Double-difference Relocation of the Aftershocks of the Tecomán, Colima, Mexico Earthquake of 22 January 2003

On 22 January 2003, the M_w = 7.6 Tecomán earthquake struck offshore of the state of Colima, Mexico, near the diffuse triple junction between the Cocos, Rivera, and North American plates. Three-hundred and fifty aftershocks of the Tecomán earthquake with magnitudes between 2.6 and 5.8, each recorded by at least 7 stations, are relocated using the double difference method. Initial locations are determined using P and S readings from the Red Sismológica Telemétrica del Estado de Colima (RESCO) and a 1-D velocity model. Because only eight RESCO stations were operating immediately following the Tecomán earthquake, uncertainties in the initial locations and depths are fairly large, with average uncertainties of 8.0 km in depth and 1.4 km in the north–south and east–west directions. Events occurring between 24 January and 31 January were located using not only RESCO phase readings but also additional P and S readings from 11 temporary stations. Average uncertainties decrease to 0.8 km in depth, 0.3 km in the east–west direction, and 0.7 km in the north–south direction for events occurring while the temporary stations were deployed. While some preliminary studies of the early aftershocks suggested that they were dominated by shallow events above the plate interface, our results place the majority of aftershocks along the plate interface, for a slab dipping between approximately 20° and 30°. This is consistent with the slab positions inferred from geodetic studies. We do see some upper plate aftershocks that may correspond to forearc fault zones, and faults inland in the upper plate, particularly among events occurring more than 3 months after the mainshock

squizofrenia: Neuroinflamação, neurodegeneração ou neurodesenvolvimento? Visão global dos aspectos genéticos

Schizophrenia is a devastating mental illness and its etiology is still largely unknown. Several gene mapping studies suggest that schizophrenia is a complex disorder, with a cumulative impact of variable genetic effects coupled with environmental factors. There is evidence that schizophrenia could be a neurodegenerative, neuroinflammatory or neurodevelopmental disorder. Neuropsychological data indicate neurocognitive functions are relatively stable over time after illness onset, whereas morphological data indicate a degenerative process; potential roles of neuroinflammation in the etiology of psychiatric diseases including schizophrenia have also been suggested. Recent research indicates genetic overlap between schizophrenia and syndromes in which psychopathology manifests in childhood and that are often grouped together as ‘neurodevelopmental disorders’. These findings challenge the etiological basis of current diagnostic categories and, together with evidence for frequent comorbidity, suggest that we should view the functional psychoses as members of a group that result in part from a combination of genetic and environmental effects on brain development and that are associated with specific and general impairments of cognitive function. The objective was to perform a systematic literature review of articles on genetics of schizophrenia relating to neurodegeneration, neuroinflammation and neurodevelopment. After proper filter, we included 40 studies and reviewed each finding and its relevance to the hypotheses. We can conclude that the evidence points to schizophrenia as a neurodevelopmental disease with the direct presence of factors related to neuroinflammation and neurodegeneration.Esquizofrenia é uma doença mental debilitante e sua etiologia é, em sua maior parte, desconhecida. Alguns estudos de mapeamento genético sugerem que esquizofrenia é uma doença complexa, com impacto acumulativo de fatores genéticos variáveis associados a fatores ambientais. Há evidência de que a esquizofrenia poderia ser uma doença neurodegenerativa, neuroinflamatória ou do neurodesenvolvimento. Dados neuropsicológicos indicam que funções cognitivas são relativamente estáveis no decorrer do tempo após o início da doença, enquanto dados morfológicos indicam processos degenerativos; papéis importantes da neuroinflamação na etiologia de doenças psiquiátricas, incluindo esquizofrenia, também foram sugeridos. Pesquisas recentes indicam sobreposição entre esquizofrenia e síndromes cuja fisiopatologia se manifesta na infância e são em geral agrupadas como “doenças do neurodesenvolvimento”. Estes achados desafiam a base etiológica das categorias atuais de diagnóstico e, juntamente com a evidência de comorbidade frequente, sugerem que devemos ver as psicoses como membros do grupo que resulta em parte da combinação de efeitos genéticos e ambientais no desenvolvimento do cérebro e que estão associados a prejuízos específicos e gerais da função cognitiva. O objetivo foi realizar uma revisão sistemática da literatura de trabalhos em genética da esquizofrenia relacionados a neurodegeneração, neuroinflamação e neurodesenvolvimento. Após buscas específicas, incluímos 40 estudos e revisamos cada achado e sua relevância para a hipótese. Nós concluímos que a evidência aponta para esquizofrenia como uma doença do neurodesenvolvimento com presença direta de fatores relacionados a neuroinflamação e neurodegeneração

