Tumoral volume measured preoperatively by magnetic resonance imaging is related to survival in endometrial cancer.

Background. The aim of the study was to determine if the endometrial tumor volume (TV) measured by magnetic resonance imaging (MRI-TV) is associated with survival in endometrial cancer and lymph nodes metastases (LN+). Patients and methods. We evaluated the MRI imaging and records of 341 women with endometrial cancer and preoperative MRI from 2008 to 2018. The MRI-TV was calculated using the ellipsoid formula measuring three perpendicular tumor diameters. Tumor myometrial invasion was also analyzed. Results. Higher MRI-TV was associated with age ≥ 65y, non-endometrioid tumors, grade-3, deep-myometrial invasion, LN+ and advanced FIGO stage. There were 37 patients with LN+ (8.8%). Non-endometrioid tumors, deep-myometrial invasion, grade-3 and MRI-TV ≥ 10 cm3 were the factors associated with LN+. Using a receiver operating characteristic [ROC] curve, the MRI-TV cut-off for survival was 10 cm3 (area under curve [AUC] = 0.70; 95% CI: 0.61–0.73). 5 years disease-free (DFS) and overall survival (OS) was significantly lower in MRI-TV ≥ 10 cm3 (69.3% vs. 84.5%, and 75.4% vs. 96.1%, respectively). MRI-TV was considered an independent factor of DFS (HR: 2.20, 95% CI: 1.09–4.45, p = 0.029) and OS (HR: 3.88, 95% CI: 1.34–11.24, p = 0.012) in multivariate analysis. Conclusions. MRI-TV was associated with LN+, and MRI-TV ≥ 10 cm3 was an independent prognostic factor of lower DFS and OS. The MRI-TV can be auxiliary information to plan the surgery strategy and predict the adjuvant treatment in women with endometrial cancer.post-print403 K

GPU acceleration of a fully 3D iterative reconstruction software for PET using CUDA

Proceeding of: 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC), Orlando, Florida, 25-31 October 2009A CUDA implementation of the existing software FIRST (Fast Iterative Reconstruction Software for (PET) Tomography) is presented. This implementation uses consumer graphics processing units (GPUs) to accelerate the compute-intensive parts of the reconstruction: forward and backward projection. FIRST was originally developed in FORTRAN, and it has been migrated to C language to be used with NVIDIA C for CUDA, as well as for a straightforward implementation and performance comparison between the C versions of the code running on the CPU and on the GPU. We measured the execution time of the CUDA version compared to the fastest available CPU. The CUDA implementation includes a loop re-ordering and an optimized memory allocation, which improves even more the performance of the reconstruction on the GPUs.This work was supported in part by MEC (FPA2007-62216), CDTEAM (Programa CENIT, Ministerio de Industria), UCM (Grupos UCM, 910059), CPAN (Consolider-Ingenio 2010) CSPD-2007-00042 and the RECAVA-RETIC networ

Games-Based Learning Framework

This work presents the authors’ experience in the field of mobile technologies, from which several initiatives have emerged. As result of this, a games-based framework for learning has been developed in these last years. This framework is composed by a competition called Mobigame, which has as main aim to stimulate the participation of the students. By participating in this competition participants learn to develop for mobile devices. A game to practice Japanese is also presented in this article, which was presented in the above mentioned competition. This game has been developed for mobile phones or PDAs (Personal Digital Assistants) based on the JME (Java Mobile Edition) technology. Finally, another initiative is also presented: A free download platform of digital contents for mobile devices based on info-educational games

The British Influence in the Birth of Spanish Sport

Sports started to gain relevance in Spain around the end of the nineteenth century and the beginning of the twentieth century as a leisure and health option of the upper classes imported from Britain. Its early development was intertwined with the spread of other kinds of physical activities with much more tradition on the continent: gymnastics and physical education. First played by the ruling classes – aristocracy and high bourgeoisie – sports permeated towards petty bourgeoisie and middle classes in urban areas such as Madrid, Barcelona, San Sebastián and Santander. This pattern meant that the expansion of sports was unavoidably tied to the degree of industrialisation and cultural modernisation of the country. Since 1910, and mainly during the 1920s, sport grew in popularity as a spectacle and, toa much lesser degree, as a practice among the Spanish population

Post-extraction mesio-distal gap reduction assessment by confocal laser scanning microscopy - a clinical 3-month follow-up study

