104 research outputs found
Effect of Carbon Dioxide Concentration on the Growth Response of Chlorella vulgaris Under Four Different Led Illumination
This experiment examined the growth response of Chlorella vulgaris exposed to CO2 concentrations increasing from ambient to 8.5% and under white, blue, red and red-blue lights after 15 days incubation. Biomass production increased with increasing CO2 concentrations under all light sources. The highest biomass production, 1.59 g L-1, was obtained when the algae were supplied with 8.5% CO2 and exposed to white light. Biomass production under blue, red and red+blue light was 1.53 g L-1, 0.45 g L-1 and 1.27 g L-1, respectively. The research suggests that C. vulgaris is not able to adapt production of its photosynthetic pigments to absorb light sources different that it is normally has evolved to
Liderazgo directivo y desempeño docente en la I.E. Nº 101000 La Ramada, Cajamarca
El presente trabajo de investigación tiene como propósito principal determinar la relación del Liderazgo directivo y el desempeño docente en el nivel primario de la Institución Educativa Nº 101000 de La Ramada, distrito de Llama, provincia de Chota, Región Cajamarca, en el primer semestre del año 2018.
A partir de los autores analizados: Idalberto Chiavenato, Jorge Torres, Albert Bandura, Lesly Estrada, el MINEDU y otros; el liderazgo se asume como un proceso donde una o más personas influyen en otra u otras con la finalidad de alcanzar determinados propósitos para la institución cuyos resultados se proyectan a la sociedad completa rompiendo fronteras en todos los subordinados.
Es una investigación de tipo descriptivo correlacional, cuya población está conformada por los 7 docentes de la I.E. Nº 101000 en el distrito de Llama, de los cuales uno es directivo con aula a cargo. A quienes se le aplicaron los instrumentos de evaluación.
Al correlacionar las variables liderazgo directivo y desempeño docente se encontró que existe una alta relación positiva de las variables, debido que existe interinfluencia entre la forma cómo el directivo evidencia o muestra su liderazgo y cómo lo perciben, en algunos casos se sigue el ejemplo de parte de la plana docente
The Effects of Public Infrastructure and Household Characteristics on Inequality and Infant Mortality in Mexico: What Has Changed Between 1990 and 2005?
The reduction of infant mortality (IM) continues to be a primary goal throughout much of the developing world, and a suite of methods have been proposed with which to achieve it. However, most attempts at IM reduction have taken place within the context of an almost bewilderingly complex regimen of simultaneous changes occurring in the physical environment, sociopolitical structure, and health care. Which of these various elements is truly causal in reducing IM and which may be merely a correlated but nonprimary agent? During the past two decades Mexico has constituted an extraordinary field laboratory with which to decipher the roles of these various potential agents of IM reduction. Health resources include community access to proper drainage, safe drinking water, electrical power, as well as a suite of individual, if highly intercorrelated, family and household characteristics. Despite considerable demographic and socioeconomic heterogeneity, dramatic reductions in IM have been achieved, and additional ones are certainly possible. We weigh the factors that have reduced infant mortality in this country. Particular infrastructure improvements in the Pacific South, the Gulf, and the Yucatan peninsula must be continued. This would impact both inequality and, in turn, infant health and survival in this country
Prototipo rápido para docencia y estrategias quirúrgicas en Pediatría
