Effects of a physical activity intervention study in obese/overweight children adipose tissue

The worldwide increase of obesity in children claim for urgent measures in several instances. One of the keys measures is to increase the children habitual physical activity (PA). The propose of this study is to analyze the effects of an PA intervention program in the children adipose tissue

Understanding caretakers\u27 dilemma in deciding whether or not to adhere with referral advice after pre-referral treatment with rectal artesunate

Background: Malaria kills. A single rectal dose of artesunate before referral can reduce mortality and prevent permanent disability. However, the success of this intervention depends on caretakers\u27 adherence to referral advice for follow-up care. This paper explores the dilemma facing caretakers when they are in the process of deciding whether or not to transit their child to a health facility after pre-referral treatment with rectal artesunate. Methods: Four focus group discussions were held in each of three purposively selected villages in Mtwara rural district of Tanzania. Data were analysed manually using latent qualitative content analysis. Results: The theme «Caretakers dilemma in deciding whether or not to adhere with referral advice after pre-referral treatment with rectal artesunate» depicts the challenge they face. Caretakers\u27 understanding of the rationale for going to hospital after treatment - when and why they should adhere - influenced adherence. Caretakers, whose children did not improve, usually adhered to referral advice. If a child had noticeably improved with pre-referral treatment however, caretakers weighed whether they should proceed to the facility, balancing the child\u27s improved condition against other competing priorities, difficulties in reaching the health facilities, and the perceived quality of care at the health facility. Some misinterpretation were found regarding the urgency and rationale for adherence among some caretakers of children who improved which were attributed to be possibly due to their prior understanding. Conclusion: Some caretakers did not adhere when their children improved and some who adhered did so without understanding why they should proceed to the facility. Successful implementation of the rectal artesunate strategy depends upon effective communication regarding referral to clinic. © 2010 Simba et al; licensee BioMed Central Ltd

Local Isometric immersions of pseudo-spherical surfaces and evolution equations

The class of differential equations describing pseudo-spherical surfaces, first introduced by Chern and Tenenblat [3], is characterized by the property that to each solution of a differential equation, within the class, there corresponds a 2-dimensional Riemannian metric of curvature equal to $-1$. The class of differential equations describing pseudo-spherical surfaces carries close ties to the property of complete integrability, as manifested by the existence of infinite hierarchies of conservation laws and associated linear problems. As such, it contains many important known examples of integrable equations, like the sine-Gordon, Liouville and KdV equations. It also gives rise to many new families of integrable equations. The question we address in this paper concerns the local isometric immersion of pseudo-spherical surfaces in ${\bf E}^{3}$ from the perspective of the differential equations that give rise to the metrics. Indeed, a classical theorem in the differential geometry of surfaces states that any pseudo-spherical surface can be locally isometrically immersed in ${\bf E}^{3}$. In the case of the sine-Gordon equation, one can derive an expression for the second fundamental form of the immersion that depends only on a jet of finite order of the solution of the pde. A natural question is to know if this remarkable property extends to equations other than the sine-Gordon equation within the class of differential equations describing pseudo-spherical surfaces. In an earlier paper [11], we have shown that this property fails to hold for all other second order equations, except for those belonging to a very special class of evolution equations. In the present paper, we consider a class of evolution equations for $u(x,t)$ of order $k\geq 3$ describing pseudo-spherical surfaces. We show that whenever an isometric immersion in ${\bf E}^3$ exists, depending on a jet of finite order of $u$, then the coefficients of the second fundamental forms are functions of the independent variables $x$ and $t$ only.Comment: Fields Institute Communications, 2015, Hamiltonian PDEs and Applications, pp.N

Effects of a physical activity intervention study in obese/overweight children adipose tissue

The worldwide increase of obesity in children claim for urgent measures in several instances. One of the keys measures is to increase the children habitual physical activity (PA). The propose of this study is to analyze the effects of an PA intervention program in the children adipose tissue

Regional scale evaluation of nitrate fluctuations in groundwater using cluster analysis and standardised hydrometeorological indices

