The Public Repository of Xenografts enables discovery and randomized phase II-like trials in mice

More than 90% of drugs with preclinical activity fail in human trials, largely due to insufficient efficacy. We hypothesized that adequately powered trials of patient-derived xenografts (PDX) in mice could efficiently define therapeutic activity across heterogeneous tumors. To address this hypothesis, we established a large, publicly available repository of well-characterized leukemia and lymphoma PDXs that undergo orthotopic engraftment, called the Public Repository of Xenografts (PRoXe). PRoXe includes all de-identified information relevant to the primary specimens and the PDXs derived from them. Using this repository, we demonstrate that large studies of acute leukemia PDXs that mimic human randomized clinical trials can characterize drug efficacy and generate transcriptional, functional, and proteomic biomarkers in both treatment-naive and relapsed/refractory disease

High-temperature Pressure Broadening of Water: Experimental Evidence for Negative Temperature Exponents

Fourier transform spectra of H2O-air mixtures have been measured at 296, 742, and 980 K for total pressures of 0.5 and 1.0 atm with a H2O VMR of 0.5% in the Þ2 band (range 1550-2300 cm-1) at a spectral resolution of 0.01 cm-1. These measurements were initially carried out in the frame of two EC projects aiming at a spectroscopic database for non-intrusive aircraft exhaust measurement. A special cell for high temperatures, good temperature homogeneity, 16 cm absorption path, equipped for continuous gas flow, has been developed to be operated stand-alone and inside the evacuated sample compartment of the Bruker IFS 120 HR FT spectrometer. Thermal emission compensation and proper transmittance calculation required high resolution sample and reference spectra for the IR source switched on and off. Temperatures were deduced from CO line intensity measurements. Line positions, linestrengths and Lorentzian halfwidths have been retrieved from the spectra. For the following analysis only air-broadening for the doublet lines with Kc=J is considered. From these data and previous experimental determinations, line-broadening parameters ×(T) are obtained at all three temperatures for the doublet lines from J=0 up to J=16. These values are then used to deduce the temperature dependence exponent n, such that . The values of n obtained using the two elevated temperatures are consistent and show that line widths decrease with T for small J values (n l +0.8), are almost temperature independent on T for Jl10, and increase with T for high J lines (n l -0.3 for Jl15). This original result, which confirms theoretical predictions made about fifteen years ago with a semi-classical approach [J Chem Phys 1987;86:144-56], is analyzed here using an improved version of the model

Collisional parameters of H2O lines: effect of temperature

High resolution Fourier transform spectra of H2O-air mixtures have been measured at 296, 742, and 980 K for total pressures of 0.5 and 1.0 atm in the region of the Þ2 band. From these recordings, air-broadening coefficients have been determined for the doublet lines with Kc=J. From these data and previous experimental determinations, line-broadening parameters ×(T) are obtained at all three temperatures for the doublet lines from J=0 up to J=16. These values are then used to deduce the temperature dependence exponent n, such that . The values of n obtained using the two elevated temperatures are consistent and show that line widths decrease with T for small J values (n l +0.8), are almost temperature independent on T for Jl10, and increase with T for high J lines (n l -0.3 for Jl15). This original result, which confirms theoretical predictions made about fifteen years ago with a semi-classical approach [J Chem Phys 1987;86:144-56], is analyzed here using an improved version of the model. Comparisons between measured and computed widths show that calculations cannot reproduce correctly the experimental results at all temperatures simultaneously. This failure is attributed to the use of an inappropriate interaction potential and to the very strong dependence of the broadening ×(v) on the relative velocity v for high J lines. This strong variation of ×(v) raises the question, which is discussed, of what calculated quantity is to be compared with measured values (i.e. , (T), or some other more complex mean to account for the velocity averaging of the spectral profile itself?). Nevertheless, when the temperature exponent n is considered, satisfactory agreement between experiments and predictions is obtained, particularly when the averaging of widths over the relative velocity distribution is made

A spectroscopic database for water vapor between 5850 and 8340cm−1

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Line positions and absolute intensities in the laser bands of carbon-12 oxygen-17 isotopic species of carbon dioxide

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Laboratory measurements and calculations of line shape parameters of the H2O-CO2 collision system

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The CO 2 absorption continuum by high pressure CRDS in the 1.74 µm window

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Evaluation of different parameterizations of temperature dependences of the line-shape parameters based on ab initio calculations: Case study for the HITRAN database

International audienceTemperature dependences of molecular line-shape parameters are important for the spectroscopic studies of the atmospheres of the Earth and other planets. A number of analytical functions have been proposed as candidates that may approximate the actual temperature dependences of the line-shape parameters. In this article, we use our ab initio collisional line-shape calculations for several molecular systems to compare the four temperature ranges (4TR) representation, adopted in the HITRAN database [J. Quant. Spectrosc. Radiat. Transfer 2017;203:3] in 2016, with the double-power-law (DPL) representation. Besides the collisional broadening and shift parameters, we consider also the most important line-shape parameters beyond Voigt, i.e., the speed dependence of broadening and shift parameters, and real and imaginary parts of the complex Dicke parameter. We demonstrate that DPL gives better overall approximation of the temperature dependencies than 4TR. It should be emphasized that DPL requires fewer parameters and its structure is much simpler and more self-consistent than the structure of 4TR. We recommend the usage of DPL representation in HITRAN, and present DPL parametrization for Voigt and beyond-Voigt line profiles that will be adopted in the HITRAN database. We also discuss the problem of the Hartmann-Tran profile parametrization in which the correlation parameter, η, and frequency of the velocity-changing collisions parameter, ν vc , diverges to infinity when collisional shift crosses zero; we recommend a simple solution for this problem

Methane line parameters in HITRAN

International audienceTwo editions of the methane line parameters (line positions, intensities and broadening coefficients) available from HITRAN in 2000 and 2001 are described. In both versions, the spectral interval covered was the same (from 0.01 to 6184.5 cm−1), but the database increased from 48,033 transitions in 2000 to 211,465 lines in 2001 because weaker transitions of 12CH4 and newbands of 13CH4 and CH3D were included. The newer list became available in 2001 in the “Update” section of HITRAN. The sources of information are described, and the prospects for future improvements are discussed