Introducción: La incorporación de la Clínica y la Imagenología permiten una mejor comprensión de la Anatomía. El objetivo de este trabajo es desarrollar un prototipo rápido en material sintético que replique detalles anatómicos para ser utilizado en la docencia y el entrenamiento quirúrgico en Pediatría.Material y Método: Presentación de caso: Paciente de un año de edad con síndrome de dificultad respiratoria. En el examen endoscópico se halló una compresión traqueal distal. La angiotomografía confirmó la presencia de una malformación vascular. Con la finalidad de analizar una conducta adecuada, se solicitó la confección de un prototipo rápido a escala 1:1 que simulara una condición idéntica a la topografía torácica del paciente, utilizando imágenes virtuales 3D almacenadas en formato DICOM.Técnica de generación de prototipo rápido: Se obtuvo una malla digital tridimensional y se generó el código “g” que se utilizó para controlar el hardware de producción. Se efectuó simulación digital y producción en material plástico (ABS) con técnica de deposición y fusión (MDF). Se validó el prototipo comparándolo con las mediciones testigos del modelo virtual en 3 D.Resultados y Discusión: El modelo replicó exactamente los defectos hallados en la tomografía y endoscopía, confirmando la presencia de la malformación vascular y su repercusión sobre el aparato respiratorio. El prototipo rápido muestra las estructuras internas y externas del cuerpo humano con máxima precisión permitiendo una visión topográfica de situaciones “normales o patológicas” que facilitaría la docencia y el entrenamiento del equipo quirúrgico para proponer un plan de tratamiento adecuado. Hay numerosas áreas de la medicina que se beneficiarían con este modelo que podría ser construído con diversos tipos de materiales de diferente flexibilidad y consistencia. Conclusiones: El prototipo rápido le da estado físico a las imágenes virtuales 3D, permitiendo la docencia y entrenamiento del equipo quirúrgico.</p
Escabiose felina no gato errante – Relato de caso / Feline scabies on wandering cat - Case Report
A sarna notoédrica é uma dermatose crostosa, descamativa e pruriginosa que acomete gatos causada pelo ácaro Notoedres cati. Por se tratar de uma zoonose o tratamento correto deve ser realizado com urgência. A terapia convencional é baseada no uso de medicamentos da classe das avermectinas. O presente relato descreve um caso de sarna notoédrica diagnosticada por raspado cutâneo em um gato errante na cidade de São Paulo. O animal apresentava lesões de pele na cabeça e regiões cervical dorsal e ventral. O tratamento foi realizado com 3 aplicações tópicas de selamectina (Revolution®) com intervalo de 30 dias entre as aplicações. Foi observada a cura completa, confirmada através de raspados cutâneos negativos. Esse resultado sugere a eficácia da Selamectina contra os ácaros Notoedres cati, apesar do tempo de duração do tratamento
Options for Decision Makers
First paragraph: The Sustainable Development Goals and the 2050 Vision for Biodiversity cannot be achieved without transformative change, the conditions for which can be put in place now (well established) {6.2; chapters 2, 3, 5}. In the short term (before 2030), all decision makers can contribute to the sustainability transformation, including through the rapid and improved deployment of existing policy instruments and new initiatives that more effectively enlist individual and collective action for transformative change, and the reform and removal of harmful existing policies and subsidies (well established). Additional measures are necessary to enable transformative change in the long term (up to 2050) to address the indirect drivers that are the root causes of nature deterioration (well established), including changes in social, economic and technological structures within and across nations {6.2, 6.3, 6.4}.Additional co-authors: Esther Turnhout, Meryl Williams, Ivis Chan, Alvaro Fernandez-Llamazares, Michelle Lim, Saleem Ali, Susan Baker, Andrew Balmford, David N. Barton, Rupert Baumgartner, Timothy Baynes, Abigail Bennett, Brent Bleys, P.M. van Bodegom, Sara Brogaard, Mireille Chiroleu Assouline, Jennifer Clapp, Neil Craik, Maylis Desrousseaux, Rui Ferrero dos Santos, Doris Fuchs, Toby Gardner, Alexandros Gasparatos, Ariane Goetz, Jeroen B. Guinée, David Hall, Duncan Halley, Michael Howard, Caroline Howe, Cynthia Isenhour, Tim Jackson, Katia Karousakis, John Knox, Berit Köhler, Janne S. Kotiaho, William F. Laurance, Elodie Le Gal, Jin Leshan, Nengye Liu, Emanuele Lobina, Derk Loorbach, Martine Maron, Peter May, Timon McPhearson, Marieke Meesters, E. Migoni Alejandre, Daniel Miller, Angus Morrison-Saunders, Lila Nath Sharma, Barbara Norman, Ingeborg Palm Helland, Fabien Quétier, Jake Rice, Irene Ring, Denis Ruysschaert, Ronald Steenblik, William J. Sutherland, Jacqueline Tao, James Watson, Dara Zalesk