[EN] AimThe aim of this 3-month follow-up study is to quantify the reduction in the mesio-distal gap dimension (MDGD) that occurs after tooth extraction through image analysis of three-dimensional images obtained with the confocal laser scanning microscopy (CLSM) technique. Materials and MethodsFollowing tooth extraction, impressions of 79 patients 1month and 72 patients 3months after tooth extraction were obtained. Cast models were processed by CLSM, and MDGD changes between time points were measured. ResultsThe mean mesio-distal gap reduction 1month after tooth extraction was 343.4m and 3months after tooth extraction was 672.3m. The daily mean gap reduction rate during the first term (between baseline and 1month post-extraction measurements) was 10.3m/day and during the second term (between 1 and 3months) was 5.4m/day. ConclusionsThe mesio-distal gap reduction is higher during the first month following the extraction and continues in time, but to a lesser extent. When the inter-dental contacts were absent, the mesio-distal gap reduction is lower. When a molar tooth is extracted or the distal tooth to the edentulous space does not occlude with an antagonist, the mesio-distal gap reduction is larger. The consideration of mesio-distal gap dimension changes can help improve dental treatment planning.The authors would like to express their gratitude to MEC (contract grant number AP2008-01653), to FEDER, to the Generalitat Valenciana for its help in the CLSM acquisition (MY08/ISIRM/S/100), to the Universitat Politecnica de Valencia (PAID-05-12) and to Dr. Asuncion Jaime for her translation assistance.García-Herraiz, A.; Silvestre, FJ.; Leiva García, R.; Crespo Abril, F.; Garcia-Anton, J. (2017). Post-extraction mesio-distal gap reduction assessment by confocal laser scanning microscopy - a clinical 3-month follow-up study. Journal Of Clinical Periodontology. 44(5):548-555. https://doi.org/10.1111/jcpe.12706S548555445Aguilar, M. L., Elias, A., Vizcarrondo, C. E. T., & Psoter, W. J. (2010). Analysis of three-dimensional distortion of two impression materials in the transfer of dental implants. The Journal of Prosthetic Dentistry, 103(4), 202-209. doi:10.1016/s0022-3913(10)60032-7Amit, G., JPS, K., Pankaj, B., Suchinder, S., & Parul, B. (2012). Periodontally accelerated osteogenic orthodontics (PAOO) - a review. Journal of Clinical and Experimental Dentistry, e292-296. doi:10.4317/jced.50822Armitage, G. C. (1999). Development of a Classification System for Periodontal Diseases and Conditions. Annals of Periodontology, 4(1), 1-6. doi:10.1902/annals.1999.4.1.1Belli, R., Pelka, M., Petschelt, A., & Lohbauer, U. (2009). In vitro wear gap formation of self-adhesive resin cements: A CLSM evaluation. Journal of Dentistry, 37(12), 984-993. doi:10.1016/j.jdent.2009.08.006Belli, R., Rahiotis, C., Schubert, E. W., Baratieri, L. N., Petschelt, A., & Lohbauer, U. (2011). Wear and morphology of infiltrated white spot lesions. Journal of Dentistry, 39(5), 376-385. doi:10.1016/j.jdent.2011.02.009Brauchli, L. M., Baumgartner, E.-M., Ball, J., & Wichelhaus, A. (2011). Roughness of enamel surfaces after different bonding and debonding procedures. Journal of Orofacial Orthopedics / Fortschritte der Kieferorthopädie, 72(1), 61-67. doi:10.1007/s00056-010-0002-3Chen, S. Y., Liang, W. M., & Chen, F. N. (2004). Factors affecting the accuracy of elastometric impression materials. Journal of Dentistry, 32(8), 603-609. doi:10.1016/j.jdent.2004.04.002Christou, P., & Kiliaridis, S. (2007). Three-dimensional changes in the position of unopposed molars in adults. The European Journal of Orthodontics, 29(6), 543-549. doi:10.1093/ejo/cjm036Craddock, H. L., Youngson, C. C., Manogue, M., & Blance, A. (2007). Occlusal Changes Following Posterior Tooth Loss in Adults. Part 2. Clinical Parameters Associated with Movement of Teeth Adjacent to the Site of Posterior Tooth Loss. Journal of Prosthodontics, 16(6), 495-501. doi:10.1111/j.1532-849x.2007.00223.xFaria, A. C. L., Rodrigues, R. C. S., Macedo, A. P., Mattos, M. da G. C. de, & Ribeiro, R. F. (2008). Accuracy of stone casts obtained by different impression materials. Brazilian Oral Research, 22(4), 293-298. doi:10.1590/s1806-83242008000400002García-Herraiz, A., Leiva-García, R., Cañigral-Ortiz, A., Silvestre, F. J., & García-Antón, J. (2011). Confocal laser scanning microscopy for the study of the morphological changes of the postextraction sites. Microscopy Research and Technique, 75(4), 513-519. doi:10.1002/jemt.21085Gragg, K. L., Shugars, D. A., Bader, J. D., Elter, J. R., & White, B. A. (2001). Movement of Teeth Adjacent to Posterior Bounded Edentulous Spaces. Journal of Dental Research, 80(11), 2021-2024. doi:10.1177/00220345010800111401LINDSKOG-STOKLAND, B., HANSEN, K., TOMASI, C., HAKEBERG, M., & WENNSTRÖM, J. L. (2011). Changes in molar position associated with missing opposed and/or adjacent tooth: a 12-year study in women. Journal of Oral Rehabilitation, 39(2), 136-143. doi:10.1111/j.1365-2842.2011.02252.xLove, W. D., & Adams, R. L. (1971). Tooth movement into edentulous areas. The Journal of Prosthetic Dentistry, 25(3), 271-278. doi:10.1016/0022-3913(71)90188-0Nishikawa, T., Masuno, K., Mori, M., Tajime, Y., Kakudo, K., & Tanaka, A. (2006). Calcification at the Interface Between Titanium Implants and Bone: Observation With Confocal Laser Scanning Microscopy. Journal of Oral Implantology, 32(5), 211-217. doi:10.1563/799.1Pereira, J. R., Murata, K. Y., Valle, A. L. do, Ghizoni, J. S., & Shiratori, F. K. (2010). Linear dimensional changes in plaster die models using different elastomeric materials. Brazilian Oral Research, 24(3), 336-341. doi:10.1590/s1806-83242010000300013Schilling, T., Müller, M., Minne, H. W., & Ziegler, R. (1998). Influence of Inflammation-Mediated Osteopenia on the Regional Acceleratory Phenomenon and the Systemic Acceleratory Phenomenon During Healing of a Bone Defect in the Rat. Calcified Tissue International, 63(2), 160-166. doi:10.1007/s002239900508Scivetti, M., Pilolli, G. P., Corsalini, M., Lucchese, A., & Favia, G. (2007). Confocal laser scanning microscopy of human cementocytes: Analysis of three-dimensional image reconstruction. Annals of Anatomy - Anatomischer Anzeiger, 189(2), 169-174. doi:10.1016/j.aanat.2006.09.009SHUGARS, D. A., BADER, J. D., PHILLIPS, S. W., WHITE, B. A., & BRANTLEY, C. F. (2000). THE CONSEQUENCES OF NOT REPLACING A MISSING POSTERIOR TOOTH. The Journal of the American Dental Association, 131(9), 1317-1323. doi:10.14219/jada.archive.2000.0385Thalmair, T., Fickl, S., Schneider, D., Hinze, M., & Wachtel, H. (2013). Dimensional alterations of extraction sites after different alveolar ridge preservation techniques - a volumetric study. Journal of Clinical Periodontology, 40(7), 721-727. doi:10.1111/jcpe.12111Thongthammachat, S., Moore, B. K., Barco, M. T., Hovijitra, S., Brown, D. T., & Andres, C. J. (2002). Dimensional accuracy of dental casts: Influence of tray material, impression material, and time. Journal of Prosthodontics, 11(2), 98-108. doi:10.1053/jopr.2002.125192Van der Weijden, F., Dell’Acqua, F., & Slot, D. E. (2009). Alveolar bone dimensional changes of post-extraction sockets in humans: a systematic review. Journal of Clinical Periodontology, 36(12), 1048-1058. doi:10.1111/j.1600-051x.2009.01482.xWeinstein, S. (1967). Minimal forces in tooth movement. American Journal of Orthodontics, 53(12), 881-903. doi:10.1016/0002-9416(67)90163-7Windisch, S. I., Jung, R. E., Sailer, I., Studer, S. P., Ender, A., & Hämmerle, C. H. F. (2007). A new optical method to evaluate three-dimensional volume changes of alveolar contours: a methodological in vitro study. 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Genetic diversity and relationships in local varieties of eggplant from different cultivar groups as assessed by genomic SSR markers