Nutrição no processo de reabilitação de ex-usuários de drogas psicoativas: mapeamento do perfil nutricional de etilistas em recuperação de um grupo de apoio do município de Foz do Iguaçu/PR

Introdução. A dependência ao álcool tem como consequência o enfraquecimentofísico e clínico. A deficiência de micronutrientes ocorre com frequênciarelacionada ao consumo do álcool, indicando que o acompanhamento nutricionalmelhoraria o estado nutricional do etilista em recuperação. Objetivo. Apresentar oestado nutricional de alcoolistas em recuperação, frequentadores do grupo deapoio alcoólicos anônimos (AA) do município de Foz do Iguaçu/PR.Metodologia. Trata-se de um estudo transversal, com caráter descritivo eobservacional, realizado a partir de um levantamento dos dados de uma amostrarepresentativa da população de etilistas em recuperação. Foram entrevistados 34indivíduos. Resultados. Foram observados a predominância de indivíduos dosexo masculino (79,41%), casados (58,82%), empregados (58,82%) e com baixonível de escolaridade (70,58% apresentando 2º grau incompleto). Verificou-se quea faixa etária predominante de início do etilismo foi de 11 – 20 anos representando(55,88%) e o tempo de consumo foi superior a 10 anos (85,29%,). Os resultadosda presente pesquisa com relação ao IMC 3% apresentaram baixo peso, 70%algum grau de excesso de peso ou obesidade, 27% eutrofia e 79,4%apresentou obesidade abdominal, permitindo assim considerar que oalcoolismo influenciou no estado físico dos etilistas em recuperação. Conclusão.Os resultados apresentados no presente estudo mostram prevalência elevada deindivíduos com excesso de peso e obesidade, além de medida de circunferência dacintura alterada. Os resultados destacam padrão de consumo alimentar inadequadoem relação à ingestão de diversos alimentos. É importante que nessa fase daabstinência o individuo seja acompanhado e orientado por um profissional danutrição para ajudar a alcançar o seu ob

Orchid bees (Hymenoptera: Apidae) in the coastal forests of southern Brazil: diversity, efficiency of sampling methods and comparison with other Atlantic forest surveys

