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Shocks and PDRs in an intermediate mass star forming globule: the case of IC1396N
The dark globule IC1396N is a typical example of a star formation process induced by radiation driven implosion due to the strong UV field from a nearby O6 star. The IRAS source embedded in the globule and its associated molecular outflow have been observed with the Long Wavelength Spectrometer (LWS) on ISO revealing an extremely rich spectrum including: CO rotational lines from J=14-13 up to J=28-27, rotational lines from ortho-H2O, OH lines involving the first four rotational levels of both ladders, atomic (OI 63μm, OI 145μm) and ionic (CII 157μm, OIII 52μm, OIII 88μm) lines. A complex picture arises, where an externally illuminated PDR coexists with strong C-shocks within IC1396N and whose origin is not clear
Asymptotic solvers for ordinary differential equations with multiple frequencies
We construct asymptotic expansions for ordinary differential equations with highly oscillatory forcing terms, focusing on the case of multiple, non-commensurate frequencies. We derive an asymptotic expansion in inverse powers of the oscillatory parameter and use its truncation as an exceedingly effective means to discretize the differential equation in question. Numerical examples illustrate the effectiveness of the method
High efficiency and high linearity power amplifier design
The optimum high-frequency Class-F loading conditions are inferred, accounting for the effects of actual output device behavior, and deriving useful charts for an effective
design. The important role of the biasing point selection is stressed, demonstrating that it must
be different from the Class-B theoretical one to get the expected improvement. The IMD behavior of the Class-F amplifier is presented and the large-signal sweet-spot origin in the
IMD output characteristics is discussed, together with possible strategies to improve intermodulation
distortion performances. The control of the sweet spot position is demonstrated
via proper terminating impedances, both at fundamental and harmonic frequencies and low frequencies
Assessment of microvascular involvement in lupus nephritis patients by retinal OCT-angiography and kidney biopsies.
Mapping water in protostellar outflows with Herschel: PACS and HIFI observations of L1448-C
We investigate on the spatial and velocity distribution of H2O along the
L1448 outflow, its relationship with other tracers, and its abundance
variations, using maps of the o-H2O 1_{10}-1_{01} and 2_{12}-1_{01} transitions
taken with the Herschel-HIFI and PACS instruments, respectively. Water emission
appears clumpy, with individual peaks corresponding to shock spots along the
outflow. The bulk of the 557 GHz line is confined to radial velocities in the
range \pm 10-50 km/s but extended emission associated with the L1448-C extreme
high velocity (EHV) jet is also detected. The H2O 1_{10}-1_{01}/CO(3-2) ratio
shows strong variations as a function of velocity that likely reflect different
and changing physical conditions in the gas responsible for the emissions from
the two species. In the EHV jet, a low H2O/SiO abundance ratio is inferred,
that could indicate molecular formation from dust free gas directly ejected
from the proto-stellar wind. We derive averaged Tkin and n(H2) values of about
300-500 K and 5 10^6 cm-3 respectively, while a water abundance with respect to
H2 of the order of 0.5-1 10^{-6} along the outflow is estimated. The fairly
constant conditions found all along the outflow implies that evolutionary
effects on the timescales of outflow propagation do not play a major role in
the H2O chemistry. The results of our analysis show that the bulk of the
observed H2O lines comes from post-shocked regions where the gas, after being
heated to high temperatures, has been already cooled down to a few hundred K.
