Ablación mediante radiofrecuencia versus microondas en el tratamiento de tumores renales de pequeño tamaño (T1a ≤4cm)

La termoablación tumoral es la aplicación local de temperaturas extremas, ya sean altas o bajas, para provocar daño celular irreversible y en última instancia, la apoptosis tumoral y la necrosis coagulativa. Esta tecnología se ha desarrollado rápidamente en la década de 1990, con el uso de pruebas de imagen que hicieron posible que procedimientos percutáneos fueran guiados . La termoablación ofrece varias ventajas sobre la resección quirúrgica. OBJETIVOS: Hipótesis En la termoablación percutánea en el tratamiento de tumores renales T1a (≤4 cm) se obtienen mayores tasas de ablación completa mediante MW que mediante RF. Objetivo principal Valorar el éxito del tratamiento (Tasa de ablación completa de la lesión tumoral) que obtenemos mediante ablación percutánea mediante RF y/o MW, en el tratamiento de tumores renales T1a ≤4 cm). DISEÑO DEL ESTUDIO: Observacional prospectivo de cohortes de pacientes desde el año 2012 al 2016 en el que se incluyeron 173 tumores renales, presentes en 117 pacientes. rmedad aguda, como por ejemplo sepsis (Venkatesan AM et al).Departamento de Biología Celular, Histología y FarmacologíaDoctorado en Investigación en Ciencias de la Salu

Reforzando contenidos desde el aula virtual extendida

La puesta en práctica de Cuestionarios para Auto-Evaluación (CAE), utilizando la actividad Cuestionario que provee la plataforma “moodle” sobre temas en los cuales con frecuencia había estudiantes que evidenciaban dificultades, permitió demostrar la efectividad del los CAE para corregir esos problemas. En este trabajo queremos mostrar una experiencia que hicimos en la asignatura “Diseño Asistido”, donde el propósito de este trabajo fue incrementar de manera significativa el porcentaje de aprobados en las pruebas parciales y contribuir a evitar la deserción de los estudiantes al mejorar el aprendizaje sobre temas en la asignatura donde muchos estudiantes evidenciaban tener dificultades al dar respuestas incorrectas en las evaluaciones. Se especuló entonces que podrían obtenerse resultados mejores si se dedicaba un espacio para Auto- Evaluación, dentro del Aula Virtual Extendida de la asignatura, donde el estudiante encontrase un refuerzo para los contenidos impartidos en clase, a lo largo de todo el cursado de la asignatura. En tal sentido se consideró de gran importancia la inclusión de imágenes en los cuestionarios, de modo que permitieran fortalecer el proceso de aprendizaje. Los resultados, por haber instrumentado los cuestionarios, fueron satisfactorios ya que brindó el refuerzo esperado sobre los contenidos impartidos en clase, evidenciado por los últimos resultados en contraste con los resultados anteriores a la creación de los cuestionarios. Posteriormente, en entrevista con algunos estudiantes se pudo conocer que hubo buena aceptación por los cuestionarios de auto-evaluación ofrecidos.The implementation of Questionnaires for Self-Assessment (QSA), using the activity Questionnaire provided by the "moodle" platform on subjects in which there were often students who showed difficulties, allowed demonstrating the effectiveness of QSA to correct these problems. The results, for having instrumented the questionnaires, were satisfactory since they provided the expected reinforcement on the contents taught in class, evidenced by the last results in contrast with the results previous to the creation of the questionnaires. Later, in an interview with some students it was learned that there was good acceptance by the selfassessment questionnaires offered.Facultad de Arquitectura y Urbanism

