836 research outputs found
Sarcoptic mange: report of an outbreak in a family and their pet
Indexación: Web of Science; Scielo.La sarna producida por el género Sarcoptes scabiei var canis, infección prevalente en perros y de alto potencial zoonótico, afecta a animales abandonados, desnutridos y hacinados y causa alopecia y una dermatitis costrosa intensamente pruriginosa. En el ser humano produce una dermatitis pruriginosa generalmente autolimitada, pero se describen casos persistentes. Se reporta un brote de sarna sarcóptica en un grupo familiar (siete personas, incluidas una lactante y su madre) cuya fuente de infección fue su mascota canina recogida de la calle. El diagnóstico fue confirmado por visualización en el ácarotest de ácaros y huevos en el perro y ácaros de S. scabiei en la lactante. La sarna sarcóptica debe sospecharse en casos de dermatitis alérgica en personas con contacto con perros. El tratamiento en el humano, habitualmente sintomático, puede necesitar acaricidas si el cuadro persiste. El control de la enfermedad requiere el adecuado tratamiento de la mascota.Scabies caused by the genus Sarcoptes scabiei var canis is a prevalent infection in dogs and affects abandoned, malnourished and overcrowded animals, causing hair loss and an intensely pruritic crusting dermatitis. In humans the manifestation is a self-limiting pruritic dermatitis, but persistent cases are described. An outbreak of sarcoptic mange is reported in a family group (seven people, including a 5 month infant and his mother). The infective source was their own house dog who was taken from the street. The diagnosis was confirmed by the detection of mites and eggs in the acarotest of the dog and mites of S. scabei in the infant. Sarcoptic mange should be suspected in individuals with allergic dermatitis who have contact with dogs. Treatment in humans is usually symptomatic and may need miticides if the infection persists. The control of the disease requires an appropriate pet treatment.http://ref.scielo.org/s2gwz
“manual para el procesamiento de agua de inyección en un campo petrolero”
El presente trabajo trata acerca de resumir las operaciones más comunes realizadas en un campo petrolero para el
análisis de aguas de rio en un proyecto de inyección de aguas. Entre los puntos que destacamos están los problemas mas
comunes en el agua de rio como son la corrosión, la escala, la presencia de gases disueltos, presencia bacterial y los
solidos disueltos.
Además se hizo un pequeño estudio de las pruebas mas comunes antes de una inyección, con datos reales de un pozo del
campo ecuatoriano, entre los puntos analizados tenemos las pruebas de compatibilidad y la prueba de Fall off test. Las
cuales nos dan la máxima tasa de inyección a la cual se podrá someter el pozo inyector, con esta prueba podremos hallar
de igual manera la presión de fractura.
La importancia de realizar estos tipos de análisis son para evitar problemas futuros en las líneas de superficie, en el
fondo del pozo o para la realización de futuras recuperaciones mejoradas con base a la presión de fondo de pozo y su
presión de fractura.
Para la realización del tratamiento del agua se recomienda un orden, el cual mejorara su calidad, los cuales son:
Desbaste
Desarenado
Clarificación
Filtración
Des aeración
Tratamiento Bacteriológico
Tratamiento anticorrosivo
Así mismo para realización de un adecuado tratamiento los parámetros a medir son:
Cationes y aniones
Ph
Bacterias
Solidos Suspendidos
Turbidez
Calidad de Agua
Gases Disueltos
Temperatura
Conductividad
Identification of latexin by a proteomic analysis in rat normal articular cartilage
<p>Abstract</p> <p>Background</p> <p>Osteoarthritis (OA) is characterized by degeneration of articular cartilage. Animal models of OA induced are a widely used tool in the study of the pathogenesis of disease. Several proteomic techniques for selective extraction of proteins have provided protein profiles of chondrocytes and secretory patterns in normal and osteoarthritic cartilage, including the discovery of new and promising biomarkers. In this proteomic analysis to study several proteins from rat normal articular cartilage, two-dimensional electrophoresis and mass spectrometry (MS) were used. Interestingly, latexin (LXN) was found. Using an immunohistochemical technique, it was possible to determine its localization within the chondrocytes from normal and osteoarthritic articular cartilage.</p> <p>Results</p> <p>In this study, 147 proteins were visualized, and 47 proteins were identified by MS. A significant proportion of proteins are involved in metabolic processes and energy (32%), as well as participating in different biological functions including structural organization (19%), signal transduction and molecular signaling (11%), redox homeostasis (9%), transcription and protein synthesis (6%), and transport (6%). The identified proteins were assigned to one or more subcellular compartments.</p> <p>Among the identified proteins, we found some proteins already recognized in other studies such as OA-associated proteins. Interestingly, we identified LXN, an inhibitor of mammalian carboxypeptidases, which had not been described in articular cartilage. Immunolabeling assays for LXN showed a granular distribution pattern in the cytoplasm of most chondrocytes of the middle, deep and calcified zones of normal articular cartilage as well as in subchondral bone. In osteoarthritic cartilage, LXN was observed in superficial and deep zones.</p> <p>Conclusions</p> <p>This study provides the first proteomic analysis of normal articular cartilage of rat. We identified LXN, whose location was demonstrated by immunolabeling in the chondrocytes from the middle, deep and calcified zones of normal articular cartilage, and superficial and deep zones of osteoarthritic cartilage.</p
Mobiliario y vivienda de autoconstrucción
El proyecto propuesto por parte del equipo PAP de Tecnología apropiada para la generación de sistemas constructivos tiene como objetivo principal dar solución a la problemática de la falta de una vivienda digna para Cristina Montoya, habitante de San Andrés de Cohamiata. Se busca mejorar la calidad de vida del usuario y su familia por medio de la adaptación de mobiliario, zonas habitables y áreas de almacenaje tomando en cuenta el contexto en el que se encuentran.