Temporal fluctuations in nitrate in groundwater can result in concentrations temporarily exceeding drinking water standards. This can bring about the need for costly water treatment or blending. Despite this, the extent and potential controls on these fluctuations are poorly understood, particularly at regional to national scales. Applied to Southeast England (UK), here we develop the first application of cluster analysis and standardised hydrometeorological indices to evaluate nitrate fluctuations in groundwater at the regional scale. Hierarchical and K-means cluster analysis of 96 groundwater nitrate time series for the period 1995–2022 showed that nitrate time series can be divided into 4 clusters: (1) long term increasing trends (n = 23, mean trend = 0.26 mg NO3/l/a), (2) long term decreasing trends (n = 19, mean trend = − 0.65 mg NO3/l/a), (3) long term increasing trends with seasonal fluctuations (n = 24, mean trend = 0.29 mg NO3/l/a) and (4) long term increasing trends superimposed on near-decadal scale fluctuations (n = 30, mean trend = 0.22 mg NO3/l/a). Boreholes in cluster 1 appear to be deeper than boreholes in cluster 2. In comparison to shallower boreholes, deeper boreholes are likely to be intersecting longer groundwater flow systems where nitrate concentrations are affected by historic “legacy nitrate” leaching. There is weak spatial coherence in the clustering, with clusters 3 and 4 present in the South and North Downs respectively. Cross-correlation analysis between groundwater nitrate time series with precipitation and groundwater level indices showed that rapid seasonal fluctuations in nitrate concentrations in cluster 3 in the South Downs are associated with rapidly responding groundwater level fluctuation. This is likely due to the highly fractured and faulted nature of the Chalk aquifer in this area. This is in contrast with the slower near-decadal fluctuations in cluster 4 in the North Downs. The strongest correlations between groundwater levels and nitrate concentrations in cluster 3 occurred when cross-correlating at a lag of zero months, which would suggest that matrix diffusion is unlikely to be a significant control on nitrate seasonality. Seasonal fluctuations in nitrate concentrations are likely to be associated with a combination of piston displacement at the water table and changing groundwater flow paths to the borehole. Future climate change may change the magnitude and timing of seasonal fluctuations caused by these processes. The methodology developed here is generic and can be applied wherever there is a large body of groundwater nitrate time series data

Regional scale evaluation of nitrate fluctuations in groundwater using cluster analysis and standardised hydrometeorological indices

Temporal fluctuations in nitrate in groundwater can result in concentrations temporarily exceeding drinking water standards, resulting in costly water treatment or blending. The extent and potential controls on these fluctuations are poorly understood, particularly at regional to national scales. Applied to southeast England (UK), we develop the first application of cluster analysis and standardised hydrometeorological indices to evaluate nitrate fluctuations in groundwater. Cluster analysis of 96 groundwater nitrate time series showed that nitrate time series can be divided into 4 clusters: (1) long term increasing trends (n = 23, mean trend = 0.26 mg NO3/l/a), (2) long term decreasing trends (n = 19, mean trend = - 0.65 mg NO3/l/a), (3) long term increasing trends with seasonal fluctuations (n = 24, mean trend = 0.29 mg NO3/l/a) and (4) long term increasing trends superimposed on near-decadal scale fluctuations (n = 30, mean trend = 0.22 mg NO3/l/a). There is weak spatial coherence in the clustering, with clusters 3 and 4 present in the South and North Downs respectively. Cross-correlation analysis between groundwater nitrate time series with precipitation and groundwater level indices showed that rapid seasonal fluctuations in nitrate concentrations in cluster 3 in the South Downs are associated with rapidly responding groundwater level fluctuation. This is likely due to the highly fractured and faulted nature of the Chalk aquifer in this area. The strongest correlations between groundwater levels and nitrate concentrations in cluster 3 occurred when cross-correlating at a lag of zero months, which suggests that matrix diffusion is unlikely to be a significant control on seasonality. Seasonal fluctuations in nitrate concentrations are likely to be associated with piston displacement and changing groundwater flow paths. The methodology developed here is generic and can be applied wherever there is a large body of groundwater nitrate time series data

Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters

This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or cannabinoid receptor type 1 (CB1) receptor agonists cause clear anxiolytic responses when injected into this region. The nitrergic and eCB systems can regulate the activity of classical neurotransmitters such as glutamate and γ-aminobutyric acid (GABA) that control PAG activity. We propose that they exert a ‘fine-tuning’ regulatory control of defensive responses in this area. This control, however, is probably complex, which may explain the usually bell-shaped dose-response curves observed with drugs that act on NO- or CB1-mediated neurotransmission. Even if the mechanisms responsible for this complex interaction are still poorly understood, they are beginning to be recognized. For example, activation of transient receptor potential vanilloid type-1 channel (TRPV1) receptors by anandamide seems to counteract the anxiolytic effects induced by CB1 receptor activation caused by this compound. Further studies, however, are needed to identify other mechanisms responsible for this fine-tuning effect

The Kuiper Belt and Other Debris Disks

We discuss the current knowledge of the Solar system, focusing on bodies in the outer regions, on the information they provide concerning Solar system formation, and on the possible relationships that may exist between our system and the debris disks of other stars. Beyond the domains of the Terrestrial and giant planets, the comets in the Kuiper belt and the Oort cloud preserve some of our most pristine materials. The Kuiper belt, in particular, is a collisional dust source and a scientific bridge to the dusty "debris disks" observed around many nearby main-sequence stars. Study of the Solar system provides a level of detail that we cannot discern in the distant disks while observations of the disks may help to set the Solar system in proper context.Comment: 50 pages, 25 Figures. To appear in conference proceedings book "Astrophysics in the Next Decade

The Correlated Colors of Transneptunian Binaries

We report resolved photometry of the primary and secondary components of 23 transneptunian binaries obtained with the Hubble Space Telescope. V-I colors of the components range from 0.7 to 1.5 with a median uncertainty of 0.06 magnitudes. The colors of the primaries and secondaries are correlated with a Spearman rank correlation probability of 99.99991%, 5 sigma for a normal distribution. Fits to the primary vs. secondary colors are identical to within measurement uncertainties. The color range of binaries as a group is indistinguishable from that of the larger population of apparently single transneptunian objects. Whatever mechanism produced the colors of apparently single TNOs acted equally on binary systems. The most likely explanation is that the colors of transneptunian objects and binaries alike are primordial and indicative of their origin in a locally homogeneous, globally heterogeneous protoplanetary disk.Comment: 28 pages, 4 figure, 4 tables. accepted to Icaru

Exploring the value of routinely collected data on EQ-5D-5L and other electronic patient-reported outcome measures as prognostic factors in adults with advanced non-small cell lung cancer receiving immunotherapy

Objective Investigate whether routinely collected electronic patient-reported outcome measures (ePROMs) add prognostic value to clinical and tumour characteristics for adults with advanced non-small cell lung cancer (NSCLC) receiving immunotherapy. Methods and analysis We retrospectively analysed data from adults with advanced NSCLC commencing immunotherapy between April 2019 and June 2022. Prognostic factors were ePROMs on quality of life (EuroQoL five-dimension five-level (EQ-5D-5L); EuroQoL Visual Analogue Scale (EQ-VAS)) and symptoms (patient-reported version of the Common Terminology Criteria for Adverse Events v5.0) completed at baseline and the first followup. We performed Cox proportional hazard regression for overall survival and time-to-progression as outcomes, and logistic regression for the onset of severe treatment toxicities (grade ≥3). Results We included 379 patients; 161 (42.5%) completed ePROMs at baseline. Median overall survival and time-to-progression were 13.5 months (95% CI 11.3 to 16.7) and 10.5 months (95% CI 8.8 to 13.7), respectively. 36 (9.5%) experienced severe treatment toxicities during follow-up. Patients with lower EQ-5D-5L utility scores (HR per 0.1 unit increase 0.84, 95% CI 0.74 to 0.95) and higher symptom burden (HR 1.11; 95% CI 1.04 to 1.19) had poorer overall survival. This was also true for those with decreased EQ-VAS and increased symptom burden between baseline and the first follow-up. Lastly, only decreased EQ-5D-5L utility scores between baseline and the first follow-up were associated with shorter time-to-progression. Conclusion ePROMs may add prognostic value to clinical and tumour characteristics for overall survival in adults with advanced NSCLC receiving immunotherapy