Anticipando correcciones desde el aula virtual extendida

The objective of this work was to be able to make the returns, of the Practical Works (PWs) made by the students, before the presentation of their works printed on paper. From this change, and from the first delivery of their finished digital works, and with the use of the Extended Virtual Classroom, it was possible to provide the student with the status of each of their works and allow corrections of them, before the presentation printed on paper.El objetivo de este trabajo fue poder realizar las devoluciones, de los Trabajos Prácticos (TPs) efectuados por los estudiantes, antes de la presentación de sus trabajos impresos en papel. A partir de este cambio, ya desde la primera entrega de sus trabajos digitales terminados, y con el empleo del Aula Virtual Extendida, fue posible brindar al estudiante el estado de cada uno de sus trabajos y permitir las correcciones de los mismos, antes de la presentación impresa en papel. En este Trabajo planteamos una experiencia que llevamos a cabo en la materia Diseño Asistido con el fin de potenciar el proceso de enseñanza aprendizaje. Utilizando la opción de “calificaciones”, de las tareas del aula virtual, se comunican los estados de los Trabajos Prácticos para hacer una devolución inmediata. Esto se logra realizando la corrección mediante la generación de imágenes donde se distinguen los errores. Estas imágenes se depositan en el Aula Virtual para cada estudiante de manera que puede observar las correcciones indicadas a su propio trabajo accediendo desde sus móviles y efectuar dichas correcciones. Con esta experiencia logramos brindar una mejor atención a los estudiantes, eliminando los tiempos inactivos del laboratorio, ya que hasta ahora se brindaba la devolución después de la primera entrega de la carpeta de TPs en papel impreso, que es cuando se imparte el tema sobre Impresiones. Adicionalmente se evitaron las congestiones ocurridas cuando se acercaban la fechas de presentación, un mejor seguimiento de las tareas de los estudiantes, obtener una retroalimentación para actuar reforzando determinados conceptos y una mayor comunicación con los estudiantes interactuando a través del Aula Virtual.Facultad de Arquitectura y Urbanism

Visualizing the Intellectual Structure and Evolution of Intelligent Transportation Systems: A Systematic Analysis of Research Themes and Trends

ording to the "i"United Nations"/i", 70% of the world’s population will live in cities by 2050. This growth will be reflected in the demand for better services that should be adjusted to the collective and individual needs of the population. Governments and organizations are working on defining and implementing strategies that will enable them to respond to these challenges. The main challenges are related to transport and its management, considering transportation as a core issue in the economy, sustainability, and development of the regions. In this way, the Intelligent Transportation Systems (ITS) play a key role in the response to these scenarios, being that they are the framework where the new hardware and software tools are integrated, allowing an efficient development of transportation systems management, attending to aspects such as: traffic management, communications between vehicles and infrastructures, and security, among others. Nevertheless, the concept of ITS evolves rapidly so it is necessary to understand its evolution. To do that, the current research develops a thematic analysis of ITS in literature, evaluating the intellectual structure and its evolution using "i"SciMAT"/i", quantifying the main bibliometric performance indicators, and identifying the main research areas, authors, journals, and countries. To this purpose, the publications related to ITS from 1993 to 2019 available in the "i"Web of Science (WoS) Core Collection"/i" were retrieved (7649 publications) and analyzed. Finally, one of the main results is the latest research themes map of ITS, considering its intellectual structure, evolution, and relationship. It assists in the definition and implementation of strategies, the identification of the scientific, academic, and business opportunities, and future research lines to consolidate the role of ITS in the new city models. Document type: Articl

Detection of aedes aegypti mosquitoes infected with dengue virus as a complementary method for increasing the sensitivity of surveillance: identification of serotypes 1, 2, and 4 by rt-pcr in Quintana Roo, Mexico

Abstract. Sensitivity of monitoring Aedes aegypti (L.) populations was determined to identify the distribution of dengue virus (DENV) during epidemics in Quintana Roo. From September to November 2012, we used a motorized aspirator to collect 2,144 female Ae. aegypti from 569 homes. These were grouped into 220 to use semi-nested RT-PCR for DENV, and positive groups were analyzed individually. Five groups (2.27%) were positive for DENV. Individual analysis yielded eight groups that tested positive, six with DENV-2, one DENV-1, and one DENV-4. The latter was not reported by the surveillance system that year. The mean number of female mosquitoes per household was 3.77 ± 5.71, and the rate of viral infection of Ae. aegypti was 0.4%. Most infected mosquitoes (49%) were concentrated in 10% of the houses. Monitoring Ae. aegypti infected with DENV has the potential to complement the current system of clinical and entomological surveillance

