L'internista naviga nel mare salato che è in noi

Il mare vivo che è in noi F. Sgambato, S. Prozzo, E. Sgambato Meccanismi fisiologici del ricambio di sodio ed acqua M. Renis Le alterazioni del bilancio del sodio e dell’acqua M. Renis Approccio clinico-pratico ai disturbi dell’equilibrio acido-base A. Casola, L. Bianchi, S. Detrenis, S. Pioli, M. del Mar Jordana-Sanchez, T. Pasquariello, D. Fasano, M. Saccò, A. Magnano, F. Spagnoli, M. Meschi Approccio clinico-diagnostico e strumentale alle iposodiemie ipotoniche e non ipotoniche I. Ambrosino Approccio clinico-diagnostico e strumentale alle ipersodiemie A. Ilardi La sindrome da inappropriata antidiuresi G. Tenconi, G. Secondo, L. Mortara Approccio clinico-diagnostico e strumentale alle ipopotassiemie T.M. Attardo Approccio diagnostico e strumentale alle iperpotassiemie M. Gambacorta Ipocalcemia: condizione comune a diverse patologie A. Montagnani, M. Alessandri, M. Migliorini Approccio clinico-diagnostico e strumentale alle ipercalcemie P. Gnerre, M. Grandi, A. Percivale Approccio clinico-diagnostico e strumentale alle ipomagnesiemie e alle ipermagnesiemie L. Lenzi Approccio al paziente con ipofosfatemia e iperfosfatemia M.T. De Donato Conclusioni ...ma hai sale in zucca? A. Fontanell

II ruolo degli omega-3 nel paziente pluripatologico complesso: dalle evidenze alla pratica clinica in Medicina Interna

II ruolo degli omega-3 nel paziente pluripatologico complesso      M. Campanini, R. Nardi II ruolo degli omega-3 nella prevenzione dell’ipertrigliceridemia pura e iperlipemia combinata, ma non solo: dalle evidenze alla pratica clinica P. Gnerre, O. Para, G. Balbi Gli omega-3 nell’obesità e nell’insulino-resistenza M. Poggiano Gli omega-3 nel diabete mellito di tipo 2 M. Poggiano Gli effetti degli omega-3 sulle aritmie C. Cenci Gli effetti degli omega-3 nella prevenzione dell’infarto miocardico R. Gerloni Omega-3 e scompenso cardiaco R. Gerloni I prodotti naturali: una possibile alternativa alle statine per la riduzione del colesterolo M.C. Pasquini Nutrizione, omega-3 e cancro A. Mazza, G. Rubello, G. Mazza Gli omega-3: trigliceridi naturali o esteri etilici? P. Zuccheri, C. Iacono, G. Benini II ruolo degli omega-3 nel paziente pluripatologico complesso: dalle evidenze alla pratica clinica in Medicina Interna A. Fontanell

An update on methods for Sarcopenia Diagnosis: From bench to bedside

Sarcopenia has been recognized as an age-related syndrome characterized by low muscle mass, low muscle strength, and low physical performance that is associated with increased likelihood of adverse outcomes including falls, fractures, hospitalization, frailty and mortality. Therefore, it is necessary to identify the condition early for applying intervention and prevention of the disastrous consequences of sarcopenia if left untreated. Clinical definition and diagnostic criteria for sarcopenia have been developed in the last years and different tools have been proposed for screening subjects with sarcopenia, evaluating the muscle mass, the muscle strength and the physical performance. In this review we analyzed the diagnostic criteria of sarcopenia and examined the current assessment tools used for the diagnosis and screening of sarcopenia

Assessment of HCC response to Yttrium-90 radioembolization with gadoxetate disodium MRI: correlation with histopathology.