Inhibition of the NLRP3 inflammasome prevents ovarian aging
Inflammation is a hallmark of aging and is negatively affecting female fertility. In this study, we evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. Age-dependent increased expression of NLRP3 in the ovary was observed in WT mice during reproductive aging. High expression of NLRP3, caspase-1, and IL-1β was also observed in granulosa cells from patients with ovarian insufficiency. Ablation of NLRP3 improved the survival and pregnancy rates and increased anti-Müllerian hormone levels and autophagy rates in ovaries. Deficiency of NLRP3 also reduced serum FSH and estradiol levels. Consistent with these results, pharmacological inhibition of NLRP3 using a direct NLRP3 inhibitor, MCC950, improved fertility in female mice to levels comparable to those of Nlrp3−/− mice. These results suggest that the NLRP3 inflammasome is implicated in the age-dependent loss of female fertility and position this inflammasome as a potential new therapeutic target for the treatment of infertility
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Efficacy and safety of autologous haematopoietic stem cell transplantation versus alemtuzumab, ocrelizumab, ofatumumab or cladribine in relapsing remitting multiple sclerosis (StarMS): protocol for a randomised controlled trial
Supplementary materials: Supplementary Data are available online at: https://doi.org/10.1136/bmjopen-2023-083582 .Introduction: Autologous haematopoietic stem cell transplantation (aHSCT) is increasingly used as treatment for patients with active multiple sclerosis (MS), typically after failure of disease-modifying therapies (DMTs). A recent phase III trial, ‘Multiple Sclerosis International Stem Cell Transplant, MIST’, showed that aHSCT resulted in prolonged time to disability progression compared with DMTs in patients with relapsing remitting MS (RRMS). However, the MIST trial did not include many of the current high-efficacy DMTs (alemtuzumab, ocrelizumab, ofatumumab or cladribine) in use in the UK within the control arm, which are now offered to patients with rapidly evolving severe MS (RES-MS) who are treatment naïve. There remain, therefore, unanswered questions about the relative efficacy and safety of aHSCT over these high-efficacy DMTs in these patient groups. The StarMS trial (Autologous Stem Cell Transplantation versus Alemtuzumab, Ocrelizumab, Ofatumumab or Cladribine in Relapsing Remitting Multiple Sclerosis) will assess the efficacy, safety and long-term impact of aHSCT compared with high-efficacy DMTs in patients with highly active RRMS despite the use of standard DMTs or in patients with treatment naïve RES-MS.
Methods and analysis: StarMS is a multicentre parallel-group rater-blinded randomised controlled trial with two arms. A total of 198 participants will be recruited from 19 regional neurology secondary care centres in the UK. Participants will be randomly allocated to the aHSCT arm or DMT arm in a 1:1 ratio. Participants will remain in the study for 2 years with follow-up visits at 3, 6, 9, 12, 18 and 24 months postrandomisation. The primary outcome is the proportion of patients who achieve ‘no evidence of disease activity’ during the 2-year postrandomisation follow-up period in an intention to treat analysis. Secondary outcomes include efficacy, safety, cost-effectiveness and immune reconstitution of aHSCT and the four high-efficacy DMTs.
Ethics and dissemination: The study was approved by the Yorkshire and Humber—Leeds West Research Ethics Committee (20/YH/0061). Participants will provide written informed consent prior to any study specific procedures. The study results will be submitted to a peer-reviewed journal and abstracts will be submitted to relevant national and international conferences.
Trial registration number: ISRCTN88667898.Efficacy and Mechanism Evaluation (EME) Programme, an MRC and NIHR partnership
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