1,340 research outputs found
Successful management of cesarean scar pregnancy complicated by an arteriovenous malformation
Background: Cesarean scar ectopic pregnancies are rare, with an incidence of approximately 1 in 2,000 pregnancies. The trauma of a cesarean section and a subsequent cesarean scar pregnancy can lead to the formation of an arteriovenous malformation (AVM). The resulting intractable bleeding is difficult to manage and can result in an emergent surgical intervention that could jeopardize a female's ability to become pregnant in the future
Misbehaviors of Front-Line Research Personnel and the Integrity of Community-Based Research
There has been little empirical research into misconduct and misbehavior among community research workers who recruit and collect data in vulnerable and marginalized health populations and are also members of those same communities. We conducted qualitative interviews with community research workers and traditional research assistants to understand the context and consequences of misbehaviors that pose a threat to research ethics and data integrity. In our sample, more community research workers acknowledged engaging in research wrongdoing than did traditional research assistants. These behaviors were most prevalent among community research workers who were not well-integrated into the research team. We suggest best practices for investigators to promote an environment that supports research integrity in research projects that employ community research workers
Recommended from our members
Real-Time Spectroscopic Analysis Enabling Quantitative and Safe Consumption of Fluoroform during Nucleophilic Trifluoromethylation in Flow
The productive use of toxic waste materials derived from industrial processes is one of the main goals of modern chemical research to increase sustainability of the large scale production. Here we devise a simple and robust strategy for the utilization of trifluoromethane, obtained in large quantities from polytetrafluoroethylene (PTFE) manufacture, and the conversion of this greenhouse gas into valuable fluorinated compounds. The generation of the trifluoromethyl carbanion and its direct and complete consumption through trapping with a number of electrophiles were achieved by a fully contained flow reactor setup. The adoption of modern in-line analytical tools, such as portable FT-IR and NMR devices, allowed the accurate reagent dosing with considerable benefits in terms of controlling the environmental impact during this continuous process. The advantages of the method, with respect to the batch procedure, will be discussed and demonstrated experimentally.The EPSRC, grant codes: EP/K009494/1, EP/K039520/1 and EP/M004120/1
Rare case of Hirayama’s disease
Hirayama’s disease is a rare benign neurological disorder also known as monomelic amyotrophy, Sobue disease,Juvenile Muscular Atrophy of Distal Upper Extremity (JMADUE). It mainly affects young males in their second or third decades and is most commonly seen in Asian countries like Japan, Malaysia and India. In majority of the cases the cause of the disease is unknown. An 18 year male came with weakness in his right hand and forearm since 1 year. Examination revealed weakness and wasting of muscles of forearm and hand without lower limb involvement and normal deep tendon reflexes. MRI showed focal short segment hyperintense signal in the ventral and right lateral aspect of the cervical cord at C5-C6 level with the involved segment measuring 4x3mm in size. Based on clinical and radiological features a diagnosis of focal amyotrophy was made. Patient is given a cervical collar to prevent flexion at the neck and physiotherapy in the form of hand and forearm exercises were started. Regular follow up of the patient once every 2 months is being done. Hirayama’s disease is a rare, benign, self-limiting neurological disorder. Early diagnosis and management by preventing cervical flexion with the help of a cervical collar has shown to halt the progression of the disease
Political Socialization and Quality of Work Life among Constituents in Davao Region, Philippines
Political socialization encompasses the overall perception of an individual in political aspects. The primary objective of this study was to identify the significant relationship of political socialization and quality of work life among the constituents in region XI. Using a descriptive-correlational method, Mean, t-Test and Pearson-r and modified survey questionnaire. Results revealed that there was a high level of political socialization and quality of work life among the constituents. Findings showed that there was no significant difference on the quality of work life among the constituents when grouped by sex and areas of abode. Furthermore, there was a significant relationship in political socialization and quality of work life among the constituents in region XI
