Las hornblenditas,gabros y dioritas del Macizo del Montnegre (Barcelona, Cordilleras costero catalanas)

En relación con los granitos tardihercínicos calcoalcalinos del Macizo del Montnegre aparecen rocas ultrabásicas-básicas a intermedias. Las más básicas son hornblenditas olivínicas, con espinela, clinopiroxeno, ortopiroxeno, anfíboles de varios tipos y flogopita. Hay además melagabros-gabros hornbléndicos y leucogabros, estos últimos con anfíbol minoritario. Las rocas más ácidas son cuarzodioritas y cuarzomonzodioritas biotítico-hornbléndicas, con cristales relictos de clinopiroxeno y ortopiroxeno. El contenido máximo en anortita de la plagioclasa en las dioritas es tan alto como en los gabros. Toda la asociación muestra una evolución típicamente calcoalcalina, pero las hornblenditas y algunos gabros podrían haberse formado a partir de diferentes tipos de magmas básicos. Las cuarzodioritas serían rocas híbridas, con participación de un magma más básico y otro más ácido. El primero estaría saturado en clinopiroxeno y ortopiroxeno, además de en plagioclasa de composición bitownita, y el otro magma sería más ácido

La biomecánica como herramienta de análisis de la técnica en barra fija

El trabajo que aquí presentamos surge como una forma más de satisfacer la necesidad de un colectivo en torno a un tema muy concreto, la mejora de la técnica. Tradicionalmente esta mejora se ha realizado en base a la observación directa del entrenador y a las sensaciones del gimnasta. En la actualidad, a pesar de no despreciar las formas anteriormente citadas, disponemos de unos métodos mucho más precisos que nos permiten ofrecer al entrenador unos resultados más objetivos del gesto gimnástico. Uno de los métodos más potentes para estudiar el gesto gimnástico es el análisis biomecánica. Este trabajo realiza el análisis biomecánico de dos elementos gimnásticos, el molino gigante hacia adelante y hacia atrás, comparando la ejecución de un gimnasta de élite, y la de un gimnasta de nivel de iniciación. El objetivo principal de este estudio es el de satisfacer las demandas técnicas de los entrenadores usando un modelo sencillo, unos medios tecnológicos asequibles y fáciles de adquirir en el mercado doméstico, y un tratamiento de los datos que no requiere forzosamente de personal superespecializado y formado en el ámbito de la biomecánica

Water tanks as ecosystems. Local ecosystemic perception for integral management of water tanks in Tamil Nadu, South India

Los tanques de agua (water tanks) ofrecen desde hace siglos soluciones en el Sur de la India a los problemas derivados de la escasez de agua. Son un sistema tradicional de recogida de agua de lluvia ampliamente distribuido por este territorio, que permite una potencial gestión de los propios recursos a nivel local, descentralizada y participativa. Aunque la principal función de los tanques de agua es la irrigación, existen muchos otros usos, funciones y recursos naturales asociados a ellos que permiten la inclusión de muchos más actores de la comunidad, aparte de aquellos agricultores que aprovechan la irrigación. Los tanques de agua configuran además una variedad de paisaje y biodiversidad, creando una valiosa heterogeneidad territorial. La complejidad de este ecosistema debe ser gestionada con una perspectiva integral que considere todos los elementos vinculados y las relaciones entre ellos, entendiendo que los tanques de agua no son simplemente depósitos de agua. Este estudio multidisciplinar intenta demostrar el concepto de tanques de agua entendidos como ecosistemas, describiendo y analizando de una manera profunda novedosa las funciones, usos, recursos naturales y actores. La investigación se centra también en el análisis de la percepción ecosistémica de la población local de algunas comunidades en Tamil Nadu (India del Sur), empleando diversas metodologías antropológicas.Water tanks offer from many centuries ago solutions in South India for several problems related with water scarcity. They are a traditional water harvesting system wide spread in this territory, allowing a potential decentralized and participatory management of the local population on their own resources. Although water tanks' main function is irrigation, they have many other uses, functions and natural resources associated, involving stakeholders in the villages apart from those farmers making use of the irrigation. Water tanks provide a variety of landscapes and biodiversity that creates a valuable heterogeneous territory. The complexity of such an ecosystem should be managed with an integral perspective, considering all the elements involved and their relations, and understanding that water tanks are not just water deposits. This multidisciplinary study tries to demonstrate the idea of water tanks as ecosystems, describing and analyzing deeply and in an unprecedentedly way the functions, uses, natural resources and stakeholders. The research also focuses in the assessment of the ecosystemic perception of the local population of some villages in Tamil Nadu, employing diverse anthropological methodology