[EN] Spain is a secondary center of diversity for eggplant (Solanum melongena). Spanish landraces of eggplant are normally classified in four cultivar groups: Round, Listada de Gandía, Semi-Long, and Long. We have used 19 genomic SSRs for the molecular characterization of 30 eggplant accessions corresponding to the four cultivar groups. Sixteen SSRs of which 15 were polymorphic could be amplified and 65 polymorphic alleles, with a range of two to 11 alleles/locus, were detected. The polymorphism information content (PIC) of SSR markers ranged from 0.07 to 0.77, with an average value of PIC=0.50. The mean observed heterozygosity (Ho) presented a very low value Ho=0.01, while the mean expected heterozygosity (He) had a value of He=0.57. Multivariate cluster analyses revealed that a considerable diversity exists within each of the cultivar groups. Listada de Gandía and Long cultivar groups were clearly separated from each other in different branches of phenogram. The principal coordinates analysis (PCoA) confirmed that each of the cultivar groups is genetically diverse and, with the exception of the Round group, they plot in different areas of the PCoA graph. Overall, the results indicate that Spanish eggplant landraces present a high degree of homozygosis, considerable intra-cultivar group diversity, and a certain degree of genetic differentiation. This information is of interest for selection and breeding of eggplant as well as for germplasm conservation.This research has been partially funded by Ministerio de Economía y Competitividad and FEDER (grant AGL2012-34213) and by Universitat Politècnica de Valencia (grants SP20120681 and PAID-06-11 Nr. 2082).Vilanova Navarro, S.; Hurtado Ricart, M.; Cardona, A.; Plazas Ávila, MDLO.; Gramazio, P.; Herraiz García, FJ.; Andújar Pérez, I.... (2014). Genetic diversity and relationships in local varieties of eggplant from different cultivar groups as assessed by genomic SSR markers. Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 42(1):59-65. https://doi.org/10.15835/nbha4219414S596542

