Multi-Partite Entanglement Inequalities via Spin Vector Geometry

We introduce inequalities for multi-partite entanglement, derived from the geometry of spin vectors. The criteria are constructed iteratively from cross and dot products between the spins of individual subsystems, each of which may have arbitrary dimension. For qubit ensembles the maximum violation for our inequalities is larger than that for the Mermin-Klyshko Bell inequalities, and the maximally violating states are different from Greenberger-Horne-Zeilinger states. Our inequalities are violated by certain bound entangled states for which no Bell-type violation has yet been found.Comment: 4 pages, 2 tables, 1 figure. A truncated version is published in Physical Review Letters, volume 95 issue 18, 180402 (October 2005

Microbial and metabolic succession on common building materials under high humidity conditions.

Despite considerable efforts to characterize the microbial ecology of the built environment, the metabolic mechanisms underpinning microbial colonization and successional dynamics remain unclear, particularly at high moisture conditions. Here, we applied bacterial/viral particle counting, qPCR, amplicon sequencing of the genes encoding 16S and ITS rRNA, and metabolomics to longitudinally characterize the ecological dynamics of four common building materials maintained at high humidity. We varied the natural inoculum provided to each material and wet half of the samples to simulate a potable water leak. Wetted materials had higher growth rates and lower alpha diversity compared to non-wetted materials, and wetting described the majority of the variance in bacterial, fungal, and metabolite structure. Inoculation location was weakly associated with bacterial and fungal beta diversity. Material type influenced bacterial and viral particle abundance and bacterial and metabolic (but not fungal) diversity. Metabolites indicative of microbial activity were identified, and they too differed by material

Impact of the atmospheric climate modes on wave climate in the North Atlantic

Trabajo presentado en la EGU General Assemby 2014, celebrada del 27 de abril al 2 de mayo de 2014 en Viena (Austria)This study establishes the relationships between the mean modes of atmospheric variability in the North Atlantic and present wave climate. The modes considered, namely the North Atlantic Oscillation (NAO), the East Atlantic pattern (EA), the East Atlantic Western Russian pattern (EA/WR) and the Scandinavian pattern (SCAN), are obtained from the NOAA Climate Prediction Centre. The wave data sets used consist of buoy records and two high-resolution simulations of significant wave height (SWH), mean wave period (MWP) and mean wave direction (MWD) forced with ERA-40 (1958-2002) and ERA-INTERIM (1989-2008) wind fields. The results show the winter impact of each mode on wave parameters which are discussed regionally. The NAO and EA pattern increase winter SWH up to 1 m per unit index at the Scottish and Spanish coasts, respectively, during their positive phase; while EA pattern causes clockwise changes of winter MWD up to more than 60 degrees per unit index at the Bay of Biscay during its negative phase. EA/WR and SCAN patterns have a weaker impactPeer Reviewe

The role of p53 in the alternation of vascular functions

Ageing is a risk factor for many degenerative diseases. Cardiovascular diseases (CVDs) are usually big burdens for elderly, caregivers and the health system. During the aging process, normal functions of vascular cells and tissue progressively lost and eventually develop vascular diseases. Endothelial dysfunction, reduced bioavailability of endothelium-derived nitric oxide are usual phenomena observed in patients with cardiovascular diseases. Myriad of studies have been done to investigate to delay the vascular dysfunction or improve the vascular function to prolong the aging process. Tumor suppressor gene p53, also a transcription factor, act as a gatekeeper to regulate a number of genes to maintain normal cell function including but not limited to cell proliferation, cell apoptosis. p53 also crosstalk with other key transcription factors like hypoxia-inducible factor 1 alpha that contribute to the progression of cardiovascular diseases. Therefore, in recent three decades, p53 has drawn scientists’ attention on its effects in vascular function. Though the role of tumor suppressor gene p53 is still not clear in vascular function, it is found to play regulatory roles and may involve in vascular remodeling, atherosclerosis or pulmonary hypertension. p53 may have a divergent role in endothelial and vascular muscle cells in those conditions. In this review, we describe the different effects of p53 in cardiovascular physiology. Further studies on the effects of endothelial cell-specific p53 deficiency on atherosclerotic plaque formation in common animal models are required before the therapeutic potential can be realized