Comparison of HE4, CA125, ROMA and CPH-I for Preoperative Assessment of Adnexal Tumors

(1) OBJECTIVE: To assess the performance of CA125, HE4, ROMA index and CPH-I index to preoperatively identify epithelial ovarian cancer (EOC) or metastatic cancer in the ovary (MCO). (2) METHODS: single center retrospective study, including women with a diagnosis of adnexal mass. We obtained the AUC, sensitivity, specificity and predictive values were of HE4, CA125, ROMA and CPH-I for the diagnosis of EOC and MCO. Subgroup analysis for women harboring adnexal masses with inconclusive diagnosis of malignancy by ultrasound features and Stage I EOC was performed. (3) RESULTS: 1071 patients were included, 852 (79.6%) presented benign/borderline tumors and 219 (20.4%) presented EOC/MCO. AUC for HE4 was higher than for CA125 (0.91 vs. 0.87). No differences were seen between AUC of ROMA and CPH-I, but they were both higher than HE4 AUC. None of the tumor markers alone achieved a sensitivity of 90%; HE4 was highly specific (93.5%). ROMA showed a sensitivity and specificity of 91.1% and 84.6% respectively, while CPH-I showed a sensitivity of 91.1% with 79.2% specificity. For patients with inconclusive diagnosis of malignancy by ultrasound features and with Stage I EOC, ROMA showed the best diagnostic performance (4) CONCLUSIONS: ROMA and CPH-I perform better than tumor markers alone to identify patients harboring EOC or MCO. They can be helpful to assess the risk of malignancy of adnexal masses, especially in cases where ultrasonographic diagnosis is challenging (stage I EOC, inconclusive diagnosis of malignancy by ultrasound features)

The population-based Barcelona-Asymptomatic Intracranial Atherosclerosis Study (ASIA) : rationale and design

Large-artery intracranial atherosclerosis may be the most frequent cause of ischemic stroke worldwide. Traditional approaches have attempted to target the disease when it is already symptomatic. However, early detection of intracranial atherosclerosis may allow therapeutic intervention while the disease is still asymptomatic. The prevalence and natural history of asymptomatic intracranial atherosclerosis in Caucasians remain unclear. The aims of the Barcelona- AS ymptomatic I ntracranial A therosclerosis (ASIA) study are (1) to determine the prevalence of ASIA in a moderate-high vascular risk population, (2) to study its prognostic impact on the risk of suffering future major ischemic events, and (3) to identify predictors of the development, progression and clinical expression of this condition. Cross-over and cohort, population-based study. A randomly selected representative sample of 1,503 subjects with a mild-moderate-high vascular risk (as defined by a REGICOR score ≥ 5%) and with neither a history of cerebrovascular nor ischemic heart disease will be studied. At baseline, all individuals will undergo extracranial and transcranial Color-Coded Duplex (TCCD) ultrasound examinations to detect presence and severity of extra and intracranial atherosclerosis. Intracranial stenoses will be assessed by magnetic resonance angiography (MRA). Clinical and demographic variables will be recorded and blood samples will be drawn to investigate clinical, biological and genetic factors associated with the presence of ASIA. A long-term clinical and sonographic follow-up will be conducted thereafter to identify predictors of disease progression and of incident vascular events. The Barcelona-ASIA is a population-based study aiming to evaluate the prevalence and clinical importance of asymptomatic intracranial large-artery atherosclerosis in Caucasians. The ASIA project may provide a unique scientific resource to better understand the dynamics of intracranial atherosclerosis from its early stages and to identify new potential therapeutic targets for this condition

Transposons played a major role in the diversification between the closely related almond and peach genomes: Results from the almond genome sequence