Brain atrophy and the risk of futile endovascular reperfusion in acute ischemic stroke

[Background and Purpose]: We aimed to evaluate the impact of brain atrophy on long-term clinical outcome in patients with acute ischemic stroke treated with endovascular therapy, and more specifically, to test whether there are interactions between the degree of atrophy and infarct volume, and between atrophy and age, in determining the risk of futile reperfusion.[Methods]: We studied consecutive patients with acute ischemic stroke with proximal anterior circulation intracranial arterial occlusions treated with endovascular therapy achieving successful arterial recanalization. Brain atrophy was evaluated on baseline computed tomography with the global cortical atrophy scale, and Evans index was calculated to assess subcortical atrophy. Infarct volume was assessed on control computed tomography at 24 hours using the formula for irregular volumes (A×B×C/2). Main outcome variable was futile recanalization, defined by functional dependence (modified Rankin Scale score >2) at 3 months. The predefined interactions of atrophy with age and infarct volume were studied in regression models.[Results]: From 361 consecutive patients with anterior circulation acute ischemic stroke treated with endovascular therapy, 295 met all inclusion criteria. Futile reperfusion was observed in 144 out of 295 (48.8%) patients. Cortical atrophy affecting parieto-occipital and temporal regions was associated with futile recanalization. Total global cortical atrophy score and Evans index were independently associated with futile recanalization in an adjusted logistic regression. Multivariable adjusted regression models disclosed significant interactions between global cortical atrophy score and infarct volume (odds ratio, 1.003 [95%CI, 1.002–1.004], P<0.001) and between global cortical atrophy score and age (odds ratio, 1.001 [95% CI, 1.001–1.002], P<0.001) in determining the risk of futile reperfusion.[Conclusions]: A higher degree of cortical and subcortical brain atrophy is associated with futile endovascular reperfusion in anterior circulation acute ischemic stroke. The impact of brain atrophy on insufficient clinical recovery after endovascular reperfusion appears to be independently amplified by age and by infarct volume.This study has been partially funded by the Spanish Ministry of Science, via FIS projects PI13/02544 and PI16/01396, and through the INVICTUS PLUS research network RD16/0019.Peer reviewe

Fire and brief human occupations in Iberia during MIS 4: Evidence from Abric del Pastor (Alcoy, Spain)

There is a relatively low amount of Middle Paleolithic sites in Europe dating to MIS 4. Of the few that exist, several of them lack evidence for anthropogenic fire, raising the question of how this period of global cooling may have affected the Neanderthal population. The Iberian Peninsula is a key area to explore this issue, as it has been considered as a glacial refugium during critical periods of the Neanderthal timeline and might therefore yield archaeological contexts in which we can explore possible changes in the behaviour and settlement patterns of Neanderthal groups during MIS 4. Here we report recent data from Abric del Pastor, a small rock shelter in Alcoy (Alicante, Spain) with a stratified deposit containing Middle Palaeolithic remains. We present absolute dates that frame the sequence within MIS 4 and multi-proxy geoarchaeological evidence of in situ anthropogenic fire, including microscopic evidence of in situ combustion residues and thermally altered sediment. We also present archaeostratigraphic evidence of recurrent, functionally diverse, brief human occupation of the rock shelter. Our results suggest that Neanderthals occupied the Central Mediterranean coast of the Iberian Peninsula during MIS 4, that these Neanderthals were not undergoing climatic stress and they were habitual fire users.This research was funded by a Leakey Foundation General Grant, Spanish Ministry of Science, Innovation and Universities Projects HAR2008-06117/HIST and HAR2015-68321-P, Junta de Castilla y León-FEDER Project BU235P18, the LabEx Sciences Archéologiques de Bordeaux (LaScArBx ANR-10-LABX-52) and ERC Consolidator Grant ERC-CoG-2014. Archaeological excavations at Abric del Pastor are supported by the Archaeological Museum of Alcoy and the Government of Valencia Cultural Heritage Department