Using internet search queries for infectious disease surveillance: screening diseases for suitability

Background: Internet-based surveillance systems provide a novel approach to monitoring infectious diseases. Surveillance systems built on internet data are economically, logistically and epidemiologically appealing and have shown significant promise. The potential for these systems has increased with increased internet availability and shifts in health-related information seeking behaviour. This approach to monitoring infectious diseases has, however, only been applied to single or small groups of select diseases. This study aims to systematically investigate the potential for developing surveillance and early warning systems using internet search data, for a wide range of infectious diseases. Methods: Official notifications for 64 infectious diseases in Australia were downloaded and correlated with frequencies for 164 internet search terms for the period 2009–13 using Spearman’s rank correlations. Time series cross correlations were performed to assess the potential for search terms to be used in construction of early warning systems. Results: Notifications for 17 infectious diseases (26.6%) were found to be significantly correlated with a selected search term. The use of internet metrics as a means of surveillance has not previously been described for 12 (70.6%) of these diseases. The majority of diseases identified were vaccine-preventable, vector-borne or sexually transmissible; cross correlations, however, indicated that vector-borne and vaccine preventable diseases are best suited for development of early warning systems. Conclusions: The findings of this study suggest that internet-based surveillance systems have broader applicability to monitoring infectious diseases than has previously been recognised. Furthermore, internet-based surveillance systems have a potential role in forecasting emerging infectious disease events, especially for vaccine-preventable and vector-borne diseases. Electronic supplementary material The online version of this article (doi:10.1186/s12879-014-0690-1) contains supplementary material, which is available to authorized users

Pulsating low-mass white dwarfs in the frame of new evolutionary sequences : III. The pre-ELM white dwarf instability strip

Context. Many low-mass (M /M <∼ 0.45) and extremely low-mass (ELM, M /M <∼ 0.18−0.20) white-dwarf stars are currently being found in the field of the Milky Way. Some of these stars exhibit long-period gravity-mode (g-mode) pulsations, and constitute the class of pulsating white dwarfs called ELMV stars. In addition, two low-mass pre-white dwarfs, which could be precursors of ELM white dwarfs, have been observed to show multiperiodic photometric variations. They could constitute a new class of pulsating low-mass pre-white dwarf stars. Aims. Motivated by this finding, we present a detailed nonadiabatic pulsation study of such stars, employing full evolutionary sequences of low-mass He-core pre-white dwarf models. Methods. Our pulsation stability analysis is based on a set of low-mass He-core pre-white dwarf models with masses ranging from 0.1554 to 0.2724 M , which were derived by computing the nonconservative evolution of a binary system consisting of an initially 1 M ZAMS star and a 1.4 M neutron star companion. We have considered models in which element diffusion is accounted for and also models in which it is neglected Results. We confirm and explore in detail a new instability strip in the domain of low gravities and low effective temperatures of the Teff− log g diagram, where low-mass pre-white dwarfs are currently found. The destabilized modes are radial and nonradial p and g modes excited by the κ − γ mechanism acting mainly at the zone of the second partial ionization of He, with non-negligible contributions from the region of the first partial ionization of He and the partial ionization of H. The computations with element diffusion are unable to explain the pulsations observed in the two known pulsating pre-white dwarfs, suggesting that element diffusion might be inhibited at these stages of the pre-white dwarf evolution. Our nonadiabatic models without diffusion, on the other hand, naturally explain the existence and range of periods of the pulsating pre-white dwarf star WASP J1628+10B, although they fail to explain the pulsations of WASP J0247−25B, the other known member of the class, indicating that the He abundance in the driving region of this star might be substantially higher than predicted by our models. Conclusions. Discoveries of additional members of this new class of pulsating stars and their analysis in the context of the theoretical background presented in this paper will shed new light on the evolutionary history of their progenitor stars

