to the metabolism and transport of metals.</p