463 research outputs found
Influence of STAT4 polymorphism in primary Sjögren's syndrome
Objective. To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS). Methods. Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date. Results. Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 = 10-6, OR 1.40, 95% CI 1.21-1.62). Conclusion. These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene. The Journal of Rheumatology Copyright © 2010. All rights reserved
On the complexity of strongly connected components in directed hypergraphs
We study the complexity of some algorithmic problems on directed hypergraphs
and their strongly connected components (SCCs). The main contribution is an
almost linear time algorithm computing the terminal strongly connected
components (i.e. SCCs which do not reach any components but themselves).
"Almost linear" here means that the complexity of the algorithm is linear in
the size of the hypergraph up to a factor alpha(n), where alpha is the inverse
of Ackermann function, and n is the number of vertices. Our motivation to study
this problem arises from a recent application of directed hypergraphs to
computational tropical geometry.
We also discuss the problem of computing all SCCs. We establish a superlinear
lower bound on the size of the transitive reduction of the reachability
relation in directed hypergraphs, showing that it is combinatorially more
complex than in directed graphs. Besides, we prove a linear time reduction from
the well-studied problem of finding all minimal sets among a given family to
the problem of computing the SCCs. Only subquadratic time algorithms are known
for the former problem. These results strongly suggest that the problem of
computing the SCCs is harder in directed hypergraphs than in directed graphs.Comment: v1: 32 pages, 7 figures; v2: revised version, 34 pages, 7 figure
Ferromagnetic models for cooperative behavior: Revisiting Universality in complex phenomena
Ferromagnetic models are harmonic oscillators in statistical mechanics.
Beyond their original scope in tackling phase transition and symmetry breaking
in theoretical physics, they are nowadays experiencing a renewal applicative
interest as they capture the main features of disparate complex phenomena,
whose quantitative investigation in the past were forbidden due to data
lacking. After a streamlined introduction to these models, suitably embedded on
random graphs, aim of the present paper is to show their importance in a
plethora of widespread research fields, so to highlight the unifying framework
reached by using statistical mechanics as a tool for their investigation.
Specifically we will deal with examples stemmed from sociology, chemistry,
cybernetics (electronics) and biology (immunology).Comment: Contributing to the proceedings of the Conference "Mathematical
models and methods for Planet Heart", INdAM, Rome 201
High-energy gamma-ray emission from the inner jet of LS I+61 303: the hadronic contribution revisited
LS I+61 303 has been detected by the Cherenkov telescope MAGIC at very high
energies, presenting a variable flux along the orbital motion with a maximum
clearly separated from the periastron passage. In the light of the new
observational constraints, we revisit the discussion of the production of
high-energy gamma rays from particle interactions in the inner jet of this
system. The hadronic contribution could represent a major fraction of the TeV
emission detected from this source. The spectral energy distribution resulting
from p-p interactions is recalculated. Opacity effects introduced by the photon
fields of the primary star and the stellar decretion disk are shown to be
essential in shaping the high-energy gamma-ray light curve at energies close to
200 GeV. We also present results of Monte Carlo simulations of the
electromagnetic cascades developed very close to the periastron passage. We
conclude that a hadronic microquasar model for the gamma-ray emission in LS I
+61 303 can reproduce the main features of its observed high-energy gamma-ray
flux.Comment: 6 pages. Sligth improvements made. Accepted version by Astrophysics
and Space Scienc
AlGaAs/GaAs/AlGaAs quantum wells as a sensitive tool for the MOVPE reactor environment
We present in this work a simple Quantum Well (QW) structure consisting of
GaAs wells with AlGaAs barriers as a probe for measuring the performance of
arsine purifiers within a MetalOrganic Vapour Phase Epitaxy system. Comparisons
between two different commercially available purifiers are based on the
analysis of low temperature photoluminescence emission spectra from thick QWs,
grown on GaAs substrates misoriented slightly from (100). Neutral excitons
emitted from these structures show extremely narrow linewidths, comparable to
those which can be obtained by Molecular Beam Epitaxy in an ultra-high vacuum
environment, suggesting that purifications well below the 1ppb level are needed
to achieve high quality quantum well growth
Global well-posedness for the KP-I equation on the background of a non localized solution
We prove that the Cauchy problem for the KP-I equation is globally well-posed
for initial data which are localized perturbations (of arbitrary size) of a
non-localized (i.e. not decaying in all directions) traveling wave solution
(e.g. the KdV line solitary wave or the Zaitsev solitary waves which are
localized in and periodic or conversely)
Learedius learedi Price 1934 (Digenea, Spirorchiidae) in Chelonia mydas Linnaeus 1758 (Testudines, Chelonidae) in Brazil: case report
Observation of hard scattering in photoproduction events with a large rapidity gap at HERA
Events with a large rapidity gap and total transverse energy greater than 5
GeV have been observed in quasi-real photoproduction at HERA with the ZEUS
detector. The distribution of these events as a function of the
centre of mass energy is consistent with diffractive scattering. For total
transverse energies above 12 GeV, the hadronic final states show predominantly
a two-jet structure with each jet having a transverse energy greater than 4
GeV. For the two-jet events, little energy flow is found outside the jets. This
observation is consistent with the hard scattering of a quasi-real photon with
a colourless object in the proton.Comment: 19 pages, latex, 4 figures appended as uuencoded fil
Observation of Scaling Violations in Scaled Momentum Distributions at HERA
Charged particle production has been measured in deep inelastic scattering
(DIS) events over a large range of and using the ZEUS detector. The
evolution of the scaled momentum, , with in the range 10 to 1280
, has been investigated in the current fragmentation region of the Breit
frame. The results show clear evidence, in a single experiment, for scaling
violations in scaled momenta as a function of .Comment: 21 pages including 4 figures, to be published in Physics Letters B.
Two references adde
D* Production in Deep Inelastic Scattering at HERA
This paper presents measurements of D^{*\pm} production in deep inelastic
scattering from collisions between 27.5 GeV positrons and 820 GeV protons. The
data have been taken with the ZEUS detector at HERA. The decay channel
(+ c.c.) has been used in the study. The
cross section for inclusive D^{*\pm} production with
and is 5.3 \pms 1.0 \pms 0.8 nb in the kinematic region
{ GeV and }. Differential cross
sections as functions of p_T(D^{*\pm}), and are
compared with next-to-leading order QCD calculations based on the photon-gluon
fusion production mechanism. After an extrapolation of the cross section to the
full kinematic region in p_T(D^{*\pm}) and (D^{*\pm}), the charm
contribution to the proton structure function is
determined for Bjorken between 2 10 and 5 10.Comment: 17 pages including 4 figure
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