Dynamic network impairments underlie cognitive fluctuations in Lewy body dementia

Cognitive fluctuations are a characteristic and distressing disturbance of attention and consciousness seen in patients with Dementia with Lewy bodies and Parkinson’s disease dementia. It has been proposed that fluctuations result from disruption of key neuromodulatory systems supporting states of attention and wakefulness which are normally characterised by temporally variable and highly integrated functional network architectures. In this study, patients with DLB (n = 25) and age-matched controls (n = 49) were assessed using dynamic resting state fMRI. A dynamic network signature of reduced temporal variability and integration was identified in DLB patients compared to controls. Reduced temporal variability correlated significantly with fluctuation-related measures using a sustained attention task. A less integrated (more segregated) functional network architecture was seen in DLB patients compared to the control group, with regions of reduced integration observed across dorsal and ventral attention, sensorimotor, visual, cingulo-opercular and cingulo-parietal networks. Reduced network integration correlated positively with subjective and objective measures of fluctuations. Regions of reduced integration and unstable regional assignments significantly matched areas of expression of specific classes of noradrenergic and cholinergic receptors across the cerebral cortex. Correlating topological measures with maps of neurotransmitter/neuromodulator receptor gene expression, we found that regions of reduced integration and unstable modular assignments correlated significantly with the pattern of expression of subclasses of noradrenergic and cholinergic receptors across the cerebral cortex. Altogether, these findings demonstrate that cognitive fluctuations are associated with an imaging signature of dynamic network impairment linked to specific neurotransmitters/neuromodulators within the ascending arousal system, highlighting novel potential diagnostic and therapeutic approaches for this troubling symptom

Lignocellulose Conversion via Catalytic Transformations Yields Methoxyterephthalic Acid Directly from Sawdust

Poly(ethylene terephthalate) polyester represents the most common class of thermoplastic polymers widely used in the textile, bottling, and packaging industries. Terephthalic acid and ethylene glycol, both of petrochemical origin, are polymerized to yield the polyester. However, an earlier report suggests that polymerization of methoxyterephthalic acid with ethylene glycol provides a methoxy-polyester with similar properties. Currently, there are no established biobased synthetic routes toward the methoxyterephthalic acid monomer. Here, we show a viable route to the dicarboxylic acid from various tree species involving three catalytic steps. We demonstrate that sawdust can be converted to valuable aryl nitrile intermediates through hydrogenolysis, followed by an efficient fluorosulfation–catalytic cyanation sequence (>90%) and then converted to methoxyterephthalic acid by hydrolysis and oxidation. A preliminary polymerization result indicates a methoxy-polyester with acceptable thermal properties

On the nature of the X-ray source in GK Per

We report XMM-Newton observations of the intermediate polar (IP) GK Per on the rise to the 2002 outburst and compare them to Chandra observations during quiescence. We find an asymmetric spin light curve implying an asymmetric shape of a semi-transparent accretion curtain. A low Fe xvii (15.01/15.26 A) line flux ratio confirms the need for an asymmetric geometry and significant effects of resonant line scattering. Medium resolution spectra in outburst and quiescence are both fitted with a leaky absorber model for the post shock hard X-ray emission, a black body (outburst) for the thermalized X-ray emission from the white dwarf and an optically thin spectrum. The difference between high and low spin as well as QPO/flares states can be explained by a variation in the absorbing column density. The Fe fluorescence at 6.4 keV (equivalent width of 447 eV) is not significantly variable during spin cycle or on QPO periods. High-resolution RGS spectra reveal a number of emission lines from H-like and He-like elements. The lines are broader than the instrumental response with a roughly constant velocity dispersion for different lines, indicating identical origin. He-like emission lines are used to give values for the electron densities of log n_e ~ 12. We do not detect any variation in the emission lines during the spin cycle, implying that the lines are not noticeably obscured or absorbed. We conclude that they originate in the accretion curtains and propose a model for their shape.Comment: 14 pages, 22 figures, accepted by A&A; text re quiescent data changed slightly, references adde