Effectiveness and cost-effectiveness of a lifestyle modification programme in the prevention and treatment of subclinical, mild and moderate depression in primary care: A randomised clinical trial protocol

Introduction Major depression is a highly prevalent pathology that is currently the second most common cause of disease-induced disability in our society. The onset and continuation of depression may be related to a wide variety of biological and psychosocial factors, many of which are linked to different lifestyle aspects. Therefore, health systems must design and implement health promotion and lifestyle modification programmes (LMPs), taking into account personal factors and facilitators. The main objective of this protocol is to analyse the clinical effectiveness, cost-effectiveness and cost utility of an LMP and an LMP with information and communication technologies (ICTs) as adjunctive treatment for depression in primary care patients. The secondary objectives are to analyse the clinical effectiveness in the subgroup that presents comorbidity and to analyse the correlation between personal factors on health behaviour and lifestyle patterns. Methods and analysis A randomised, multicenter pragmatic clinical trial with three parallel groups consisting of primary healthcare patients suffering from subclinical, mild or moderate depression. The following interventions will be used: (1) Usual antidepressant treatment with psychological advice and/or psychotropic drugs prescribed by the general practitioner (treatment as usual (TAU)). (2) TAU+LMP. A programme to be imparted in six weekly 90-minute group sessions, intended to improve the following aspects: behavioural activation+daily physical activity+adherence to the Mediterranean diet pattern+sleep hygiene+careful exposure to sunlight. (3) TAU+LMP+ICTs: healthy lifestyle recommendations (TAU+LMP)+monitoring using ICTs (a wearable smartwatch). The primary outcome will be the depressive symptomatology and the secondary outcomes will be the quality of life, the use of health and social resources, personal factors on health behaviour, social support, lifestyle patterns and chronic comorbid pathology. Data will be collected before and after the intervention, with 6-month and 12-month follow-ups. Ethics and dissemination This study has been approved by the Clinical Research Ethics Committee of Aragón (approval number: C.P.-C.I. PI18/286) and the Research Ethics Committee of the Balearic Islands (IB3950/19 PI). Data distribution will be anonymous. Results will be disseminated via conferences and papers published in peer-reviewed, open-access journals. Trial registration number ClinicalTrials.gov Registry (NCT03951350)

Дискурсивные стратегии в политическом дискурсе Ксении Собчак, кандидата в президенты Российской Федерации

The article examines the main strategies of Ksenia Sobchak’s personal discourse and their linguistic implementation. The study is based on the texts from the electoral programme for her presidential candidacy, posted on the official “Civic Initiative” party website, appearances in debates on various Russian TV channels, and posts on social media accounts during the 2018 Russian presidential election campaign. We develop a corpus that presents communicative, pragmatic, gender-based and linguocultural features of the public speeches of an oppositional female politician. Critical discourse analysis and the linguopragmatic method are applied. The linguistic method she uses to create identity is also analysed. The work explores the discursive strategies and techniques, as well as the linguistic and rhetorical resources, used by the candidate to influence the electorate. The analysis proves that Ksenia Sobchak’s discursive activity is based on word play, which is determined by the communicative objective of her electoral campaignВ статье рассматриваются основные стратегии персонального дискурса Ксении Собчак и их языковая реализация. Материалом исследования послужили тексты предвыборной программы кандидата в президенты, размещенные на официальном сайте партии “Гражданская инициатива”, выступления в дебатах на различных российских телеканалах, а также публикации в социальных сетях во время президентской избирательной кампании 2018 года в России. Составлен корпус, выделены коммуникативные, прагматические, гендерные и лингвокультурные особенности публичных оппозиционных выступлений женщины-политика. Применяются методы дискурс-анализа, лингвопрагматический, описательный, позволяющие воссоздать языковую личность политика. Выделены дискурсивные стратегии и тактики, лингвистические и риторические ресурсы, используемые кандидатом для воздействия на электорат. Анализ доказывает, что дискурсивная деятельность Ксении Собчак основана на языковой игре, имеющей коммуникативную обусловленност

Primitive Cretaceous island-arc volcanic rocks in eastern Cuba : the Téneme Formation

The Téneme Formation is located in the Mayarí-Cristal ophiolitic massif and represents one of the three Cretaceous volcanic Formations established in northeastern Cuba. Téneme volcanics are cut by small bodies of 89.70 ± 0.50 Ma quarz-diorite rocks (Río Grande intrusive), and are overthrusted by serpentinized ultramafics. Téneme volcanic rocks are mainly basalts, basaltic andesites, andesites, and minor dacites, and their geochemical signature varies between low-Ti island arc tholeiites (IAT) with boninitic affinity (TiO2 < 0.4 %; high field strength elements « N-type MORB) and typical oceanic arc tholeiites (TiO2 = 0.5-0.8 %). Basaltic rocks exhibit low light REE/Yb ratios (La/Yb < 5), typical of intraoceanic arcs and are comparable to Maimón Formation in Dominican Republic (IAT, pre Albian) and Puerto Rican lavas of volcanic phase I (island arc tholeiites, Aptian to Early Albian). The mantle wedge signature of the Téneme Formation indicates a highly depleted MORB-type mantle source, without any contribution of E-MORB or OIB components. Our results suggest that Téneme volcanism represents a primitive oceanic island arc environment. If the Late Cretaceous age (Turonian or early Coniacian) proposed for Téneme Formation is correct, our results indicate that the Cretaceous volcanic rocks of eastern Cuba and the Dominican Republic are not segments of a single arc system, and that in Late Cretaceous (Albian-Campanian) Caribbean island arc development is not represented only by calc-alkaline (CA) volcanic rocks as has been suggested in previous works

Platinum-group elements, S, Se and Cu in highly depleted abyssal peridotites from the Mid-Atlantic Ocean Ridge (ODP Hole 1274A): Influence of hydrothermal and magmatic processes

Highly depleted harzburgites and dunites were recovered from ODP Hole 1274A, near the intersection between the Mid-Atlantic Ocean Ridge and the 15°20′N Fracture Zone. In addition to high degrees of partial melting, these peridotites underwent multiple episodes of melt-rock reaction and intense serpentinization and seawater alteration close to the seafloor. Low concentrations of Se, Cu and platinum-group elements (PGE) in harzburgites drilled at around 35-85 m below seafloor are consistent with the consumption of mantle sulfides after high degrees (>15-20 %) of partial melting and redistribution of chalcophile and siderophile elements into PGE-rich residual microphases. Higher concentrations of Cu, Se, Ru, Rh and Pd in harzburgites from the uppermost and lowest cores testify to late reaction with a sulfide melt. Dunites were formed by percolation of silica- and sulfur-undersaturated melts into low-Se harzburgites. Platinum-group and chalcophile elements were not mobilized during dunite formation and mostly preserve the signature of precursor harzburgites, except for higher Ru and lower Pt contents caused by precipitation and removal of platinum-group minerals. During serpentinization at low temperature (<250 °C) and reducing conditions, mantle sulfides experienced desulfurization to S-poor sulfides (mainly heazlewoodite) and awaruite. Contrary to Se and Cu, sulfur does not record the magmatic evolution of peridotites but was mostly added in hydrothermal sulfides and sulfate from seawater. Platinum-group elements were unaffected by post-magmatic low-temperature processes, except Pt and Pd that may have been slightly remobilized during oxidative seawater alteration