The relatively low derived abundances, however, call for some mechanism to
diminish the H2O gas in the post-shock region. Among the possible scenarios, we
favor H2O photodissociation, which requires the superposition of a low velocity
non-dissociative shock with a fast dissociative shock able to produce a FUV
field of sufficient strength.Comment: 16 pages, 13 figures, accepted for publication on Astronomy &
Astrophysic
Treatment of hepatocellular carcinoma with immune checkpoint inhibitors and applicability of first-line atezolizumab/bevacizumab in a real-life setting
Immune checkpoint inhibitors (ICIs) are the new frontier for the treatment of advanced hepatocellular carcinoma (HCC). Since the first trial with tremelimumab, a cytotoxic T-lymphocyte-associated protein 4 inhibitor, increasing evidence has confirmed that these drugs can significantly extend the survival of patients with advanced hepatocellular carcinoma (HCC). As a matter of fact, the overall survival and objective response rates reported in patients with advanced HCC treated with ICIs are the highest ever reported in the second-line setting and, most recently, the combination of the anti-programmed death ligand protein-1 atezolizumab with bevacizumab—an anti-vascular endothelial growth factor monoclonal antibody—demonstrated superiority to sorafenib in a Phase III randomized clinical trial. Therefore, this regimen has been approved in several countries as first-line treatment for advanced HCC and is soon expected to be widely used in clinical practice. However, despite the promising results of trials exploring ICIs alone or in combination with other agents, there are still some critical issues to deal with to optimize the prognosis of advanced HCC patients. For instance, the actual proportion of patients who are deemed eligible for ICIs in the real-life ranges from 10% to 20% in the first-line setting, and is even lower in the second-line scenario. Moreover, long-term data regarding the safety of ICIs in the population of patients with cirrhosis and impaired liver function are lacking. Lastly, no biomarkers have been identified to predict response, and thus to help clinicians to individually tailor treatment. This review aimed to summarize the state of the art immunotherapy in HCC and, by analyzing a large, multicenter cohort of Italian patients with HCC, to assess the potential applicability of the combination of atezolizumab/bevacizumab in the real-life setting
Molecular interactions, characterization and photoactivity of Chlorophyll a/chitosan/2-HP-β-cyclodextrin composite films as functional and active surfaces for ROS production
Novel photosensitizing film based on the natural hybrid polymer Chitosan/2-hydroxy-propyl-β-Cyclodextrin (CH/CD) is synthesized introducing Chlorophyll a (CH/CD/Chla) as a photoactive agent for possible application in antimicrobial photodynamic therapy (PDT). The polymer absorbs visible light, in turn able to generate reactive oxygen species (ROS) and, therefore it can be used as environmental friendly and biodegradable polymeric photosensitizer (PS). The modified film is characterized by means of different spectroscopic, calorimetric, diffraction techniques and microscopic imaging methods including time-resolved absorption spectroscopy. UV–Vis, FTIR-ATR and X-ray Photoelectron Spectroscopy (XPS) analyses suggest that Chla shows a strong affinity toward Chitosan introducing interactions with amino groups present on the polymer chains. Nanosecond laser flash photolysis technique provides evidence for the population of the excited triplet state of Chla. Photogeneration of singlet oxygen is demonstrated by both direct detection by using infrared luminescence spectroscopy and chemical methods based on the use of suitable traps. Scanning Electron Microscopy (SEM), Atomic Force Microscopy (AFM) and Differential Scanning Calorimetry (DSC) analyses confirm also the occurrence of structural changes both on the film surface and within the film layer induced by the insertion of the pigment. Moreover, X-ray Diffraction data (XRD) shows the existence of an amorphous phase for the chitosan films in all the compared conditions
Reversible melting and equilibrium phase formation of (Bi,Pb)2Sr2Ca2Cu3O10+d
The decomposition and the reformation of the (Bi,Pb)2Sr2Ca2Cu3O10+d
(?Bi,Pb(2223)?) phase have been investigated in-situ by means of
High-Temperature Neutron Diffraction, both in sintered bulk samples and in
Ag-sheathed monofilamentary tapes. Several decomposition experiments were
performed at various temperatures and under various annealing atmospheres,
under flowing gas as well as in sealed tubes, in order to study the appropriate
conditions for Bi,Pb(2223) formation from the melt. The Bi,Pb(2223) phase was
found to melt incongruently into (Ca,Sr)2CuO3, (Sr,Ca)14Cu24O41 and a
Pb,Bi-rich liquid phase. Phase reformation after melting was successfully
obtained both in bulk samples and Ag-sheathed tapes. The possibility of
crystallising the Bi,Pb(2223) phase from the melt was found to be extremely
sensitive to the temperature and strongly dependent on the Pb losses. The study
of the mass losses due to Pb evaporation was complemented by thermogravimetric
analysis which proved that Pb losses are responsible for moving away from
equilibrium and therefore hinder the reformation of the Bi,Pb(2223) phase from
the melt. Thanks to the full pattern profile refinement, a quantitative phase
analysis was carried out as a function of time and temperature and the role of
the secondary phases was investigated. Lattice distortions and/or transitions
were found to occur at high temperature in Bi,Pb(2223), Bi,Pb(2212),
(Ca,Sr)2CuO3 and (Sr,Ca)14Cu24O41, due to cation diffusion and stoichiometry
changes. The results indicate that it is possible to form the Bi,Pb(2223) phase
from a liquid close to equilibrium conditions, like Bi(2212) and Bi(2201), and
open new unexplored perspectives for high-quality Ag-sheathed Bi,Pb(2223) tape
processing.Comment: 45 pages (including references,figures and captions), 13 figures
Submitted to Supercond. Sci. Techno
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