Energy-Efficient Cooperative Spectrum Sensing based on Stochastic Programming in Dynamic Cognitive Radio Sensor Networks Normal

Nowadays, Cognitive Radio Sensor Networks (CRSN) arise as an emergent technology to deal with the spectrum scarcity issue and the focus is on devising novel energy-efficient solutions. In static CRSN, where nodes have spatial fixed positions, several reported solutions are implemented via sensor selection strategies to reduce consumed energy during cooperative spectrum sensing. However, energy-efficient solutions for dynamic CRSN, where nodes are able to change their spatial positions due to their movement, are nearly reported despite today's growing applications of mobile networks. This paper investigates a novel framework to optimally predict energy consumption in cooperative spectrum sensing tasks, considering node mobility patterns suitable to model dynamic CRSN. A solution based on the Kataoka criterion is presented, that allows to minimize the consumed energy. It accurately estimates -with a given probability-the spent energy on the network, then to derive an optimal energy-efficient solution. An algorithm of reduced-complexity is also implemented to determine the total number of active nodes improving the exhaustive search method. Proper performance of the proposed strategy is illustrated by extensive simulation results for pico-cells and femto-cells in dynamic scenarios.This work was supported in part by the DICYT Project, Direction of Research, Development and Innovation, Universidad de Santiago de Chile, USACH, under Grant 061813KC, in part by the CONICYT-PFCHA/Doctorado Nacional/2016-21160292, and in part by the Spanish National Project TERESA-ADA (MINECO/AEI/FEDER, UE) under Grant TEC2017-90093-C3-2-R

Current ozone levels threaten gross primary production and yield of Mediterranean annual pastures and nitrogen modulates the response

Pastures are among the most important ecosystems in Europe considering their biodiversity and dis- tribution area. However, their response to increasing tropospheric ozone (O 3 ) and nitrogen (N) deposi- tion, two of the main drivers of global change, is still uncertain. A new Open-Top Chamber (OTC) experiment was performed in central Spain, aiming to study annual pasture response to O 3 and N in close to natural growing conditions. A mixture of six species of three representative families was sowed in the fi eld. Plants were exposed for 40 days to four O 3 treatments: fi ltered air, non- fi ltered air (NFA) repro- ducing ambient levels and NFA supplemented with 20 and 40 nl l � 1 O 3 . Three N treatments were considered to reach the N integrated doses of “ background ” , þ 20 or þ 40 kg N ha � 1 . Ozone signi fi cantly reduced green and total aboveground biomass (maximum reduction 25%) and increased the senescent biomass (maximum increase 40%). Accordingly, O 3 decreased community Gross Primary Production due to both a global reduction of ecosystem CO 2 exchange and an increase of ecosystem respiration. Nitrogen could partially counterbalance O 3 effects on aboveground biomass when the levels of O 3 were moderate, but at the same time O 3 exposure reduced the fertilization effect of higher N availability. Therefore, O 3 must be considered as a stress factor for annual pastures in the Mediterranean areas

The Interactivity of a Virtual Museum at the Service of the Teaching of Applied Geology

[EN] In a framework in which teaching practice is a dynamic process, predisposed to continuous innovation, the Geological Collection of the University of León (CGULe), with 2000 copies of minerals, rocks and fossils, offers an opportunity for teaching innovation, in relationship with subjects of the geological disciplines that are taught in the Degrees of Mining Engineering and Energy Engineering. At http://laboratorio.wesped.es/, the first phase of development of the Virtual Museum of the CGULe is shown, where information and images of minerals and mineral deposits from León are offered. Likewise, videos of tests of characterization of minerals, made by students as a practice of the subject "Mineralogy and Petrography" (Degree in Mining Engineering), are offered as part of a teaching innovation. This teaching innovation was evaluated in two ways: a) comparing the academic results of students in this practice with equivalent results from previous courses and b) conducting a satisfaction survey. Given the small number of students who participated in this experience, the results of this evaluation are inconclusive. For this reason, teacher innovation will be extended in time and will be extended to other subjects of the above mentioned degrees.The work was partially funded by the project "Design of practical teaching-learning experiences in relation to the virtual musealization of the Geological Collection of the University of León", in the framework of the Support Plan for Teaching Innovation of the University of León (PAID & PAGID 2016). Likewise, the authors express their gratitude to D. Luis Armando Conejo Lombas, donor of copies to the Geological Collection of the University of Leon, as well as photographs of deposits to the Virtual Museum, and to the collaborators: Mr. Ángel Díez Bragado, Mr. Jesús García del Canto, Mr. Manuel Urcera Valladares and Mr. Guillermo Salazar Brugos.Gómez-Fernández, F.; Fernández-Raga, M.; Alaiz-Moretón, H.; Castañon-García, A.; Palencia, C. (2017). The Interactivity of a Virtual Museum at the Service of the Teaching of Applied Geology. En Proceedings of the 3rd International Conference on Higher Education Advances. Editorial Universitat Politècnica de València. 712-719. https://doi.org/10.4995/HEAD17.2017.5366OCS71271