Transarterial <sup>90</sup> Y radioembolization (TARE) is increasingly being used for hepatocellular carcinoma (HCC) treatment. However, tumor response assessment after TARE may be challenging. We aimed to assess the diagnostic performance of gadoxetate disodium MRI for predicting complete pathologic necrosis (CPN) of HCC treated with TARE, using histopathology as the reference standard. This retrospective study included 48 patients (M/F: 36/12, mean age: 62 years) with HCC treated by TARE followed by surgery with gadoxetate disodium MRI within 90 days of surgery. Two radiologists evaluated tumor response using RECIST1.1, mRECIST, EASL, and LI-RADS-TR criteria and evaluated the percentage of necrosis on subtraction during late arterial, portal venous, and hepatobiliary phases (AP/PVP/HBP). Statistical analysis included inter-reader agreement, correlation between radiologic and pathologic percentage of necrosis, and prediction of CPN using logistic regression and ROC analyses. Histopathology demonstrated 71 HCCs (2.8 ± 1.7 cm, range: 0.5-7.5 cm) including 42 with CPN, 22 with partial necrosis, and 7 without necrosis. EASL and percentage of tumor necrosis on subtraction at the AP/PVP were independent predictors of CPN (p = 0.02-0.03). Percentage of necrosis, mRECIST, EASL, and LI-RADS-TR had fair to good performance for diagnosing CPN (AUCs: 0.78 - 0.83), with a significant difference between subtraction and LI-RADS-TR for reader 2, and in specificity between subtraction and other criteria for both readers (p-range: 0.01-0.04). Radiologic percentage of necrosis was significantly correlated to histopathologic degree of tumor necrosis (r = 0.66 - 0.8, p < 0.001). Percentage of tumor necrosis on subtraction and EASL criteria were significant independent predictors of CPN in HCC treated with TARE. Image subtraction should be considered for assessing HCC response to TARE when using MRI. • Percentage of tumor necrosis on image subtraction and EASL criteria are significant independent predictors of complete pathologic necrosis in hepatocellular carcinoma treated with <sup>90</sup> Y radioembolization. • Subtraction, mRECIST, EASL, and LI-RADS-TR have fair to good performance for diagnosing complete pathologic necrosis in hepatocellular carcinoma treated with <sup>90</sup> Y radioembolization

Subfactors of index less than 5, part 3: quadruple points

One major obstacle in extending the classification of small index subfactors beyond 3+\sqrt{3} is the appearance of infinite families of candidate principal graphs with 4-valent vertices (in particular, the "weeds" Q and Q' from Part 1 (arXiv:1007.1730)). Thus instead of using triple point obstructions to eliminate candidate graphs, we need to develop new quadruple point obstructions. In this paper we prove two quadruple point obstructions. The first uses quadratic tangles techniques and eliminates the weed Q' immediately. The second uses connections, and when combined with an additional number theoretic argument it eliminates both weeds Q and Q'. Finally, we prove the uniqueness (up to taking duals) of the 3311 Goodman-de la Harpe-Jones subfactor using a combination of planar algebra techniques and connections.Comment: 21 page

Italian good practice recommendations on management of persons with Long-COVID

A significant number of people, following acute SARS-CoV-2 infection, report persistent symptoms or new symptoms that are sustained over time, often affecting different body systems. This condition, commonly referred to as Long-COVID, requires a complex clinical management. In Italy new health facilities specifically dedicated to the diagnosis and care of Long-COVID were implemented. However, the activity of these clinical centers is highly heterogeneous, with wide variation in the type of services provided, specialistic expertise and, ultimately, in the clinical care provided. Recommendations for a uniform management of Long-COVID were therefore needed. Professionals from different disciplines (including general practitioners, specialists in respiratory diseases, infectious diseases, internal medicine, geriatrics, cardiology, neurology, pediatrics, and odontostomatology) were invited to participate, together with a patient representative, in a multidisciplinary Panel appointed to draft Good Practices on clinical management of Long-COVID. The Panel, after extensive literature review, issued recommendations on 3 thematic areas: access to Long-COVID services, clinical evaluation, and organization of the services. The Panel highlighted the importance of providing integrated multidisciplinary care in the management of patients after SARS-CoV-2 infection, and agreed that a multidisciplinary service, one-stop clinic approach could avoid multiple referrals and reduce the number of appointments. In areas where multidisciplinary services are not available, services may be provided through integrated and coordinated primary, community, rehabilitation and mental health services. Management should be adapted according to the patient's needs and should promptly address possible life-threatening complications. The present recommendations could provide guidance and support in standardizing the care provided to Long-COVID patients

Minimal Absent Words in Four Human Genome Assemblies

Minimal absent words have been computed in genomes of organisms from all domains of life. Here, we aim to contribute to the catalogue of human genomic variation by investigating the variation in number and content of minimal absent words within a species, using four human genome assemblies. We compare the reference human genome GRCh37 assembly, the HuRef assembly of the genome of Craig Venter, the NA12878 assembly from cell line GM12878, and the YH assembly of the genome of a Han Chinese individual. We find the variation in number and content of minimal absent words between assemblies more significant for large and very large minimal absent words, where the biases of sequencing and assembly methodologies become more pronounced. Moreover, we find generally greater similarity between the human genome assemblies sequenced with capillary-based technologies (GRCh37 and HuRef) than between the human genome assemblies sequenced with massively parallel technologies (NA12878 and YH). Finally, as expected, we find the overall variation in number and content of minimal absent words within a species to be generally smaller than the variation between species

The Cyprinodon variegatus genome reveals gene expression changes underlying differences in skull morphology among closely related species

Genes in durophage intersection set at 15 dpf. This is a comma separated table of the genes in the 15 dpf durophage intersection set. Given are edgeR results for each pairwise comparison. Columns indicating whether a gene is included in the intersection set at a threshold of 1.5 or 2 fold are provided. (CSV 13 kb