El método de construcción está pensado con un método viable, rentable y factible para el usuario, de manera que sea apto para cualquier persona, de esta forma se planea el uso de un sistema de vigas primaria y secundarias terminadas con tejas para generar la cubierta impermeable, a su vez estas se apoyan sobre muros o columnas dependiendo de la ubicación que tengan, como no se planea realizar algo muy fuera de lo común como cubrir claros muy grandes o diseños que requieren de un material 100% moldeable, será sencilla
la ejecución para llegar al resultado final. Una parte de los muebles tiene un sistema de ensambles sencillos de armar y otra cuenta con un procedimiento de autoconstrucción con tableros y madera. Para que sea posible sus construcción se brindarán instrucciones, planos y especificaciones para evitar confusiones y accidentes.
Los planos del mobiliario serán entregados por medios de un USB, donde contará con especificaciones exactas para que las láminas de Triplay de pino puedan ser cortados en router CNC, con el fin de que las piezas lleguen ya cortadas y listas para armarse por el usuario en la comunidad de San Andrés Cohamiata, a su vez los que corresponden a la estructura se entregarán en formato pdf, para que puedan ser revisados y si es el caso se realice la impresión de los mismos.
La validación del proyecto se realizó a través de modelos digitales hechos en Solidworks y modelos físicos a escala en corte láser, donde se comprobó tanto el ensamblaje y su eficiencia a la hora del armado, como su resistencia, la estructura se modeló con Staad pro, haciendo uso de las cargas que se puedan presentar en el sitio, tanto de servicio, como empuje lateral por medio de un sismo, de esta forma se observó los desplazamientos presentados y se validó la propuesta estructural
PPARGC1A gene promoter methylation as a biomarker of insulin secretion and sensitivity in response to glucose challenges
Methylation in CpG sites of the PPARGC1A gene (encoding PGC1-α) has been associated
with adiposity, insulin secretion/sensitivity indexes and type 2 diabetes. We assessed the association
between the methylation profile of the PPARGC1A gene promoter gene in leukocytes with insulin
secretion/sensitivity indexes in normoglycemic women. A standard oral glucose tolerance test (OGTT)
and an abbreviated version of the intravenous glucose tolerance test (IVGTT) were carried out in
n = 57 Chilean nondiabetic women with measurements of plasma glucose, insulin, and C-peptide.
Bisulfite-treated DNA from leukocytes was evaluated for methylation levels in six CpG sites of the
proximal promoter of the PPARGC1A gene by pyrosequencing (positions -816, -783, -652, -617, -521
and -515). A strong correlation between the DNA methylation percentage of different CpG sites of the
PPARGC1A promoter in leukocytes was found, suggesting an integrated epigenetic control of this
region. We found a positive association between the methylation levels of the CpG site -783 with the
insulin sensitivity Matsuda composite index (rho = 0.31; p = 0.02) derived from the OGTT. The CpG
hypomethylation in the promoter position -783 of the PPARGC1A gene in leukocytes may represent a
biomarker of reduced insulin sensitivity after the ingestion of glucose
Psychometric evidence of a brief version of the Coping Humor Scale in elderly peruvians]
Introducción: El humor tiene un papel importante en la promoción de un envejecimiento exitoso y saluda-ble. Sin embargo, su estudio científico es aún limitado, en parte debido a la ausencia de medidas validadaspara su uso en el ámbito latinoamericano. El objetivo del estudio fue traducir al espa˜nol y examinar lasevidencias de fiabilidad y validez basadas en la estructura interna, convergente y discriminante de laversión peruana de la Coping with Humor Scale-5 ítems.Materiales y métodos: Los participantes fueron 236 adultos mayores peruanos (78,4% mujeres y 21,6%hombres) con un promedio de edad de 72,8 años (DE = 6,90).Revisión por pare
Effect of immunocastration on behaviour and blood parameters (cortisol and testosterone) of Holstein bulls
To evaluate the effect that immunocastration has on behaviour, testosterone and cortisol levels of feedlot Holstein bulls, 720 intact animals aged between 7 and 8 months, weighing 232±1.19 kg were randomly assigned to two treatments: immunocastration using the Bopriva vaccine and a placebo (360 animals per treatment). The bulls were slaughtered at day 239 of treatment. Animals were vaccinated on days 1, 21, 101, and 181, and on those same days testosterone levels were measured; while cortisol, glucose and creatin kinase measurements were done on day 181 and during exanguination at slaughter. Sexual, aggressive and social behaviours were evaluated and it was found that intact bulls showed a higher average of head butts, mounting, threats, flehmen sign and sniffing (P<0.05), no differences were found for vocalisations, lowering of the head and grooming (P>0.05). Testosterone levels in intact bulls remained at 0.47ng/mL throughout the study, however, by day 181 differences (P<0.05) were observed in immunised bulls, with values of 0.22ng/mL. At slaughter, testosterone levels were 0.21 ± 0.06 ng/mL in immunocastrated bulls and 0.54 ± 0.06 ng/mL in the placebo group. The use of immunocastration with Bopriva has shown to be effective to reduce testosterone, sexual and aggressive behaviours on Holstein bulls