Impact of stress on inhibitory neuronal circuits, our tribute to Bruce McEwen

This manuscript is dedicated to the memory of Bruce S. McEwen, to commemorate the impact he had on how we understand stress and neuronal plasticity, and the profound influence he exerted on our scientific careers. The focus of this review is the impact of stressors on inhibitory circuits, particularly those of the limbic system, but we also consider other regions affected by these adverse experiences. We revise the effects of acute and chronic stress during different stages of development and lifespan, taking into account the influence of the sex of the animals. We review first the influence of stress on the physiology of inhibitory neurons and on the expression of molecules related directly to GABAergic neurotransmission, and then focus on specific interneuron subpopulations, particularly on parvalbumin and somatostatin expressing cells. Then we analyze the effects of stress on molecules and structures related to the plasticity of inhibitory neurons: the polysialylated form of the neural cell adhesion molecule and perineuronal nets. Finally, we review the potential of antidepressants or environmental manipulations to revert the effects of stress on inhibitory circuits

Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability

Lysyl oxidase-like 3 (LOXL3) is a member of the lysyl oxidase family comprising multifunctional enzymes with depicted roles in extracellular matrix maturation, tumorigenesis, and metastasis. In silico expression analyses followed by experimental validation in a comprehensive cohort of human cell lines revealed a significant upregulation of LOXL3 in human melanoma. We show that LOXL3 silencing impairs cell proliferation and triggers apoptosis in various melanoma cell lines. Further supporting a pro-oncogenic role in melanoma, LOXL3 favors tumor growth in vivo and cooperates with oncogenic BRAF in melanocyte transformation. Upon LOXL3 depletion, melanoma cells display a faulty DNA damage response (DDR), characterized by ATM checkpoint activation and inefficient ATR activation leading to the accumulation of double-strand breaks (DSBs) and aberrant mitosis. Consistent with these findings, LOXL3 binds to proteins involved in the maintenance of genome integrity, in particular BRCA2 and MSH2, whose levels dramatically decrease upon LOXL3 depletion. Moreover, LOXL3 is required for efficient DSB repair in melanoma cells. Our results reveal an unexpected role for LOXL3 in the control of genome stability and melanoma progression, exposing its potential as a novel therapeutic target in malignant melanoma, a very aggressive condition yet in need for more effective treatment options

Relaxin-3 Innervation From the Nucleus Incertus to the Parahippocampal Cortex of the Rat

Spatial learning and memory processes depend on anatomical and functional interactions between the hippocampus and the entorhinal cortex. A key neurophysiological component of these processes is hippocampal theta rhythm, which can be driven from subcortical areas including the pontine nucleus incertus (NI). The NI contains the largest population of neurons that produce and presumably release the neuropeptide, relaxin-3, which acts via the Gi/o-protein-coupled receptor, relaxin-family peptide 3 receptor (RXFP3). NI activation induces general arousal including hippocampal theta, and inactivation induces impairment of spatial memory acquisition or retrieval. The primary aim of this study was to map the NI/relaxin-3 innervation of the parahippocampal cortex (PHC), including the medial and lateral entorhinal cortex, endopiriform cortex, perirhinal, postrhinal, and ectorhinal cortex, the amygdalohippocampal transition area and posteromedial cortical amygdala. Retrograde tracer injections were placed in different parts of the medial and lateral entorhinal cortex, which produced prominent retrograde labeling in the ipsilateral NI and some labeling in the contralateral NI. Anterograde tracer injections into the NI and immunostaining for relaxin-3 produced fiber labeling in deep layers of all parahippocampal areas and some dispersed fibers in superficial layers. Double-labeling studies revealed that both hippocampal projecting and calcium-binding protein-positive (presumed GABAergic) neurons received a relaxin-3 NI innervation. Some of these fibers also displayed synaptophysin (Syn) immunoreactivity, consistent with the presence of the peptide at synapses; and relaxin-3-positive fibers containing Syn bouton-like staining were frequently observed in contact with hippocampal-projecting or calcium-binding protein-positive neuronal somata and more distal elements. Finally, in situ hybridization studies revealed that entorhinal neurons in the superficial layers, and to a lesser extent in deep layers, contain RXFP3 mRNA. Together, our data support functional actions of the NI/relaxin-3-parahippocampal innervation on processes related to memory, spatial navigation and contextual analysis