We sequenced the genome of the highly heterozygous almond Prunus dulcis cv. Texas combining short and long‐read sequencing. We obtained a genome assembly totaling 227.6 Mb of the estimated 238 Mb almond genome size, of which 91% is anchored to eight pseudomolecules corresponding to its haploid chromosome complement, and annotated 27,969 protein‐coding genes and 6,747 non‐coding transcripts. By phylogenomic comparison with the genomes of 16 additional close and distant species we estimated that almond and peach (P. persica) diverged around 5.88 Mya. These two genomes are highly syntenic and show a high degree of sequence conservation (20 nucleotide substitutions/kb). However, they also exhibit a high number of presence/absence variants, many attributable to the movement of transposable elements (TEs). TEs have generated an important number of presence/absence variants between almond and peach, and we show that the recent history of TE movement seems markedly different between them. TEs may also be at the origin of important phenotypic differences between both species, and in particular, for the sweet kernel phenotype, a key agronomic and domestication character for almond. Here we show that in sweet almond cultivars, highly methylated TE insertions surround a gene involved in the biosynthesis of amygdalin, whose reduced expression has been correlated with the sweet almond phenotype. Altogether, our results suggest a key role of TEs in the recent history and diversification of almond and its close relative peach.info:eu-repo/semantics/publishedVersio

Economic evaluation of health services costs during pandemic influenza A (H1N1) pdm09 infection in pregnant and non-pregnant women in Spain (2009)

Background: The healthcare and socio-economic burden resulting from influenza A (H1N1) pdm09 in Spain was considerable. Our aim was to estimate and compare the management (resource utilization) and economic healthcare impact in an at-risk group of unvaccinated pregnant women with an unvaccinated group of non-pregnant woman of childbearing age (15-44 yr old). Methods: We addressed this question with a longitudinal, observational, multicentre study. Inputs were the require-ments in managing both groups of women. Outcome measures were healthcare costs. Direct healthcare (including medical utilisation, prescriptions of antivirals, medication, diagnostic tests, and hospitalisation) costs and indirect (productivity loss) costs were considered. Unit of cost was attributed to the frequency of health service resources utili-sation. The mean cost per patient was calculated in this group of women. Results: We found that the influenza clinical pattern was worse in non-pregnant women as they had a high medical risk of 20.4% versus 6.1% of pregnant women. Non-pregnant required more antipyretics and antibiotics, and needed more health service resource utilisation (338 medical visits in non-pregnant women vs. 42 in pregnant women). The total cost of non-pregnant women was higher ( 4,689.4/non-pregnant and 2,945.07/pregnant). Conclusions: Cost per (H1N1) pdm09 was lower for pregnant women, probably due to more preventive measures adopted for their protection in Spain. The highest costs were incurred by hospitalisations/day and work absenteeism for non-pregnant than for pregnant women. These data will allow better future pandemic influenza planning

Oral contraceptives do not modify the risk of a second attack and disability accrual in a prospective cohort of women with a clinically isolated syndrome and early multiple sclerosis

Cohort study; Oral contraceptives; Second relapseEstudio de cohorte; Anticonceptivos orales; Segunda recaídaEstudi de cohorts; Anticonceptius orals; Segona recaigudaObjective: To evaluate whether oral contraceptive (OC) use is associated with the risk of a second attack and disability accrual in women with a clinically isolated syndrome (CIS) and early multiple sclerosis (MS). Methods: Reproductive information from women included in the Barcelona CIS prospective cohort was collected through a self-reported cross-sectional survey. We examined the relationship of OC exposure with the risk of a second attack and confirmed Expanded Disability Status Scale of 3.0 using multivariate Cox regression models, adjusted by age, topography of CIS, oligoclonal bands, baseline brain T2 lesions, body size at menarche, smoking, and disease-modifying treatment (DMT). OC and DMT exposures were considered as time-varying variables. Findings were confirmed with sensitivity analyses using propensity score models. Results: A total of 495 women were included, 389 (78.6%) referred to ever use OC and 341 (68.9%) started OC before the CIS. Exposure to OC was not associated with a second attack (adjusted hazard ratio (aHR) = 0.73, 95% confidence interval (CI) = 0.33–1.61) or disability accrual (aHR = 0.81, 95% CI = 0.17–3.76). Sensitivity analyses confirmed these results. Conclusion: OC use does not modify the risk of second attack or disability accrual in patients with CIS and early MS, once considered as a time-dependent exposure and adjusted by other potential confounders.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This project was supported by FIS PI15/0070 from Ministry of Economy and Competitiveness of Spain