Surveys of orchid bees at the Brazilian Atlantic forest have been restricted to a few regions, making difficult to understand latitudinal patterns of distribution and diversity of these bees. For this reason we sampled the euglossine fauna at Atlantic forest areas at the coastal region of São Paulo (Sete Barras, Faz. Morro do Capim: SP3) and state of Paraná (Antonina, Reserva Natural do Rio Cachoeira: PR3), in southern Brazil. In PR3, we also evaluated the efficiency of collecting methods for sampling the fauna, comparing bait traps with direct collecting using entomological nets on fragrance baits. The diversity and abundance of bees was very low: we caught only 39 males of eight species in SP3 (Euglossa iopoecila, Euglossa roderici, Eulaema nigrita, Euglossa annectans, Eulaema cingulata, Euglossa pleosticta, Euglossa viridis and Exaerete smaragdina) and 254 males of six species in PR3 (Euglossa iopoecila, Euglossa annectans, Euglossa stellfeldi, Euglossa roderici, Euglossa pleosticta and Eulaema nigrita). Comparing the sampling methodologies, use of insect nets on fragrance baits (six species; 221 specimens) was more efficient than bait traps (three species; 33 specimens). When comparing the faunas of these two areas with other surveys at the Atlantic forest sites, through a DCA analysis, we found that the two surveys presented in this paper were placed relatively close to each other, but apart from the other sites analyzed, not clustering with the southernmost survey at the subtropical Atlantic forest of Rio Grande do Sul or with the remaining surveys carried out at northern lowland sites of this biome.Os levantamentos da fauna de abelhas euglossíneas realizados até o momento ao longo da floresta Atlântica são restritos a poucas regiões e não permitem um entendimento mais aprofundado dos padrões latitudinais de distribuição e diversidade dessas abelhas. Por este motivo, duas áreas de floresta Atlântica do sul do Brasil, na planície costeira de São Paulo (Sete Barras, Faz. Morro do Capim: SP3) e do Paraná (Antonina, Reserva Natural do Rio Cachoeira: PR3), tiveram sua fauna de euglossíneos amostrada. Em PR3, foi avaliada também a eficiência de dois métodos alternativos de coleta, fazendo-se a comparação entre armadilhas plásticas, iscadas com fragrâncias, e coleta direta com rede entomológica em iscas odoríferas. A diversidade e abundância das abelhas foram muito baixas: apenas 39 machos de oito espécies foram coletados em SP3 (Euglossa iopoecila, Euglossa roderici, Eulaema nigrita, Euglossa annectans, Eulaema cingulata, Euglossa pleosticta, Euglossa viridis e Exaerete smaragdina) e 254 machos de seis espécies em PR3 (Euglossa iopoecila, Euglossa annectans, Euglossa stellfeldi, Euglossa roderici, Euglossa pleosticta e Eulaema nigrita). A comparação entre os métodos de amostragem mostrou que a coleta direta (seis espécies; 221 espécimes) foi mais eficiente do que o uso de armadilhas (três espécies; 33 espécimes). A análise de correspondência (DCA) mostrou que os dois levantamentos apresentados aqui se posicionaram relativamente próximos entre si, porém afastados dos outros locais comparados, não se agrupando com o levantamento mais meridional nos domínios da floresta Atlântica do Rio Grande do Sul, nem com aqueles conduzidos em áreas de terras baixas mais ao norte nesse bioma

Vascular Damage In Resistant Hypertension: Tnf-alpha Inhibition Effects On Endothelial Cells

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Inflammatory cytokines have been associated with the pathophysiology of hypertension and target organ damage (TOD). Resistant hypertensive patients (RHTN) are characterized by poor blood pressure control and higher prevalence of TOD. This study evaluated the relationship between plasma levels of TNF-alpha and arterial stiffness (pulse wave velocity-PWV) in 32 RHTN and 19 normotensive subjects. Moreover, we investigated the effect of TNF-alpha inhibition on human endothelial cells (HUVECs) incubated with serum from RHTN and normotensive subjects. HUVECs containing serum obtained from normotensive (n = 8) and hypertensive (n = 8) individuals were treated with TNF-alpha inhibitor (infliximab). Cell suspensions were used for measurement of DNA fragmentation and reactive oxygen species (ROS) content. RHTN patients showed higher levels of TNF-alpha compared to normotensive subjects, as well as higher PWV. Positive correlation was found between TNF-alpha levels and PWV measures in the whole group. HUVECs incubated with serum from RHTN showed increased cell apoptosis and higher ROS content compared to normotensive subjects. Infliximab attenuated the apoptosis of HUVECs incubated with serum from RHTN, but no effect in ROS production was observed. Our findings suggest that TNF-alpha might mediate, at least in part, vascular damage in resistant hypertension.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES

“MODULACIÓN DEL TONO MUSCULAR A TRAVÉS DE LA EQUINOTERAPIA EN PACIENTES CON PARÁLISIS CEREBRAL ESPÁSTICA DEL CENTRO DE REHABILITACIÓN INFANTIL DE LA SECRETARÍA DE LA DEFENSA NACIONAL DE JUNIO-AGOSTO DEL 2012”.