One-year cardiovascular outcomes after coronavirus disease 2019: The cardiovascular COVID-19 registry

Background: The long-term cardiovascular (CV) outcomes of COVID-19 have not been fully explored. Methods: This was an international, multicenter, retrospective cohort study conducted between February and December 2020. Consecutive patients ?18 years who underwent a real-time reverse transcriptase-polymerase chain reaction (RT-PCR) for SARS-CoV2 were included. Patients were classified into two cohorts depending on the nasopharyngeal swab result and clinical status: confirmed COVID-19 (positive RT-PCR) and control (without suggestive symptoms and negative RT-PCR). Data were obtained from electronic records, and clinical follow-up was performed at 1-year. The primary outcome was CV death at 1-year. Secondary outcomes included arterial thrombotic events (ATE), venous thromboembolism (VTE), and serious cardiac arrhythmias. An independent clinical event committee adjudicated events. A Cox proportional hazards model adjusted for all baseline characteristics was used for comparing outcomes between groups. A prespecified landmark analysis was performed to assess events during the post-acute phase (31-365 days). Results: A total of 4,427 patients were included: 3,578 (80.8%) in the COVID-19 and 849 (19.2%) control cohorts. At one year, there were no significant differences in the primary endpoint of CV death between the COVID-19 and control cohorts (1.4% vs. 0.8%; HRadj 1.28 [0.56-2.91]; p = 0.555), but there was a higher risk of all-cause death (17.8% vs. 4.0%; HRadj 2.82 [1.99-4.0]; p = 0.001). COVID-19 cohort had higher rates of ATE (2.5% vs. 0.8%, HRadj 2.26 [1.02-4.99]; p = 0.044), VTE (3.7% vs. 0.4%, HRadj 9.33 [2.93-29.70]; p = 0.001), and serious cardiac arrhythmias (2.5% vs. 0.6%, HRadj 3.37 [1.35-8.46]; p = 0.010). During the post-acute phase, there were no significant differences in CV death (0.6% vs. 0.7%; HRadj 0.67 [0.25-1.80]; p = 0.425), but there was a higher risk of deep vein thrombosis (0.6% vs. 0.0%; p = 0.028). Re-hospitalization rate was lower in the COVID-19 cohort compared to the control cohort (13.9% vs. 20.6%; p = 0.001). Conclusions: At 1-year, patients with COVID-19 experienced an increased risk of all-cause death and adverse CV events, including ATE, VTE, and serious cardiac arrhythmias, but not CV death

Comportamientos del profesor universitario y éxito académico de los estudiantes de los grados de maestro de infantil y primaria

 It´s disturbing to think about the idea that the teacher can lead a student to achieve great successes or, on the contrary, beat him academically. It´s for this reason that it´s necessary to explore the behavior of teaching professionals, from the point of view of the student, to know which ones they consider that will impact positively on their academic success. In order to this, a sample of 486 pupils from grades Primary Education Teachers (199) and Primary (287) in the Faculty of Education of Albacete (University of Castilla La Mancha) Education was analized. A questionnaire (Tuncel, 2009) (from few questions and the type of response ) was applied and, using a Factor Analysis Exploratory, there were found six dimensions to which the students gave the highest importance: "Emotional aptitude of teachers " ; " Teacher-student interaction " ; " Achieving the goals of education" , "Connecting between teaching of theory and practices " ; "Planning and organization of teaching " ; "Correct and provide information to students about their advance and progress." Es inquietante la idea de pensar que el profesor puede conseguir que un alumno alcance grandes éxitos o que, por el contrario se hunda académicamente.Es por ello por lo que se hace necesario explorar los comportamientos de los profesionales de la enseñanza en la Educación superior, desde el punto de vista del alumno, para conocer cuáles son los que ellos consideran que repercutirán de forma positiva en su éxito académico.Para ello se contó con una muestra de 486 alumnos, pertenecientes a los grados de Maestros de Educación Infantil (199) y Educación Primaria (287) en la Facultad de Educación de Albacete (Universidad de Castilla la Mancha).Se aplicó  un cuestionario (Tuncel, 2009)  y mediante un Análisis Factorial exploratorio, aparecieron seis dimensiones a las cuales los alumnos le otorgaron la mayor importancia, siendo estas: “Aptitud emocional de los profesores”; “Interacción profesor-alumno”; “Lograr y conseguir los objetivos de la enseñanza”, “Conexión durante la instrucción de la teoría con las practicas”; “Planificación y organización  de la docencia”; “Corregir y proporcionar informaciones a los alumnos de sus avances y progresos”