Deciphering multiple sclerosis disability with deep learning attention maps on clinical MRI

Deep learning; Disability; Structural MRIAprendizaje profundo; Discapacidad; Resonancia magnética estructuralAprenentatge profund; Discapacitat; Ressonància magnètica estructuralThe application of convolutional neural networks (CNNs) to MRI data has emerged as a promising approach to achieving unprecedented levels of accuracy when predicting the course of neurological conditions, including multiple sclerosis, by means of extracting image features not detectable through conventional methods. Additionally, the study of CNN-derived attention maps, which indicate the most relevant anatomical features for CNN-based decisions, has the potential to uncover key disease mechanisms leading to disability accumulation. From a cohort of patients prospectively followed up after a first demyelinating attack, we selected those with T1-weighted and T2-FLAIR brain MRI sequences available for image analysis and a clinical assessment performed within the following six months (N = 319). Patients were divided into two groups according to expanded disability status scale (EDSS) score: ≥3.0 and < 3.0. A 3D-CNN model predicted the class using whole-brain MRI scans as input. A comparison with a logistic regression (LR) model using volumetric measurements as explanatory variables and a validation of the CNN model on an independent dataset with similar characteristics (N = 440) were also performed. The layer-wise relevance propagation method was used to obtain individual attention maps. The CNN model achieved a mean accuracy of 79% and proved to be superior to the equivalent LR-model (77%). Additionally, the model was successfully validated in the independent external cohort without any re-training (accuracy = 71%). Attention-map analyses revealed the predominant role of frontotemporal cortex and cerebellum for CNN decisions, suggesting that the mechanisms leading to disability accrual exceed the mere presence of brain lesions or atrophy and probably involve how damage is distributed in the central nervous system.MS PATHS is funded by Biogen. This study has been possible thanks to a Junior Leader La Caixa Fellowship awarded to C. Tur (fellowship code is LCF/BQ/PI20/11760008) by “la Caixa” Foundation (ID 100010434). The salaries of C. Tur and Ll. Coll are covered by this award

Hornblendites, gabbros and diorites from the Montnegre Massif (Barcelona, Catalonian Coastal Ranges)

En relación con los granitos tardihercínicos calcoalcalinos del Macizo del Montnegre aparecen rocas ultrabásicas-básicas a intermedias. Las más básicas son hornblenditas olivínicas, con espinela, clinopiroxeno, ortopiroxeno, anfíboles de varios tipos y flogopita. Hay además melagabros-gabros hornbléndicos y leucogabros, estos últimos con anfíbol minoritario. Las rocas más ácidas son cuarzodioritas y cuarzomonzodioritas biotítico-hornbléndicas, con cristales relictos de clinopiroxeno y ortopiroxeno. El contenido máximo en anortita de la plagioclasa en las dioritas es tan alto como en los gabros. Toda la asociación muestra una evolución típicamente calcoalcalina, pero las hornblenditas y algunos gabros podrían haberse formado a partir de diferentes tipos de magmas básicos. Las cuarzodioritas serían rocas híbridas, con participación de un magma más básico y otro más ácido. El primero estaría saturado en clinopiroxeno y ortopiroxeno, además de en plagioclasa de composición bitownita, y el otro magma sería más ácidoUltrabasic-basic to intermediate rocks appear associated with Late Hercynian calcoalcaline granites of the Montnegre Massif. The most basic rocks are olivine hornblendites, with spinel, clinopyroxene, orthopyroxene, different types of amphibole, and phlogopite. There are also hornblende melagabbros- gabbros and leucogabbros, with subordinate amphibole. The most acid rocks are hornblende-biotite quartz diorites and monzodiorites with clinopyroxene and orthopyroxene relics. Maximun anorthite composition in plagioclase from the diorites is comparable to that in the gabbros. The evolutionary trend of this association is typically calcoalcaline, but the hornblendites and the leucogabbros could be formed from different types of basic magmas. Quartz diorites would be hybrid rocks, derived from a more basic magma, saturated in clinopyroxene, ortopyroxene and in bytownite plagioclase, and a more acid on