Working Group for the Bay of Biscay and the Iberian Waters Ecoregion (ICES WGBIE) (2-9 May 2109)

The ICES Working Group for the Bay of Biscay and the Iberian Waters Ecoregion (WGBIE) assesses the status of 23 stocks distributed from ICES Divisions 3.a–4.a though to Subarea 9, mostly distributed in Subareas 7, 8 and 9. The group was tasked with conducting assessments of stock status for 23 stocks using analytical, forecast methods or trends indicators to provide catch forecasts and a first draft of the ICES advice for 2019. For two of the Nephrops stocks updates were provided on catch data with the advice release delayed until October after the completion of the surveys used for the assessment. Analytical assessments using age-structured models were conducted for the northern stock of white anglerfish, the northern and southern stocks of megrim, four-spot megrim and sole in the Bay of Biscay. The two hake stocks and one southern stock of anglerfish were assessed using models that allow the use of length-structured data (no age data). A surplus-production model, without age or length structure, was used to assess the second southern stock of anglerfish and an age-length structure model was used for the European seabass in the Bay of Biscay. The state of stocks for which no analytical assessment could be performed was inferred from examination of catch, commercial LPUE or CPUE data and from survey information, where available. The northern stock of hake was benchmarked this year to incorporate discards into the model that were previously omitted. New reference points with the accepted benchmark assessment were proposed by the group and new proxy biomass reference points where proposed for black anglerfish in Division’s 7b-k, 8abd. A recurrent issue significantly constrained the group’s ability to fully address the terms of reference this year. Despite an ICES data call with a deadline of six weeks before the meeting, data for most stocks were submitted to ICES only two days before the start of the meeting and in one case 2 days after the meeting commenced. This delayed the process of having the data quality checked and the assessment completed before the start of the working group. This is an important matter of concerns for the working group members. The structure of the report is set out with section 1 presenting a summary of each stock, discussing general issues and conclusions. Section 2 provides descriptions of the relevant fishing fleets and surveys used in the assessment of the stocks. Sections 3–18 contains the single stock assessments

One-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvención con DIeta MEDiterránea-Plus (PREDIMED-Plus) trial

Choline and betaine intakes have been related to cardiovascular health. We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial. We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m 2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of choline and betaine were estimated from the FFQ. The greatest 1-y increase in dietary choline or betaine intake (quartile 4) was associated with improved serum glucose concentrations (−3.39 and −2.72 mg/dL for choline and betaine, respectively) and HbA1c levels (−0.10% for quartile 4 of either choline or betaine intake increase). Other significant changes associated with the greatest increase in choline or betaine intake were reduced body weight (−2.93 and −2.78 kg, respectively), BMI (−1.05 and −0.99, respectively), waist circumference (−3.37 and −3.26 cm, respectively), total cholesterol (−4.74 and −4.52 mg/dL, respectively), and LDL cholesterol (−4.30 and −4.16 mg/dL, respectively). Urine creatinine was reduced in quartile 4 of 1-y increase in choline or betaine intake (−5.42 and −5.74 mg/dL, respectively). Increases in dietary choline or betaine intakes were longitudinally related to improvements in cardiometabolic parameters. Markers of renal function were also slightly improved, and they require further investigation. This trial was registered at as ISRCTN89898870