Transcription Factor Binding Site Enrichment Analysis In Co-Expression Modules In Celiac Disease

The aim of this study was to construct celiac co-expression patterns at a whole genome level and to identify transcription factors (TFs) that could drive the gliadin-related changes in coordination of gene expression observed in celiac disease (CD). Differential co-expression modules were identified in the acute and chronic responses to gliadin using expression data from a previous microarray study in duodenal biopsies. Transcription factor binding site (TFBS) and Gene Ontology (GO) annotation enrichment analyses were performed in differentially co-expressed genes (DCGs) and selection of candidate regulators was performed. Expression of candidates was measured in clinical samples and the activation of the TFs was further characterized in C2BBe1 cells upon gliadin challenge. Enrichment analyses of the DCGs identified 10 TFs and five were selected for further investigation. Expression changes related to active CD were detected in four TFs, as well as in several of their in silico predicted targets. The activation of TFs was further characterized in C2BBe1 cells upon gliadin challenge, and an increase in nuclear translocation of CAMP Responsive Element Binding Protein 1 (CREB1) and IFN regulatory factor-1 (IRF1) in response to gliadin was observed. Using transcriptome-wide co-expression analyses we are able to propose novel genes involved in CD pathogenesis that respond upon gliadin stimulation, also in non-celiac models.The authors thank the technical and human support provided by SGIker of the UPV/EHU. The work was funded by ISCIII Research Project Grants PI13/01201 and PI16/00258, cofunded by the European Union ERDF/ESF "A way to make Europe" and by Basque Department of Health project 2011/111034 to JRB and Basque Department of Health project 2015/111068 to I.S., N.F.-J. was supported by an IARC Postodctoral Fellowship (FP7 Marie Curie Actions-People-COFUND) and a Postdoctoral Fellowship from the Basque Department of Education. I.R.-G. and A.J.-M. are supported by predoctoral fellowship grants from the UPV/EHU and the Basque Department of Education, respectively

Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma

Malignant melanoma (MM) is the most aggressive and life-threatening form of skin cancer. It is characterized by an extraordinary metastasis capacity and chemotherapy resistance, mainly due to melanoma cancer stem cells (CSCs). To date, there are no suitable clinical diagnostic, prognostic or predictive biomarkers for this neoplasia. Therefore, there is an urgent need for new MM biomarkers that enable early diagnosis and effective disease monitoring. Exosomes represent a novel source of biomarkers since they can be easily isolated from different body fluids. In this work, a primary patient-derived MM cell line enriched in CSCs was characterized by assessing the expression of specific markers and their stem-like properties. Exosomes derived from CSCs and serums from patients with MM were characterized, and their metabolomic profile was analysed by highresolution mass spectrometry (HRMS) following an untargeted approach and applying univariate and multivariate statistical analyses. The aim of this study was to search potential biomarkers for the diagnosis of this disease. Our results showed significant metabolomic differences in exosomes derived from MM CSCs compared with those from differentiated tumour cells and also in serum-derived exosomes from patients with MM compared to those from healthy controls. Interestingly, we identified similarities between structural lipids differentially expressed in CSC-derived exosomes and those derived from patients with MM such as the glycerophosphocholine PC 16:0/0:0. To our knowledge, this is the first metabolomic-based study aimed at characterizing exosomes derived from melanoma CSCs and patients’ serum in order to identify potential biomarkers for MM diagnosis. We conclude that metabolomic characterization of CSC-derived exosomes sets an open door to the discovery of clinically useful biomarkers in this neoplasia.MICIU FPU15/03682 FPU15/02350Ministerio de Ciencia, Innovación y Universidades (MICIU) MAT2015-62644.C2.2.R RTI2018-101309-BC2Instituto de Salud Carlos III PIE16-00045Junta de Andalucía SOMM17/6109/UGR (UCE-PP2017-3)European Union (EU) SOMM17/6109/UGR (UCE-PP2017-3)Chair 'Doctors Galera-Requena in cancer stem cell research' CMC-CTS963Fundación MEDIN