Communicating identities : a sociology of house names in Malta

19,683 house names from a convenience sample of ten localities across the island of Malta were collected and analysed in late 2022, with the aim of teasing out how they communicate social identities. Trends in multilingualism and secularisation were particularly explored, from two sets of house names that represent different historical epochs, one dating from 1977 and one from 1977–2022. Results, secured from the ten localities studied, suggest that: (1) English remains by far the preferred language for naming houses, followed by Maltese; (2) house names that involve two or more languages have increased; (3) house names that relate to the religious or sacred have declined (from around 16% to 10%); and (4) in spite of evident secularisation in house-naming practices, the most common house name is ‘St Joseph’.peer-reviewe

Key sustainability issues and the spatial classification of sensitive regions in Europe

Cross-cutting environmental, social and economic changes may have harsh impacts on sensitive regions. To address sustainability issues by governmental policy measures properly, the geographical delineation of sensitive regions is essential. With reference to the European impact assessment guidelines from 2005, sensitive regions were identified by using environmental, social and economic data and by applying cluster analysis, United Nation Environmental Policy priorities and expert knowledge. On a regionalised ‘Nomenclature of Territorial Units for Statistics’ (NUTS) level and for pre-defined sensitive region types (post-industrial zones, mountains, coasts and islands) 31 % of the European area was identified as sensitive. However, the delineation mainly referred to social and economic issues since the regional data bases on environmental indicators are limited and do not allow the separation of medium-term vital classes of sensitive regions. Overall, the sensitive regions showed indicator values differing from the EU- 25 average.peer-reviewe

The era of reference genomes in conservation genomics

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics

The era of reference genomes in conservation genomics

Progress in genome sequencing now enables the large-scale generation of reference genomes. Various international initiatives aim to generate reference genomes representing global biodiversity. These genomes provide unique insights into genomic diversity and architecture, thereby enabling comprehensive analyses of population and functional genomics, and are expected to revolutionize conservation genomics

The era of reference genomes in conservation genomics

info:eu-repo/semantics/publishedVersio

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

The revaluation of catacombs as a common symbol towards appreciation of traditions across borders

The Ta’ Bistra, or ‘Tal-Bistra’ Catacombs, as they were previously known, are early burial sites which are located in the area known as ‘il-Bisbeżija’ close to Tarġa Gap in Mosta. These hypogea date back to the first century A.D., a period which represents an important phase in the history of Christianity.peer-reviewe