911 research outputs found
GePEToS : A Geant4 Monte Carlo simulation package for Positron Emission Tomography
GePEToS is a simulation framework developed over the last few years for
assessing the instrumental performance of future PET scanners. It is based on
Geant4, written in Object-Oriented C++ and runs on Linux platforms. The
validity of GePEToS has been tested on the well-known Siemens ECAT EXACT HR+
camera. The results of two application examples are presented : the design
optimization of a liquid Xe micro-PET camera dedicated to small animal imaging
as well as the evaluation of the effect of a strong axial magnetic field on the
image resolution of a Concorde P4 micro-PET camera.Comment: 5 pages, 12 figures, submitted to IEEE Transactions on Nuclear
Scienc
Experimental study of a liquid Xenon PET prototype module
A detector using liquid Xenon in the scintillation mode is studied for
Positron Emission Tomography (PET). The specific design aims at taking full
advantage of the liquid Xenon properties. It does feature a promising
insensitive to any parallax effect. This work reports on the performances of
the first LXe prototype module, equipped with a position sensitive PMT
operating in the VUV range (178 nm).Comment: Proc. of the 7th International Workshops on Radiation Imaging
Detectors (IWORID-7), Grenoble, France 4-7 July 200
Experimental results and first 22Na source image reconstruction by two prototype modules in coincidence of a liquid xenon positron emission tomograph for small animal imaging
International audienceA detector with a very specific design using liquid Xenon (LXe) in the scintillation mode is studied for Positron Emission Tomography (PET) of small animals. Two prototype modules equipped with Position Sensitive Photo Multiplier Tubes (PSPMTs) operating in the VUV range (178 nm) and at 165 K were built and studied in coincidence. This paper reports on energy, time and spatial resolution capabilities of this experimental test bench. Furthermore, these experimental results were used to perform the first image reconstruction of a 22Na source placed in the experimental setup
A liquid Xenon Positron Emission Tomograph for small animal imaging : first experimental results of a prototype cell
A detector using liquid Xenon (LXe) in the scintillation mode is studied for
Positron Emission Tomography (PET) of small animals. Its specific design aims
at taking full advantage of the Liquid Xenon scintillation properties. This
paper reports on energy, time and spatial resolution capabilities of the first
LXe prototype module equipped with a Position Sensitive Photo- Multiplier tube
(PSPMT) operating in the VUV range (178 nm) and at 165 K. The experimental
results show that such a LXe PET configuration might be a promising solution
insensitive to any parallax effect.Comment: 34 pages, 18 pages, to appear in NIM
NIKEL: Electronics and data acquisition for kilopixels kinetic inductance camera
A prototype of digital frequency multiplexing electronics allowing the real
time monitoring of microwave kinetic inductance detector (MKIDs) arrays for
mm-wave astronomy has been developed. Thanks to the frequency multiplexing, it
can monitor simultaneously 400 pixels over a 500 MHz bandwidth and requires
only two coaxial cables for instrumenting such a large array. The chosen
solution and the performances achieved are presented in this paper.Comment: 21 pages, 14 figure
A very low power and low signal 5 bit 50 M samples/s double sampling pipelined ADC for Monolithic Active Pixel Sensors in high energy physics and biomedical imaging applications
International audienc
Critical values for Lawshe's content validity ratio: revisiting the original methods of calculation
YesThe content validity ratio originally proposed by Lawshe is widely used to quantify content validity and yet methods used to calculate the original critical values were never reported. Methods for original calculation of critical values are suggested along with tables of exact binomial probabilities
Redundancy or GaAs? Two different approaches to solve the problem of SEU (Single Event Upset) in a digital optical link
Neutrophil activation in systemic capillary leak syndrome (Clarkson disease)
Systemic capillary leak syndrome (SCLS; Clarkson disease) is a rare orphan disorder characterized by transient yet recurrent episodes of hypotension and peripheral oedema due to diffuse vascular leakage of fluids and proteins into soft tissues. Humoral mediators, cellular responses and genetic features accounting for the clinical phenotype of SCLS are virtually unknown. Here, we searched for factors altered in acute SCLS plasma relative to matched convalescent samples using multiplexed aptamerâbased proteomic screening. Relative amounts of 612 proteins were changed greater than twofold and 81 proteins were changed at least threefold. Among the most enriched proteins in acute SCLS plasma were neutrophil granule components including bactericidal permeability inducing protein, myeloperoxidase and matrix metalloproteinase 8. Neutrophils isolated from blood of subjects with SCLS or healthy controls responded similarly to routine proâinflammatory mediators. However, acute SCLS sera activated neutrophils relative to remission sera. Activated neutrophil supernatants increased permeability of endothelial cells from both controls and SCLS subjects equivalently. Our results suggest systemic neutrophil degranulation during SCLS acute flares, which may contribute to the clinical manifestations of acute vascular leak
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