A la Equinoterapia se le conoce como la alternativa terapéutica que utiliza al caballo como un instrumento terapéutico que coadyuva a la rehabilitación física, social, mental y temperamental de pacientes con algunas deficiencias físicas, esta se realiza a través de la transmisión de calor corporal del caballo, del impulso rítmico y del patrón tridimensional, equivalente al patrón fisiológico del ser human

Towards strategic design: the experience of two Colombian MSMEs

This qualitative-interpretive study reflects on the experience of two MSMEs that adapted rapidly to meet the need for protection products and maintain their production in the midst of confinement decreed by the city and country authorities, as a containment measure for the pandemic caused by the Covid-19, and where design was a key factor. The different experiences are organized taken the Product sociotechnical Cycles (PstC) model as a conceptual basis, analyzing the case studies from the organizational capabilities of industrial design, as well as from design-driven innovation. The article ends by summarizing the learnings, emphasizing the value of design with a strategic focus, in these processes of change

COPD And Family Care: Orientations For Developing Psychoeducational Programs

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Planning for climate change northern monsoon cluster: decision making and planning for natural resource management

Natural resource managers are tasked with a range of challenging and sometimes competing management objectives but often have limited resources with which to achieve them. Natural resource management (NRM) objectives typically include conserving biodiversity, maintaining healthy ecosystems, achieving water quality targets and restoring degraded habitats. A key challenge is to identify where, when and how to implement effective activities to achieve these objectives with the least cost and impact on stakeholders. This project provided and tested an appropriate decision support framework for cross-realm planning and supporting synthesis of NRM plans to assist natural resource management groups in northern Australia successfully tackle this challenge

A prospective study of the sensitivity, specificity and diagnostic performance of soluble intercellular adhesion molecule 1, highly sensitive C-reactive protein, soluble E-selectin and serum amyloid A in the diagnosis of neonatal infection

<p>Abstract</p> <p>Background</p> <p>Diagnosis of neonatal infection is difficult, because of it's non-specific clinical presentation and the lack of reliable diagnostic tests. The purpose of this study was to examine the potential diagnostic value of serum soluble intercellular adhesion molecule-1 (sICAM-1), soluble E-selectin (sE-selectin), highly sensitive C-reactive protein (hsCRP) and serum amyloid A (SAA) measurements, both individually and in combination in the setting of a neonatal intensive care unit.</p> <p>Methods</p> <p>219 consecutive serum samples were taken from 149 infants undergoing sepsis work up in a neonatal intensive care unit. Clinical diagnosis was established in a prospective manner, blind to the results of the study measurements. Infants were classified by an experienced paediatrician as infected or not-infected, one week after presentation. Classification was based on clinical presentation, routine laboratory and radiological investigations and response to therapy. The infected group were sub-classified as (a) culture positive infection or (b) culture negative infection. sICAM-1, sE-selectin, hsCRP and SAA levels were determined from stored serum samples after diagnosis was established. Further sub-group analysis of results was undertaken according to early or late onset of infection and preterm or term status. Statistical analysis utilised Mann Whitney U test and ROC curve analysis.</p> <p>Results</p> <p>There were significantly increased serum levels of sICAM-1, hsCRP, E selectin (p < 0.001) and SAA (p = 0.004) in infected infants compared with non-infected. ROC curve analysis indicated area under the curve values of 0.79 (sICAM-1), 0.73 (hsCRP), 0.72 (sE-selectin) and 0.61 (SAA). ROC curve analysis also defined optimum diagnostic cut-off levels for each measurement. The performance characteristics of sICAM-1, hsCRP and sE-selectin included a high negative predictive value (NPV) for culture positive infection and this was enhanced by combination of all 4 measurements. Clinical subgroup analysis suggested particularly high NPV for early onset symptoms, however further studies are required to elucidate this finding.</p> <p>Conclusions</p> <p>All four study measurements demonstrated some diagnostic value for neonatal infection however sICAM-1, hsCRP and sE-selectin demonstrated the highest NPV individually. The optimum diagnostic cut off level for hsCRP measurement in this study was much lower than currently used in routine clinical practice. Use of a combination of measurements enhanced diagnostic performance, demonstrating sensitivity of 90.3% and NPV of 91.3%. This study suggests there may be value in use of several of these markers, individually and in combination to assist in excluding neonatal infection. Further work is needed to confirm a specific role in the exclusion of early onset infection.</p