Zeros and the functional equation of the quadrilateral zeta function
In this paper, we show that all real zeros of the bilateral Hurwitz zeta
function with are on
only the non-positive even integers exactly same as in the case of . We also prove that all real zeros of the bilateral periodic zeta
function
with are on only the negative even integers just like
. Moreover, we show that all real zeros of the quadrilateral zeta
function with are on only the
negative even integers. On the other hand, we prove that , and
have at least one real zero in when is sufficiently
small. The complex zeros of these zeta functions are also discussed when is rational or transcendental. As a corollary, we show that
with rational or does not satisfy the
analogue of the Riemann hypothesis even though satisfies the
functional equation that appeared in Hamburger's or Hecke's theorem and all
real zeros of are located at only the negative even integers again as
in the case of .Comment: 12 pages. We changed the title. Some typos are correcte
Strategies for meiotic sex chromosome dynamics and telomeric elongation in Marsupials
During meiotic prophase I, homologous chromosomes pair, synapse and recombine in a
tightly regulated process that ensures the generation of genetically variable haploid gametes. Although the mechanisms underlying meiotic cell division have been well studied in
model species, our understanding of the dynamics of meiotic prophase I in non-traditional
model mammals remains in its infancy. Here, we reveal key meiotic features in previously
uncharacterised marsupial species (the tammar wallaby and the fat-tailed dunnart), plus the
fat-tailed mouse opossum, with a focus on sex chromosome pairing strategies, recombina tion and meiotic telomere homeostasis. We uncovered differences between phylogroups
with important functional and evolutionary implications. First, sex chromosomes, which lack
a pseudo-autosomal region in marsupials, had species specific pairing and silencing strategies, with implications for sex chromosome evolution. Second, we detected two waves of
γH2AX accumulation during prophase I. The first wave was accompanied by low γH2AX lev els on autosomes, which correlated with the low recombination rates that distinguish marsupials from eutherian mammals. In the second wave, γH2AX was restricted to sex
chromosomes in all three species, which correlated with transcription from the X in tammar
wallaby. This suggests non-canonical functions of γH2AX on meiotic sex chromosomes.
Finally, we uncover evidence for telomere elongation in primary spermatocytes of the fattailed dunnart, a unique strategy within mammals. Our results provide new insights into meiotic progression and telomere homeostasis in marsupials, highlighting the importance of
capturing the diversity of meiotic strategies within mammalsThis work was supported by the Ministry
of Economy, Industry and Competitiveness
(CGL2017-83802-P to A.R-H. and CGL2014-
53106-P to J.P.), the Spanish Ministry of Science
and Innovation (PID2020-112557GB-I00 to A.R H.) and the Agència de Gestio´ d’Ajuts Universitaris i
de Recerca, AGAUR (SGR1215 to A.R-H.
Surgical reversal of prolonged blindness from a metastatic neuroblastoma
Reports of tumor-related anterior visual pathway blindness that have resolved after surgical decompression are rare. The longest reported duration of tumor-related blindness completely reversed by optic nerve decompression is 3Â days. We describe a pediatric patient with 7Â days of no light perception who experienced reversal of blindness following tumor resection and optic nerve decompression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47141/1/381_2004_Article_1062.pd
Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction
[EN] Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria x anahassa) cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutaturn spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5, and FaPR10) were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen.Authors are grateful to Dr. JM Lopez-Aranda (IFAPA-Centro de Churriana) for providing micropropagated strawberry plants and to Nicolas Garcia-Caparros for technical assistance. Authors also want to thank Kevin M. Folta for his insightful comments on the paper. This work was supported by Junta de Andalucia, Spain [Proyectos de Excelencia P07-AGR-02482/P12-AGR-2174, and grants to Grupo-BIO278].Amil-Ruiz, F.; Garrido-Gala, J.; Gadea Vacas, J.; Blanco-Portales, R.; Munoz-Merida, A.; Trelles, O.; De Los Santos, B.... (2016). Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction. Frontiers in Plant Science. 7(1036). https://doi.org/10.3389/fpls.2016.01036S71036Acosta, I. F., & Farmer, E. E. (2010). Jasmonates. The Arabidopsis Book, 8, e0129. doi:10.1199/tab.0129Al-Shahrour, F., Diaz-Uriarte, R., & Dopazo, J. (2004). 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