What Is the Support for Conspiracy Beliefs About COVID-19 Vaccines in Latin America? A Prospective Exploratory Study in 13 Countries
Conspiracy theories about COVID-19 began to emerge immediately after the first news about the disease and threaten to prolong the negative impact of the COVID-19 pandemic by limiting people’s willingness of receiving a life-saving vaccine. In this context, this study aimed to explore the variation of conspiracy beliefs regarding COVID-19 and the vaccine against it in 5779 people living in 13 Latin American countries (Argentina, Bolivia, Chile, Colombia, Cuba, Ecuador, El Salvador, Guatemala, Mexico, Paraguay, Peru, Uruguay and Venezuela) according to sociodemographic variables such as gender, age, educational level and source of information about COVID-19. The study was conducted during the COVID-19 pandemic between September 15 and October 25, 2021. The Spanish-language COVID-19 Vaccine Conspiracy Beliefs Scale (ECCV-COVID) and a sociodemographic survey were used. The results indicate that, in most countries, women, people with a lower educational level and those who receive information about the vaccine and COVID-19 from family/friends are more supportive of conspiracy ideas regarding the COVID-19 vaccine. In the case of age, the results vary by country. The analysis of the responses to each of the questions of the ECCV-COVID reveals that, in general, the countries evaluated are mostly in some degree of disagreement or indecision regarding conspiratorial beliefs about COVID-19 vaccines. The findings could help open further study which could support prevention and treatment efforts during the COVID-19 pandemic
Design and Cross-Cultural Invariance of the COVID-19 Vaccine Conspiracy Beliefs Scale (COVID-VCBS) in 13 Latin American Countries
"Aims: Over the past 2 years, the vaccine conspiracy beliefs construct has been used in
a number of different studies. These publications have assessed the determinants and
outcomes of vaccine conspiracy beliefs using, in some cases, pooled data from different
countries, and compared the results across these contexts. However, studies often
do not consider measurement invariance as a necessary requirement for comparative
analyses. Therefore, the aim of this study was to develop and evaluate the crosscultural MI of the COVID-19 Vaccine Conspiracy Beliefs Scale (COVID-VCBS) in 12 Latin
American countries.
Methods: Confirmatory factor analysis, item response theory analysis and alignment
method were applied to test measurement invariance in a large number of groups. Results: The COVID-VCBS showed robust psychometric properties and measurement
invariance for both factor loadings and crosstabs. Also, a higher level of acceptance of
conspiracy beliefs about vaccines is necessary to respond to higher response categories.
Similarly, greater acceptance of conspiracy beliefs about COVID-19 vaccines was related
to a lower intention to be vaccinated.
Conclusion: The results allow for improved understanding of conspiracy beliefs about
COVID-19 vaccines in the countries assessed; furthermore, they provide researchers
and practitioners with an invariant measure that they can use in cross-cultural studies in
Latin America. However, further studies are needed to test invariance in other countries,
with the goal of developing a truly international measure of conspiracy beliefs about
COVID-19 vaccines.
Initial psychometric evidence of a brief measure of cancer worry
Objective: The cancer worry is associated with preventive behaviors for the detection of this disease; However, there is no instrument with evidence of validity and reliability to measure this construct in Latin American countries, including Peru. The objectives of this study were to evaluate the evidence of validity based on the internal structure and reliability of the Cancer Worry Scale (CWS) ina sample of people without cancer diagnosis with a family history of cancer. Method: It counted withthe participation of 215 healthy people with a family history of cancer who attended the outpatientservice of two public and private health institutions in the city of Chimbote with an average age of42.10 years (SD = 14.05). For the collection of information, an ad hoc sociodemographic record andthe Cancer Worry Scale were used. Results: The one-dimensional model presented a good fit of the data(SBχ2 (8) = 14.39, SB χ2 / df = 1.79, CFI = 0.991, SRMR = 0.025, RMSEA = 0.061 [IC90%: 0.000-0.111], AIC = 47.701) and adequate reliability (ω corrected = 0.90; IC95%: 0.88-0.92). Conclusion: Itis concluded that the CWS presents adequate psychometric properties, being a measure that providesvalid and reliable interpretations of the cáncer worry in the peruvian context
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