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Association between Adherence to the Mediterranean Diet and Anthropometric and Health Variables in College-Aged Males

The present study aimed to verify the association between adherence to the Mediterranean diet (MD) and anthropometric and health variables. Four-hundred-and-ninety-five college-aged males aged 18&ndash;25 participated in this cross-sectional research. The KIMED (Mediterranean Diet Quality Index for children and adolescents) was used to assess the adherence to MD. The following variables were also assessed: body mass (BM), height (HE), body mass index (BMI), body fat percentage (%FAT), lean mass (LEAN), abdominal girth (AG), waist-to-hip ratio (WHR), oxygen saturation (SPO2), systolic blood pressure (SBP), diastolic blood pressure (DBP), double product (DP), and fasting blood glucose (GLU). The results showed that adherence to MD presented a strong negative correlation with most of the anthropometric parameters (BM: r = &minus;0.571; BMI: r = &minus;0.614; %FAT: r = &minus;0.558; and AG: r = &minus;0.564), a moderate or weak correlation with most of the health variables (GLU: r = &minus;0.407; SBP: r = &minus;0.238; DBP: r = &minus;0.217, and DP: r = &minus;0.265) and LEAN (r = &minus;0.497), and a very weak correlation with WHR (r = &minus;0.090). Many anthropometric parameters (BM, BMI, %FAT, LEAN, AG, WHR) present significant correlations with health variables (SBP, DBP, DP, and GLU). We conclude that greater adherence to Mediterranean diet is associated with healthier values of the selected anthropometric and health parameters. Since most of the anthropometric and health parameters present significant correlations among themselves, this finding could be useful in medical diagnosis, health monitoring, and risk detection. Based on the level of adherence to Mediterranean diet and the KIDMED found in the present study, and considering the prevalence of obesity in the Middle East, it is imperative to implement nutritional interventions with the target population of this research to prevent nutrition-related diseases and promote public health

The Post-Activation Potentiation Effects on Sprinting Abilities in Junior Tennis Players

Objective: This study aimed to compare the acute effects of a full squat (SQ) or hip thrust (HT) with two different loading intensities (60% and 85% 1 RM) on sprint ability in junior male tennis players. Methods: Nineteen tennis players were included in this research. They underwent four different experimental conditions: HT at 60% 1 RM, HT at 85% 1 RM, SQ at 60% 1 RM, or SQ at 85%. The force&ndash;velocity (F&ndash;V) profile was used to assess tennis players&rsquo; sprint acceleration ability before and after applying the conditioning stimulus. The variables registered were as follows: 5 m test (5 m), 10 m test (10 m), maximum theoretical force (F0), maximum power (Pmax), and the maximal ratio of horizontal-to-resultant force (RFpeak). Results: Significant improvements in 5 m, Pmax, and RFpeak were observed when the conditioning stimulus was performing one set of seven reps of HT at 60% 1 RM. When the activation protocol was one set of seven reps of SQ at 60% 1 RM, significant improvements in 5 m, 10 m, F0, Pmax (N), and RFpeak were detected. Additionally, performing one set of three reps of SQ at 85% 1 RM as an activation protocol provided significant improvements in F0. Conclusion: The use of HT and SQ with a load of 60% 1 RM improved the sprint F&ndash;V profile components related to the acceleration phase of the sprint in junior tennis players. Using intensity loads of 85% 1 RM is not adequate to increase acute sprint performance in this population. HT presents a higher transferability to sprinting in the first 5 m of sprinting, whereas SQ provides acute improvements in different sprinting phases